Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.1902 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0072 | 0.0000000015497 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0072 | 0.0381 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.1902 | 0.1843 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0072 | 0.0381 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.1902 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.1902 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.1902 | 0.5 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.1902 | 0.1902 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.1902 | 0.1902 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.1902 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.1902 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.1902 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0072 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.1902 | 0.1843 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.1902 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.1902 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1902 | 0.1843 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0072 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.1902 | 0.5 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.1902 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.002 | 0.1902 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0047 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.