Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1663 | 0.2148 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.1663 | 0.1663 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.7742 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.1663 | 0.2148 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1663 | 0.2148 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.586 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.2156 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.1669 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.1663 | 0.1663 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.586 | 0.7569 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.1663 | 0.2148 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.586 | 0.7569 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.6141 | 0.6141 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0.1669 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.2156 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0.1669 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.1669 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.1663 | 0.2148 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0.1669 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.7742 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.1663 | 0.2148 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.7742 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.586 | 0.7569 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.1669 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.586 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.586 | 0.586 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1663 | 0.1663 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.586 | 0.7569 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.1663 | 0.1663 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.2156 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.7742 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.1669 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.2156 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.6141 | 0.6141 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0.1669 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.6141 | 0.7932 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1663 | 0.2148 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.2156 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.1663 | 0.2148 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0.1669 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.7742 | 0.7742 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.7742 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.7742 | 0.7742 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.1669 | 0.2156 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1663 | 0.2148 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.1669 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.586 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.7742 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.1663 | 0.2148 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.1669 | 0.2156 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.1669 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.7742 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.586 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2 uM | Effective dose to inhibit the replication of P388 cell line in vitro. | ChEMBL. | 1995894 |
ED50 (functional) | = 3 uM | Inhibit the replication of CCRF-CEM cell line in vitro. | ChEMBL. | 1995894 |
ED50 (functional) | = 5 uM | Effective dose to inhibit the replication of L1210 cell line in vitro. | ChEMBL. | 1995894 |
ED50 (functional) | = 20 uM | Effective dose to inhibit the replication of S180 cell line in vitro. | ChEMBL. | 1995894 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.