Detailed information for compound 1541381

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.378 | Formula: C20H20NO2+
  • H donors: 0 H acceptors: 0 LogP: 4.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1/C=C/c1ccc2c([n+]1C)cccc2)OC
  • InChi: 1S/C20H20NO2/c1-21-17(10-8-15-6-4-5-7-19(15)21)11-9-16-14-18(22-2)12-13-20(16)23-3/h4-14H,1-3H3/q+1/b11-9+
  • InChiKey: KXEHIPMQYAOXGJ-PKNBQFBNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0012 0.0034 0.0075
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0126 0.1553
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0008 0.0008
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0015 0.0071 0.0497
Onchocerca volvulus 0.0015 0.0071 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0023 0.005
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0059 0.0629 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0015 0.0071 0.0825
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0478 0.1053
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0012 0.0034 0.0194
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.1895 0.4178
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0012 0.0034 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Loa Loa (eye worm) hypothetical protein 0.0195 0.2339 0.4821
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0152
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0186 0.0356
Mycobacterium tuberculosis Probable thioesterase TesA 0.0195 0.2349 0.5424
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0857 0.1767
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0059 0.0629 0.2058
Plasmodium falciparum acyl carrier protein 0.0024 0.0186 0.2552
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0126 0.1243
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0034 0.0075
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0186 0.0271
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0106 0.0106
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0435 0.0959
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0015 0.0071 0.0087
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0429 0.5308
Loa Loa (eye worm) hypothetical protein 0.0036 0.0341 0.0702
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0015 0.0071 0.0087
Echinococcus multilocularis geminin 0.0369 0.4535 0.4535
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0023 0.005
Leishmania major hypothetical protein, conserved 0.0071 0.0777 1
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0034 0.0199
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0015 0.0071 0.0129
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0028 0.0028
Toxoplasma gondii acyl transferase domain-containing protein 0.0015 0.0074 0.0218
Giardia lamblia GTOR 0.0019 0.0126 0.1243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Brugia malayi hypothetical protein 0.0043 0.0435 0.0792
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0024 0.0186 0.0356
Trypanosoma cruzi oxidoreductase, putative 0.0015 0.0071 0.0803
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0015 0.0071 0.0087
Brugia malayi nuclear hormone receptor 0.0011 0.0023 0.0041
Mycobacterium ulcerans Type I modular polyketide synthase 0.0234 0.2842 0.6547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Mycobacterium tuberculosis Possible dehydrogenase 0.0015 0.0071 0.0087
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0227 0.2751 0.6365
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0038 0.0098
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0106 0.0106
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0023 0.005
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0059 0.0629 0.1387
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0008 0.0008
Schistosoma mansoni elf1 0.0011 0.0028 0.0062
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0126 0.1717
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0034 0.0156
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0057 0.0609 0.1348
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0249 0.3026 0.6981
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.1895 0.3453
Leishmania major acyl carrier protein, putative 0.0024 0.0186 0.2043
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0022 0.0049
Leishmania major d-xylulose reductase, putative 0.0015 0.0071 0.0497
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0034 0.0199
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0126 0.0278
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0106 0.0106
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0028 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0186 0.0271
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0435 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0023 0.0047
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0186 0.0271
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0034 0.0034
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0023 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Toxoplasma gondii type I fatty acid synthase 0.0036 0.0341 0.1102
Schistosoma mansoni [ACP] S-malonyltransferase 0.0015 0.0074 0.0163
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0023 0.005
Schistosoma mansoni coup transcription factor 0.0011 0.0023 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0613 0.1352
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.035
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0008 0.0015
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.017 0.243
Brugia malayi N-terminal motif family protein 0.0195 0.2339 0.4262
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0059 0.0629 0.8003
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0034 0.0075
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0015 0.0071 0.0087
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0106 0.0193
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0126 0.023
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0127 0.1725
Mycobacterium ulcerans polyketide synthase MbtC 0.0059 0.0629 0.1319
Brugia malayi hypothetical protein 0.001 0.0008 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0034 0.0194
Schistosoma mansoni ap endonuclease 0.0058 0.0613 0.1352
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0478 0.6032
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0126 0.1717
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0015 0.0071 0.0803
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0015 0.0071 0.0803
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0015 0.0074 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0023 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.1895 0.1895
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0613 0.9742
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0023 0.0041
Brugia malayi hypothetical protein 0.001 0.0008 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0023 0.0028
Onchocerca volvulus 0.0219 0.2648 0.5071
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0036 0.0341 0.0718
Mycobacterium ulcerans hypothetical protein 0.0024 0.0186 0.0271
Echinococcus granulosus geminin 0.0369 0.4535 1
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0024 0.0186 0.0356
Onchocerca volvulus 0.0015 0.0071 0.0121
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0023 0.0047
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0106 0.0219
Leishmania major zinc binding dehydrogenase-like protein 0.0015 0.0071 0.0497
Toxoplasma gondii type I fatty acid synthase, putative 0.0167 0.1991 0.657
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0106 0.0106
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0028 0.0062
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0022 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0023 0.005
Entamoeba histolytica hypothetical protein 0.0043 0.0435 0.6982
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0189 0.2265 0.5183
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0028 0.0062
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0024 0.0186 0.2059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0023 0.005
Leishmania major zinc-binding dehydrogenase-like protein 0.0015 0.0071 0.0497
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0034 0.0075
Loa Loa (eye worm) fli-1 protein 0.0234 0.2832 0.5838
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0024 0.0186 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0023 0.0047
Onchocerca volvulus Putative alcohol dehydrogenase 0.0015 0.0071 0.0121
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0059 0.0629 0.0629
Mycobacterium ulcerans acyl carrier protein 0.0024 0.0186 0.0271
Chlamydia trachomatis acyl carrier protein 0.0024 0.0186 0.2016
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0234 0.2842 0.5179
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0008 0.0015
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0015 0.0071 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Schistosoma mansoni cpg binding protein 0.0032 0.0294 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Leishmania major quinone oxidoreductase, putative 0.0015 0.0071 0.0497
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0311 0.4654
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Schistosoma mansoni cpg binding protein 0.0031 0.0272 0.06
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Entamoeba histolytica hypothetical protein 0.0026 0.0216 0.3273
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0023 0.0041
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0429 0.6632
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0023 0.0041
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0059 0.0629 1
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0015 0.0074 0.0671
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0023 0.0041
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0126 0.026
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0034 0.0075
Schistosoma mansoni [ACP] S-malonyltransferase 0.0015 0.0074 0.0163
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0478 0.6032
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0126 0.1243
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0219 0.2648 0.5459
Mycobacterium ulcerans Type I modular polyketide synthase 0.0234 0.2842 0.6547
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0146
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0023 0.0047
Loa Loa (eye worm) hypothetical protein 0.0394 0.4851 1
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0008 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0023 0.0041
Brugia malayi transcription factor E74 isoform 0.0011 0.0028 0.0051
Brugia malayi Fli-1 protein 0.0234 0.2832 0.516
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0034 0.0156
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0195 0.2349 0.5384
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0126 0.0126
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0015 0.0071 0.0146
Schistosoma mansoni dishevelled 0.001 0.0008 0.0018
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0189 0.2265 0.5183
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0015 0.0071 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Echinococcus granulosus cpg binding protein 0.0032 0.0294 0.0648
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0023 0.0023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0023 0.0041
Trypanosoma cruzi oxidoreductase, putative 0.0015 0.0071 0.0803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0034 0.0075
Loa Loa (eye worm) acetyltransferase 0.0159 0.1895 0.3907
Mycobacterium tuberculosis Polyketide synthase Pks13 0.035 0.4303 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0127 0.1249
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.007
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0015 0.0071 0.0645
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0023 0.0028
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0168 0.201 0.4628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0023 0.0047
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0023 0.005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0023 0.0023
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0249 0.3026 0.6981
Schistosoma mansoni cpg binding protein 0.0032 0.0294 0.0648
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0034 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0023 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0023 0.0023
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0028 0.0058
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0126 0.1553
Trypanosoma cruzi oxidoreductase, putative 0.0015 0.0071 0.0803
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0435 0.0959
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0008 0.0018
Echinococcus granulosus AMP dependent ligase 0.0024 0.0186 0.041
Schistosoma mansoni dep domain containing protein 0.001 0.0008 0.0018
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0186 0.0356
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0126 0.0392
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0613 0.9719
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0028 0.0062
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0023 0.0047
Echinococcus granulosus NADH dehydrogenase 0.0024 0.0186 0.041
Mycobacterium leprae Probable polyketide synthase Pks1 0.0249 0.3026 0.6981
Echinococcus multilocularis synaptojanin 1 0.0012 0.0034 0.0034
Schistosoma mansoni cript-related 0.0012 0.0034 0.0075
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0008 0.0018
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Trypanosoma brucei oxidoreductase, putative 0.0015 0.0071 0.0621
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0028 0.0058
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0126 0.1553
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0249 0.3026 0.7007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0613 0.9737
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0034 0.0156
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0059 0.0629 0.1319
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0034 0.0199
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0023 0.0041
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0106 0.1385
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0024 0.0186 0.0383
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0034 0.0194
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0028 0.0062
Onchocerca volvulus 0.0011 0.0023 0.0028
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0155 0.1841 0.4183
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0106 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0106 0.1215
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0272 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0023 0.0041
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0023 0.005
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0613 0.7827
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0613 0.7792
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0106 0.0106
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0234 0.2842 0.6577
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0015 0.0074 0.0135
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0126 0.1553
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0059 0.0629 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0613 0.0613
Mycobacterium ulcerans Type I modular polyketide synthase 0.0234 0.2842 0.6547
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0234 0.2842 0.6547
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0015 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Toxoplasma gondii quinone oxidoreductase, putative 0.0015 0.0071 0.0208
Brugia malayi Ets-domain containing protein 0.0077 0.0857 0.1562
Schistosoma mansoni nocturnin 0.0012 0.0034 0.0075
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0034 0.0156
Schistosoma mansoni ap endonuclease 0.0058 0.0613 0.1352
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0015 0.0074 0.0163
Brugia malayi MH2 domain containing protein 0.0131 0.1541 0.2808
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0216 0.0688
Toxoplasma gondii acyl carrier protein ACP 0.0024 0.0186 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0216 0.2561
Echinococcus multilocularis cpg binding protein 0.0032 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0146
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0034 0.0034
Brugia malayi Alcohol dehydrogenase class III 0.0015 0.0071 0.0129
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0024 0.0186 0.0271
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0478 0.1557
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0024 0.0186 0.0342
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0034 0.0194
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0186 0.0356
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0014
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0008 0.0016
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0234 0.2842 0.6577
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0186 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Entamoeba histolytica hypothetical protein 0.0043 0.0435 0.6982
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0015 0.0071 0.0129
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0059 0.0629 1
Mycobacterium tuberculosis Hypothetical protein 0.0071 0.0777 0.1742
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0034 0.0075
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0126 0.0278
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0008 0.0018
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0034 0.0156
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0059 0.0629 0.1146
Mycobacterium tuberculosis Conserved protein 0.0071 0.0777 0.1742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0023 0.005
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0059 0.0629 1
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0024 0.0186 0.0186
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0008 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0613 0.9742
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0186 0.0356
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0023 0.005
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0216 0.0216
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0189 0.2265 0.5183
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0857 0.0857
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0126 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0023 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0023 0.0041
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0613 0.1357
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.035 0.4303 1
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0028 0.0058
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0015 0.0071 0.0803
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1541 0.3177
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0023 0.005
Trypanosoma cruzi acyl transferase-like protein 0.0015 0.0074 0.0852
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0126 0.0278
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Mycobacterium ulcerans acyl carrier protein 0.0024 0.0186 0.0271
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0126 0.1553
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0034 0.0199
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0186 0.0271
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.007
Schistosoma mansoni hypothetical protein 0.0011 0.0028 0.0062
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0024 0.0186 0.0339
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0038 0.0061
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0106 0.0234
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0023 0.0047
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Leishmania major oxidoreductase, putative 0.0015 0.0071 0.0497
Loa Loa (eye worm) hypothetical protein 0.0131 0.1543 0.318
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0106 0.0325
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0034 0.0075
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0023 0.0023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0613 0.1264
Mycobacterium ulcerans polyketide synthase 0.0249 0.3026 0.6981
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0186 0.2768
Onchocerca volvulus Fatty acid synthase homolog 0.0423 0.5214 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0023 0.0023
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0024 0.0186 0.2552
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0777 1
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0034 0.0034
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0008 0.0018
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0028 0.0062
Echinococcus multilocularis protein C ets 2 0.0011 0.0028 0.0028
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0015 0.0071 0.0803
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0034 0.0156
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0034 0.0075
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0249 0.3026 0.6981
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0015 0.0071 0.0803
Schistosoma mansoni gabp alpha 0.0077 0.0857 0.189
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0015 0.0071 0.0156
Schistosoma mansoni zinc binding dehydrogenase 0.0015 0.0071 0.0156
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0133 0.1567 0.3591
Mycobacterium ulcerans thioesterase TesA 0.0195 0.2349 0.5384
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0023 0.005
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0015 0.0071 0.0825
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0023 0.0041
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0034 0.0156
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0008 0.0018
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0216 0.0475
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0227 0.2751 0.6365
Schistosoma mansoni ets-related 0.0011 0.0028 0.0062
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0186 0.0271
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0106 0.1215
Loa Loa (eye worm) fatty acid synthase 0.0231 0.2803 0.5778
Mycobacterium tuberculosis Possible dehydrogenase 0.0015 0.0071 0.0087
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0015 0.0071 0.0803
Brugia malayi nuclear receptor NHR-88 0.0011 0.0023 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0613 0.1282
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0028 0.0058
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0015 0.0074 0.0053
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0015 0.0071 0.0208
Schistosoma mansoni synaptojanin 0.0012 0.0034 0.0075
Trypanosoma cruzi acyl transferase-like protein, putative 0.0015 0.0074 0.0852
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0106 0.1215
Giardia lamblia Methyltransferase like 2 0.0071 0.0777 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0022 0.004
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0118 0.1381 0.4549
Leishmania major oxidoreductase-like protein 0.0015 0.0071 0.0497
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0023 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0038 0.0204
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0126 0.1243
Trypanosoma brucei oxidoreductase, putative 0.0015 0.0071 0.0621
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0046
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.1839 0.4054
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0023 0.005
Echinococcus multilocularis AMP dependent ligase 0.0024 0.0186 0.0186
Brugia malayi steroid hormone receptor 0.0011 0.0023 0.0041
Entamoeba histolytica hypothetical protein 0.0043 0.0435 0.6982
Toxoplasma gondii exonuclease III APE 0.0058 0.0613 0.2006
Echinococcus granulosus acyl carrier protein mitochondrial 0.0024 0.0186 0.041
Schistosoma mansoni hypothetical protein 0.0043 0.0435 0.0959
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0012 0.0034 0.0194
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0186 0.0356
Mycobacterium leprae Polyketide synthase Pks13 0.035 0.4303 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0249 0.3026 0.7007
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0023 0.005
Echinococcus granulosus synaptojanin 1 0.0012 0.0034 0.0075
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0015 0.0071 0.0645
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0008 0.0008
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0034 0.0194
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0059 0.0629 1
Brugia malayi ecdysteroid receptor 0.0011 0.0023 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1541 0.3177
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0126 0.1243
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0008 0.0018
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0036 0.0341 0.0718
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0219 0.2648 0.6123
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0023 0.005
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0034 0.0034
Brugia malayi CXXC zinc finger family protein 0.0031 0.0272 0.0496
Toxoplasma gondii type I fatty acid synthase, putative 0.0249 0.3026 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0106 0.0325
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0146
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0796 0.145
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0126 0.1243
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0015 0.0071 0.0087
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0126 0.1717
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0023 0.0041
Leishmania major nuclear receptor binding factor-like protein 0.0015 0.0071 0.0497
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0023 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Loa Loa (eye worm) hypothetical protein 0.0011 0.0028 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0023 0.0041
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0155 0.1841 0.4183
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0015 0.0071 0.0087
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0857 0.189
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0028 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0146
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0072 0.0796 0.1784
Entamoeba histolytica hypothetical protein 0.0043 0.0435 0.6982
Treponema pallidum acyl carrier protein 0.0024 0.0186 0.2621
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0009
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Echinococcus multilocularis NADH dehydrogenase 0.0024 0.0186 0.0186
Brugia malayi Ets-domain containing protein 0.0011 0.0028 0.0051
Brugia malayi isocitrate dehydrogenase 0.0017 0.0106 0.0193
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0703 0.155
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0022 0.0022
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0106 0.1385
Brugia malayi Methyltransferase-like protein 4 0.0071 0.0777 0.1417
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0126 0.1763
Brugia malayi Phosphopantetheine attachment site family protein 0.0024 0.0186 0.0339
Mycobacterium ulcerans polyketide synthase MbtD 0.0072 0.0796 0.1713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0152 0.1804 0.5952
Brugia malayi AMP-binding enzyme family protein 0.0219 0.2648 0.4825
Trypanosoma brucei acyl transferase-like protein 0.0015 0.0074 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0665 0.2178
Echinococcus granulosus protein C ets 2 0.0011 0.0028 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0023 0.0023
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0613 0.7827
Schistosoma mansoni regulator of G protein signaling 0.001 0.0008 0.0018
Schistosoma mansoni [ACP] S-malonyltransferase 0.0015 0.0074 0.0163
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0015 0.0071 0.0825
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0015 0.0071 0.0087
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0034 0.007
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0186 0.0271
Schistosoma mansoni ets 0.0011 0.0028 0.0062
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0034 0.0199
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0186 0.0339
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.2339 0.4477
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0613 0.7792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Schistosoma mansoni alcohol dehydrogenase 0.0015 0.0071 0.0156
Mycobacterium ulcerans polyketide synthase 0.0234 0.2842 0.6547
Onchocerca volvulus 0.0024 0.0186 0.0342
Schistosoma mansoni dishevelled 0.001 0.0008 0.0018
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0034 0.0034
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0081 0.0903 0.2036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0023 0.005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0186 0.2768
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0015 0.0074 0.0074
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0074 0.0815 0.1759
Loa Loa (eye worm) hypothetical protein 0.0036 0.0341 0.0702
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0028 0.0062
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0024 0.0186 0.0356
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0126 0.0126
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0311 0.4654
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0429 0.6875
Mycobacterium ulcerans thioesterase 0.0195 0.2349 0.5384
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0126 0.1763
Schistosoma mansoni hypothetical protein 0.0369 0.4535 1
Brugia malayi CCR4 0.0012 0.0034 0.0062
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0024 0.0186 0.2697
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Onchocerca volvulus 0.0012 0.0034 0.005
Schistosoma mansoni methyltransferase-related 0.0071 0.0777 0.1714
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0023 0.005
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0015 0.0071 0.0621
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0478 0.1557
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0034 0.0156
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0249 0.3026 0.7007
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0059 0.0629 0.1319
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0126 0.026
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0015 0.0074 0.0671
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0034 0.0194
Schistosoma mansoni synaptojanin 0.0012 0.0034 0.0075
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0234 0.2842 0.6547
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0059 0.0629 0.1297
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0613 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0106 0.0972
Onchocerca volvulus 0.0012 0.0034 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0613 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0444 0.5488 1
Schistosoma mansoni hypothetical protein 0.0024 0.0186 0.041
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0126 0.1717
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0015 0.0071 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0126 0.0278
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0015 0.0071 0.0129
Schistosoma mansoni hypothetical protein 0.0011 0.0028 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Schistosoma mansoni acyl carrier protein 0.0024 0.0186 0.041
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0106 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0106 0.1215
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0478 0.7459
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0613 0.1118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0023 0.005
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0216 0.3188
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0012 0.0034 0.0194
Schistosoma mansoni ets-related 0.0234 0.2832 0.6244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0024 0.0186 0.0271
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0234 0.2842 0.6577
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0023 0.0041
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0216 0.0393
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0613 0.9737
Loa Loa (eye worm) acyl carrier protein 0.0108 0.1246 0.2569
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0077
Leishmania major hypothetical protein, conserved 0.0015 0.0074 0.0537
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0059 0.0629 0.1387
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0074 0.0815 0.1831
Mycobacterium ulcerans polyketide synthase Pks9 0.0155 0.1841 0.4183
Mycobacterium ulcerans fatty acid synthase Fas 0.0074 0.0815 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0613 0.9737
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0186 0.0356
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Brugia malayi DIX domain containing protein 0.001 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0066 0.0717 0.1477
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.007
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0008 0.0008
Onchocerca volvulus 0.0408 0.503 0.9647
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0216 0.0475
Echinococcus multilocularis ets variant gene 4 0.0011 0.0028 0.0028
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0071 0.0087
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0028 0.0028
Onchocerca volvulus 0.0031 0.0272 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0023 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0028 0.0058
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0126 0.1717
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0216 0.3053
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0186 0.0271
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0249 0.3026 0.6981
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0192 0.2304 0.5316
Plasmodium vivax acyl carrier protein, putative 0.0024 0.0186 0.2552
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0095 0.1082 0.2455
Schistosoma mansoni hypothetical protein 0.0369 0.4535 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0023 0.0041
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0036 0.0341 0.0637
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0234 0.2842 0.6547
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0028 0.0028
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0034 0.0156
Mycobacterium ulcerans polyketide synthase Pks13 0.035 0.4303 1
Brugia malayi Ets-domain containing protein 0.0077 0.0857 0.1562
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0036 0.0341 0.0718
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0036 0.0341 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0038 0.0204
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0059 0.0629 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3078 uM PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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