TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.471 | Formula: C21H27N5O2
H donors: 2 H acceptors: 4 LogP: 2.62 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1ncc2c(c1O)nc1c2cccc1)NCCCN1CCCCC1C
InChi: 1S/C21H27N5O2/c1-15-7-4-5-11-25(15)12-6-10-22-19(27)14-26-21(28)20-17(13-23-26)16-8-2-3-9-18(16)24-20/h2-3,8-9,13,15,28H,4-7,10-12,14H2,1H3,(H,22,27)
InChiKey: QVXVPSFAAXIIDI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0049	0.3698	0.4014
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Brugia malayi	Bromodomain containing protein	0.0046	0.3249	0.2919
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.2822	0.3615
Onchocerca volvulus		0.0061	0.5443	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0061	0.5443	0.6939
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0061	0.5443	0.745
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0028	0.0466	0.0168
Schistosoma mansoni	nAChR subunit	0.0061	0.5443	0.6939
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0033	0.1182	0.1506
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0028	0.0466	0.0168
Schistosoma mansoni	acetylcholine receptor-related	0.0028	0.0466	0.0594
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0028	0.0466	0.0168
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0061	0.5443	0.745
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.5443	0.522
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Loa Loa (eye worm)	LGC-31 protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0061	0.5443	0.6939
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0033	0.1182	0.1506
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3262	0.3541
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.5443	0.522
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0061	0.5443	0.522
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.4618	0.5013
Onchocerca volvulus		0.0061	0.5443	1
Brugia malayi	Cation transporter family protein	0.0061	0.5443	0.522
Loa Loa (eye worm)	acetylcholine receptor protein	0.0028	0.0466	0.0506
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.2822	0.3615
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.4618	0.6243
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0061	0.5443	0.6939
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0061	0.5443	0.745
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0061	0.5443	0.522
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0061	0.5443	0.745
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Echinococcus granulosus	glycine receptor subunit beta	0.0061	0.5443	0.745
Echinococcus granulosus	nAChR subunit	0.0061	0.5443	0.745
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.4618	0.6243
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0061	0.5443	0.5908
Echinococcus multilocularis	glycine receptor subunit beta	0.0061	0.5443	0.745
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0033	0.1182	0.075
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0028	0.0466	0.0506
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0061	0.5443	0.745
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.5443	0.522
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.4618	0.6243
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0061	0.5443	0.745
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Schistosoma mansoni	bromodomain containing protein	0.0076	0.7844	1
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0028	0.0466	0.0594
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0028	0.0466	0.0506
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0061	0.5443	0.522
Onchocerca volvulus		0.0033	0.1182	0.1438
Loa Loa (eye worm)	hypothetical protein	0.006	0.5374	0.5833
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0061	0.5443	0.745
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0085	0.9213	1
Entamoeba histolytica	hypothetical protein	0.0043	0.2822	1
Brugia malayi	Cation transporter family protein	0.0061	0.5443	0.522
Schistosoma mansoni	nAChR subunit	0.0061	0.5443	0.6939
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.7186	1
Schistosoma mansoni	hypothetical protein	0.0043	0.2822	0.3598
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Entamoeba histolytica	hypothetical protein	0.0043	0.2822	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0061	0.5443	0.522
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Schistosoma mansoni	hypothetical protein	0.0041	0.2473	0.3153
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0061	0.5443	0.745
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0061	0.5443	0.522
Echinococcus granulosus	glycine receptor subunit beta	0.0061	0.5443	0.745
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.4618	0.6243
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Onchocerca volvulus		0.0061	0.5443	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.2473	0.2684
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0061	0.5443	0.6939
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0028	0.0466	0.0168
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.5443	0.522
Schistosoma mansoni	nAChR subunit	0.0061	0.5443	0.6939
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.4618	0.5887
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.2822	0.3598
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0061	0.5443	0.745
Entamoeba histolytica	hypothetical protein	0.0043	0.2822	1
Schistosoma mansoni	nAChR subunit	0.0061	0.5443	0.6939
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0061	0.5443	0.745
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0061	0.5443	0.745
Echinococcus granulosus	nAChR subunit	0.0033	0.1182	0.1215
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0061	0.5443	0.6939
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0061	0.5443	0.745
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.5374	0.5833
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0061	0.5443	0.745
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0061	0.5443	0.745
Loa Loa (eye worm)	hypothetical protein	0.0052	0.4049	0.4395
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Loa Loa (eye worm)	ACC-1 protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0351	0.0448
Schistosoma mansoni	nAChR subunit	0.0028	0.0466	0.0594
Brugia malayi	PHD-finger family protein	0.003	0.0787	0.0336
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.7186	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.5443	0.522
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0061	0.5443	0.522
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0061	0.5443	0.522
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.2814	0.3603
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0061	0.5443	0.745
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0061	0.5443	0.745
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.5443	0.522
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0033	0.1182	0.075
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Schistosoma mansoni	nAChR subunit	0.0061	0.5443	0.6939
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0028	0.0466	0.0168
Echinococcus multilocularis	nAChR subunit	0.0033	0.1182	0.1215
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.5374	0.5148
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1182	0.1282
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0061	0.5443	0.5908
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0061	0.5443	0.745
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0061	0.5443	0.522
Onchocerca volvulus	Putative nachr subunit	0.0061	0.5443	1
Onchocerca volvulus		0.0061	0.5443	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0061	0.5443	0.6939
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0033	0.1182	0.075
Schistosoma mansoni	nAChR subunit	0.0061	0.5443	0.6939
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.5374	0.5148
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Brugia malayi	hypothetical protein	0.0043	0.2822	0.2471
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0033	0.1182	0.075
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Schistosoma mansoni	nAChR subunit	0.0028	0.0466	0.0594
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0061	0.5443	0.5908
Echinococcus multilocularis	nAChR subunit	0.0061	0.5443	0.745
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0061	0.5443	0.522
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.2473	0.2105
Loa Loa (eye worm)	hypothetical protein	0.0061	0.5443	0.5908
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0061	0.5443	0.745
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0061	0.5443	0.745
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.2814	0.3603
Schistosoma mansoni	neurotransmitter gated ion channel	0.0028	0.0466	0.0594
Brugia malayi	Cation transporter family protein	0.0061	0.5443	0.522
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.4618	0.5887
Onchocerca volvulus		0.0061	0.5443	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0061	0.5443	0.745
Loa Loa (eye worm)	GABA receptor subunit	0.0033	0.1182	0.1282
Loa Loa (eye worm)	ACC-1 protein	0.0061	0.5443	0.5908
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0466	0.0506
Schistosoma mansoni	nAChR subunit	0.0061	0.5443	0.6939
Schistosoma mansoni	neurotransmitter gated ion channel	0.0033	0.1182	0.1506
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.4618	0.4355
Onchocerca volvulus		0.0033	0.1182	0.1438
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0061	0.5443	0.522
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0061	0.5443	0.745
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.4618	0.5887
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0061	0.5443	0.522
Onchocerca volvulus		0.0061	0.5443	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0028	0.0466	0.0594
Echinococcus multilocularis	glycine receptor subunit beta	0.0061	0.5443	0.745
Entamoeba histolytica	hypothetical protein	0.0043	0.2822	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.122 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	3.2643 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	75.193 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1902910

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1541462