Detailed information for compound 1540771

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 660.835 | Formula: C37H56O10
  • H donors: 3 H acceptors: 6 LogP: 4.83 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=CC(=C)[C@@H]([C@@H]1CCC23C1(CC[C@H]1[C@@]3(C)[C@H](O[C@@H]3O[C@H](COC(=O)C)[C@H]([C@@H]([C@H]3O)O)O)C[C@@H]3[C@]1(C)CC[C@H](C3(C)C)OC(=O)C)C2)C
  • InChi: 1S/C37H56O10/c1-19(16-38)20(2)23-9-14-37-18-36(23,37)13-10-25-34(7)12-11-27(45-22(4)40)33(5,6)26(34)15-28(35(25,37)8)47-32-31(43)30(42)29(41)24(46-32)17-44-21(3)39/h16,20,23-32,41-43H,1,9-15,17-18H2,2-8H3/t20-,23-,24+,25+,26-,27+,28+,29+,30-,31+,32-,34+,35-,36?,37?/m0/s1
  • InChiKey: PLLGLZXFRKRKBT-RECXVKIASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii DNA topoisomerase family protein 0.0155 0.0089 0.092
Brugia malayi DNA topoisomerase II, alpha isozyme 0.1367 0.0959 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0011 0.006
Brugia malayi Histone deacetylase family protein 0.0762 0.0525 0.547
Brugia malayi Probable DNA topoisomerase II 0.1367 0.0959 1
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0046 0.0011 0.0109
Plasmodium falciparum endoplasmin, putative 0.0115 0.0061 0.036
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0011 0.0061
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0155 0.0089 0.023
Loa Loa (eye worm) hypothetical protein 0.0102 0.0052 0.0529
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Trichomonas vaginalis histone deacetylase, putative 0.0936 0.065 0.6758
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0046 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Plasmodium vivax histone deacetylase, putative 0.0551 0.0374 0.2681
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0011 0.0042
Schistosoma mansoni histone deacetylase 4 5 0.0762 0.0525 0.1353
Echinococcus multilocularis BRCA1 associated protein 0.0046 0.0011 0.0027
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0102 0.0052 0.0046
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Plasmodium falciparum potassium channel 0.0046 0.0011 0.0001
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.1367 0.0959 0.2473
Loa Loa (eye worm) histone deacetylase 0.0762 0.0525 0.547
Loa Loa (eye worm) hypothetical protein 0.0638 0.0436 0.4543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Brugia malayi heat shock protein 90 0.0128 0.007 0.0718
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0046 0.0011 0.0109
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 1.3973 1 1
Trypanosoma brucei heat shock protein, putative 0.0128 0.007 0.0469
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0712 0.0489 0.0484
Leishmania major cathepsin L-like protease 0.0068 0.0027 0.0155
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Plasmodium falciparum heat shock protein 90 0.0128 0.007 0.0423
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0102 0.0052 0.0046
Trypanosoma cruzi histone deacetylase, putative 0.0551 0.0374 0.2693
Mycobacterium leprae Probable two-component sensor kinase 0.0102 0.0052 0.0046
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0155 0.0089 0.0228
Mycobacterium ulcerans two component sensor kinase MprB 0.0102 0.0052 0.0046
Schistosoma mansoni histone deacetylase 0.0936 0.065 0.1675
Trypanosoma cruzi DNA topoisomerase III, putative 0.0155 0.0089 0.0612
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 1.3973 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0936 0.065 0.6758
Trypanosoma cruzi DNA topoisomerase III, putative 0.0155 0.0089 0.0612
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.197 0.1391 0.1386
Echinococcus multilocularis histone deacetylase 8 0.5431 0.3873 1
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0011 0.0042
Trichomonas vaginalis histone deacetylase, putative 0.0936 0.065 0.6758
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0155 0.0089 0.0878
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Schistosoma mansoni brca1-associated protein (brap2) 0.0046 0.0011 0.0027
Schistosoma mansoni hypothetical protein 0.018 0.0107 0.0274
Chlamydia trachomatis DNA gyrase subunit B 0.1393 0.0977 0.6911
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0011 0.0042
Leishmania major DNA topoisomerase III, putative 0.0155 0.0089 0.0612
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0011 0.0042
Trypanosoma brucei histone deacetylase 4 0.0762 0.0525 0.3799
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0769 0.053 0.5524
Loa Loa (eye worm) histone deacetylase 1 0.0936 0.065 0.6774
Echinococcus granulosus histone deacetylase 6 0.0808 0.0558 0.144
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0102 0.0052 0.0046
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0612 0.0417 0.0412
Toxoplasma gondii ion channel protein 0.0046 0.0011 0.0109
Trypanosoma brucei heat shock protein, putative 0.0128 0.007 0.0469
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0155 0.0089 0.0878
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 1.3973 1 1
Schistosoma mansoni hypothetical protein 0.0046 0.0011 0.0027
Leishmania major cathepsin L-like protease 0.0068 0.0027 0.0155
Chlamydia trachomatis DNA topoisomerase I 0.0155 0.0089 0.0281
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0046 0.0011 0.0027
Echinococcus granulosus calcium activated potassium channel variant 0.0046 0.0011 0.0029
Brugia malayi Histone deacetylase family protein 0.0762 0.0525 0.547
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0046 0.0011 0.0109
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0011 0.0108
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0155 0.0089 0.0281
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0102 0.0052 0.0046
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0102 0.0052 0.0046
Trypanosoma brucei histone deacetylase 3 0.0762 0.0525 0.3799
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Entamoeba histolytica heat shock protein 90, putative 0.0128 0.007 0.0617
Toxoplasma gondii ion channel protein 0.0046 0.0011 0.0109
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0046 0.0011 0.0109
Toxoplasma gondii histone deacetylase HDAC2 0.0936 0.065 0.6759
Onchocerca volvulus DNA topoisomerase 2 homolog 0.1047 0.0729 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0046 0.0011 0.0108
Leishmania major hypothetical protein, conserved 0.0102 0.0052 0.0337
Plasmodium vivax histone deacetylase, putative 0.0762 0.0525 0.3769
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0769 0.053 0.1366
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0102 0.0052 0.0046
Trypanosoma cruzi heat shock protein 90, putative 0.0115 0.006 0.0401
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0046 0.0011 0.0109
Onchocerca volvulus 0.0038 0.0005 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0046 0.0011 0.0109
Chlamydia trachomatis DNA gyrase subunit A 0.0612 0.0417 0.2732
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0046 0.0011 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Echinococcus granulosus potassium channel subfamily K 0.0046 0.0011 0.0029
Leishmania major histone deacetylase, putative 0.0936 0.065 0.4713
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0027 0.0155
Leishmania major developmentally regulated phosphoprotein-like protein 0.0102 0.0052 0.0337
Toxoplasma gondii histone deacetylase HDAC3 0.0936 0.065 0.6759
Loa Loa (eye worm) uncoordinated protein 58 0.0046 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0136 0.0075 0.0778
Loa Loa (eye worm) hypothetical protein 0.0769 0.053 0.5524
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.0137 0.1421
Plasmodium vivax heat shock protein 86, putative 0.0128 0.007 0.0494
Plasmodium vivax potassium channel, putative 0.0046 0.0011 0.0075
Echinococcus granulosus BRCA1 associated protein 0.0046 0.0011 0.0029
Schistosoma mansoni calcium-activated potassium channel 0.0046 0.0011 0.0027
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0102 0.0052 0.0046
Echinococcus granulosus histone deacetylase 0.0762 0.0525 0.1355
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0102 0.0052 0.0046
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0155 0.0089 0.0084
Trichomonas vaginalis set domain proteins, putative 0.0252 0.0159 0.161
Echinococcus multilocularis histone deacetylase 3 0.0936 0.065 0.1675
Loa Loa (eye worm) heat shock protein 90 0.0128 0.007 0.0718
Trypanosoma brucei calcium-activated potassium channel, putative 0.0046 0.0011 0.0043
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 1.3973 1 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0102 0.0052 0.0133
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0102 0.0052 0.0484
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0011 0.0042
Plasmodium falciparum histone deacetylase 2 0.0762 0.0525 0.3722
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0046 0.0011 0.0074
Schistosoma mansoni endoplasmin 0.0128 0.007 0.0177
Onchocerca volvulus Histone deacetylase 10 homolog 0.0551 0.0374 0.5118
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0011 0.0061
Plasmodium vivax DNA gyrase subunit B, putative 0.197 0.1391 1
Echinococcus multilocularis histone deacetylase 0.0762 0.0525 0.1353
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0046 0.0011 0.0142
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0046 0.0011 0.0029
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0011 0.006
Trypanosoma brucei heat shock protein, putative 0.0128 0.007 0.0469
Loa Loa (eye worm) hypothetical protein 0.0709 0.0487 0.5075
Brugia malayi Histone deacetylase 1 0.0936 0.065 0.6774
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0102 0.0052 0.0046
Entamoeba histolytica heat shock protein 90, putative 0.0128 0.007 0.0617
Toxoplasma gondii DNA topoisomerase 2, putative 0.1367 0.0959 0.9977
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trichomonas vaginalis histone deacetylase, putative 0.0936 0.065 0.6758
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0155 0.0089 0.023
Schistosoma mansoni heat shock protein 0.0128 0.007 0.0177
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0046 0.0011 0.0027
Echinococcus multilocularis geminin 0.018 0.0107 0.0274
Mycobacterium ulcerans ion transport protein 0.0046 0.0011 0.0006
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0769 0.053 0.1368
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0046 0.0011 0.0001
Echinococcus multilocularis potassium channel subfamily K 0.0046 0.0011 0.0027
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0102 0.0052 0.0131
Onchocerca volvulus 0.0038 0.0005 0.0063
Trypanosoma cruzi histone deacetylase, putative 0.0762 0.0525 0.3799
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0005 0.0048
Trichomonas vaginalis histone deacetylase, putative 0.0936 0.065 0.6758
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0046 0.0011 0.0108
Echinococcus granulosus histone deacetylase 3 0.0936 0.065 0.1677
Schistosoma mansoni heat shock protein 0.0128 0.007 0.0177
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0011 0.0061
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Chlamydia trachomatis DNA gyrase subunit A 0.0254 0.016 0.0811
Loa Loa (eye worm) hypothetical protein 0.0723 0.0497 0.5177
Leishmania major DNA topoisomerase III, putative 0.0155 0.0089 0.0612
Loa Loa (eye worm) beta-lactamase 0.0038 0.0005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Schistosoma mansoni calcium-activated potassium channel 0.0046 0.0011 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Trypanosoma cruzi DNA topoisomerase II, putative 0.1212 0.0847 0.6161
Brugia malayi DNA topoisomerase III beta-1 0.0155 0.0089 0.0922
Echinococcus multilocularis heat shock protein 90 0.0128 0.007 0.0177
Giardia lamblia DNA topoisomerase II 0.1265 0.0885 1
Schistosoma mansoni twik family of potassium channels-related 0.0046 0.0011 0.0027
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0046 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0102 0.0052 0.0046
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0016 0.0079
Loa Loa (eye worm) hypothetical protein 0.0709 0.0487 0.5075
Trypanosoma brucei heat shock protein 90, putative 0.0128 0.007 0.0469
Loa Loa (eye worm) hypothetical protein 0.0769 0.053 0.5524
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0046 0.0011 0.0109
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0102 0.0052 0.0528
Onchocerca volvulus 0.0046 0.0011 0.0143
Leishmania major cathepsin L-like protease 0.0068 0.0027 0.0155
Trypanosoma cruzi heat shock protein 85, putative 0.0128 0.007 0.0469
Toxoplasma gondii ABC1 family protein 0.0038 0.0005 0.0048
Echinococcus multilocularis potassium channel subfamily K 8 0.0046 0.0011 0.0027
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0102 0.0052 0.0046
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Loa Loa (eye worm) glutaminase 2 0.029 0.0186 0.1932
Trypanosoma cruzi ion transport protein, putative 0.0046 0.0011 0.0043
Leishmania major hypothetical protein, conserved 0.0046 0.0011 0.0043
Onchocerca volvulus 0.0046 0.0011 0.0143
Trypanosoma brucei heat shock protein, putative 0.0128 0.007 0.0469
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.197 0.1391 1
Plasmodium falciparum DNA gyrase subunit B 0.197 0.1391 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0936 0.065 0.6758
Brugia malayi Endoplasmin precursor 0.0128 0.007 0.0718
Echinococcus granulosus geminin 0.018 0.0107 0.0276
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0046 0.0011 0.0109
Leishmania major histone deacetylase, putative 0.0762 0.0525 0.3799
Echinococcus granulosus potassium channel subfamily K 8 0.0046 0.0011 0.0029
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0155 0.0089 0.0922
Mycobacterium ulcerans DNA gyrase subunit B 0.197 0.1391 0.1386
Leishmania major DNA topoisomerase ii 0.1212 0.0847 0.6161
Brugia malayi BRCA1-associated protein 2 containing protein 0.0046 0.0011 0.0108
Schistosoma mansoni histone deacetylase 1 2 3 0.5431 0.3873 1
Schistosoma mansoni twik family of potassium channels-related 0.0046 0.0011 0.0027
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0046 0.0011 0.0108
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trichomonas vaginalis histone deacetylase, putative 0.0936 0.065 0.6758
Treponema pallidum DNA topoisomerase I (topA) 0.0155 0.0089 0.0281
Trypanosoma brucei developmentally regulated phosphoprotein 0.0102 0.0052 0.0337
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0102 0.0052 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0011 0.0043
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0046 0.0011 0.0043
Trypanosoma brucei heat shock protein, putative 0.0128 0.007 0.0469
Schistosoma mansoni twik family of potassium channels-related 0.0769 0.053 0.1366
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0102 0.0052 0.0484
Leishmania major ion transport protein-like protein 0.0046 0.0011 0.0043
Schistosoma mansoni histone deacetylase 4 5 0.0762 0.0525 0.1353
Trypanosoma brucei heat shock protein 90, putative 0.0128 0.007 0.0469
Toxoplasma gondii histone deacetylase HDAC1 0.0762 0.0525 0.5457
Schistosoma mansoni endoplasmin 0.0128 0.007 0.0177
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0612 0.0417 0.2732
Plasmodium vivax DNA topoisomerase 3, putative 0.0155 0.0089 0.0635
Loa Loa (eye worm) histone deacetylase 3 0.0936 0.065 0.6774
Brugia malayi hypothetical protein 0.0046 0.0011 0.0109
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0102 0.0052 0.0046
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0859 0.0594 0.1533
Onchocerca volvulus 0.0038 0.0005 0.0063
Plasmodium vivax DNA gyrase subunit A, putative 0.0612 0.0417 0.2997
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trypanosoma cruzi histone deacetylase, putative 0.0762 0.0525 0.3799
Trypanosoma brucei heat shock protein, putative 0.0128 0.007 0.0469
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 1.3973 1 1
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0011 0.0042
Leishmania major calcium/potassium channel (CAKC), putative 0.0046 0.0011 0.0043
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0046 0.0011 0.0109
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trichomonas vaginalis brca1-associated protein, putative 0.0046 0.0011 0.006
Echinococcus multilocularis histone deacetylase 6 0.0808 0.0558 0.1438
Echinococcus multilocularis small conductance calcium activated potassium 0.0046 0.0011 0.0027
Chlamydia trachomatis DNA gyrase subunit B 0.197 0.1391 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0936 0.065 0.6758
Entamoeba histolytica histone deacetylase, putative 0.0936 0.065 0.6739
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0052 0.0365
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0046 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0048
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Schistosoma mansoni twik family of potassium channels-related 0.0046 0.0011 0.0027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0005 0.0012
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0046 0.0011 0.0109
Echinococcus multilocularis twik family of potassium channels 0.0046 0.0011 0.0027
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0046 0.0011 0.0074
Brugia malayi kinase, mitochondrial precursor 0.0102 0.0052 0.0529
Leishmania major histone deacetylase, putative 0.0936 0.065 0.4713
Loa Loa (eye worm) hypothetical protein 0.0136 0.0075 0.0778
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0638 0.0436 0.4543
Trypanosoma brucei DNA topoisomerase ii 0.1944 0.1372 1
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0155 0.0089 0.0612
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0011 0.0061
Echinococcus granulosus twik family of potassium channels 0.0046 0.0011 0.0029
Mycobacterium tuberculosis Possible two component sensor kinase 0.0102 0.0052 0.0046
Schistosoma mansoni histone deacetylase 0.0936 0.065 0.1675
Mycobacterium ulcerans two component regulator - sensor kinase 0.0102 0.0052 0.0046
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0046 0.0011 0.0029
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0102 0.0052 0.0131
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0155 0.0089 0.092
Brugia malayi beta-lactamase 0.0038 0.0005 0.0048
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0046 0.0011 0.0043
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0046 0.0011 0.0043
Plasmodium vivax endoplasmin, putative 0.0128 0.007 0.0494
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0102 0.0052 0.0046
Loa Loa (eye worm) endoplasmin 0.0128 0.007 0.0718
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1944 0.1372 1
Entamoeba histolytica DNA topoisomerase III, putative 0.0155 0.0089 0.0823
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0011 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0011 0.0074
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0046 0.0011 0.0109
Brugia malayi histone deacetylase 11 0.0551 0.0374 0.3892
Schistosoma mansoni twik family of potassium channels-related 0.0046 0.0011 0.0027
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1944 0.1372 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Plasmodium falciparum potassium channel 0.0046 0.0011 0.0001
Schistosoma mansoni calcium-activated potassium channel 0.0046 0.0011 0.0027
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0011 0.006
Toxoplasma gondii histone deacetylase HDAC5 0.0551 0.0374 0.3883
Echinococcus multilocularis histone deacetylase 6 0.0762 0.0525 0.1353
Trypanosoma brucei heat shock protein, putative 0.0128 0.007 0.0469
Brugia malayi glutaminase DH11.1 0.029 0.0186 0.1932
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0011 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Schistosoma mansoni DNA topoisomerase II 0.1367 0.0959 0.2473
Giardia lamblia DNA topoisomerase III 0.0155 0.0089 0.0892
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0046 0.0011 0.0109
Leishmania major hypothetical protein, conserved 0.0046 0.0011 0.0042
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0102 0.0052 0.0046
Onchocerca volvulus 0.0252 0.0159 0.217
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0102 0.0052 0.0484
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0046 0.0011 0.0042
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0011 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Plasmodium vivax histone deacetylase 2, putative 0.0762 0.0525 0.3769
Echinococcus granulosus histone deacetylase 7 0.0762 0.0525 0.1355
Mycobacterium ulcerans DNA gyrase subunit A 0.0612 0.0417 0.0412
Schistosoma mansoni histone deacetylase hda2 0.0551 0.0374 0.0962
Mycobacterium tuberculosis Conserved protein 0.0102 0.0052 0.0046
Plasmodium falciparum DNA topoisomerase 2 0.1367 0.0959 0.6867
Mycobacterium ulcerans transmembrane cation transporter 0.0046 0.0011 0.0006
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0102 0.0052 0.0293
Loa Loa (eye worm) TWK-28 protein 0.0046 0.0011 0.0109
Trichomonas vaginalis receptor histidine kinase, putative 0.0102 0.0052 0.0484
Schistosoma mansoni histone deacetylase hda2 0.0808 0.0558 0.1438
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trypanosoma cruzi heat shock protein 85, putative 0.0128 0.007 0.0469
Plasmodium falciparum histone deacetylase, putative 0.0762 0.0525 0.3722
Loa Loa (eye worm) TOPoisomerase family member 0.1367 0.0959 1
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0612 0.0417 0.4339
Trichomonas vaginalis DNA topoisomerase II, putative 0.1367 0.0959 1
Toxoplasma gondii histone deacetylase HDAC4 0.0551 0.0374 0.3883
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0046 0.0011 0.0027
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0155 0.0089 0.0228
Loa Loa (eye worm) hypothetical protein 0.0936 0.065 0.6774
Trypanosoma cruzi ion transport protein, putative 0.0046 0.0011 0.0043
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0011 0.006
Leishmania major DNA topoisomerase 1A 0.0155 0.0089 0.0612
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0155 0.0089 0.0228
Trypanosoma brucei DNA topoisomerase III, putative 0.0155 0.0089 0.0612
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0001 0.0002
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 1.3973 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0005 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0005 0.0048
Giardia lamblia Histone deacetylase 0.0936 0.065 0.7305
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0046 0.0011 0.0108
Mycobacterium tuberculosis Probable two component sensor kinase 0.0102 0.0052 0.0046
Echinococcus granulosus DNA topoisomerase 2 alpha 0.1367 0.0959 0.2475
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0046 0.0011 0.0109
Trypanosoma brucei DNA topoisomerase III, putative 0.0155 0.0089 0.0612
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0046 0.0011 0.0108
Trichomonas vaginalis heat shock protein, putative 0.0115 0.0061 0.0581
Echinococcus multilocularis potassium channel subfamily K 8 0.0046 0.0011 0.0027
Loa Loa (eye worm) TWK-7 protein 0.0046 0.0011 0.0109
Onchocerca volvulus 0.0155 0.0089 0.1212
Echinococcus granulosus potassium channel subfamily K 8 0.0046 0.0011 0.0029
Mycobacterium ulcerans glutaminase 0.029 0.0186 0.0181
Trypanosoma brucei DNA topoisomerase IA, putative 0.0155 0.0089 0.0612
Schistosoma mansoni twik family of potassium channels-related 0.0046 0.0011 0.0027
Trypanosoma brucei Heat shock protein 83, putative 0.0128 0.007 0.0469
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0046 0.0011 0.0043
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0046 0.0011 0.0029
Trypanosoma brucei histone deacetylase, putative 0.0762 0.0525 0.3799
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0027 0.0155
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0046 0.0011 0.0108
Plasmodium vivax DNA topoisomerase II, putative 0.1367 0.0959 0.689
Onchocerca volvulus 0.0046 0.0011 0.0143
Toxoplasma gondii heat shock protein HSP90 0.0128 0.007 0.0716
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.1212 0.0847 0.6161
Trichomonas vaginalis glutaminase, putative 0.029 0.0186 0.1893
Onchocerca volvulus 0.0046 0.0011 0.0143
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Leishmania major mitochondrial DNA topoisomerase II 0.1944 0.1372 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0048
Schistosoma mansoni brca1-associated protein (brap2) 0.0046 0.0011 0.0027
Plasmodium vivax histone deacetylase 1, putative 0.0936 0.065 0.4667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0048
Plasmodium falciparum DNA topoisomerase 3, putative 0.0155 0.0089 0.0565
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0011 0.0108
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0155 0.0089 0.0612
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trypanosoma cruzi heat shock protein 85, putative 0.0128 0.007 0.0469
Loa Loa (eye worm) hypothetical protein 0.0257 0.0162 0.1686
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0046 0.0011 0.0006
Brugia malayi histone deacetylase 1 (HD1) 0.0936 0.065 0.6774
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trichomonas vaginalis receptor histidine kinase, putative 0.0102 0.0052 0.0484
Trypanosoma cruzi DNA topoisomerase III, putative 0.0155 0.0089 0.0612
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0048
Brugia malayi beta-lactamase family protein 0.0038 0.0005 0.0048
Echinococcus granulosus histone deacetylase 8 0.5431 0.3873 1
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0046 0.0011 0.0108
Echinococcus granulosus histone deacetylase 1 0.0936 0.065 0.1677
Schistosoma mansoni twik family of potassium channels-related 0.0046 0.0011 0.0027
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0046 0.0011 0.0109
Toxoplasma gondii heat shock protein 90, putative 0.0128 0.007 0.0716
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Mycobacterium leprae Probable two component sensor kinase MprB 0.0102 0.0052 0.0046
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Echinococcus granulosus histone deacetylase 6 0.0762 0.0525 0.1355
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0102 0.0052 0.0337
Leishmania major potassium channel subunit-like protein 0.0046 0.0011 0.0043
Loa Loa (eye worm) hypothetical protein 0.0551 0.0374 0.3892
Trypanosoma cruzi histone deacetylase, putative 0.0551 0.0374 0.2693
Echinococcus multilocularis heat shock protein 0.0128 0.007 0.0177
Onchocerca volvulus 0.0046 0.0011 0.0143
Echinococcus multilocularis calcium activated potassium channel variant 0.0046 0.0011 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0102 0.0052 0.0046
Schistosoma mansoni hypothetical protein 0.018 0.0107 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Plasmodium falciparum DNA gyrase subunit A 0.0612 0.0417 0.2944
Trypanosoma cruzi histone deacetylase, putative 0.0762 0.0525 0.3799
Plasmodium vivax potassium channel, putative 0.0046 0.0011 0.0075
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Trypanosoma brucei histone deacetylase 1 0.0936 0.065 0.4713
Trypanosoma cruzi histone deacetylase 1, putative 0.0936 0.065 0.4713
Trichomonas vaginalis heat shock protein, putative 0.0128 0.007 0.0673
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0046 0.0011 0.0027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.0153 0.0148
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0046 0.0011 0.0027
Echinococcus multilocularis histone deacetylase 6 0.0762 0.0525 0.1353
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0011 0.0042
Entamoeba histolytica DNA topoisomerase III, putative 0.0155 0.0089 0.0823
Entamoeba histolytica DNA topoisomerase II, putative 0.1367 0.0959 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.1367 0.0959 1
Brugia malayi DNA topoisomerase III 0.0155 0.0089 0.0922
Brugia malayi GRF zinc finger family protein 0.0155 0.0089 0.0922
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0102 0.0052 0.0337
Loa Loa (eye worm) DNA topoisomerase III 0.0155 0.0089 0.0922
Trichomonas vaginalis BRCA1-associated protein, putative 0.0046 0.0011 0.006
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0046 0.0011 0.0109
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0612 0.0417 0.2732
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0046 0.0011 0.0027
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0102 0.0052 0.0046
Brugia malayi histone deacetylase 3 (HD3) 0.0936 0.065 0.6774
Trypanosoma brucei heat shock protein, putative 0.0128 0.007 0.0469
Echinococcus multilocularis twik family of potassium channels 0.0046 0.0011 0.0027
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0102 0.0052 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0005 0.0033
Giardia lamblia DNA topoisomerase III 0.0155 0.0089 0.0892
Loa Loa (eye worm) hypothetical protein 0.0136 0.0075 0.0778
Trypanosoma brucei DNA topoisomerase II beta, putative 0.1212 0.0847 0.6161
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 1.3973 1 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0102 0.0052 0.0528
Plasmodium falciparum histone deacetylase 1 0.0936 0.065 0.4627
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Giardia lamblia Pms1-like protein 0.0102 0.0052 0.0462
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0102 0.0052 0.0484
Onchocerca volvulus DNA topoisomerase 2 homolog 0.1047 0.0729 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0102 0.0052 0.0484
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0102 0.0052 0.0046
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Onchocerca volvulus 0.0046 0.0011 0.0143
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.1047 0.0729 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0936 0.065 0.6758
Echinococcus granulosus histone deacetylase 6 0.0762 0.0525 0.1355
Loa Loa (eye worm) glutaminase 0.029 0.0186 0.1932
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0046 0.0011 0.0109
Echinococcus multilocularis rho GTPase activating protein 20 0.0155 0.0089 0.0228
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0102 0.0052 0.0046
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0011 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Brugia malayi beta-lactamase family protein 0.0038 0.0005 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0027 0.0155
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0191 0.0115 0.011
Brugia malayi Pre-SET motif family protein 0.0222 0.0137 0.1421
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 1.3973 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Echinococcus multilocularis histone deacetylase 7 0.0762 0.0525 0.1353
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Leishmania major hypothetical protein, conserved 0.0046 0.0011 0.0043
Trypanosoma cruzi Heat shock protein 83, putative 0.0128 0.007 0.0469
Loa Loa (eye worm) histone deacetylase 7A 0.0762 0.0525 0.547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0027 0.0155
Trypanosoma brucei histone deacetylase 2 0.0551 0.0374 0.2693
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0046 0.0011 0.0108
Leishmania major hypothetical protein, conserved 0.0046 0.0011 0.0042
Trypanosoma cruzi histone deacetylase 1, putative 0.0936 0.065 0.4713
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0046 0.0011 0.0042
Echinococcus granulosus heat shock protein 90 0.0128 0.007 0.018
Echinococcus multilocularis histone deacetylase 1 0.0936 0.065 0.1675
Onchocerca volvulus 0.0046 0.0011 0.0143
Echinococcus granulosus twik family of potassium channels 0.0046 0.0011 0.0029
Schistosoma mansoni pyruvate dehydrogenase 0.0102 0.0052 0.0131
Trypanosoma cruzi heat shock protein 90, putative 0.0128 0.007 0.0469
Schistosoma mansoni glutaminase 0.029 0.0186 0.0478
Giardia lamblia Heat shock protein HSP 90-alpha 0.0128 0.007 0.0668
Schistosoma mansoni hypothetical protein 0.0046 0.0011 0.0027
Mycobacterium ulcerans DNA topoisomerase I 0.0155 0.0089 0.0084
Schistosoma mansoni twik family of potassium channels-related 0.0046 0.0011 0.0027
Echinococcus granulosus heat shock protein 0.0128 0.007 0.018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0022 0.0124
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0102 0.0052 0.0484
Trichomonas vaginalis endoplasmin, putative 0.0115 0.0061 0.0581
Loa Loa (eye worm) hypothetical protein 0.0211 0.0129 0.134
Echinococcus granulosus small conductance calcium activated potassium 0.0046 0.0011 0.0029
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.137 0.0961 1
Leishmania major heat shock protein 83-1 0.0128 0.007 0.0469
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Onchocerca volvulus 0.0046 0.0011 0.0143
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0102 0.0052 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0027 0.0155
Trypanosoma cruzi DNA topoisomerase II, putative 0.1212 0.0847 0.6161
Giardia lamblia Hypothetical protein 0.0046 0.0011 0.0001
Brugia malayi hypothetical protein 0.0046 0.0011 0.0109
Loa Loa (eye worm) histone deacetylase 11 0.0551 0.0374 0.3892
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.197 0.1391 1
Leishmania major histone deacetylase, putative 0.0762 0.0525 0.3799
Mycobacterium ulcerans putative regultory protein 0.0102 0.0052 0.0046
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0109
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0046 0.0011 0.0043

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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