Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0196 | 0.3615 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0196 | 0.3615 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0196 | 0.3615 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.031 | 0.0858 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.162 | 0.7605 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.031 | 0.031 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0501 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.162 | 0.162 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0501 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0196 | 0.3615 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0957 | 0.4493 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.2131 | 0.2131 |
Brugia malayi | hypothetical protein | 0.0038 | 0.031 | 0.031 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0188 | 0.0188 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0188 | 0.052 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0957 | 0.0957 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0196 | 0.3615 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0501 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.031 | 0.031 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0188 | 0.052 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.031 | 0.0858 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0196 | 0.3615 | 0.3615 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0501 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0501 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0188 | 0.0188 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0957 | 0.0957 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0196 | 0.3615 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0188 | 0.0882 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0188 | 0.0882 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0501 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.031 | 0.0858 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0196 | 0.3615 | 0.3615 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0501 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.031 | 0.0858 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.2131 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0501 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0196 | 0.3615 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0188 | 0.052 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0196 | 0.3615 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.031 | 0.0858 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0196 | 0.3615 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0188 | 0.0188 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.162 | 0.7605 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.031 | 0.0858 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0501 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0501 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0188 | 0.052 |
Leishmania major | dihydroorotate dehydrogenase | 0.0501 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0188 | 0.052 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0501 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0501 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0188 | 0.052 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0196 | 0.3615 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.2131 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0501 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0188 | 0.0188 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.162 | 0.162 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0196 | 0.3615 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.