Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 71 % | Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cells | ChEMBL. | 9873612 |
Efficacy (functional) | = 71 % | Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cells | ChEMBL. | 9873612 |
IC50 (functional) | = 496 nM | Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cells | ChEMBL. | 9873612 |
IC50 (functional) | = 496 nM | Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cells | ChEMBL. | 9873612 |
Ki (binding) | = -7.81 | Displacement of [3H]progesterone from Progesterone receptor | ChEMBL. | 16821785 |
Ki (binding) | = 15.5 nM | Binding affinity against human progesterone receptor-A (hPR-A) | ChEMBL. | 9873612 |
Ki (binding) | = 15.5 nM | Binding affinity against human progesterone receptor-A (hPR-A) | ChEMBL. | 9873612 |
Log Ki (binding) | = 7.81 | Displacement of [3H]progesterone from Progesterone receptor | ChEMBL. | 16821785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.