Detailed information for compound 1541009

Basic information

Technical information
  • TDR Targets ID: 1541009
  • Name: (4-methoxyphenyl)-spiro[1,5,6,7-tetrahydroimi dazo[4,5-c]pyridine-4,4'-piperidine]-1'-ylmet hanone
  • MW: 326.393 | Formula: C18H22N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)N1CCC2(CC1)NCCc1c2nc[nH]1
  • InChi: 1S/C18H22N4O2/c1-24-14-4-2-13(3-5-14)17(23)22-10-7-18(8-11-22)16-15(6-9-21-18)19-12-20-16/h2-5,12,21H,6-11H2,1H3,(H,19,20)
  • InChiKey: PGMHSTPSDGMBHS-UHFFFAOYSA-N  

Network

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Synonyms

  • (4-methoxyphenyl)-spiro[1,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4,4'-piperidine]-1'-yl-methanone
  • (4-methoxyphenyl)-(1'-spiro[1,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4,4'-piperidine]yl)methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0267 0.0301
Echinococcus granulosus dna polymerase eta 0.0023 0.0117 0.0292
Loa Loa (eye worm) hypothetical protein 0.0076 0.0519 0.0586
Trypanosoma cruzi acyl transferase-like protein 0.0044 0.0272 0.2124
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0106 0.0752 0.0819
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0473 0.046
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0066 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0081 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0066 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0186 0.0301
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0519 0.3005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0043 0.0267 0.0194
Schistosoma mansoni smad1 5 8 and 0.0017 0.0065 0.0163
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0267 0.0434
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0066 0.0066
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0473 0.9124
Schistosoma mansoni dishevelled 0.0009 0.001 0.0025
Plasmodium falciparum acyl carrier protein 0.007 0.0473 0.3712
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0066 0.1209
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.007 0.0473 0.2059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0267 0.1738
Mycobacterium tuberculosis Conserved protein 0.0208 0.1537 0.1831
Leishmania major oxidoreductase-like protein 0.0043 0.0267 0.1369
Onchocerca volvulus 0.0017 0.0066 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0081 0.0081
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0081 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus multilocularis smad 0.0017 0.0065 0.0106
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0252 0.196
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.007 0.0473 0.046
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0117 0.0292
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0043 0.0267 0.0194
Schistosoma mansoni DNA polymerase eta 0.0023 0.0117 0.0292
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0043 0.0267 0.0194
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0456 0.3448 0.4183
Chlamydia trachomatis acyl carrier protein 0.007 0.0473 0.2016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0026
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0186 0.1438
Leishmania major DNA polymerase kappa, putative 0.0023 0.0117 0.0347
Echinococcus multilocularis cpg binding protein 0.003 0.017 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0363 0.0908
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0732 0.5576 0.6981
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1814 0.2048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Loa Loa (eye worm) acetyltransferase 0.0151 0.1103 0.1246
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0473 0.046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0018 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0473 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0066 0.0492
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.007 0.0473 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0173 0.127 0.1434
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.069 0.5246 0.6614
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0192 0.1418 0.1483
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.1071 0.2683
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0519 0.3375
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0186 0.0815
Brugia malayi DIX domain containing protein 0.0009 0.001 0.001
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0117 0.0189
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0117 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0061 0.0455
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0081 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Echinococcus granulosus geminin 0.0526 0.3991 1
Toxoplasma gondii acyl transferase domain-containing protein 0.0044 0.0272 0.0471
Loa Loa (eye worm) hypothetical protein 0.0043 0.0267 0.0301
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0555 0.4209 0.5183
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0066 0.1209
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0267 0.0669
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0081 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0043 0.0267 0.0194
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0023 0.0023
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0065 0.0163
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0519 0.4068
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.028 0.1823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0003 0.0022
Onchocerca volvulus 0.12 0.9178 0.9653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0173 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0043 0.0267 0.0301
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0267 0.2082
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.007 0.0473 0.046
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0279 0.2084 0.2537
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.069 0.5246 0.6547
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0044 0.0272 0.2124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0061 0.0455
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.069 0.5246 0.6614
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0267 0.2082
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0003 0.0008
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0081 0.0203
Mycobacterium ulcerans oxidoreductase 0.0043 0.0267 0.0194
Echinococcus granulosus cathepsin l1 0.0011 0.0023 0.0058
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0117 0.0894
Onchocerca volvulus 0.0017 0.0066 0.0058
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0173 0.127 0.3182
Onchocerca volvulus Putative alcohol dehydrogenase 0.0043 0.0267 0.027
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0575 0.4361 0.5384
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0066 0.0058
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.1103 0.1103
Mycobacterium ulcerans polyketide synthase Pks13 0.1031 0.7872 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0186 0.0301
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0555 0.4209 0.5277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Brugia malayi CXXC zinc finger family protein 0.0029 0.0158 0.0158
Loa Loa (eye worm) ctsf protein 0.0017 0.0066 0.0074
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0013
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0043 0.0267 0.0194
Leishmania major zinc binding dehydrogenase-like protein 0.0043 0.0267 0.1369
Schistosoma mansoni hypothetical protein 0.0407 0.3075 0.7705
Mycobacterium ulcerans short-chain dehydrogenase 0.0043 0.0267 0.0194
Toxoplasma gondii quinone oxidoreductase, putative 0.0043 0.0267 0.0462
Mycobacterium ulcerans quinone reductase Qor 0.0043 0.0267 0.0194
Mycobacterium ulcerans quinone oxidoreductase 0.0043 0.0267 0.0194
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.3075 0.4994
Loa Loa (eye worm) fibroinase 0.0017 0.0066 0.0074
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0043 0.0267 0.0194
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0003 0.0008
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0043 0.0267 0.0194
Onchocerca volvulus 0.0011 0.0023 0.0014
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0018 0.0046
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.028 0.0702
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0009
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0267 0.2082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Schistosoma mansoni hypothetical protein 0.007 0.0473 0.1186
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0081 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Brugia malayi MH2 domain containing protein 0.0017 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0363 0.0908
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0519 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0043 0.0267 0.0194
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0173 0.127 0.1487
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0043 0.0267 0.0194
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.007 0.0473 0.3712
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0018 0.0119
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0135 0.0338
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0066 0.0165
Mycobacterium tuberculosis Hypothetical protein 0.0208 0.1537 0.1831
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0186 0.021
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.001 0.001
Toxoplasma gondii type I fatty acid synthase, putative 0.0732 0.5576 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0081 0.0614
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0519 0.3375
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0117 0.0117
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0186 0.1438
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.007 0.0473 0.046
Loa Loa (eye worm) cysteine protease 0.0017 0.0066 0.0074
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.028 0.1823
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0066 0.0058
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.028 0.2186
Loa Loa (eye worm) Smad1 0.0017 0.0065 0.0073
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0668 0.5083 0.6404
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.001 0.0025
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0186 0.1438
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0065 0.0163
Trypanosoma brucei acyl transferase-like protein 0.0044 0.0272 0.2124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Echinococcus granulosus cysteine protease 0.0009 0.0003 0.0008
Entamoeba histolytica cysteine protease, putative 0.0017 0.0066 0.1209
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0026
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0495 0.3751 0.4686
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0043 0.0267 0.0462
Brugia malayi hypothetical protein 0.0009 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Mycobacterium ulcerans Type I modular polyketide synthase 0.069 0.5246 0.6614
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0252 0.4818
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0081 0.0614
Leishmania major hypothetical protein, conserved 0.0044 0.0272 0.1405
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.007 0.0473 0.046
Giardia lamblia Methyltransferase like 2 0.0208 0.1537 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0519 0.3375
Echinococcus granulosus acyl carrier protein mitochondrial 0.007 0.0473 0.1186
Loa Loa (eye worm) hypothetical protein 0.0106 0.0752 0.0849
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.007 0.0473 0.046
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.001 0.0025
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0267 0.2082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0173 0.127 1
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0217 0.1605 0.1919
Schistosoma mansoni acyl carrier protein 0.007 0.0473 0.1186
Brugia malayi Cathepsin L-like precursor 0.0011 0.0023 0.0023
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0023 0.0385
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0043 0.0267 0.0301
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0043 0.0267 0.0194
Onchocerca volvulus 0.0043 0.0267 0.027
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0081 0.0614
Trypanosoma brucei unspecified product 0.0016 0.0061 0.0455
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0173 0.127 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0117 0.0894
Leishmania major oxidoreductase, putative 0.0043 0.0267 0.1369
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0065 0.0106
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0186 0.0315
Loa Loa (eye worm) hypothetical protein 0.0192 0.1418 0.1602
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0135 0.0878
Brugia malayi Phosphopantetheine attachment site family protein 0.007 0.0473 0.0473
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0043 0.0267 0.0194
Mycobacterium ulcerans quinone oxidoreductase 0.0043 0.0267 0.0194
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0267 0.2082
Trypanosoma cruzi acyl transferase-like protein, putative 0.0044 0.0272 0.2124
Brugia malayi MH1 domain containing protein 0.0009 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0081 0.0106
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.069 0.5246 0.6614
Schistosoma mansoni regulator of G protein signaling 0.0009 0.001 0.0025
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0555 0.4209 0.5277
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.069 0.5246 0.5246
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0158 0.0178
Schistosoma mansoni hypothetical protein 0.0526 0.3991 1
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0044 0.0272 0.2124
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0267 0.2082
Loa Loa (eye worm) hypothetical protein 0.0044 0.0272 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Loa Loa (eye worm) hypothetical protein 0.1158 0.8856 1
Onchocerca volvulus 0.0043 0.0267 0.027
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0043 0.0267 0.5116
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0237 0.1762 0.2122
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.007 0.0473 0.046
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0272 0.0682
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0267 0.2082
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0117 0.0894
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0081 0.151
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0107 0.082
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0117 0.0117
Mycobacterium tuberculosis Probable thioesterase TesA 0.0575 0.4361 0.5473
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0473 0.9124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.001 0.001
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0564 0.4279 0.5367
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0363 0.0409
Mycobacterium ulcerans polyketide synthase Pks9 0.0456 0.3448 0.4296
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0519 0.1299
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.001 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0061 0.0455
Treponema pallidum acyl carrier protein 0.007 0.0473 0.5
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0081 0.0128
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0519 0.1299
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0519 0.1299
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0081 0.0203
Onchocerca volvulus 0.0017 0.0066 0.0058
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0018 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0186 0.0465
Echinococcus granulosus AMP dependent ligase 0.007 0.0473 0.1186
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0186 0.0089
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0081 0.0614
Mycobacterium ulcerans hypothetical protein 0.007 0.0473 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0028 0.018
Mycobacterium ulcerans oxidoreductase FadB5 0.0043 0.0267 0.0194
Brugia malayi Methyltransferase-like protein 4 0.0208 0.1537 0.1537
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0028 0.018
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0186 0.1438
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0066 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0426
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0081 0.0092
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0005 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0173 0.127 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0044 0.0272 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0031
Mycobacterium ulcerans thioesterase TesA 0.0575 0.4361 0.5473
Mycobacterium ulcerans fatty acid synthase Fas 0.0217 0.1605 0.1919
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0066 0.0165
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0186 0.0186
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0117 0.0759
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0186 0.1438
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0698 0.5486
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0081 0.0614
Onchocerca volvulus 0.0029 0.0158 0.0155
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.007 0.0473 0.3712
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0117 0.0759
Schistosoma mansoni dep domain containing protein 0.0009 0.001 0.0025
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1031 0.7872 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.001 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0066 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Schistosoma mansoni dishevelled 0.0009 0.001 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0405 0.1014
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0348 0.262 0.469
Echinococcus granulosus cpg binding protein 0.003 0.017 0.0426
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.1103 0.1792
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0384 0.3007
Echinococcus granulosus dna polymerase kappa 0.0023 0.0117 0.0292
Brugia malayi isocitrate dehydrogenase 0.0032 0.0186 0.0186
Mycobacterium ulcerans Type I modular polyketide synthase 0.069 0.5246 0.6614
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0519 0.4068
Mycobacterium leprae Probable polyketide synthase Pks1 0.0732 0.5576 0.6981
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0363 0.0589
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0427 0.3342
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0065 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0186 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0173 0.127 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0081 0.151
Loa Loa (eye worm) acyl carrier protein 0.007 0.0473 0.0535
Mycobacterium ulcerans acyl carrier protein 0.007 0.0473 0.046
Mycobacterium ulcerans polyketide synthase MbtC 0.0173 0.127 0.1487
Echinococcus multilocularis cysteine protease 0.0017 0.0066 0.0107
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0267 0.0267
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0519 0.4068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0043 0.0267 0.0194
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0117 0.2199
Brugia malayi MH1 domain containing protein 0.0009 0.0008 0.0008
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0252 0.1171
Echinococcus granulosus smad 0.0017 0.0065 0.0163
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0106 0.0752 0.0637
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0043 0.0267 0.0194
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0173 0.127 0.3182
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0081 0.0614
Brugia malayi Cathepsin L-like precursor 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0644 0.4897 0.6165
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0363 0.0908
Brugia malayi Smad1 0.0017 0.0065 0.0065
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.007 0.0473 0.046
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0519 0.1299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium ulcerans polyketide synthase 0.0732 0.5576 0.704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0322 0.2515
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0081 0.0614
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0447 0.3381 0.6057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Plasmodium vivax vivapain-2 0.0017 0.0066 0.0492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0023 0.0151
Mycobacterium ulcerans Type I modular polyketide synthase 0.069 0.5246 0.6614
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0005
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.007 0.0473 0.0488
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.6158 1
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0427 0.3342
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0044 0.0272 0.0201
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0267 0.0194
Mycobacterium ulcerans polyketide synthase MbtD 0.0212 0.1569 0.1873
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.001 0.0016
Schistosoma mansoni smad 0.0017 0.0065 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0644 0.4897 0.4897
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0272 0.0682
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.007 0.0473 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0267 0.5116
Schistosoma mansoni zinc binding dehydrogenase 0.0043 0.0267 0.0669
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.001 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0003 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1814 0.2048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0081 0.0081
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0018 0.003
Echinococcus granulosus NADH dehydrogenase 0.007 0.0473 0.1186
Echinococcus granulosus dnaJ subfamily B 0.0407 0.3075 0.7705
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.007 0.0473 0.046
Giardia lamblia DINP protein human, muc B family 0.0023 0.0117 0.0244
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0644 0.4897 0.553
Toxoplasma gondii acyl carrier protein ACP 0.007 0.0473 0.0832
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.001 0.0025
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0106 0.0752 0.0819
Echinococcus multilocularis Smad4 0.0017 0.0065 0.0106
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0732 0.5576 0.704
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0363 0.0589
Onchocerca volvulus 0.0017 0.0066 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0081 0.0132
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.001 0.0016
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.069 0.5246 0.6614
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Leishmania major nuclear receptor binding factor-like protein 0.0043 0.0267 0.1369
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0168 0.1234 0.1441
Brugia malayi MH1 domain containing protein 0.0017 0.0065 0.0065
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.001 0.001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0135 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0732 0.5576 0.704
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0456 0.3448 0.4296
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0028 0.0192
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0135 0.0219
Onchocerca volvulus 0.0644 0.4897 0.5146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0043 0.0267 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0066 0.0427
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.0473 0.0473
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0363 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0732 0.5576 0.704
Toxoplasma gondii cathepsin CPL 0.0017 0.0066 0.01
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0267 0.5116
Trypanosoma brucei unspecified product 0.0023 0.0117 0.0894
Loa Loa (eye worm) fatty acid synthase 0.068 0.5176 0.5844
Schistosoma mansoni cpg binding protein 0.0029 0.0158 0.0395
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0066 0.0165
Plasmodium vivax vivapain-2 0.0017 0.0066 0.0492
Brugia malayi Alcohol dehydrogenase class III 0.0043 0.0267 0.0267
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0427 0.3342
Echinococcus multilocularis dna polymerase eta 0.0023 0.0117 0.0189
Echinococcus granulosus cathepsin l1 0.0017 0.0066 0.0165
Mycobacterium leprae Polyketide synthase Pks13 0.1031 0.7872 1
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0272 0.0682
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0519 0.0842
Echinococcus multilocularis AMP dependent ligase 0.007 0.0473 0.0769
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.028 0.0485
Echinococcus multilocularis cathepsin L 0.0009 0.0003 0.0006
Schistosoma mansoni smad1 5 8 and 0.0017 0.0065 0.0163
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0267 0.0267
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0043 0.0267 0.0194
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0117 0.0894
Onchocerca volvulus Fatty acid synthase homolog 0.1243 0.9507 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Schistosoma mansoni methyltransferase-related 0.0208 0.1537 0.385
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0044 0.0272 0.0272
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0267 0.2082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0066 0.0074
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0267 0.2082
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0186 0.1438
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0081 0.0203
Brugia malayi hypothetical protein 0.0009 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1537 1
Trypanosoma brucei unspecified product 0.0016 0.0061 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0043 0.0267 0.2082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0023 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0363 0.0363
Mycobacterium ulcerans acyl carrier protein 0.007 0.0473 0.046
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.007 0.0473 0.0535
Mycobacterium ulcerans dehydrogenase 0.0043 0.0267 0.0194
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0081 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0363 0.0908
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0267 0.1738
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.001 0.0025
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.001 0.0011
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0018 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Entamoeba histolytica hypothetical protein 0.0026 0.0135 0.2554
Loa Loa (eye worm) nuclear factor I 0.0009 0.0008 0.0009
Leishmania major zinc-binding dehydrogenase-like protein 0.0043 0.0267 0.1369
Loa Loa (eye worm) acyl carrier protein 0.0317 0.2378 0.2686
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0426
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0043 0.0267 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0106 0.0752 0.0819
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0173 0.127 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.001 0.0025
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0217 0.1605 0.1759
Mycobacterium leprae conserved hypothetical protein 0.007 0.0473 0.0271
Loa Loa (eye worm) hypothetical protein 0.0106 0.0752 0.0849
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.001 0.0025
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0135 0.0224
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.007 0.0473 0.046
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.028 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Echinococcus granulosus Smad4 0.0017 0.0065 0.0163
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0081 0.0108
Schistosoma mansoni smad1 5 8 and 0.0017 0.0065 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0212 0.1569 0.1873
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0018 0.0292
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0186 0.0301
Brugia malayi N-terminal motif family protein 0.0192 0.1418 0.1418
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0117 0.0292
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0003 0.0003
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0698 0.5486
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0267 0.1369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0023 0.0151
Schistosoma mansoni hypothetical protein 0.0526 0.3991 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.1103 0.2765
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0267 0.2082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Brugia malayi MH2 domain containing protein 0.0244 0.1814 0.1814
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.007 0.0473 0.046
Mycobacterium ulcerans polyketide synthase 0.069 0.5246 0.6614
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0173 0.127 0.8186
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0003 0.0003
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0043 0.0267 0.0194
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0106 0.0752 0.0819
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0117 0.0347
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0519 0.0842
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0135 0.0338
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0272 0.0682
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0519 0.1299
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0066 0.0074
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0117 0.0292
Brugia malayi MH1 domain containing protein 0.0017 0.0065 0.0065
Onchocerca volvulus 0.0017 0.0066 0.0058
Onchocerca volvulus 0.007 0.0473 0.0488
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1031 0.7872 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0117 0.0894
Brugia malayi MH2 domain containing protein 0.0017 0.0065 0.0065
Leishmania major quinone oxidoreductase, putative 0.0043 0.0267 0.1369
Leishmania major d-xylulose reductase, putative 0.0043 0.0267 0.1369
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0081 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0066 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0212 0.1569 0.1569
Loa Loa (eye worm) hypothetical protein 0.0043 0.0267 0.0301
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0021
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0267 0.1738
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0173 0.127 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Toxoplasma gondii type I fatty acid synthase 0.0106 0.0752 0.1332
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0028 0.0032
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0081 0.0106
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0081 0.0106
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.007 0.0473 0.0769
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0267 0.2082
Leishmania major cathepsin L-like protease 0.0064 0.0427 0.2454
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0272 0.0442
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.007 0.0473 0.0473
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.001 0.0011
Onchocerca volvulus 0.0017 0.0066 0.0058
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0003 0.0008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0081 0.0614
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0173 0.127 0.2062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0732 0.5576 0.704
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0732 0.5576 0.6981
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0066 0.0107
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0473 0.0271
Loa Loa (eye worm) hypothetical protein 0.0023 0.0117 0.0132
Leishmania major DNA polymerase eta, putative 0.0023 0.0117 0.0347
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0011
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0392 0.2955 0.366
Schistosoma mansoni alcohol dehydrogenase 0.0043 0.0267 0.0669
Echinococcus multilocularis NADH dehydrogenase 0.007 0.0473 0.0769
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0135 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus multilocularis cysteine protease 0.0017 0.0066 0.0107
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.007 0.0473 0.046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0117 0.0189
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0043 0.0267 0.0194
Leishmania major cathepsin L-like protease 0.0064 0.0427 0.2454
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0173 0.127 0.2263
Echinococcus granulosus cathepsin L 0.0009 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0386 0.2912 0.3288
Leishmania major cathepsin L-like protease 0.0064 0.0427 0.2454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Mycobacterium ulcerans oxidoreductase 0.0043 0.0267 0.0194
Schistosoma mansoni Smad4 0.0017 0.0065 0.0163
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0043 0.0267 0.0194
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0186 0.0301
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0186 0.0465
Toxoplasma gondii type I fatty acid synthase, putative 0.0491 0.3716 0.6659
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0173 0.127 1
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0267 0.0194
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0668 0.5083 0.6404
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0519 0.0842
Echinococcus multilocularis geminin 0.0526 0.3991 0.6481
Plasmodium vivax acyl carrier protein, putative 0.007 0.0473 0.3712
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0267 0.0267
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0186 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0081 0.0203
Mycobacterium tuberculosis Probable oxidoreductase 0.0043 0.0267 0.0194
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0065 0.0163
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.069 0.5246 0.6547
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0026
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0066 0.0492
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0173 0.127 0.1487
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0066 0.0492
Onchocerca volvulus 0.0017 0.0066 0.0058
Mycobacterium ulcerans thioesterase 0.0575 0.4361 0.5473
Brugia malayi cathepsin L-like precursor 0.0011 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0732 0.5576 0.704
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0519 0.3079
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.007 0.0473 0.046
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0065 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0066 0.0492
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0383 0.067
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0066 0.0107
Leishmania major hypothetical protein, conserved 0.0208 0.1537 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0107 0.0121
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0065 0.0073
Leishmania major acyl carrier protein, putative 0.007 0.0473 0.2772
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0427 0.3342

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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