Detailed information for compound 1540917

Basic information

Technical information
  • TDR Targets ID: 1540917
  • Name: 1-[3-[1-(4-ethoxyphenyl)sulfonyl-2H-imidazo[4 ,5-b]quinoxalin-3-yl]phenyl]ethanone
  • MW: 474.532 | Formula: C25H22N4O4S
  • H donors: 0 H acceptors: 5 LogP: 4.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)S(=O)(=O)N1CN(c2c1nc1ccccc1n2)c1cccc(c1)C(=O)C
  • InChi: 1S/C25H22N4O4S/c1-3-33-20-11-13-21(14-12-20)34(31,32)29-16-28(19-8-6-7-18(15-19)17(2)30)24-25(29)27-23-10-5-4-9-22(23)26-24/h4-15H,3,16H2,1-2H3
  • InChiKey: XAOLSYXUSLMLBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • T5245422
  • ZINC02653508

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone binding protein No references
Homo sapiens corticotropin releasing hormone receptor 2 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0005 0.0018
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0008 0.0001 0.0003
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0009 0.0008 0.0029
Schistosoma mansoni hypothetical protein 0.0014 0.0027 0.0225
Schistosoma mansoni hypothetical protein 0.0015 0.0033 0.0279
Echinococcus granulosus disks large 1 0.0019 0.0049 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0075 0.4565
Echinococcus granulosus lamin 0.0026 0.0079 0.0286
Leishmania major trypanothione reductase 0.0046 0.0163 0.7451
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0027 0.1185
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0008 0.0001 0.001
Echinococcus multilocularis MAGUK p55 subfamily 0.0019 0.0049 0.0146
Echinococcus granulosus high voltage activated calcium channel beta 0.0019 0.0049 0.0178
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.017 0.0611
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0009 0.0008 0.0401
Entamoeba histolytica hypothetical protein 0.0019 0.0047 0.1717
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0013 0.0024 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0174
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0064 0.0229
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0036 0.2155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0049 0.0146
Brugia malayi cytochrome P450 0.0014 0.0027 0.0267
Loa Loa (eye worm) solute carrier family 6 member 4 0.0045 0.0159 0.1256
Brugia malayi Peripheral plasma membrane protein CASK 0.0019 0.0049 0.0491
Brugia malayi Dihydrofolate reductase 0.0013 0.0024 0.0239
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0075 0.4549
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0009 0.0008 0.0024
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0573 0.5698
Echinococcus granulosus thymidylate synthase 0.0032 0.0104 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0373
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0047 0.0398
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0036 0.2155
Schistosoma mansoni maguk P55 subfamily member 35 0.0019 0.0049 0.0415
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.012 0.0432
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.2374 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0047 0.0398
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0056 0.0166
Plasmodium falciparum thioredoxin reductase 0.0016 0.0036 0.2155
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0027 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0047 0.0471
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0047 0.014
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0047 0.0471
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0302
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0063 0.0494
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0009 0.0008 0.0299
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0005 0.0255
Brugia malayi Bromodomain containing protein 0.0078 0.0299 0.2974
Mycobacterium tuberculosis Probable guanylate kinase Gmk 0.0019 0.0049 0.0045
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0036 0.0032
Chlamydia trachomatis dihydrofolate reductase 0.0013 0.0024 0.0708
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0197 0.0583
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0028 0.1658
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0008 0.0001 0.001
Mycobacterium leprae ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0037 0.0127 0.0113
Chlamydia trachomatis cysteine--tRNA ligase 0.0035 0.0115 0.352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0373
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0153 0.9434
Mycobacterium tuberculosis Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0037 0.0127 0.0123
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0041 0.0341
Echinococcus granulosus kelch ECH associated protein 1 0.0186 0.0754 0.2716
Echinococcus granulosus intermediate filament protein 0.0026 0.0079 0.0286
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0047 0.014
Brugia malayi thymidylate synthase 0.0032 0.0104 0.1038
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0036 0.1588
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0143 0.1418
Echinococcus granulosus flap endonuclease 1 0.0008 0.0002 0.0006
Brugia malayi dihydrofolate reductase family protein 0.0013 0.0024 0.0239
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0106
Echinococcus granulosus guanylate kinase 0.0019 0.0049 0.0178
Echinococcus granulosus kelch ECH associated protein 1 like 0.0186 0.0754 0.2716
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0027 0.0023
Schistosoma mansoni cytochrome P450 0.0014 0.0027 0.0225
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0047 0.014
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0008 0.0001 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0077 0.065
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0411 0.0407
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0045 0.0159 0.1256
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0061 0.0225 0.1772
Schistosoma mansoni hypothetical protein 0.0186 0.0756 0.6359
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0027 0.0097
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0546 0.1968
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0035 0.0115 0.7044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.1588
Echinococcus granulosus cysteinyl tRNA synthetase 0.0035 0.0115 0.0414
Loa Loa (eye worm) hypothetical protein 0.0054 0.0197 0.1555
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0047 0.0398
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0075 0.3404
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0036 0.2132
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0013 0.0024 0.002
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0009 0.0008 0.043
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0046 0.2755
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Plasmodium falciparum glutathione reductase 0.0046 0.0163 1
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0008 0.0004 0.0104
Echinococcus granulosus GPCR family 2 0.0019 0.0049 0.0177
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0009 0.0008 0.0068
Echinococcus granulosus MAGUK p55 subfamily 0.0019 0.0049 0.0178
Plasmodium vivax flap endonuclease 1, putative 0.0008 0.0002 0.003
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0047 0.0171
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.026 0.1069 0.8989
Echinococcus multilocularis kelch ECH associated protein 1 0.0186 0.0754 0.223
Schistosoma mansoni zinc finger protein 0.0023 0.0066 0.0553
Schistosoma mansoni hypothetical protein 0.0071 0.0268 0.2253
Brugia malayi Muscleblind-like protein 0.0149 0.0598 0.5943
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0047 0.1768
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.046 0.0457
Echinococcus granulosus guanylate kinase 0.0019 0.0049 0.0178
Loa Loa (eye worm) acetyltransferase 0.0143 0.0573 0.4514
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0047 0.014
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0056 0.2111
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0027 0.0023
Brugia malayi glutathione reductase 0.0046 0.0163 0.1617
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0027 0.0023
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0047 0.0398
Echinococcus granulosus dihydrofolate reductase 0.0013 0.0024 0.0087
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0009
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0032 0.0104 0.009
Plasmodium falciparum guanylate kinase 0.0019 0.0049 0.2986
Mycobacterium leprae Probable guanylate kinase Gmk (GMP kinase). 0.0019 0.0049 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0027 0.0023
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0008 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.1124
Onchocerca volvulus 0.0047 0.0167 0.4385
Echinococcus granulosus disks large 3 0.0019 0.0049 0.0178
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0005 0.0038
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0045 0.016 0.9814
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0047 0.014
Trypanosoma brucei trypanothione reductase 0.0046 0.0163 1
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.017 0.0611
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0005 0.0014
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0047 0.0471
Entamoeba histolytica guanylate kinase, putative 0.0019 0.0049 0.1792
Plasmodium vivax SET domain protein, putative 0.0009 0.0006 0.0271
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0222 0.0905 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0049 0.049
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0045 0.0159 0.1586
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0047 0.0171
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0075 0.4565
Brugia malayi mbt repeat family protein 0.0048 0.017 0.1686
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0411 0.0407
Brugia malayi ZU5 domain containing protein 0.0019 0.0049 0.0491
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0035 0.0115 0.4259
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0009 0.0008 0.0249
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0027 0.0023
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.0009 0.0008 0.0004
Loa Loa (eye worm) thymidylate synthase 0.0032 0.0104 0.0822
Plasmodium vivax cysteine--tRNA ligase, putative 0.0035 0.0115 0.7053
Brugia malayi Guanylate kinase family protein 0.0019 0.0049 0.0491
Treponema pallidum sodium- and chloride- dependent transporter 0.0045 0.0159 0.4277
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0047 0.0171
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0047 0.0171
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0008 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.1026
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0047 0.0398
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0268 0.2253
Echinococcus multilocularis lamin 0.0026 0.0079 0.0235
Leishmania major cysteinyl-tRNA synthetase, putative 0.0035 0.0115 0.5249
Mycobacterium tuberculosis Probable glycosyltransferase 0.0011 0.0015 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Brugia malayi hypothetical protein 0.0008 0.0004 0.0039
Brugia malayi Bromodomain containing protein 0.0042 0.0145 0.1437
Trypanosoma cruzi ISWI complex protein 0.0015 0.0033 0.1959
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0197 0.0583
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0173
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0047 0.0398
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0943 0.7429
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0009 0.0008 0.0321
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0027 0.0023
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0862
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.1886 0.5577
Leishmania major hypothetical protein, conserved 0.0015 0.0033 0.1459
Plasmodium falciparum flap endonuclease 1 0.0008 0.0002 0.003
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0027 0.0023
Schistosoma mansoni hypothetical protein 0.0021 0.0056 0.0468
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0031
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0222 0.0905 0.0902
Onchocerca volvulus 0.0069 0.026 0.6856
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0045 0.016 0.7313
Leishmania major guanylate kinase, putative 0.0019 0.0049 0.2209
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Plasmodium vivax guanylate kinase, putative 0.0019 0.0049 0.2986
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0008 0.0001 0.0011
Echinococcus multilocularis 0.0014 0.0027 0.0079
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.046 0.0446
Mycobacterium tuberculosis Probable reductase 0.0105 0.0411 0.0407
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0047 0.014
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0047 0.0471
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0027 0.0023
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0036 0.1327
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0008 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.059
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0027 0.0023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0223 0.1758
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0047 0.0471
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0047 0.014
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0573 0.1694
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.0832 0.2459
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0009 0.0008 0.0242
Loa Loa (eye worm) hypothetical protein 0.0035 0.0115 0.0906
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0063 0.3795
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0035 0.0115 0.1144
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0005 0.0018
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.1886 0.6794
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.2132
Schistosoma mansoni DNA helicase recq5 0.0009 0.0005 0.0041
Loa Loa (eye worm) hypothetical protein 0.0045 0.0159 0.1256
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0035 0.0115 0.5259
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0027 0.0023
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.017 0.1336
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0035 0.0115 0.0967
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0163 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0041 0.0146
Giardia lamblia Guanylate kinase 0.0019 0.0049 0.3749
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0027 0.0023
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0027 0.1564
Trypanosoma cruzi guanylate kinase, putative 0.0019 0.0049 0.2965
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0008 0.0001 0.0009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0064 0.0535
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0036 0.1076
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0036 0.1327
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.1886 0.5577
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0009
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0197 0.0711
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0153 0.587
Echinococcus multilocularis high voltage activated calcium channel beta 0.026 0.1069 0.3161
Plasmodium falciparum cysteine--tRNA ligase 0.0035 0.0115 0.7053
Schistosoma mansoni survival motor neuron protein 0.0047 0.0167 0.14
Schistosoma mansoni MAGUK homolog 0.0019 0.0049 0.0415
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0009 0.0006 0.0202
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0036 0.0357
Loa Loa (eye worm) cytochrome P450 0.0014 0.0027 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0006 0.0046
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0153 0.7034
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0373
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0009
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0027 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0027 0.0023
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0016 0.0521
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0009 0.0008 0.043
Entamoeba histolytica hypothetical protein 0.0071 0.0268 1
Schistosoma mansoni mannosidase endo-alpha 0.0019 0.0049 0.0415
Schistosoma mansoni guanylate kinase 0.0019 0.0049 0.0415
Brugia malayi Flap endonuclease-1 0.0008 0.0002 0.0016
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0019 0.0049 0.0146
Schistosoma mansoni hypothetical protein 0.0289 0.1189 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.0938 0.7391
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0158
Brugia malayi Pre-SET motif family protein 0.0061 0.0225 0.2237
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0047 0.014
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.076 0.2247
Schistosoma mansoni sodium/chloride dependent transporter 0.0045 0.0159 0.1341
Echinococcus granulosus tumor protein p63 0.0665 0.2777 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0036 0.2132
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0013 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0389
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0009 0.0008 0.008
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0008 0.0001 0.001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0036 0.2132
Echinococcus granulosus kelch ECH associated protein 1 like 0.0186 0.0754 0.2716
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0036 0.0032
Brugia malayi hypothetical protein 0.0019 0.0049 0.0491
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0027 0.0023
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0389
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0027 0.0023
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0019 0.0049 0.0146
Schistosoma mansoni sodium/chloride dependent transporter 0.0008 0.0001 0.001
Plasmodium falciparum glutathione reductase 0.0016 0.0036 0.2155
Mycobacterium ulcerans glycosyltransferase 0.0011 0.0015 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0218 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0047 0.1768
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0027 0.0023
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0009 0.0008 0.0507
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0047 0.0471
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0414
Echinococcus multilocularis sodium and chloride dependent glycine 0.0008 0.0001 0.0003
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0047 0.0373
Treponema pallidum undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0051 0.0185 0.5159
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0027 0.1564
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.2132
Schistosoma mansoni DNA helicase recq1 0.0009 0.0005 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0218 0.1831
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0019 0.0049 0.0389
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0038 0.0318
Wolbachia endosymbiont of Brugia malayi guanylate kinase 0.0019 0.0049 0.0154
Mycobacterium ulcerans thymidylate synthase 0.0032 0.0104 0.01
Echinococcus multilocularis flap endonuclease 1 0.0008 0.0002 0.0005
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0047 0.0398
Loa Loa (eye worm) hypothetical protein 0.0308 0.1269 1
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0035 0.0115 0.4384
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0027 0.0023
Entamoeba histolytica hypothetical protein 0.0071 0.0268 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0938 0.2774
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0056 0.0559
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0047 0.1768
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.0832 0.2995
Loa Loa (eye worm) hypothetical protein 0.0245 0.1006 0.7921
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0032 0.0104 0.01
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0008 0.0001 0.0004
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0019 0.0049 0.0415
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0035 0.0115 0.0906
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0036 0.2155
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0033 0.1223
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0027 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Onchocerca volvulus 0.0097 0.038 1
Mycobacterium tuberculosis Hypothetical protein 0.0015 0.0033 0.0029
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0032 0.0104 0.0877
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0063 0.3795
Echinococcus multilocularis disks large 1 0.0019 0.0049 0.0146
Echinococcus granulosus sodium and chloride dependent glycine 0.0008 0.0001 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0163 0.0481
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0075 0.4565
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0047 0.1768
Echinococcus granulosus sodium and chloride dependent glycine 0.0008 0.0001 0.0004
Giardia lamblia Hypothetical protein 0.0008 0.0004 0.0183
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0235 0.0694
Schistosoma mansoni zinc finger protein 0.0015 0.0033 0.0279
Giardia lamblia Cysteinyl-tRNA synthetase 0.0035 0.0115 0.8907
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0049 0.049
Schistosoma mansoni intermediate filament proteins 0.0026 0.0079 0.0667
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0047 0.0171
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0027 0.0023
Echinococcus multilocularis musashi 0.0026 0.0079 0.0235
Schistosoma mansoni bromodomain containing protein 0.0008 0.0001 0.0011
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0019 0.0049 0.0491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.2132
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0079 0.0625
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0129 0.7915
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0411 0.0407
Onchocerca volvulus 0.0009 0.0006 0.0145
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0027 0.0023
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0019 0.0049 0.0389
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0268 0.0792
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0008 0.0001 0.001
Echinococcus granulosus expressed protein 0.0362 0.1499 0.54
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.046 0.0457
Brugia malayi Pre-SET motif family protein 0.0009 0.0006 0.0055
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0008 0.0001 0.0011
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0022 0.0065
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0008 0.0004 0.009
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.017 0.1426
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0009 0.0008 0.0068
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0862
Mycobacterium ulcerans guanylate kinase 0.0019 0.0049 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0009 0.0008 0.0401
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0084 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0598 0.4707
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0047 0.1768
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0938 0.3379
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0129 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Echinococcus multilocularis MAGUK p55 subfamily 0.0019 0.0049 0.0146
Schistosoma mansoni maguk P55 subfamily member 26 0.0019 0.0049 0.0415
Brugia malayi hypothetical protein 0.0025 0.0075 0.0745
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0049 0.0388
Onchocerca volvulus 0.0045 0.0159 0.4199
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.017 0.4465
Echinococcus multilocularis serotonin transporter 0.0045 0.0159 0.0471
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0045 0.016 0.9814
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.017 0.0501
Echinococcus multilocularis expressed protein 0.0362 0.1499 0.4433
Trichomonas vaginalis calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative 0.0019 0.0049 0.1845
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0027 0.0023
Onchocerca volvulus 0.0035 0.0115 0.303
Schistosoma mansoni cell polarity protein 0.0019 0.0049 0.0415
Brugia malayi hypothetical protein 0.0008 0.0001 0.0011
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0027 0.1165
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0047 0.1768
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0036 0.2155
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0019 0.0049 0.0415
Trichomonas vaginalis set domain proteins, putative 0.0069 0.026 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0027 0.1564
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0036 0.2132
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0197 0.1659
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0008 0.0001 0.0003
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0019 0.0049 0.0389
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0036 0.1607
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0008 0.0001 0.0004
Echinococcus multilocularis zinc finger protein 0.0023 0.0066 0.0194
Echinococcus multilocularis kelch ECH associated protein 1 0.0186 0.0754 0.223
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0009
Trichomonas vaginalis discs large, putative 0.0019 0.0049 0.1845
Entamoeba histolytica hypothetical protein 0.0071 0.0268 1
Schistosoma mansoni bromodomain containing protein 0.0066 0.025 0.2099
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.046 0.0457
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0609
Brugia malayi Cytochrome P450 family protein 0.0051 0.0183 0.1822
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0159 0.1256
Echinococcus multilocularis tumor protein p63 0.0665 0.2777 0.8209
Echinococcus multilocularis sodium and chloride dependent glycine 0.0008 0.0001 0.0003
Echinococcus multilocularis disks large 3 0.0019 0.0049 0.0146
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0625
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0036 0.0129
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0009
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0045 0.016 0.9815
Brugia malayi hypothetical protein 0.0019 0.0047 0.0471
Brugia malayi abnormal cell lineage protein 2 0.0019 0.0049 0.0491
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0388
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0045 0.0159 0.1341
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0027 0.0023
Brugia malayi Thioredoxin reductase 0.0046 0.0163 0.1617
Echinococcus multilocularis muscleblind protein 0.0149 0.0598 0.1767
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0016 0.0536
Loa Loa (eye worm) flap endonuclease-1 0.0008 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0047 0.0398
Echinococcus multilocularis dihydrofolate reductase 0.0013 0.0024 0.0071
Entamoeba histolytica hypothetical protein 0.0071 0.0268 1
Echinococcus granulosus leucyl tRNA synthetase 0.0035 0.0115 0.0414
Onchocerca volvulus 0.0008 0.0001 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0163 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0155 0.1219
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0019 0.0049 0.0178
Mycobacterium tuberculosis Probable glycosyltransferase 0.0011 0.0015 0.0011
Brugia malayi hypothetical protein 0.0016 0.0037 0.0371
Brugia malayi Cytochrome P450 family protein 0.0022 0.0063 0.0624
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0063 0.0059
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0197 0.1962
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0064 0.0188
Loa Loa (eye worm) hypothetical protein 0.0149 0.0598 0.4707
Loa Loa (eye worm) dihydrofolate reductase 0.0013 0.0024 0.0189
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.1588
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0153 0.0553
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0027 0.0023
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0008 0.0001 0.0011
Loa Loa (eye worm) guanylate kinase 0.0019 0.0049 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Trichomonas vaginalis guanylate kinase, putative 0.0019 0.0049 0.1845
Onchocerca volvulus 0.0009 0.0008 0.0213
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.017 0.1426
Leishmania major guanylate kinase-like protein 0.0019 0.0049 0.2209
Toxoplasma gondii thioredoxin reductase 0.0046 0.0163 0.7457
Loa Loa (eye worm) RecQ helicase 0.0021 0.0056 0.0443
Echinococcus granulosus MAGUK p55 subfamily 0.0019 0.0049 0.0178
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0027 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Plasmodium falciparum thioredoxin reductase 0.0046 0.0163 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0036 0.2132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.2132
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0163 0.0586
Schistosoma mansoni cell polarity protein 0.0019 0.0049 0.0415
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0218 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0075 0.4549
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0047 0.0171
Leishmania major hypothetical protein, conserved 0.0025 0.0075 0.3389
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0218 0.0644
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0218 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0047 0.0171
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0167 0.1656
Loa Loa (eye worm) MBCTL1 0.0054 0.0197 0.1555
Treponema pallidum cysteinyl-tRNA synthetase 0.0035 0.0115 0.2739
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.1199
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0008 0.0002 0.0023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0235 0.0845
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0016 0.0059
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0063 0.0494
Onchocerca volvulus 0.0019 0.0049 0.13
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0008 0.0001 0.001
Echinococcus granulosus lamin dm0 0.0026 0.0079 0.0286
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0027 0.0023
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0009 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0373
Echinococcus granulosus MAGUK p55 subfamily 0.0019 0.0049 0.0178
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0027 0.1204
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0027 0.0023
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0027 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0028 0.0278
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0018 0.018
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0642
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0027 0.0023
Brugia malayi Guanylate kinase family protein 0.0019 0.0049 0.0491
Schistosoma mansoni maguk P55 subfamily member 26 0.0019 0.0049 0.0415
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0022 0.008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0163 0.1283
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0047 0.0171
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0047 0.0398
Echinococcus granulosus muscleblind protein 0.0149 0.0598 0.2152
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.1006 1
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.038 0.3193
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0035 0.0115 0.7044
Trypanosoma brucei guanylate kinase, putative 0.0019 0.0049 0.2965
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0411 0.0407
Schistosoma mansoni lamin 0.0026 0.0079 0.0667
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0047 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0027 0.0023
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0008 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0031
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0197 0.0711
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0036 0.2695
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0008 0.0001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0163 0.1281
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0058 0.0454
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0063 0.3795
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0015 0.0033 0.1965
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0056 0.0438
Leishmania major cytochrome p450-like protein 0.0014 0.0027 0.1165
Echinococcus granulosus serotonin transporter 0.0045 0.0159 0.0574
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0036 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0063 0.0494
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0598 0.1767
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0035 0.0115 0.0111
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0036 0.1588
Brugia malayi Sulfatase family protein 0.0008 0.0004 0.0039
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0222 0.0905 0.0902
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0036 0.1607
Schistosoma mansoni lamin 0.0026 0.0079 0.0667
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0019 0.0049 0.0178
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0218 0.0784
Brugia malayi Cytochrome P450 family protein 0.0014 0.0027 0.0267
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0008 0.0004 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.012 0.0355
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0079 0.0789
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0389
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0049 0.0177
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0027 0.0023
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0027 0.0023
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0137
Onchocerca volvulus 0.0048 0.017 0.4465
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0047 0.0398
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.2132
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0036 0.2132
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0222 0.0905 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0008 0.0001 0.0011
Echinococcus multilocularis 0.0019 0.0049 0.0146
Echinococcus granulosus bloom syndrome protein 0.0021 0.0056 0.0203
Schistosoma mansoni sodium-dependent amino acid transporter 0.0008 0.0001 0.001
Brugia malayi Cytochrome P450 family protein 0.0022 0.0063 0.0624
Trypanosoma cruzi ISWI complex protein 0.0015 0.0033 0.1959
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0027 0.0023
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0035 0.0115 0.034
Entamoeba histolytica hypothetical protein 0.0019 0.0047 0.1717
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0163 0.0159
Echinococcus multilocularis lamin dm0 0.0026 0.0079 0.0235
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0027 0.0023
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0411 0.0407
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0047 0.014
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0573 0.4818
Brugia malayi hypothetical protein 0.0071 0.0268 0.2665
Trypanosoma cruzi guanylate kinase, putative 0.0019 0.0049 0.2965
Brugia malayi hypothetical protein 0.0118 0.0468 0.4653
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0028 0.0221
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0008 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0097 0.038 0.2991
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0047 0.0398
Leishmania major cytochrome p450-like protein 0.0022 0.0063 0.2827
Schistosoma mansoni dihydrofolate reductase 0.0013 0.0024 0.0202
Brugia malayi mbt repeat family protein 0.0048 0.017 0.1686
Trichomonas vaginalis sap-102, putative 0.0019 0.0049 0.1845
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0218 0.0214
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0045 0.016 0.7319
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase 0.0051 0.0185 0.1714
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0056 0.2111
Echinococcus multilocularis guanylate kinase 0.0019 0.0049 0.0146
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0268 0.0965
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0173
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0223 0.2219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0218 0.0214
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.2374 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0414
Trypanosoma brucei ISWI complex protein 0.0015 0.0033 0.1959
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.076 0.2737
Loa Loa (eye worm) hypothetical protein 0.007 0.0266 0.2099
Entamoeba histolytica hypothetical protein 0.0019 0.0047 0.1717
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0411 0.0397
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0077 0.0229
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0041 0.0341
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0045 0.016 0.9815
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0027 0.1564
Plasmodium falciparum cysteine--tRNA ligase 0.0035 0.0115 0.7053
Echinococcus granulosus zinc finger protein 0.0023 0.0066 0.0237
Brugia malayi PHD-finger family protein 0.0028 0.0088 0.0877
Brugia malayi PXA domain containing protein 0.0019 0.0047 0.0471
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0036 0.2132
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0047 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0009 0.0006 0.0046
Trypanosoma brucei guanylate kinase, putative 0.0019 0.0049 0.2965
Onchocerca volvulus 0.0008 0.0001 0.003
Brugia malayi hypothetical protein 0.0015 0.0033 0.0331
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0075 0.4549
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0047 0.014
Mycobacterium leprae putative cytochrome p450 0.0014 0.0027 0.0012
Echinococcus multilocularis guanylate kinase 0.0019 0.0049 0.0146
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0047 0.0373
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0414
Onchocerca volvulus 0.0032 0.0104 0.2748
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0047 0.1768
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0035 0.0115 0.091
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0008 0.0001 0.0003
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0009 0.0008 0.0401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0077 0.065
Schistosoma mansoni sodium/chloride dependent transporter 0.0008 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0048 0.017 0.1336
Chlamydia trachomatis UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 0.0051 0.0185 0.5679
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0036 0.2132
Mycobacterium ulcerans undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0051 0.0185 0.0181
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0047 0.0398
Loa Loa (eye worm) serotonin transporter b 0.0045 0.0159 0.1256
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0153 0.587
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0035 0.0115 0.7044
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.017 0.0501
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0414
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0064
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0027 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0218 0.1831
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0019 0.0049 0.0178
Schistosoma mansoni ATP-dependent RNA Helicase 0.0019 0.0049 0.0415
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0047 0.0373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0373
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0183 0.1444
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0041 0.012
Echinococcus multilocularis GPCR, family 2 0.0019 0.0049 0.0146
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Echinococcus multilocularis high voltage activated calcium channel beta 0.0019 0.0049 0.0146
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0047 0.0398
Loa Loa (eye worm) glutathione reductase 0.0046 0.0163 0.1281
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0018 0.018
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0943 0.9379
Chlamydia trachomatis guanylate kinase 0.0019 0.0049 0.149
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Echinococcus multilocularis thymidylate synthase 0.0032 0.0104 0.0309
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0027 0.0023
Brugia malayi hypothetical protein 0.0229 0.0938 0.9331
Leishmania major cytochrome p450-like protein 0.0014 0.0027 0.1165
Giardia lamblia Hypothetical protein 0.0008 0.0004 0.0183
Brugia malayi guanylate kinase 0.0019 0.0049 0.0491
Schistosoma mansoni MAGUK homolog 0.0019 0.0049 0.0415
Toxoplasma gondii guanylate kinase family protein 0.0019 0.0049 0.2227
Onchocerca volvulus 0.0026 0.0079 0.2089
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0005 0.0232
Echinococcus multilocularis Kelch repeat type 1 0.0186 0.0756 0.2236
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0048
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0035 0.0115 0.0967
Loa Loa (eye worm) norepinephrine transporter 0.0045 0.0159 0.1256
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0153 0.7034
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.009
Brugia malayi intermediate filament protein 0.0026 0.0079 0.0789
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0129 0.4781
Echinococcus multilocularis MAGUK p55 subfamily 0.0019 0.0049 0.0146
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0077 0.0278
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.0084 0.0325 1
Brugia malayi PXA domain containing protein 0.0019 0.0047 0.0471
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0079 0.0625
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0016 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0218 0.0214
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0047 0.0373
Plasmodium vivax glutathione reductase, putative 0.0046 0.0163 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0027 0.0023
Onchocerca volvulus 0.0008 0.0001 0.003
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0027 0.0023
Echinococcus granulosus high voltage activated calcium channel beta 0.026 0.1069 0.3851
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0027 0.0023
Brugia malayi hypothetical protein 0.0019 0.0047 0.0471
Loa Loa (eye worm) guanylate kinase 0.0019 0.0049 0.0389
Echinococcus granulosus neuropeptide s receptor 0.0454 0.1886 0.6794
Onchocerca volvulus 0.0026 0.0079 0.2089
Brugia malayi Guanylate kinase family protein 0.0019 0.0049 0.0491
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.017 0.1426
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0047 0.0171
Schistosoma mansoni hypothetical protein 0.0047 0.0167 0.14

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) < 0.368 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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