Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.8085 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3632 | 0.3632 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0882 | 0.0882 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.8085 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4751 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3632 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3632 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0882 | 0.0882 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.8085 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0882 | 0.1857 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0882 | 0.1857 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4751 | 0.5371 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0882 | 0.0882 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0882 | 0.1857 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3632 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0882 | 0.0882 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0882 | 0.1857 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0882 | 0.0882 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0882 | 0.1091 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0071 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3632 | 0.7644 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0882 | 0.0882 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.8085 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4751 | 0.5877 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0882 | 0.1091 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3632 | 0.3632 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3632 | 0.3817 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3632 | 0.7644 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.