Detailed information for compound 1540862

Basic information

Technical information
  • TDR Targets ID: 1540862
  • Name: 1-[4-[3-[(4-methoxyphenyl)amino]piperidin-1-y l]-4-oxobutyl]piperidin-2-one
  • MW: 373.489 | Formula: C21H31N3O3
  • H donors: 1 H acceptors: 2 LogP: 2.14 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC1CCCN(C1)C(=O)CCCN1CCCCC1=O
  • InChi: 1S/C21H31N3O3/c1-27-19-11-9-17(10-12-19)22-18-6-4-15-24(16-18)21(26)8-5-14-23-13-3-2-7-20(23)25/h9-12,18,22H,2-8,13-16H2,1H3
  • InChiKey: OLINAFKJBHQTTQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-[3-[(4-methoxyphenyl)amino]-1-piperidyl]-4-oxo-butyl]piperidin-2-one
  • 1-[4-[3-[(4-methoxyphenyl)amino]-1-piperidinyl]-4-oxobutyl]-2-piperidinone
  • 1-[4-keto-4-[3-[(4-methoxyphenyl)amino]-1-piperidyl]butyl]-2-piperidone
  • 1-[4-[3-[(4-methoxyphenyl)amino]piperidin-1-yl]-4-oxo-butyl]piperidin-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TAR-binding protein 0.014 0.3703 0.3703
Brugia malayi MH2 domain containing protein 0.0132 0.3389 0.3389
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.3389 0.3389
Schistosoma mansoni tar DNA-binding protein 0.014 0.3703 0.3703
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0638 0.0638
Schistosoma mansoni tar DNA-binding protein 0.014 0.3703 0.3703
Schistosoma mansoni glutaminase 0.0314 1 1
Schistosoma mansoni tar DNA-binding protein 0.014 0.3703 0.3703
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0638 0.0638
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0638 0.0638
Trichomonas vaginalis glutaminase, putative 0.0314 1 0.5
Echinococcus granulosus tar DNA binding protein 0.014 0.3703 0.5
Loa Loa (eye worm) RNA binding protein 0.014 0.3703 0.3703
Mycobacterium ulcerans glutaminase 0.0314 1 0.5
Echinococcus multilocularis tar DNA binding protein 0.014 0.3703 0.5
Brugia malayi TAR-binding protein 0.014 0.3703 0.3703
Brugia malayi RNA recognition motif domain containing protein 0.014 0.3703 0.3703
Schistosoma mansoni tar DNA-binding protein 0.014 0.3703 0.3703
Brugia malayi RNA binding protein 0.014 0.3703 0.3703
Loa Loa (eye worm) hypothetical protein 0.0056 0.0638 0.0638
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.3389 0.3389
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.014 0.3703 0.3703
Loa Loa (eye worm) glutaminase 0.0314 1 1
Loa Loa (eye worm) glutaminase 2 0.0314 1 1
Schistosoma mansoni tar DNA-binding protein 0.014 0.3703 0.3703

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1651 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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