Detailed information for compound 154149

Basic information

Technical information
  • TDR Targets ID: 154149
  • Name: N-[4-(3-bromoanilino)quinazolin-6-yl]-2-methy lprop-2-enamide
  • MW: 383.242 | Formula: C18H15BrN4O
  • H donors: 2 H acceptors: 3 LogP: 4.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)Nc1ncnc2c1cc(cc2)NC(=O)C(=C)C
  • InChi: 1S/C18H15BrN4O/c1-11(2)18(24)23-14-6-7-16-15(9-14)17(21-10-20-16)22-13-5-3-4-12(19)8-13/h3-10H,1H2,2H3,(H,23,24)(H,20,21,22)
  • InChiKey: YBGIIBLAQDXGRC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(3-bromoanilino)quinazolin-6-yl]-2-methyl-prop-2-enamide
  • N-[4-(3-bromoanilino)-6-quinazolinyl]-2-methyl-2-propenamide
  • N-[4-[(3-bromophenyl)amino]quinazolin-6-yl]-2-methyl-prop-2-enamide
  • N-[4-(3-bromoanilino)quinazolin-6-yl]-2-methyl-acrylamide
  • N-[4-[(3-bromophenyl)amino]quinazolin-6-yl]-2-methylprop-2-enamide
  • N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-methylprop-2-enamide
  • N-[4-[(3-bromophenyl)amino]quinazolin-6-yl]-2-methyl-acrylamide
  • 4-anilinoquinazoline deriv. 17

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens erb-b2 receptor tyrosine kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/INSR protein kinase 0.0115 0.0019 0.0019
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0432 0.046 0.0442
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0432 0.046 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0577 0.0662 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.036 0.036 0.0347
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0204 0.0142 0.0129
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0204 0.0142 0.0124
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0577 0.0662 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0204 0.0142 0.0124
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.2448 0.3268 1
Loa Loa (eye worm) prolyl oligopeptidase 0.7282 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0432 0.046 0.0447
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0432 0.046 0.0442
Schistosoma mansoni tyrosine kinase 0.0194 0.0128 0.0109
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.2448 0.3268 1
Trichomonas vaginalis conserved hypothetical protein 0.0577 0.0662 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0577 0.0662 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0432 0.046 0.0447
Loa Loa (eye worm) nuclear receptor NHR-67 0.0204 0.0142 0.0142
Schistosoma mansoni tyrosine kinase 0.036 0.036 0.0342
Echinococcus multilocularis FTZ F1 alpha 0.0432 0.046 0.0447
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0228 0.0176 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0432 0.046 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0432 0.046 0.0442
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0577 0.0662 0.5
Brugia malayi nuclear receptor NHR-88 0.0204 0.0142 0.0124
Loa Loa (eye worm) hypothetical protein 0.0432 0.046 0.046
Schistosoma mansoni nuclear hormone receptor 0.0432 0.046 0.0442
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0432 0.046 0.0442
Brugia malayi Nuclear hormone receptor E75 0.0204 0.0142 0.0124
Loa Loa (eye worm) hypothetical protein 0.0577 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Brugia malayi nuclear receptor RXR 0.0228 0.0176 0.0158
Brugia malayi Furin-like cysteine rich region family protein 0.036 0.036 0.0342
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0176
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0117 0.0022 0.0008
Brugia malayi nuclear receptor NHR-88 0.0432 0.046 0.0442
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0432 0.046 0.0442
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0432 0.046 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0432 0.046 0.0442
Schistosoma mansoni zinc finger protein 0.0204 0.0142 0.0124
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0204 0.0142 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0432 0.046 0.0442
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0228 0.0176 0.0158
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0433 0.0461 0.0448
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0432 0.046 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0432 0.046 0.0442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0432 0.046 0.046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0432 0.046 0.046
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0577 0.0662 0.0645
Loa Loa (eye worm) TK/EGFR protein kinase 0.036 0.036 0.036
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0432 0.046 0.0447
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0432 0.046 0.0442
Brugia malayi Nuclear hormone receptor-like 1 0.0228 0.0176 0.0158
Loa Loa (eye worm) hypothetical protein 0.0577 0.0662 0.0662
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.2448 0.3268 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.7282 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.2889 0.3881 0.3873
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0577 0.0662 0.5
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0577 0.0662 0.0645
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Schistosoma mansoni coup transcription factor 0.0432 0.046 0.0442
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0204 0.0142 0.0129
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0432 0.046 0.0447
Schistosoma mansoni tyrosine kinase 0.0191 0.0125 0.0107
Loa Loa (eye worm) steroid hormone receptor 0.0432 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0432 0.046 0.046
Echinococcus multilocularis ecdysone induced protein 78C 0.0432 0.046 0.0447
Onchocerca volvulus Prolyl endopeptidase homolog 0.0577 0.0662 0.0528
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0204 0.0142 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0432 0.046 0.046
Brugia malayi ecdysone receptor 0.0204 0.0142 0.0124
Schistosoma mansoni nuclear receptor 0.0204 0.0142 0.0124
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0432 0.046 0.0442
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.7282 1 1
Echinococcus granulosus epidermal growth factor receptor 0.036 0.036 0.0342
Brugia malayi orphan nuclear receptor NR2E1 0.0204 0.0142 0.0124
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Giardia lamblia Alanyl dipeptidyl peptidase 0.0577 0.0662 0.5
Brugia malayi nuclear hormone receptor family member nhr-6 0.0204 0.0142 0.0124
Brugia malayi hypothetical protein 0.0204 0.0142 0.0124
Echinococcus granulosus Dipeptidyl peptidase 9 0.2448 0.3268 0.3255
Brugia malayi conserved hypotetical protein 0.0204 0.0142 0.0124
Brugia malayi nuclear receptor RXR 0.0204 0.0142 0.0124
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.2448 0.3268 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Echinococcus granulosus thyroid hormone receptor alpha 0.0204 0.0142 0.0124
Loa Loa (eye worm) hypothetical protein 0.0432 0.046 0.046
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.5171 0.706 0.7017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0432 0.046 0.0442
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0204 0.0142 0.0124
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0176
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0577 0.0662 0.5
Brugia malayi prolyl oligopeptidase family protein 0.0577 0.0662 0.0645
Echinococcus granulosus epidermal growth factor receptor 0.0194 0.0128 0.0109
Loa Loa (eye worm) hypothetical protein 0.1871 0.2464 0.2464
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Echinococcus granulosus nuclear receptor nhr 48 0.0204 0.0142 0.0124
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0577 0.0662 0.0645
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Brugia malayi steroid hormone receptor 0.0432 0.046 0.0442
Loa Loa (eye worm) nuclear hormone receptor 0.0204 0.0142 0.0142
Onchocerca volvulus 0.0432 0.046 0.0322
Echinococcus multilocularis acylamino acid releasing enzyme 0.0577 0.0662 0.0649
Schistosoma mansoni retinoic acid receptor RXR 0.3117 0.4199 0.4188
Loa Loa (eye worm) DR-78 0.0204 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Echinococcus multilocularis prolyl endopeptidase 0.0577 0.0662 0.0649
Loa Loa (eye worm) hypothetical protein 0.0432 0.046 0.046
Schistosoma mansoni thyroid hormone receptor 0.0432 0.046 0.0442
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0432 0.046 0.046
Schistosoma mansoni nuclear receptor 0.0204 0.0142 0.0124
Brugia malayi tailless protein 0.0204 0.0142 0.0124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0432 0.046 0.0447
Echinococcus granulosus FTZ F1 alpha 0.0432 0.046 0.0442
Onchocerca volvulus Bile acid receptor homolog 0.0432 0.046 0.0322
Brugia malayi hypothetical protein 0.0204 0.0142 0.0124
Brugia malayi nuclear receptor NHR-67 0.0204 0.0142 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0432 0.046 0.0442
Echinococcus multilocularis insulin receptor 0.0115 0.0019 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0432 0.046 0.0442
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0228 0.0176 0.0176
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0228 0.0176 0.0158
Brugia malayi photoreceptor-specific nuclear receptor 0.0432 0.046 0.0442
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0432 0.046 0.0447
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0432 0.046 0.046
Schistosoma mansoni RAR-like nuclear receptor 0.0432 0.046 0.0442
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0194 0.0128 0.0109
Plasmodium falciparum peptidase, putative 0.0577 0.0662 0.5
Brugia malayi prolyl oligopeptidase family protein 0.0577 0.0662 0.0645
Brugia malayi nuclear hormone receptor family member odr-7 0.0204 0.0142 0.0124
Giardia lamblia Alanyl dipeptidyl peptidase 0.0577 0.0662 0.5
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0176
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0432 0.046 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0432 0.046 0.0442
Loa Loa (eye worm) hypothetical protein 0.0432 0.046 0.046
Loa Loa (eye worm) prolyl oligopeptidase 0.0577 0.0662 0.0662
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0115 0.0019 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.3117 0.4199 0.4188
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.7282 1 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0577 0.0662 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0432 0.046 0.0442
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0432 0.046 0.0442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0432 0.046 0.046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0432 0.046 0.0442
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0577 0.0662 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0432 0.046 0.0442
Loa Loa (eye worm) hypothetical protein 0.0432 0.046 0.046
Entamoeba histolytica prolyl oligopeptidase family protein 0.0577 0.0662 0.5
Brugia malayi nuclear hormone receptor 0.0432 0.046 0.0442
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0204 0.0142 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0228 0.0176 0.0158
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0204 0.0142 0.0124
Loa Loa (eye worm) hypothetical protein 0.0432 0.046 0.046
Brugia malayi nuclear hormone receptor 0.4943 0.6742 0.6736
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0432 0.046 0.0442
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0204 0.0142 0.0129
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0577 0.0662 0.0645
Echinococcus multilocularis epidermal growth factor receptor 0.0194 0.0128 0.0114
Loa Loa (eye worm) hypothetical protein 0.0577 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Brugia malayi prolyl oligopeptidase family protein 0.0577 0.0662 0.0645
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0117 0.0022 0.0003
Entamoeba histolytica hypothetical protein, conserved 0.0577 0.0662 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0432 0.046 0.0442
Schistosoma mansoni voltage-gated potassium channel 0.0128 0.0036 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0204 0.0142 0.0124
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0577 0.0662 0.5
Brugia malayi hypothetical protein 0.1871 0.2464 0.245
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0577 0.0662 1
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0433 0.0461 0.0443
Echinococcus granulosus ecdysone induced protein 78C 0.0432 0.046 0.0442
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0117 0.0022 0.0022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0204 0.0142 0.0124
Loa Loa (eye worm) hypothetical protein 0.0432 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.4739 0.6458 0.6458
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.2448 0.3268 0.3255
Brugia malayi ecdysteroid receptor 0.0432 0.046 0.0442
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0432 0.046 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0432 0.046 0.0442
Schistosoma mansoni tyrosine kinase 0.0194 0.0128 0.0109
Echinococcus multilocularis Dipeptidyl peptidase 9 0.2448 0.3268 0.3259
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0176
Echinococcus multilocularis nuclear receptor nhr 48 0.0204 0.0142 0.0129
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.7282 1 1
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0433 0.0461 0.0443
Schistosoma mansoni voltage-gated potassium channel 0.0128 0.0036 0.0018
Onchocerca volvulus Protein ultraspiracle homolog 0.0432 0.046 0.0322
Schistosoma mansoni tyrosine kinase 0.0191 0.0125 0.0107
Echinococcus granulosus acylamino acid releasing enzyme 0.0577 0.0662 0.0645
Brugia malayi hypothetical protein 0.0228 0.0176 0.0158
Brugia malayi Nuclear hormone receptor E75 0.0204 0.0142 0.0124
Mycobacterium tuberculosis Probable peptidase 0.0577 0.0662 0.5
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.2448 0.3268 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.4943 0.6742 0.6742
Brugia malayi prolyl oligopeptidase family protein 0.2448 0.3268 0.3255
Schistosoma mansoni nuclear receptor nhr-48 0.0204 0.0142 0.0124
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0117 0.0022 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0432 0.046 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0432 0.046 0.0442
Echinococcus granulosus prolyl endopeptidase 0.0577 0.0662 0.0645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0432 0.046 0.046
Brugia malayi hypothetical protein 0.0228 0.0176 0.0158
Loa Loa (eye worm) hypothetical protein 0.0204 0.0142 0.0142
Schistosoma mansoni tyrosine kinase 0.0191 0.0125 0.0107
Loa Loa (eye worm) hypothetical protein 0.0228 0.0176 0.0176
Schistosoma mansoni nuclear hormone receptor 0.0204 0.0142 0.0124
Brugia malayi Steroid receptor seven-up type 2 0.0432 0.046 0.0442
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.2448 0.3268 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0228 0.0176 0.0163

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.2 nM Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme (from human A431 carcinoma cell vesicles) ChEMBL. 11462982
IC50 (binding) = 16 nM Inhibition of autophosphorylation of EGFR in A431 cells ChEMBL. 11462982
IC50 (binding) = 16 nM Inhibition of autophosphorylation of EGFR in A431 cells ChEMBL. 11462982
IC50 (binding) = 0.339 uM Inhibition of epidermal growth factor receptor using enzyme assay ChEMBL. 11495584
IC50 (binding) = 0.339 uM Inhibition of epidermal growth factor receptor using enzyme assay ChEMBL. 11495584
IC50 (functional) = 1.31 uM Inhibition of human epidermoid carcinoma xenograft (A431) tumour growth ChEMBL. 11495584
IC50 (functional) = 1.31 uM Inhibition of human epidermoid carcinoma xenograft (A431) tumour growth ChEMBL. 11495584
IC50 (functional) = 2.22 uM Inhibition of cell growth of SKBr3 cell lines using cell-based assay ChEMBL. 11495584
IC50 (functional) = 2.22 uM Inhibition of cell growth of SKBr3 cell lines using cell-based assay ChEMBL. 11495584
IC50 (binding) = 15.238 uM Inhibition of human epidermal growth factor receptor (HER-2) using enzyme assay ChEMBL. 11495584
IC50 (binding) = 15.238 uM Inhibition of human epidermal growth factor receptor (HER-2) using enzyme assay ChEMBL. 11495584
IC50 (functional) = 20.7 uM Inhibition of cell growth of SW620 cell lines using cell-based assay ChEMBL. 11495584
IC50 (functional) = 20.7 uM Inhibition of cell growth of SW620 cell lines using cell-based assay ChEMBL. 11495584
IC50 app (binding) = 1.2 nM Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme (from human A431 carcinoma cell vesicles) ChEMBL. 11462982
Inhibition (functional) < 20 % Irreversible inhibition of formation of phosphorylated EGFR in A431 cells 8 hr after washing cells free of compound ChEMBL. 11462982
Inhibition (functional) < 20 % Irreversible inhibition of formation of phosphorylated EGFR in A431 cells 8 hr after washing cells free of compound ChEMBL. 11462982

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11495584

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.