Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.0368 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0535 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.036 | 0.3728 | 0.3676 |
Echinococcus granulosus | GPCR family 2 | 0.0296 | 0.3038 | 0.5535 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0535 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0296 | 0.3038 | 0.5535 |
Brugia malayi | Smad1 | 0.0025 | 0.0082 | 0.0082 |
Schistosoma mansoni | tar DNA-binding protein | 0.0515 | 0.5423 | 0.7976 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0936 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.0368 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0082 | 0.0082 |
Schistosoma mansoni | tar DNA-binding protein | 0.0515 | 0.5423 | 0.7976 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.3038 | 0.298 |
Schistosoma mansoni | hypothetical protein | 0.0296 | 0.3038 | 0.4415 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0101 | 0.0101 |
Brugia malayi | RNA binding protein | 0.0515 | 0.5423 | 0.5423 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0296 | 0.3038 | 0.3038 |
Brugia malayi | MH2 domain containing protein | 0.036 | 0.3728 | 0.3728 |
Echinococcus multilocularis | tar DNA binding protein | 0.0515 | 0.5423 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0051 | 0.0368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0101 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.0296 | 0.3038 | 0.4415 |
Brugia malayi | isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0368 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0296 | 0.3038 | 0.3038 |
Schistosoma mansoni | hypothetical protein | 0.0296 | 0.3038 | 0.4415 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0296 | 0.3038 | 0.298 |
Schistosoma mansoni | hypothetical protein | 0.0296 | 0.3038 | 0.4415 |
Loa Loa (eye worm) | TAR-binding protein | 0.0515 | 0.5423 | 0.5385 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0051 | 0.0368 | 0.0535 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0051 | 0.0368 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0051 | 0.0368 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0082 | 0.0082 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0051 | 0.0368 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0368 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0535 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.064 | 0.6778 | 0.6778 |
Brugia malayi | TAR-binding protein | 0.0515 | 0.5423 | 0.5423 |
Loa Loa (eye worm) | RNA binding protein | 0.0515 | 0.5423 | 0.5385 |
Schistosoma mansoni | hypothetical protein | 0.064 | 0.6778 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0515 | 0.5423 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0051 | 0.0368 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0535 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.036 | 0.3728 | 0.3676 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0426 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.6778 | 0.6751 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0051 | 0.0368 | 0.0535 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0515 | 0.5423 | 0.5385 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0051 | 0.0368 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0051 | 0.0368 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0296 | 0.3038 | 0.5535 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0082 | 0.0082 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0051 | 0.0368 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0082 | 0.0082 |
Schistosoma mansoni | tar DNA-binding protein | 0.0515 | 0.5423 | 0.7976 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0936 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0296 | 0.3038 | 0.5535 |
Schistosoma mansoni | tar DNA-binding protein | 0.0515 | 0.5423 | 0.7976 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0296 | 0.3038 | 0.5535 |
Schistosoma mansoni | tar DNA-binding protein | 0.0515 | 0.5423 | 0.7976 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0296 | 0.3038 | 0.5535 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0515 | 0.5423 | 0.5423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.