TDR Targets

Basic information

Technical information

TDR Targets ID: 1540685
Name: methyl 3-[[4-[(2-methoxyphenyl)-methylsulfamo yl]benzoyl]amino]benzoate
MW: 454.496 | Formula: C23H22N2O6S
H donors: 1 H acceptors: 4 LogP: 3.29 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1cccc(c1)NC(=O)c1ccc(cc1)S(=O)(=O)N(c1ccccc1OC)C
InChi: 1S/C23H22N2O6S/c1-25(20-9-4-5-10-21(20)30-2)32(28,29)19-13-11-16(12-14-19)22(26)24-18-8-6-7-17(15-18)23(27)31-3/h4-15H,1-3H3,(H,24,26)
InChiKey: ZQUQAKWQZYUNSE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl 3-[[4-[(2-methoxyphenyl)-methyl-sulfamoyl]benzoyl]amino]benzoate
3-[[[4-[(2-methoxyphenyl)-methylsulfamoyl]phenyl]-oxomethyl]amino]benzoic acid methyl ester
3-[[4-[(2-methoxyphenyl)-methyl-sulfamoyl]benzoyl]amino]benzoic acid methyl ester
methyl 3-[[4-[(2-methoxyphenyl)-methyl-sulfamoyl]phenyl]carbonylamino]benzoate
ZINC03284856
T0520-1281

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Rap guanine nucleotide exchange factor (GEF) 4	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	Get druggable targets OG5_131726	All targets in OG5_131726
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131726	All targets in OG5_131726
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	N-terminal motif family protein	Get druggable targets OG5_131726	All targets in OG5_131726
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0017	0.0054	0.0043
Brugia malayi	hypothetical protein	0.0133	0.19	0.1891
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0017	0.0054	0.0043
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0277	0.4213	0.4206
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0017	0.0054	0.0043
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0019	0.0088	0.0124
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0017	0.0054	0.0087
Entamoeba histolytica	G protein alpha subunit, putative	0.0017	0.0054	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0639	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0403	0.6224	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0096	0.1308	0.2087
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0106	0.0094
Schistosoma mansoni	smad	0.0044	0.0474	0.0761
Echinococcus granulosus	Smad4	0.0044	0.0474	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0054	0.0043
Brugia malayi	Latrophilin receptor protein 2	0.0096	0.1308	0.1298
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0017	0.0054	0.0069
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0017	0.0054	0.0087
Onchocerca volvulus		0.0017	0.0054	0.0066
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0034	0.0023
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0034	0.0037
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0017	0.0054	0.0069
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0403	0.6224	1
Schistosoma mansoni	dep domain containing protein	0.0021	0.0106	0.017
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0017	0.0054	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0207	0.3085	0.3077
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0017	0.0054	0.0043
Schistosoma mansoni	smad1 5 8 and	0.0044	0.0474	0.0761
Echinococcus granulosus	regulator of G protein signaling 7	0.0021	0.0106	0.0152
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0096	0.1308	0.2087
Schistosoma mansoni	hypothetical protein	0.0096	0.1308	0.2102
Echinococcus granulosus	mothers against decapentaplegic 6	0.0019	0.0088	0.0124
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0044	0.0474	0.0744
Schistosoma mansoni	Smad4	0.0019	0.0088	0.0142
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0034	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0417	0.6456	0.6452
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.4213	0.6769
Brugia malayi	TAR-binding protein	0.0277	0.4213	0.4206
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0017	0.0054	0.0069
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.4213	0.6769
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0403	0.6224	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0088	0.0077
Brugia malayi	hypothetical protein	0.0021	0.0106	0.0094
Loa Loa (eye worm)	DIX domain-containing protein	0.0021	0.0106	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0054	0.0043
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0021	0.0106	0.0146
Schistosoma mansoni	hypothetical protein	0.0096	0.1308	0.2102
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0302	0.4616	0.461
Schistosoma mansoni	hypothetical protein	0.0096	0.1308	0.2102
Echinococcus multilocularis	segment polarity protein dishevelled	0.0021	0.0106	0.0152
Trypanosoma brucei	PAB1-binding protein , putative	0.0133	0.19	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0034	0.5
Echinococcus multilocularis	regulator of G protein signaling 7	0.0021	0.0106	0.0152
Brugia malayi	MH1 domain containing protein	0.0044	0.0474	0.0463
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0044	0.0474	0.0744
Echinococcus multilocularis	tar DNA binding protein	0.0277	0.4213	0.6763
Echinococcus granulosus	segment polarity protein dishevelled	0.0021	0.0106	0.0152
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0017	0.0054	0.0087
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0017	0.0054	0.0043
Brugia malayi	MH1 domain containing protein	0.0024	0.0162	0.0151
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.4213	0.6769
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0015	0.0011	0.0018
Onchocerca volvulus		0.0017	0.0054	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0054	0.0043
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0015	0.0011	0.0018
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0302	0.4616	0.461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0403	0.6224	1
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0017	0.0054	0.0043
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0044	0.0474	0.0761
Schistosoma mansoni	smad1 5 8 and	0.0044	0.0474	0.0761
Brugia malayi	RNA recognition motif domain containing protein	0.0277	0.4213	0.4206
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0054	0.0043
Loa Loa (eye worm)	MH1 domain-containing protein	0.0019	0.0088	0.0077
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0017	0.0054	1
Brugia malayi	MH2 domain containing protein	0.0044	0.0474	0.0463
Toxoplasma gondii	hypothetical protein	0.0021	0.0106	0.0384
Brugia malayi	regulator of G-protein signaling egl-10	0.0021	0.0106	0.0094
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0096	0.1308	0.2087
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0403	0.6224	1
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0017	0.0054	0.0069
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0017	0.0054	1
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0017	0.0054	0.0087
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0302	0.4616	0.461
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0017	0.0054	1
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0017	0.0054	0.0087
Trypanosoma cruzi	PAB1-binding protein , putative	0.0133	0.19	1
Schistosoma mansoni	hypothetical protein	0.006	0.0729	0.1172
Brugia malayi	Smad1	0.0044	0.0474	0.0463
Onchocerca volvulus		0.0021	0.0106	0.0146
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0015	0.0011	0.0018
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0034	0.0037
Loa Loa (eye worm)	MH1 domain-containing protein	0.0044	0.0474	0.0463
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0017	0.0054	0.0043
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0017	0.0054	0.0069
Schistosoma mansoni	ras GTP exchange factor	0.0015	0.0011	0.0018
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0417	0.6456	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.006	0.0729	0.1156
Schistosoma mansoni	hypothetical protein	0.0207	0.3085	0.4957
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0017	0.0054	0.0069
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0017	0.0054	0.0043
Echinococcus granulosus	expressed protein	0.0017	0.0054	0.0069
Schistosoma mansoni	Smad4	0.0019	0.0088	0.0142
Schistosoma mansoni	hypothetical protein	0.0096	0.1308	0.2102
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0034	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0106	0.0094
Brugia malayi	hypothetical protein	0.0021	0.0106	0.0094
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0096	0.1308	0.1298
Brugia malayi	DIX domain containing protein	0.0021	0.0106	0.0094
Loa Loa (eye worm)	G protein alpha subunit 3	0.0017	0.0054	0.0043
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0017	0.0054	0.0043
Plasmodium vivax	ataxin-2 like protein, putative	0.0133	0.19	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.4616	0.461
Plasmodium falciparum	ataxin-2 like protein, putative	0.0133	0.19	1
Brugia malayi	N-terminal motif family protein	0.0417	0.6456	0.6452
Loa Loa (eye worm)	MH2 domain-containing protein	0.0044	0.0474	0.0463
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.4213	0.6769
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0017	0.0054	1
Echinococcus granulosus	GPCR family 2	0.0096	0.1308	0.2087
Brugia malayi	MH2 domain containing protein	0.0044	0.0474	0.0463
Echinococcus multilocularis	smad	0.0044	0.0474	0.0744
Echinococcus granulosus	segment polarity protein dishevelled	0.0021	0.0106	0.0152
Loa Loa (eye worm)	MH2 domain-containing protein	0.0019	0.0088	0.0077
Brugia malayi	mothers against decapentaplegic homolog 3	0.0019	0.0088	0.0077
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.006	0.0729	0.1156
Schistosoma mansoni	smad1 5 8 and	0.0044	0.0474	0.0761
Schistosoma mansoni	dishevelled	0.0021	0.0106	0.017
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0096	0.1308	0.1298
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0021	0.0106	0.0152
Schistosoma mansoni	Smad4	0.0044	0.0474	0.0761
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0034	0.0023
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0034	0.0055
Echinococcus granulosus	mothers against decapentaplegic 5	0.0044	0.0474	0.0744
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0403	0.6224	0.6219
Loa Loa (eye worm)	Smad1	0.0044	0.0474	0.0463
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0017	0.0054	0.0069
Trypanosoma cruzi	PAB1-binding protein , putative	0.0133	0.19	1
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0017	0.0054	0.0087
Loa Loa (eye worm)	RNA binding protein	0.0277	0.4213	0.4206
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0017	0.0054	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0034	0.0037
Schistosoma mansoni	z-protein (S1r protein)	0.0021	0.0106	0.017
Loa Loa (eye worm)	hypothetical protein	0.0133	0.19	0.1891
Brugia malayi	hypothetical protein	0.0017	0.0054	0.0043
Schistosoma mansoni	smad	0.0019	0.0088	0.0142
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0017	0.0054	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1308	0.1298
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0044	0.0474	0.0744
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0017	0.0054	0.0087
Onchocerca volvulus		0.0017	0.0054	0.0066
Brugia malayi	MH2 domain containing protein	0.0019	0.0088	0.0077
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0034	0.0121
Brugia malayi	G-protein alpha subunit	0.0017	0.0054	0.0043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0403	0.6224	1
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0021	0.0106	0.017
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0017	0.0054	0.0043
Loa Loa (eye worm)	TAR-binding protein	0.0277	0.4213	0.4206
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0021	0.0106	0.0094
Brugia malayi	latrophilin 2 splice variant baaae	0.0207	0.3085	0.3077
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0054	0.0043
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0017	0.0054	0.0087
Brugia malayi	hypothetical protein	0.0086	0.1148	0.1138
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0034	0.0037
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0017	0.0054	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0021	0.0106	0.0094
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0019	0.0088	0.0119
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0096	0.1308	0.2087
Plasmodium falciparum	ataxin-2 like protein, putative	0.0133	0.19	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0021	0.0106	0.0152
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0017	0.0054	1
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0017	0.0054	0.0087
Echinococcus multilocularis	expressed protein	0.0017	0.0054	0.0069
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0034	0.0121
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0017	0.0054	0.0087
Loa Loa (eye worm)	nuclear factor I	0.0024	0.0162	0.0151
Echinococcus granulosus	tar DNA binding protein	0.0277	0.4213	0.6763
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0017	0.0054	0.0087
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0019	0.0088	0.0124
Echinococcus multilocularis	Smad4	0.0044	0.0474	0.0744
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0017	0.0054	0.0043
Schistosoma mansoni	regulator of G protein signaling	0.0021	0.0106	0.017
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0403	0.6224	0.6219
Schistosoma mansoni	tar DNA-binding protein	0.0277	0.4213	0.6769
Echinococcus granulosus	smad	0.0044	0.0474	0.0744
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0034	0.0023
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0017	0.0054	0.0043
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0015	0.0011	0.0018
Leishmania major	hypothetical protein, conserved	0.0133	0.19	1
Brugia malayi	MH1 domain containing protein	0.0044	0.0474	0.0463
Brugia malayi	RNA binding protein	0.0277	0.4213	0.4206
Loa Loa (eye worm)	transcription factor SMAD2	0.0639	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0403	0.6224	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0106	0.0094
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0021	0.0106	0.0152
Echinococcus multilocularis	regulator of G protein signaling 7	0.0021	0.0106	0.0152
Schistosoma mansoni	dishevelled	0.0021	0.0106	0.017
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0162	0.0151
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0017	0.0054	0.0069
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0017	0.0054	0.0087
Toxoplasma gondii	LsmAD domain-containing protein	0.0133	0.19	1
Brugia malayi	MH1 domain containing protein	0.0024	0.0162	0.0151
Echinococcus multilocularis	GPCR, family 2	0.0096	0.1308	0.2087
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0017	0.0054	0.0087
Echinococcus granulosus	mothers against decapentaplegic 2	0.0019	0.0088	0.0124
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0021	0.0106	0.0094
Echinococcus multilocularis	segment polarity protein dishevelled	0.0021	0.0106	0.0152
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0017	0.0054	1
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0017	0.0054	0.0043

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1900256

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1540685