TDR Targets

Basic information

Technical information

TDR Targets ID: 1541326
Name: N-ethyl-4-(morpholine-4-carbonyl)-N-phenylben zenesulfonamide
MW: 374.454 | Formula: C19H22N2O4S
H donors: 0 H acceptors: 3 LogP: 2.08 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN(S(=O)(=O)c1ccc(cc1)C(=O)N1CCOCC1)c1ccccc1
InChi: 1S/C19H22N2O4S/c1-2-21(17-6-4-3-5-7-17)26(23,24)18-10-8-16(9-11-18)19(22)20-12-14-25-15-13-20/h3-11H,2,12-15H2,1H3
InChiKey: HMSHUJYVFJLMBV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-ethyl-4-(morpholine-4-carbonyl)-N-phenyl-benzenesulfonamide
N-ethyl-4-(morpholino-oxomethyl)-N-phenylbenzenesulfonamide
N-ethyl-4-morpholin-4-ylcarbonyl-N-phenyl-benzenesulfonamide
T5527632
ZINC07988620

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references
Homo sapiens	snurportin 1		No references
Homo sapiens	karyopherin (importin) beta 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MH2 domain containing protein	0.121	0.6579	0.6579
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0141	0.0538	0.0698
Brugia malayi	TAR-binding protein	0.1344	0.7336	0.7336
Echinococcus granulosus	snurportin 1	0.0372	0.1843	0.2485
Brugia malayi	hypothetical protein	0.0074	0.0161	0.0161
Schistosoma mansoni	smad1 5 8 and	0.0082	0.0208	0.0248
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0574	0.2988	0.4051
Chlamydia trachomatis	DNA ligase	0.005	0.0027	0.5
Loa Loa (eye worm)	MH1 domain-containing protein	0.0082	0.0208	0.0208
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0141	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.1815	1	1
Schistosoma mansoni	hypothetical protein	0.0574	0.2988	0.4051
Toxoplasma gondii	LsmAD domain-containing protein	0.0074	0.0161	0.2622
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0027	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.0027	0.0027
Brugia malayi	RNA, U transporter 1	0.0099	0.0302	0.0302
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.005	0.0027	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0574	0.2988	0.4051
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.005	0.0027	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.121	0.6579	0.6579
Echinococcus granulosus	mothers against decapentaplegic 5	0.0082	0.0208	0.0248
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0141	0.0538	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0082	0.0208	0.0248
Loa Loa (eye worm)	hypothetical protein	0.1241	0.6754	0.6754
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.005	0.0027	0.5
Brugia malayi	Isocitrate dehydrogenase	0.0141	0.0538	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0027	0.5
Echinococcus multilocularis	tar DNA binding protein	0.1344	0.7336	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0574	0.2988	0.2988
Loa Loa (eye worm)	hypothetical protein	0.0574	0.2988	0.2988
Schistosoma mansoni	hypothetical protein	0.0574	0.2988	0.4051
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0027	0.5
Schistosoma mansoni	tar DNA-binding protein	0.1344	0.7336	1
Schistosoma mansoni	hypothetical protein	0.0372	0.1843	0.2485
Brugia malayi	isocitrate dehydrogenase	0.0141	0.0538	0.0538
Schistosoma mansoni	smad1 5 8 and	0.0082	0.0208	0.0248
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.005	0.0027	0.5
Schistosoma mansoni	tar DNA-binding protein	0.1344	0.7336	1
Brugia malayi	RNA recognition motif domain containing protein	0.1344	0.7336	0.7336
Trypanosoma brucei	PAB1-binding protein , putative	0.0074	0.0161	0.2622
Plasmodium vivax	ataxin-2 like protein, putative	0.0074	0.0161	0.2622
Loa Loa (eye worm)	hypothetical protein	0.0443	0.2245	0.2245
Treponema pallidum	DNA ligase (lig)	0.005	0.0027	0.5
Echinococcus multilocularis	snurportin 1	0.0372	0.1843	0.2485
Plasmodium falciparum	ataxin-2 like protein, putative	0.0074	0.0161	0.2622
Loa Loa (eye worm)	transcription factor SMAD2	0.121	0.6579	0.6579
Giardia lamblia	Replication factor C, subunit 1	0.005	0.0027	0.5
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0141	0.0538	1
Brugia malayi	DKFZp564C0469 protein	0.005	0.0027	0.0027
Brugia malayi	hypothetical protein	0.0443	0.2245	0.2245
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0141	0.0538	0.0698
Brugia malayi	Calcitonin receptor-like protein seb-1	0.1815	1	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0027	0.0027
Brugia malayi	RNA binding protein	0.1344	0.7336	0.7336
Loa Loa (eye worm)	hypothetical protein	0.005	0.0027	0.0027
Trypanosoma cruzi	PAB1-binding protein , putative	0.0074	0.0161	0.2622
Brugia malayi	Pax transcription activation domain interacting protein	0.005	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0161	0.0161
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.1815	1	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0141	0.0538	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0574	0.2988	0.2988
Toxoplasma gondii	isocitrate dehydrogenase	0.0141	0.0538	1
Schistosoma mansoni	smad	0.0082	0.0208	0.0248
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.005	0.0027	0.0027
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0141	0.0538	0.0698
Loa Loa (eye worm)	hypothetical protein	0.005	0.0027	0.0027
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0574	0.2988	0.4051
Schistosoma mansoni	tar DNA-binding protein	0.1344	0.7336	1
Trichomonas vaginalis	replication factor C large subunit, putative	0.005	0.0027	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0074	0.0161	0.2622
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0027	0.5
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.005	0.0027	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0574	0.2988	0.4051
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0082	0.0208	0.0248
Echinococcus granulosus	Smad4	0.0082	0.0208	0.0248
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0027	0.5
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0141	0.0538	0.0698
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.1843	0.1843
Echinococcus granulosus	smad	0.0082	0.0208	0.0248
Echinococcus granulosus	tar DNA binding protein	0.1344	0.7336	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0141	0.0538	0.0698
Loa Loa (eye worm)	hypothetical protein	0.005	0.0027	0.0027
Toxoplasma gondii	isocitrate dehydrogenase	0.0141	0.0538	1
Brugia malayi	hypothetical protein	0.005	0.0027	0.0027
Brugia malayi	topoisomerase	0.005	0.0027	0.0027
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0141	0.0538	1
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.005	0.0027	0.5
Schistosoma mansoni	hypothetical protein	0.0574	0.2988	0.4051
Schistosoma mansoni	tar DNA-binding protein	0.1344	0.7336	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0141	0.0538	0.0698
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0082	0.0208	0.0248
Echinococcus multilocularis	smad	0.0082	0.0208	0.0248
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0141	0.0538	0.0538
Brugia malayi	hypothetical protein	0.0048	0.0013	0.0013
Brugia malayi	MH1 domain containing protein	0.0082	0.0208	0.0208
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0141	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0027	0.0027
Echinococcus multilocularis	GPCR, family 2	0.0574	0.2988	0.4051
Schistosoma mansoni	hypothetical protein	0.0574	0.2988	0.4051
Trypanosoma cruzi	PAB1-binding protein , putative	0.0074	0.0161	0.2622
Echinococcus multilocularis	Smad4	0.0082	0.0208	0.0248
Brugia malayi	hypothetical protein	0.005	0.0027	0.0027
Schistosoma mansoni	tar DNA-binding protein	0.1344	0.7336	1
Brugia malayi	MH1 domain containing protein	0.0082	0.0208	0.0208
Loa Loa (eye worm)	MH2 domain-containing protein	0.0082	0.0208	0.0208
Echinococcus multilocularis	isocitrate dehydrogenase	0.0141	0.0538	0.0698
Schistosoma mansoni	hypothetical protein	0.1241	0.6754	0.9204
Loa Loa (eye worm)	TAR-binding protein	0.1344	0.7336	0.7336
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0141	0.0538	1
Loa Loa (eye worm)	RNA binding protein	0.1344	0.7336	0.7336
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0141	0.0538	1
Schistosoma mansoni	smad1 5 8 and	0.0082	0.0208	0.0248
Brugia malayi	latrophilin 2 splice variant baaae	0.1241	0.6754	0.6754
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.1344	0.7336	0.7336
Brugia malayi	MH2 domain containing protein	0.0082	0.0208	0.0208
Brugia malayi	MH2 domain containing protein	0.0082	0.0208	0.0208
Brugia malayi	Smad1	0.0082	0.0208	0.0208
Brugia malayi	Latrophilin receptor protein 2	0.0574	0.2988	0.2988
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.005	0.0027	0.5
Schistosoma mansoni	Smad4	0.0082	0.0208	0.0248
Echinococcus granulosus	GPCR family 2	0.0574	0.2988	0.4051
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.005	0.0027	0.5
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0082	0.0208	0.0248
Onchocerca volvulus		0.0443	0.2245	1
Entamoeba histolytica	hypothetical protein	0.005	0.0027	0.5
Loa Loa (eye worm)	Smad1	0.0082	0.0208	0.0208

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1890698

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1541326