Detailed information for compound 1540778

Basic information

Technical information
  • TDR Targets ID: 1540778
  • Name: N,4-di(phenyl)piperazine-1-carbothioamide
  • MW: 297.418 | Formula: C17H19N3S
  • H donors: 1 H acceptors: 0 LogP: 3.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N1CCN(CC1)c1ccccc1)Nc1ccccc1
  • InChi: 1S/C17H19N3S/c21-17(18-15-7-3-1-4-8-15)20-13-11-19(12-14-20)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,21)
  • InChiKey: XDEQBZBOCYNXRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,4-di(phenyl)-1-piperazinecarbothioamide
  • 2512-27-8
  • 4-Phenyl-piperazine-1-carbothioic acid phenylamide
  • NCIOpen2_005199
  • BAS 00843743
  • ZINC00282175
  • NSC88248
  • Oprea1_257550

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0633 0.4649 0.6626
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium ulcerans hypothetical protein 0.0064 0.0388 0.0492
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0007 0.0009
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0063 0.1463
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0046 0.0295
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0064 0.0388 0.0492
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0064 0.0388 0.0492
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0169 0.0214
Echinococcus granulosus GPCR family 2 0.0035 0.0169 0.0165
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.021 0.148 0.1744
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0064 0.0388 0.0492
Loa Loa (eye worm) hypothetical protein 0.004 0.0209 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0578 0.0575
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0578 0.0575
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0159 0.1099 1
Echinococcus granulosus NADH dehydrogenase 0.0064 0.0388 0.0385
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0204 0.1488
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0046 0.0359
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0039 0.0204 0.0227
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0204 0.1488
Onchocerca volvulus Putative alcohol dehydrogenase 0.0039 0.0204 0.0233
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0007 0.0009
Entamoeba histolytica hypothetical protein 0.0036 0.0175 0.4417
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.005 0.0004
Mycobacterium ulcerans oxidoreductase FadB5 0.0039 0.0204 0.0227
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0172 0.1195 0.1192
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.12 0.8892 1
Schistosoma mansoni lamin 0.0026 0.0105 0.0059
Mycobacterium ulcerans polyketide synthase 0.0672 0.4943 0.705
Onchocerca volvulus 0.0028 0.0122 0.0136
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.012 0.1044
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0039 0.0204 0.02
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0159 0.1099 0.1096
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0039 0.0204 0.1812
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0195 0.1367 0.1901
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0288 0.0571
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0175 0.0172
Schistosoma mansoni hypothetical protein 0.0036 0.0175 0.013
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0204 0.0222
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0063 0.0063
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0204 0.1804
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0159 0.1099 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0672 0.4943 0.705
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0063 0.0521
Leishmania major zinc-binding dehydrogenase-like protein 0.0039 0.0204 0.1481
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.012 0.0116
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0159 0.1099 0.1058
Toxoplasma gondii FATC domain-containing protein 0.0028 0.012 0.0231
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0159 0.1099 0.2214
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0172 0.1195 0.1154
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0014 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0469 0.0521
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0171 0.0335
Loa Loa (eye worm) hypothetical protein 0.0109 0.0729 0.0926
Mycobacterium ulcerans quinone reductase Qor 0.0039 0.0204 0.0227
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0171 0.1503
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.005 0.0046
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0039 0.0204 0.0259
Loa Loa (eye worm) hypothetical protein 0.0039 0.0204 0.0259
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0169 0.0182
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0204 0.1804
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0171 0.1241
Brugia malayi isocitrate dehydrogenase 0.0019 0.005 0.0048
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0064 0.0388 0.0451
Brugia malayi Alcohol dehydrogenase class III 0.0039 0.0204 0.0222
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0063 0.0511
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1088 0.1085
Schistosoma mansoni intermediate filament proteins 0.0026 0.0105 0.0059
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0169 0.0165
Loa Loa (eye worm) hypothetical protein 0.021 0.148 0.188
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0064 0.0388 0.3498
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0063 0.0513
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0039 0.0204 0.0227
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0122 0.0155
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0351 0.0699
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0591 0.4337 0.5511
Leishmania major acyl carrier protein, putative 0.0064 0.0388 0.2866
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0169 0.0165
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0175 0.0172
Mycobacterium ulcerans short-chain dehydrogenase 0.0039 0.0204 0.0227
Loa Loa (eye worm) hypothetical protein 0.0026 0.0101 0.0128
Entamoeba histolytica hypothetical protein 0.0036 0.0175 0.4417
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0672 0.4943 0.705
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0063 0.0059
Onchocerca volvulus 0.0026 0.0105 0.0116
Mycobacterium ulcerans polyketide synthase MbtC 0.0159 0.1099 0.1516
Brugia malayi CXXC zinc finger family protein 0.0028 0.0122 0.0129
Mycobacterium ulcerans Type I modular polyketide synthase 0.0633 0.4649 0.6626
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.5901 0.5899
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.1241
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0005
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0039 0.0204 0.1804
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0133
Mycobacterium leprae Polyketide synthase Pks13 0.0946 0.6993 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0171 0.4304
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0039 0.0204 0.0401
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0064 0.0388 0.3249
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0672 0.4943 0.705
Leishmania major hypothetical protein, conserved 0.004 0.0209 0.1517
Loa Loa (eye worm) hypothetical protein 0.0039 0.0204 0.0259
Echinococcus multilocularis GPCR, family 2 0.0035 0.0169 0.0165
Trypanosoma brucei oxidoreductase, putative 0.0039 0.0204 0.1812
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1088 0.1085
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0518 0.3785 0.5383
Brugia malayi hypothetical protein 0.0032 0.0147 0.0158
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0039 0.0204 0.1488
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0075 0.0071
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.005 0.0391
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0199 0.1398 0.1946
Onchocerca volvulus Fatty acid synthase homolog 0.1141 0.8453 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.005 0.0046
Echinococcus multilocularis musashi 0.0026 0.0105 0.0101
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0007 0.0009
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0063 0.0419
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0729 0.0812
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.004 0.0209 0.0205
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0159 0.1099 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0171 0.1241
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0256 0.1994
Loa Loa (eye worm) hypothetical protein 0.0233 0.1657 0.2105
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0063 0.0017
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0014 0.0008
Schistosoma mansoni cpg binding protein 0.003 0.0134 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0278 0.2483
Brugia malayi intermediate filament protein 0.0026 0.0105 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0578 0.0575
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0256 0.6535
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0063 0.0521
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.005 0.0046
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0039 0.0204 0.0227
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0063 0.008
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0633 0.4649 0.6547
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0351 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0063 0.0115
Toxoplasma gondii quinone oxidoreductase, putative 0.0039 0.0204 0.0401
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0063 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0204 0.5166
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0633 0.4649 0.6547
Echinococcus granulosus cpg binding protein 0.003 0.0134 0.013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.005 0.0046
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0278 0.2203
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0039 0.0204 0.0227
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0509 0.3723 0.5183
Mycobacterium tuberculosis Hypothetical protein 0.0191 0.1337 0.1859
Echinococcus granulosus histone acetyltransferase KAT2B 0.0167 0.1159 0.1156
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0039 0.0204 0.0227
Trypanosoma cruzi acyl transferase-like protein, putative 0.004 0.0209 0.1847
Entamoeba histolytica acyl-CoA synthetase, putative 0.0064 0.0388 1
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0256 0.1626
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0278 0.2203
Onchocerca volvulus 0.0091 0.0591 0.0692
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0064 0.0388 0.0492
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0097 0.0636 0.085
Treponema pallidum acyl carrier protein 0.0064 0.0388 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0578 0.0735
Leishmania major d-xylulose reductase, putative 0.0039 0.0204 0.1481
Mycobacterium leprae Probable polyketide synthase Pks1 0.0672 0.4943 0.6981
Echinococcus multilocularis AMP dependent ligase 0.0064 0.0388 0.0385
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.1088 0.1217
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0064 0.0388 0.0492
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0591 0.4337 0.6178
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.005 0.0401
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.004 0.0209 0.1543
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0064 0.0388 0.0385
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0063 0.0419
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0046 0.0303
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0075 0.0469 0.0425
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0046 0.0303
Schistosoma mansoni cpg binding protein 0.003 0.0134 0.0088
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0419 0.3043 0.4315
Toxoplasma gondii type I fatty acid synthase 0.0097 0.0636 0.1277
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.1241
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0039 0.0204 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Schistosoma mansoni methyltransferase-related 0.0191 0.1337 0.1297
Leishmania major zinc binding dehydrogenase-like protein 0.0039 0.0204 0.1481
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0039 0.0204 0.5166
Mycobacterium ulcerans thioesterase 0.0527 0.3859 0.5488
Trypanosoma cruzi oxidoreductase, putative 0.0039 0.0204 0.1804
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0288 0.2117
Brugia malayi acetyltransferase, GNAT family protein 0.0172 0.1195 0.1337
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0278 0.2483
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0209 0.0163
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0256 0.1826 0.2562
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0729 0.0926
Toxoplasma gondii exonuclease III APE 0.0018 0.0046 0.0082
Schistosoma mansoni alpha-glucosidase 0.0135 0.0924 0.0882
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0199 0.1398 0.1759
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0171 0.0167
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0589 0.5154
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0175 0.013
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0007 0.0009
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0171 0.1241
Mycobacterium tuberculosis Possible dehydrogenase 0.0039 0.0204 0.0227
Onchocerca volvulus 0.0026 0.0105 0.0116
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.005 0.0033
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0046 0.1029
Mycobacterium ulcerans fatty acid synthase Fas 0.0199 0.1398 0.1946
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0946 0.6993 1
Brugia malayi AMP-binding enzyme family protein 0.0591 0.4337 0.4874
Mycobacterium ulcerans Type I modular polyketide synthase 0.0633 0.4649 0.6626
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0039 0.0204 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0064 0.0388 0.0492
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0159 0.1099 0.1396
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2932 0.2929
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0672 0.4943 0.705
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.004 0.0209 0.0227
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0351 0.0438
Giardia lamblia GTOR 0.002 0.0063 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.1241
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.005 0.0046
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.004 0.0209 0.0205
Entamoeba histolytica hypothetical protein 0.0028 0.012 0.2963
Onchocerca volvulus 0.0048 0.0266 0.0307
Entamoeba histolytica acyl-CoA synthetase, putative 0.0064 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0355 0.2565 0.3258
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0155 0.1067 0.147
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0351 0.0438
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0063 0.0421
Brugia malayi hypothetical protein 0.0233 0.1657 0.1857
Echinococcus multilocularis NADH dehydrogenase 0.0064 0.0388 0.0385
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.1241
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0614 0.4504 0.6417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0388 0.0492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0578 0.0535
Echinococcus multilocularis microtubule associated protein 2 0.1348 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0046 0.0044
Mycobacterium leprae conserved hypothetical protein 0.0064 0.0388 0.0271
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.004 0.0209 0.1543
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0091 0.0589 0.5154
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0278 0.2203
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0115
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0218 0.1539 0.2149
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1657 0.1654
Mycobacterium ulcerans polyketide synthase MbtD 0.0195 0.1367 0.1901
Entamoeba histolytica hypothetical protein 0.0036 0.0175 0.4417
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.1088 0.1085
Trypanosoma brucei acyl transferase-like protein 0.004 0.0209 0.1856
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0159 0.1099 1
Schistosoma mansoni lamin 0.0026 0.0105 0.0059
Schistosoma mansoni microtubule-associated protein tau 0.1348 1 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0204 0.1804
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0159 0.1099 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0075 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0171 0.0217
Leishmania major hypothetical protein, conserved 0.0049 0.0278 0.2038
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.0968 0.123
Toxoplasma gondii type I fatty acid synthase, putative 0.0672 0.4943 1
Schistosoma mansoni hypothetical protein 0.0561 0.4112 0.4085
Plasmodium vivax acyl carrier protein, putative 0.0064 0.0388 0.3249
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0946 0.6993 1
Mycobacterium ulcerans polyketide synthase 0.0633 0.4649 0.6626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.012 0.0127
Echinococcus granulosus lamin dm0 0.0026 0.0105 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.005 0.0046
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0039 0.0204 0.0227
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0039 0.0204 0.0227
Loa Loa (eye worm) fatty acid synthase 0.0625 0.4586 0.5826
Schistosoma mansoni hypothetical protein 0.0035 0.0169 0.0123
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0388 0.0492
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.005 0.0089
Loa Loa (eye worm) hypothetical protein 0.0075 0.0469 0.0596
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0171 0.0167
Trypanosoma cruzi acyl transferase-like protein 0.004 0.0209 0.1847
Leishmania major oxidoreductase, putative 0.0039 0.0204 0.1481
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0064 0.0388 0.0429
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0509 0.3723 0.5293
Leishmania major quinone oxidoreductase, putative 0.0039 0.0204 0.1481
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0351 0.0306
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0039 0.0204 0.0227
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.005 0.0033
Schistosoma mansoni hypothetical protein 0.0035 0.0169 0.0123
Brugia malayi AMP-binding enzyme family protein 0.0195 0.1367 0.153
Toxoplasma gondii acyl carrier protein ACP 0.0064 0.0388 0.0775
Schistosoma mansoni alpha-glucosidase 0.0135 0.0924 0.0882
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0672 0.4943 0.705
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0039 0.0204 0.02
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.005 0.0089
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0672 0.4943 0.6981
Schistosoma mansoni alcohol dehydrogenase 0.0039 0.0204 0.0158
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0063 0.0059
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0509 0.3723 0.5293
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.1337 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0064 0.0388 0.0492
Mycobacterium ulcerans thioesterase TesA 0.0527 0.3859 0.5488
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0204 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0064 0.0388 0.0492
Schistosoma mansoni alpha glucosidase 0.0035 0.0171 0.0125
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1657 0.1654
Toxoplasma gondii acyl transferase domain-containing protein 0.004 0.0209 0.0411
Mycobacterium ulcerans quinone oxidoreductase 0.0039 0.0204 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0171 0.1503
Leishmania major oxidoreductase-like protein 0.0039 0.0204 0.1481
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0171 0.1234
Leishmania major hypothetical protein, conserved 0.0191 0.1337 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0169 0.0182
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0007 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium tuberculosis Possible dehydrogenase 0.0039 0.0204 0.0227
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0411 0.2984 0.6032
Brugia malayi N-terminal motif family protein 0.021 0.148 0.1658
Mycobacterium tuberculosis Probable thioesterase TesA 0.0527 0.3859 0.5488
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0064 0.0388 0.0492
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0064 0.0388 0.0492
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0046 0.0359
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0266 0.0291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0578 0.0643
Mycobacterium ulcerans polyketide synthase Pks9 0.0419 0.3043 0.4315
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0064 0.0388 0.0492
Trypanosoma brucei oxidoreductase, putative 0.0039 0.0204 0.1812
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0578 0.0535
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0288 0.0571
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0063 0.0521
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0039 0.0204 0.0227
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0039 0.0204 0.0227
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0097 0.0636 0.0637
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0046 0.0043
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0105 0.0133
Leishmania major nuclear receptor binding factor-like protein 0.0039 0.0204 0.1481
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0039 0.0204 0.0227
Onchocerca volvulus 0.0039 0.0204 0.0233
Loa Loa (eye worm) hypothetical protein 0.0097 0.0636 0.0808
Brugia malayi Phosphopantetheine attachment site family protein 0.0064 0.0388 0.0429
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0007 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0171 0.1241
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0039 0.0204 0.0227
Echinococcus granulosus serine protein kinase ATM 0.0028 0.012 0.0116
Onchocerca volvulus 0.0039 0.0204 0.0233
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0159 0.1099 0.1096
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0063 0.0059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0105 0.0133
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.005 0.0391
Onchocerca volvulus 0.0064 0.0388 0.0451
Brugia malayi MH2 domain containing protein 0.0141 0.0968 0.1082
Loa Loa (eye worm) acetyltransferase 0.0172 0.1195 0.1518
Mycobacterium tuberculosis Probable oxidoreductase 0.0039 0.0204 0.0227
Entamoeba histolytica hypothetical protein 0.0036 0.0175 0.4417
Brugia malayi Methyltransferase-like protein 4 0.0191 0.1337 0.1497
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0288 0.2117
Schistosoma mansoni hypothetical protein 0.0404 0.2932 0.2899
Echinococcus multilocularis geminin 0.0561 0.4112 0.411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.012 0.0857
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0633 0.4649 0.6626
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0046 0.0369
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0351 0.2584
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0063 0.0511
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0105 0.011
Schistosoma mansoni survival motor neuron protein 0.0048 0.0266 0.0221
Echinococcus granulosus intermediate filament protein 0.0026 0.0105 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0578 0.0575
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0204 0.5166
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0063 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0578 0.0535
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0039 0.0204 0.0227
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0419 0.3043 0.4183
Echinococcus multilocularis lamin 0.0026 0.0105 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0064 0.0388 0.0492
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0278 0.0552
Loa Loa (eye worm) hypothetical protein 0.0035 0.0169 0.0214
Brugia malayi Isocitrate dehydrogenase 0.0019 0.005 0.0048
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0039 0.0204 0.0227
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0159 0.1099 0.1229
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0351 0.0438
Loa Loa (eye worm) hypothetical protein 0.0097 0.0636 0.0808
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0063 0.0511
Echinococcus granulosus lamin 0.0026 0.0105 0.0101
Mycobacterium tuberculosis Conserved protein 0.0191 0.1337 0.1859
Toxoplasma gondii type I fatty acid synthase, putative 0.0451 0.3283 0.6638
Loa Loa (eye worm) hypothetical protein 0.0087 0.0561 0.0712
Plasmodium falciparum acyl carrier protein 0.0064 0.0388 0.3249
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0097 0.0636 0.085
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0288 0.0284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0351 0.0438
Echinococcus multilocularis lamin dm0 0.0026 0.0105 0.0101
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.005 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0007 0.0009
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0672 0.4943 0.6981
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0288 0.2293
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0159 0.1099 0.1516
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0169 0.0165
Trypanosoma brucei glucosidase, putative 0.0035 0.0171 0.1512
Loa Loa (eye worm) acyl carrier protein 0.0291 0.2089 0.2654
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Loa Loa (eye worm) hypothetical protein 0.0039 0.0204 0.0259
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.036 0.0315
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0039 0.0204 0.0227
Echinococcus multilocularis cpg binding protein 0.003 0.0134 0.013
Mycobacterium ulcerans acyl carrier protein 0.0064 0.0388 0.0492
Schistosoma mansoni acyl carrier protein 0.0064 0.0388 0.0344
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0171 0.4304
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0633 0.4649 0.6626
Onchocerca volvulus 0.0591 0.4337 0.5127
Schistosoma mansoni hypothetical protein 0.0064 0.0388 0.0344
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0063 0.0419
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0046 0.0059
Brugia malayi hypothetical protein 0.0087 0.0561 0.0623
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.036 0.2604 0.3682
Echinococcus granulosus AMP dependent ligase 0.0064 0.0388 0.0385
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0063 0.0017
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0159 0.1099 0.821
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.012 0.1035
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0063 0.1463
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0097 0.0636 0.085
Mycobacterium ulcerans oxidoreductase 0.0039 0.0204 0.0227
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.032 0.2305 0.4656
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0063 0.0511
Echinococcus granulosus geminin 0.0561 0.4112 0.411
Schistosoma mansoni zinc binding dehydrogenase 0.0039 0.0204 0.0158
Mycobacterium ulcerans oxidoreductase 0.0039 0.0204 0.0227
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0063 0.0521
Brugia malayi hypothetical protein 0.0049 0.0278 0.0305
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0159 0.1099 0.1516
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0633 0.4649 0.5224
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0171 0.1241
Mycobacterium ulcerans quinone oxidoreductase 0.0039 0.0204 0.0227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0729 0.0812
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0063 0.0419
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0204 0.1804
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0064 0.0388 0.0493
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0204 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0209 0.0163
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0169 0.0165
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0388 0.0271
Loa Loa (eye worm) hypothetical protein 0.0039 0.0204 0.0259
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0046 0.0043
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.0968 0.123
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.004 0.0209 0.1543
Schistosoma mansoni hypothetical protein 0.0035 0.0169 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0388 0.0492
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0064 0.0388 0.0271
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0204 0.1804
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0063 0.0511
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0351 0.0347
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0039 0.0204 0.1804
Onchocerca volvulus 0.1102 0.8158 0.9651
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.005 0.0063
Giardia lamblia Methyltransferase like 2 0.0191 0.1337 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0527 0.3859 0.5384
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.009 0.0765
Schistosoma mansoni eyes absent homolog 0.0087 0.0561 0.0517
Mycobacterium ulcerans polyketide synthase Pks13 0.0946 0.6993 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0278 0.0353
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0351 0.0347
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0039 0.0204 0.1804
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0388 0.0429
Loa Loa (eye worm) acyl carrier protein 0.0064 0.0388 0.0493
Mycobacterium ulcerans dehydrogenase 0.0039 0.0204 0.0227
Mycobacterium ulcerans Type I modular polyketide synthase 0.0633 0.4649 0.6626
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0159 0.1099 1
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0039 0.0204 0.1481
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.005 0.0401
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0343 0.0683
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2932 0.2929
Schistosoma mansoni hypothetical protein 0.0561 0.4112 0.4085
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0039 0.0204 0.0227
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0063 0.008
Mycobacterium ulcerans acyl carrier protein 0.0064 0.0388 0.0492
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0171 0.0185
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0039 0.0204 0.1498
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0064 0.0388 0.0492
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0097 0.0636 0.085
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Schistosoma mansoni hypothetical protein 0.0022 0.0075 0.0029
Loa Loa (eye worm) hypothetical protein 0.0087 0.0561 0.0712
Schistosoma mansoni hypothetical protein 0.0048 0.0266 0.0221
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.1088 0.1382
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0614 0.4504 0.6417
Brugia malayi hypothetical protein 0.0036 0.0175 0.019
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0063 0.0419
Echinococcus granulosus acyl carrier protein mitochondrial 0.0064 0.0388 0.0385
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0007 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0007 0.0009
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0039 0.0204 0.0227
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0159 0.1099 1
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0278 0.2491
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0455 0.3314 0.4704
Loa Loa (eye worm) hypothetical protein 0.1063 0.7871 1
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0064 0.0388 0.3491
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.012 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Chlamydia trachomatis acyl carrier protein 0.0064 0.0388 0.2016
Schistosoma mansoni [ACP] S-malonyltransferase 0.004 0.0209 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0063 0.0427
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0633 0.4649 0.6626
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.005 0.0321
Schistosoma mansoni cpg binding protein 0.0028 0.0122 0.0076
Schistosoma mansoni hypothetical protein 0.0035 0.0169 0.0123
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.004 0.0209 0.0234

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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