Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.5069 | 0.5069 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.5069 | 0.5069 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.