Detailed information for compound 1541009

Basic information

Technical information
  • TDR Targets ID: 1541009
  • Name: (4-methoxyphenyl)-spiro[1,5,6,7-tetrahydroimi dazo[4,5-c]pyridine-4,4'-piperidine]-1'-ylmet hanone
  • MW: 326.393 | Formula: C18H22N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)N1CCC2(CC1)NCCc1c2nc[nH]1
  • InChi: 1S/C18H22N4O2/c1-24-14-4-2-13(3-5-14)17(23)22-10-7-18(8-11-22)16-15(6-9-21-18)19-12-20-16/h2-5,12,21H,6-11H2,1H3,(H,19,20)
  • InChiKey: PGMHSTPSDGMBHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-methoxyphenyl)-spiro[1,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4,4'-piperidine]-1'-yl-methanone
  • (4-methoxyphenyl)-(1'-spiro[1,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4,4'-piperidine]yl)methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0023 0.0151
Loa Loa (eye worm) cysteine protease 0.0017 0.0066 0.0074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0158 0.0178
Leishmania major zinc binding dehydrogenase-like protein 0.0043 0.0267 0.1369
Echinococcus granulosus dna polymerase eta 0.0023 0.0117 0.0292
Onchocerca volvulus 0.0017 0.0066 0.0058
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0066 0.0492
Mycobacterium ulcerans polyketide synthase 0.069 0.5246 0.6614
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0267 0.0434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0066 0.0074
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0117 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0427 0.3342
Mycobacterium leprae Polyketide synthase Pks13 0.1031 0.7872 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0456 0.3448 0.4296
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0272 0.0682
Brugia malayi cathepsin L-like precursor 0.0011 0.0023 0.0023
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0173 0.127 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0267 0.5116
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0066 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.007 0.0473 0.3712
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0026
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0081 0.0106
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0186 0.0465
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0644 0.4897 0.553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0106 0.0752 0.0819
Trypanosoma cruzi acyl transferase-like protein 0.0044 0.0272 0.2124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0026
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.007 0.0473 0.046
Echinococcus granulosus smad 0.0017 0.0065 0.0163
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0081 0.0614
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0519 0.0842
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0066 0.0066
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0081 0.0614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0043 0.0267 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0135 0.0135
Schistosoma mansoni dishevelled 0.0009 0.001 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0043 0.0267 0.5116
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0555 0.4209 0.5277
Loa Loa (eye worm) hypothetical protein 0.0386 0.2912 0.3288
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0066 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0363 0.0908
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0186 0.0301
Toxoplasma gondii type I fatty acid synthase 0.0106 0.0752 0.1332
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0668 0.5083 0.6404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Loa Loa (eye worm) hypothetical protein 0.0043 0.0267 0.0301
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0043 0.0267 0.0194
Onchocerca volvulus 0.0017 0.0066 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0405 0.1014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.6158 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0272 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.007 0.0473 0.046
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0081 0.0203
Echinococcus granulosus geminin 0.0526 0.3991 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0192 0.1418 0.1483
Brugia malayi MH1 domain containing protein 0.0017 0.0065 0.0065
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1031 0.7872 1
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0267 0.0194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0363 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium ulcerans dehydrogenase 0.0043 0.0267 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0066 0.0074
Leishmania major cathepsin L-like protease 0.0064 0.0427 0.2454
Brugia malayi MH1 domain containing protein 0.0009 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0026 0.0135 0.2554
Leishmania major oxidoreductase-like protein 0.0043 0.0267 0.1369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Brugia malayi DIX domain containing protein 0.0009 0.001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0698 0.5486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0043 0.0267 0.0194
Leishmania major cathepsin L-like protease 0.0064 0.0427 0.2454
Schistosoma mansoni cpg binding protein 0.0029 0.0158 0.0395
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0267 0.1738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0043 0.0267 0.0194
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0427 0.3342
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0043 0.0267 0.0194
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0081 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0061 0.0455
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0519 0.0519
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0066 0.0165
Schistosoma mansoni smad1 5 8 and 0.0017 0.0065 0.0163
Mycobacterium ulcerans quinone reductase Qor 0.0043 0.0267 0.0194
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0117 0.0894
Loa Loa (eye worm) fatty acid synthase 0.068 0.5176 0.5844
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.1103 0.2765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.028 0.2186
Onchocerca volvulus Putative alcohol dehydrogenase 0.0043 0.0267 0.027
Mycobacterium ulcerans oxidoreductase 0.0043 0.0267 0.0194
Mycobacterium tuberculosis Probable thioesterase TesA 0.0575 0.4361 0.5473
Echinococcus multilocularis cathepsin L 0.0009 0.0003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Brugia malayi MH2 domain containing protein 0.0244 0.1814 0.1814
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0519 0.1299
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0043 0.0267 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.001 0.0016
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0173 0.127 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0066 0.0492
Loa Loa (eye worm) acyl carrier protein 0.0317 0.2378 0.2686
Echinococcus multilocularis NADH dehydrogenase 0.007 0.0473 0.0769
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.007 0.0473 0.046
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0066 0.0058
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.007 0.0473 0.046
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0009
Mycobacterium ulcerans thioesterase TesA 0.0575 0.4361 0.5473
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.069 0.5246 0.6614
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.001 0.0016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0117 0.0759
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.007 0.0473 0.0769
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.007 0.0473 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0186 0.1438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Schistosoma mansoni alcohol dehydrogenase 0.0043 0.0267 0.0669
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0018 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0081 0.0106
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1814 0.2048
Brugia malayi CXXC zinc finger family protein 0.0029 0.0158 0.0158
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0117 0.0292
Schistosoma mansoni regulator of G protein signaling 0.0009 0.001 0.0025
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.001 0.0025
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0173 0.127 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0363 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0028 0.018
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0732 0.5576 0.6981
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0066 0.0107
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0081 0.0203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0363 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0519 0.1299
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.028 0.0485
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.007 0.0473 0.046
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.007 0.0473 0.046
Mycobacterium ulcerans polyketide synthase Pks9 0.0456 0.3448 0.4296
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0173 0.127 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0081 0.0203
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0023 0.0023
Toxoplasma gondii cathepsin CPL 0.0017 0.0066 0.01
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0519 0.4068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0363 0.0908
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0173 0.127 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0065 0.0106
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0267 0.2082
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0135 0.0338
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0272 0.0682
Schistosoma mansoni acyl carrier protein 0.007 0.0473 0.1186
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0018 0.0119
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0081 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Schistosoma mansoni dep domain containing protein 0.0009 0.001 0.0025
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0065 0.0163
Echinococcus granulosus dnaJ subfamily B 0.0407 0.3075 0.7705
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0043 0.0267 0.0194
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.007 0.0473 0.046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0186 0.1438
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.007 0.0473 0.0535
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0107 0.0121
Trypanosoma brucei acyl transferase-like protein 0.0044 0.0272 0.2124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Onchocerca volvulus 0.0017 0.0066 0.0058
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.001 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0363 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.001 0.0025
Mycobacterium ulcerans Type I modular polyketide synthase 0.069 0.5246 0.6614
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0564 0.4279 0.5367
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0322 0.2515
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0348 0.262 0.469
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0061 0.0455
Brugia malayi N-terminal motif family protein 0.0192 0.1418 0.1418
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.001 0.0011
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0186 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0043 0.0267 0.0194
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0173 0.127 1
Mycobacterium leprae conserved hypothetical protein 0.007 0.0473 0.0271
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0519 0.3005
Brugia malayi Smad1 0.0017 0.0065 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0081 0.0614
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0173 0.127 0.1434
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0267 0.0267
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0003 0.0003
Giardia lamblia DINP protein human, muc B family 0.0023 0.0117 0.0244
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0043 0.0267 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0066 0.1209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0005
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0519 0.3079
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0267 0.2082
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0043 0.0267 0.0301
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0252 0.1171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0065 0.0073
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0081 0.0614
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0519 0.4068
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0267 0.2082
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0043 0.0267 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0021
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.028 0.1823
Mycobacterium ulcerans acyl carrier protein 0.007 0.0473 0.046
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0267 0.2082
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0473 0.046
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0081 0.0617
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.3075 0.4994
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0044 0.0272 0.2124
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0473 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0066 0.0427
Schistosoma mansoni hypothetical protein 0.007 0.0473 0.1186
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.007 0.0473 0.046
Schistosoma mansoni hypothetical protein 0.0526 0.3991 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0011
Mycobacterium tuberculosis Conserved protein 0.0208 0.1537 0.1831
Schistosoma mansoni hypothetical protein 0.0407 0.3075 0.7705
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0018 0.0046
Mycobacterium ulcerans oxidoreductase 0.0043 0.0267 0.0194
Echinococcus granulosus Smad4 0.0017 0.0065 0.0163
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0009
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0081 0.0132
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0426
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0173 0.127 0.3182
Onchocerca volvulus 0.0029 0.0158 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Schistosoma mansoni dishevelled 0.0009 0.001 0.0025
Brugia malayi isocitrate dehydrogenase 0.0032 0.0186 0.0186
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0135 0.0219
Schistosoma mansoni zinc binding dehydrogenase 0.0043 0.0267 0.0669
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0043 0.0267 0.0669
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0237 0.1762 0.2122
Trypanosoma brucei unspecified product 0.0023 0.0117 0.0894
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0427 0.3342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Brugia malayi Cathepsin L-like precursor 0.0011 0.0023 0.0023
Brugia malayi Alcohol dehydrogenase class III 0.0043 0.0267 0.0267
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0081 0.151
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0081 0.0614
Schistosoma mansoni hypothetical protein 0.0526 0.3991 1
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.007 0.0473 0.3712
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0173 0.127 0.1487
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0456 0.3448 0.4183
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0066 0.0058
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0186 0.021
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0011
Toxoplasma gondii type I fatty acid synthase, putative 0.0732 0.5576 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0186 0.1438
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0732 0.5576 0.704
Loa Loa (eye worm) acyl carrier protein 0.007 0.0473 0.0535
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0519 0.3375
Mycobacterium tuberculosis Hypothetical protein 0.0208 0.1537 0.1831
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0117 0.0189
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0065 0.0163
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0066 0.0492
Loa Loa (eye worm) hypothetical protein 0.0043 0.0267 0.0301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0363 0.0908
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0267 0.2082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0495 0.3751 0.4686
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0186 0.1438
Onchocerca volvulus 0.0043 0.0267 0.027
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0135 0.0224
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0473 0.046
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0066 0.0107
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.007 0.0473 0.046
Brugia malayi AMP-binding enzyme family protein 0.0644 0.4897 0.4897
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0117 0.0117
Mycobacterium ulcerans quinone oxidoreductase 0.0043 0.0267 0.0194
Mycobacterium ulcerans quinone oxidoreductase 0.0043 0.0267 0.0194
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Loa Loa (eye worm) Smad1 0.0017 0.0065 0.0073
Onchocerca volvulus 0.0017 0.0066 0.0058
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0117 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.069 0.5246 0.6614
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0732 0.5576 0.704
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.001 0.0011
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.007 0.0473 0.0271
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0555 0.4209 0.5183
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0732 0.5576 0.704
Loa Loa (eye worm) hypothetical protein 0.0076 0.0519 0.0586
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0272 0.0682
Echinococcus granulosus cpg binding protein 0.003 0.017 0.0426
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0018 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0081 0.0081
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0081 0.151
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.1103 0.1792
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0005 0.0006
Onchocerca volvulus Fatty acid synthase homolog 0.1243 0.9507 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0267 0.5116
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0081 0.0106
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0173 0.127 0.3182
Leishmania major oxidoreductase, putative 0.0043 0.0267 0.1369
Loa Loa (eye worm) hypothetical protein 0.0106 0.0752 0.0849
Schistosoma mansoni smad1 5 8 and 0.0017 0.0065 0.0163
Plasmodium vivax vivapain-2 0.0017 0.0066 0.0492
Brugia malayi Methyltransferase-like protein 4 0.0208 0.1537 0.1537
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0426
Mycobacterium ulcerans fatty acid synthase Fas 0.0217 0.1605 0.1919
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0023 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0081 0.0092
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0212 0.1569 0.1873
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.028 0.0702
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0519 0.1299
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0044 0.0272 0.0272
Chlamydia trachomatis acyl carrier protein 0.007 0.0473 0.2016
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0066 0.0165
Onchocerca volvulus 0.12 0.9178 0.9653
Toxoplasma gondii acyl carrier protein ACP 0.007 0.0473 0.0832
Leishmania major acyl carrier protein, putative 0.007 0.0473 0.2772
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0644 0.4897 0.6165
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0473 0.9124
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0217 0.1605 0.1759
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0081 0.0106
Echinococcus granulosus cathepsin L 0.0009 0.0003 0.0008
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0384 0.3007
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0698 0.5486
Plasmodium vivax acyl carrier protein, putative 0.007 0.0473 0.3712
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0279 0.2084 0.2537
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0028 0.0192
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0044 0.0272 0.0442
Trypanosoma brucei unspecified product 0.0016 0.0061 0.0455
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0117 0.0894
Leishmania major zinc-binding dehydrogenase-like protein 0.0043 0.0267 0.1369
Onchocerca volvulus 0.0017 0.0066 0.0058
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0117 0.0292
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0026
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0081 0.0614
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0363 0.0589
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0267 0.1738
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0392 0.2955 0.366
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.069 0.5246 0.6614
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.1103 0.1103
Echinococcus granulosus acyl carrier protein mitochondrial 0.007 0.0473 0.1186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0011
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0043 0.0267 0.0194
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0066 0.1209
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.069 0.5246 0.6547
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0575 0.4361 0.5384
Mycobacterium ulcerans polyketide synthase Pks13 0.1031 0.7872 1
Leishmania major hypothetical protein, conserved 0.0208 0.1537 1
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0023 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus multilocularis cysteine protease 0.0017 0.0066 0.0107
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0117 0.2199
Loa Loa (eye worm) hypothetical protein 0.0043 0.0267 0.0301
Loa Loa (eye worm) hypothetical protein 0.0023 0.0117 0.0132
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0065 0.0163
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0186 0.0815
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0519 0.0842
Leishmania major DNA polymerase kappa, putative 0.0023 0.0117 0.0347
Giardia lamblia Methyltransferase like 2 0.0208 0.1537 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0519 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0066 0.0074
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0519 0.1299
Brugia malayi Cathepsin L-like precursor 0.0011 0.0023 0.0023
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0003 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1814 0.2048
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0043 0.0267 0.1738
Loa Loa (eye worm) fibroinase 0.0017 0.0066 0.0074
Schistosoma mansoni [ACP] S-malonyltransferase 0.0044 0.0272 0.0682
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0066 0.0492
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0028 0.0032
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0173 0.127 0.127
Schistosoma mansoni Smad4 0.0017 0.0065 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0363 0.0589
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0555 0.4209 0.5277
Mycobacterium ulcerans short-chain dehydrogenase 0.0043 0.0267 0.0194
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0186 0.0301
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0186 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0173 0.127 0.2263
Mycobacterium tuberculosis Probable oxidoreductase 0.0043 0.0267 0.0194
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0519 0.0842
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.001 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0117 0.0132
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0447 0.3381 0.6057
Schistosoma mansoni DNA polymerase eta 0.0023 0.0117 0.0292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0003 0.0008
Brugia malayi MH1 domain containing protein 0.0009 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0473 0.046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0066 0.0165
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0081 0.0108
Mycobacterium ulcerans hypothetical protein 0.007 0.0473 0.046
Mycobacterium ulcerans thioesterase 0.0575 0.4361 0.5473
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0066 0.0107
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0043 0.0267 0.1369
Entamoeba histolytica cysteine protease, putative 0.0017 0.0066 0.1209
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.001 0.0016
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.007 0.0473 0.2059
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.001 0.0025
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0106 0.0752 0.0819
Treponema pallidum acyl carrier protein 0.007 0.0473 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0732 0.5576 0.6981
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0043 0.0267 0.0194
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.007 0.0473 0.046
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0018 0.0046
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.0473 0.0473
Leishmania major cathepsin L-like protease 0.0064 0.0427 0.2454
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0018 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0519 0.3375
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0519 0.4068
Trypanosoma cruzi acyl transferase-like protein, putative 0.0044 0.0272 0.2124
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.028 0.1823
Brugia malayi MH1 domain containing protein 0.0017 0.0065 0.0065
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.007 0.0473 0.046
Leishmania major d-xylulose reductase, putative 0.0043 0.0267 0.1369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0252 0.196
Loa Loa (eye worm) hypothetical protein 0.0192 0.1418 0.1602
Mycobacterium ulcerans polyketide synthase MbtC 0.0173 0.127 0.1487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.012
Toxoplasma gondii type I fatty acid synthase, putative 0.0491 0.3716 0.6659
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0044 0.0272 0.0053
Mycobacterium tuberculosis Possible dehydrogenase 0.0043 0.0267 0.0194
Onchocerca volvulus 0.0017 0.0066 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.069 0.5246 0.5246
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0186 0.0301
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0081 0.0614
Brugia malayi hypothetical protein 0.0009 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0186 0.0301
Plasmodium vivax vivapain-2 0.0017 0.0066 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0383 0.067
Mycobacterium ulcerans Type I modular polyketide synthase 0.069 0.5246 0.6614
Brugia malayi MH2 domain containing protein 0.0017 0.0065 0.0065
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0043 0.0267 0.0194
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Leishmania major hypothetical protein, conserved 0.0044 0.0272 0.1405
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.007 0.0473 0.0488
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0107 0.082
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0044 0.0272 0.0201
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0117 0.0894
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0065 0.0073
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0081 0.0614
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0217 0.1605 0.1919
Toxoplasma gondii acyl transferase domain-containing protein 0.0044 0.0272 0.0471
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0173 0.127 0.8186
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0519 0.3375
Leishmania major quinone oxidoreductase, putative 0.0043 0.0267 0.1369
Loa Loa (eye worm) nuclear factor I 0.0009 0.0008 0.0009
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0081 0.0128
Schistosoma mansoni smad 0.0017 0.0065 0.0163
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0081 0.0132
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0066 0.0058
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1031 0.7872 1
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1537 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0065 0.0106
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0081 0.0203
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0043 0.0267 0.2082
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0003 0.0008
Onchocerca volvulus 0.0011 0.0023 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Echinococcus multilocularis geminin 0.0526 0.3991 0.6481
Brugia malayi MH2 domain containing protein 0.0017 0.0065 0.0065
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.001 0.001
Echinococcus granulosus cysteine protease 0.0009 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0106 0.0752 0.0849
Trypanosoma brucei unspecified product 0.0016 0.0061 0.0455
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.001 0.001
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0043 0.0267 0.2082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0135 0.1039
Onchocerca volvulus 0.0043 0.0267 0.027
Leishmania major nuclear receptor binding factor-like protein 0.0043 0.0267 0.1369
Mycobacterium ulcerans Type I modular polyketide synthase 0.069 0.5246 0.6614
Mycobacterium ulcerans acyl carrier protein 0.007 0.0473 0.046
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0267 0.0267
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0117 0.0189
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0003 0.0008
Echinococcus granulosus cathepsin l1 0.0011 0.0023 0.0058
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0003 0.0003
Mycobacterium ulcerans polyketide synthase 0.0732 0.5576 0.704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0043 0.0267 0.0194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Echinococcus multilocularis dna polymerase eta 0.0023 0.0117 0.0189
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0732 0.5576 0.704
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0117 0.0894
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.069 0.5246 0.6547
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0106 0.0752 0.0637
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0732 0.5576 0.704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0081 0.0092
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0186 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Mycobacterium ulcerans oxidoreductase FadB5 0.0043 0.0267 0.0194
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0186 0.0315
Leishmania major DNA polymerase eta, putative 0.0023 0.0117 0.0347
Echinococcus granulosus AMP dependent ligase 0.007 0.0473 0.1186
Onchocerca volvulus 0.0644 0.4897 0.5146
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0427 0.3342
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0043 0.0267 0.0194
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Brugia malayi Phosphopantetheine attachment site family protein 0.007 0.0473 0.0473
Mycobacterium ulcerans polyketide synthase MbtD 0.0212 0.1569 0.1873
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0117 0.0292
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0135 0.0338
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0106 0.0752 0.0819
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0081 0.0614
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0043 0.0267 0.0194
Echinococcus multilocularis AMP dependent ligase 0.007 0.0473 0.0769
Echinococcus multilocularis cysteine protease 0.0017 0.0066 0.0107
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0117 0.0347
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0043 0.0267 0.0194
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0252 0.4818
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0135 0.1039
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0018 0.003
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0043 0.0267 0.0194
Echinococcus multilocularis Smad4 0.0017 0.0065 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0135 0.0878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0061 0.0455
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0043 0.0267 0.0194
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0519 0.1299
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0117 0.0759
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.007 0.0473 0.046
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.001 0.0025
Schistosoma mansoni smad1 5 8 and 0.0017 0.0065 0.0163
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0173 0.127 0.1487
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0173 0.127 0.2062
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Loa Loa (eye worm) acetyltransferase 0.0151 0.1103 0.1246
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.001 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0186 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Onchocerca volvulus 0.0017 0.0066 0.0058
Mycobacterium leprae Probable polyketide synthase Pks1 0.0732 0.5576 0.6981
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.1071 0.2683
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Toxoplasma gondii quinone oxidoreductase, putative 0.0043 0.0267 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0013
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0043 0.0267 0.0462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0003 0.0022
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0186 0.1438
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0186 0.0315
Schistosoma mansoni methyltransferase-related 0.0208 0.1537 0.385
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.028 0.0485
Brugia malayi hypothetical protein 0.0009 0.001 0.001
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0043 0.0267 0.2082
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.001 0.0025
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0168 0.1234 0.1441
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0267 0.2082
Echinococcus granulosus dna polymerase kappa 0.0023 0.0117 0.0292
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.069 0.5246 0.6614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Loa Loa (eye worm) hypothetical protein 0.1158 0.8856 1
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0173 0.127 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0267 0.0267
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0186 0.1438
Echinococcus multilocularis smad 0.0017 0.0065 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0267 0.2082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0003 0.0022
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0267 0.2082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0267 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0066 0.0427
Trypanosoma brucei oxidoreductase, putative 0.0043 0.0267 0.2082
Echinococcus granulosus NADH dehydrogenase 0.007 0.0473 0.1186
Plasmodium falciparum acyl carrier protein 0.007 0.0473 0.3712
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0106 0.0752 0.0819
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0473 0.9124
Brugia malayi Cathepsin L-like precursor 0.0017 0.0066 0.0066
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0044 0.0272 0.2124
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.007 0.0473 0.046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0117 0.0894
Brugia malayi AMP-binding enzyme family protein 0.0212 0.1569 0.1569
Echinococcus multilocularis cpg binding protein 0.003 0.017 0.0276
Onchocerca volvulus 0.007 0.0473 0.0488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0066 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0023 0.0058
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.001 0.0016
Echinococcus granulosus cathepsin l1 0.0017 0.0066 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0427 0.3342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0081 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0028 0.018
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0668 0.5083 0.6404

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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