TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 481.67 | Formula: C29H43N3O3
H donors: 1 H acceptors: 3 LogP: 4.42 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CC1CC(=C(N(C1=O)Cc1ccccc1)C)C(=O)N(C(C)C)C(C)C)NCC1CCCCC1
InChi: 1S/C29H43N3O3/c1-20(2)32(21(3)4)29(35)26-16-25(17-27(33)30-18-23-12-8-6-9-13-23)28(34)31(22(26)5)19-24-14-10-7-11-15-24/h7,10-11,14-15,20-21,23,25H,6,8-9,12-13,16-19H2,1-5H3,(H,30,33)
InChiKey: IIBFOFJBWBWTNW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0047	0.006	0.0058
Echinococcus granulosus	calcium activated potassium channel variant	0.0047	0.006	0.0367
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0012	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Echinococcus multilocularis	calcium activated potassium channel variant	0.0047	0.006	0.0367
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0223	0.042	0.268
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Schistosoma mansoni	nuclear hormone receptor	0.0223	0.042	0.268
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0047	0.006	0.0198
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0105	0.0179	0.1132
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0069	0.0358
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0012	0.0009
Schistosoma mansoni	nuclear hormone receptor	0.0105	0.0179	0.1132
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0223	0.042	0.0427
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0045	0.0272
Brugia malayi	nuclear receptor NHR-88	0.0223	0.042	0.0427
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0223	0.042	0.0427
Loa Loa (eye worm)	nuclear hormone receptor	0.0105	0.0179	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Onchocerca volvulus		0.0047	0.006	0.0048
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0223	0.042	0.268
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0039	0.0228
Leishmania major	hypothetical protein, conserved	0.0047	0.006	0.0859
Plasmodium falciparum	potassium channel	0.0047	0.006	1
Schistosoma mansoni	hypothetical protein	0.0047	0.006	0.0367
Echinococcus granulosus	thyroid hormone receptor alpha	0.0105	0.0179	0.1132
Echinococcus granulosus	potassium channel subfamily K	0.0047	0.006	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0205	0.021
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0012	0.0012
Echinococcus multilocularis	potassium channel subfamily K 8	0.0047	0.006	0.0367
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0045	0.0272
Trypanosoma cruzi	hypothetical protein, conserved	0.0047	0.006	0.0198
Schistosoma mansoni	nuclear receptor nhr-48	0.0105	0.0179	0.1132
Leishmania major	hypothetical protein, conserved	0.0047	0.006	0.0859
Echinococcus granulosus	nuclear receptor nhr 48	0.0105	0.0179	0.1132
Brugia malayi	hypothetical protein	0.0047	0.006	0.0058
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.4792	0.9759	1
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0047	0.006	0.0062
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0003	0.0003
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0047	0.006	0.0198
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0223	0.042	0.0427
Schistosoma mansoni	thyroid hormone receptor	0.0223	0.042	0.268
Schistosoma mansoni	calcium-activated potassium channel	0.0047	0.006	0.0367
Brugia malayi	ecdysone receptor	0.0105	0.0179	0.0181
Brugia malayi	Nuclear hormone receptor-like 1	0.0223	0.042	0.0427
Leishmania major	mitochondrial DNA polymerase beta	0.0298	0.0573	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0105	0.0179	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0223	0.042	0.0427
Echinococcus multilocularis	potassium channel subfamily K 8	0.0047	0.006	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0012	0.0424
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0012	0.0424
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.0573	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0223	0.042	0.268
Onchocerca volvulus		0.0047	0.006	0.0048
Brugia malayi	hypothetical protein	0.0047	0.006	0.0058
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.078	0.1559	0.1595
Echinococcus multilocularis	FTZ F1 alpha	0.0223	0.042	0.268
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0047	0.006	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0118	0.0205	0.1298
Schistosoma mansoni	zinc finger protein	0.0105	0.0179	0.1132
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.0253	0.3871
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	nuclear hormone receptor family member odr-7	0.0105	0.0179	0.0181
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0105	0.0179	0.1132
Giardia lamblia	Hypothetical protein	0.0047	0.006	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0047	0.006	0.0058
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0105	0.0179	0.1132
Trypanosoma cruzi	hypothetical protein, conserved	0.0047	0.006	0.0198
Schistosoma mansoni	retinoic acid receptor RXR	0.0223	0.042	0.268
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Brugia malayi	Steroid receptor seven-up type 2	0.0223	0.042	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0223	0.042	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0223	0.042	0.0427
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0223	0.042	0.0431
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0223	0.042	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0105	0.0179	0.1132
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0105	0.0179	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0012	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0223	0.042	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0087	0.0086
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.006	0.0367
Brugia malayi	Nuclear hormone receptor-like 1	0.0118	0.0205	0.0207
Loa Loa (eye worm)	hypothetical protein	0.4687	0.9544	0.978
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Onchocerca volvulus		0.0047	0.006	0.0048
Onchocerca volvulus		0.0223	0.042	0.0409
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0052	0.007	0.1414
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Onchocerca volvulus	Bile acid receptor homolog	0.0223	0.042	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0223	0.042	0.0431
Onchocerca volvulus	Protein ultraspiracle homolog	0.0223	0.042	0.0409
Brugia malayi	hypothetical protein	0.0118	0.0205	0.0207
Echinococcus granulosus	twik family of potassium channels	0.0047	0.006	0.0367
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0047	0.006	0.0058
Brugia malayi	MH2 domain containing protein	0.0144	0.0259	0.0262
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0012	0.0424
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0047	0.006	0.0058
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.078	0.1559	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0223	0.042	0.0427
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0223	0.042	0.268
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0	0.5
Schistosoma mansoni	calcium-activated potassium channel	0.0047	0.006	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Echinococcus multilocularis	small conductance calcium activated potassium	0.0047	0.006	0.0367
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0223	0.042	0.268
Loa Loa (eye worm)	DR-78	0.0105	0.0179	0.0184
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0047	0.006	0.0198
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.013	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Toxoplasma gondii	hypothetical protein	0.0048	0.0063	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0223	0.042	0.268
Brugia malayi	orphan nuclear receptor NR2E1	0.0105	0.0179	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0223	0.042	0.0431
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0047	0.006	0.0058
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0223	0.042	0.268
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0047	0.006	0.0058
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0039	0.0036
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0118	0.0205	0.1298
Mycobacterium ulcerans	hypothetical protein	0.0157	0.0285	1
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0205	0.021
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0105	0.0179	0.1132
Mycobacterium ulcerans	ion transport protein	0.0047	0.006	0.2114
Trypanosoma cruzi	ion transport protein, putative	0.0047	0.006	0.0198
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0223	0.042	0.268
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0223	0.042	0.0431
Loa Loa (eye worm)	hypothetical protein	0.078	0.1559	0.1598
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0081	0.013	1
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0047	0.006	0.0367
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0223	0.042	0.268
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0105	0.0179	0.1132
Leishmania major	calcium/potassium channel (CAKC), putative	0.0047	0.006	0.0859
Brugia malayi	hypothetical protein	0.0105	0.0179	0.0181
Brugia malayi	nuclear receptor NHR-67	0.0105	0.0179	0.0181
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0118	0.0205	0.1298
Echinococcus multilocularis	potassium channel subfamily K	0.0047	0.006	0.0367
Loa Loa (eye worm)	steroid hormone receptor	0.0223	0.042	0.0431
Loa Loa (eye worm)	hypothetical protein	0.006	0.0087	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.0253	0.3871
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0087	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0223	0.042	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0047	0.006	0.0058
Schistosoma mansoni	thyroid hormone receptor	0.0223	0.042	0.268
Onchocerca volvulus		0.0047	0.006	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0105	0.0179	0.1132
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0223	0.042	0.0431
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0047	0.006	0.0058
Brugia malayi	steroid hormone receptor	0.0223	0.042	0.0427
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0105	0.0179	0.1132
Echinococcus multilocularis	twik family of potassium channels	0.0047	0.006	0.0367
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0223	0.042	0.0431
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0223	0.042	0.0427
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.078	0.1559	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0012	0.0424
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0223	0.042	0.0427
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0259	0.0265
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0048	0.0046
Brugia malayi	nuclear receptor RXR	0.0118	0.0205	0.0207
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0047	0.006	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0029	0.003
Plasmodium vivax	potassium channel, putative	0.0047	0.006	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Schistosoma mansoni	nuclear receptor	0.0105	0.0179	0.1132
Onchocerca volvulus		0.0047	0.006	0.0048
Echinococcus multilocularis	nuclear receptor nhr 48	0.0105	0.0179	0.1132
Onchocerca volvulus		0.0105	0.0179	0.0167
Leishmania major	ion transport protein-like protein	0.0047	0.006	0.0859
Echinococcus granulosus	ecdysone induced protein 78C	0.0223	0.042	0.268
Loa Loa (eye worm)	uncoordinated protein 58	0.0047	0.006	0.0062
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0105	0.0179	0.0181
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0223	0.042	0.0431
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0047	0.006	0.2114
Schistosoma mansoni	calcium-activated potassium channel	0.0047	0.006	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0003	0.0003
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0012	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0223	0.042	0.268
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.006	0.0367
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0105	0.0179	0.0167
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0012	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0223	0.042	0.0431
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.006	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Echinococcus multilocularis	ecdysone induced protein 78C	0.0223	0.042	0.268
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0047	0.006	0.0198
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0118	0.0205	0.021
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0012	0.0424
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0105	0.0179	0.1132
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0047	0.006	0.0058
Schistosoma mansoni	coup transcription factor	0.0223	0.042	0.268
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0047	0.006	0.0058
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.0285	1
Trypanosoma cruzi	ion transport protein, putative	0.0047	0.006	0.0198
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0047	0.006	1
Echinococcus granulosus	potassium channel subfamily K 8	0.0047	0.006	0.0367
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0087	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Onchocerca volvulus		0.0047	0.006	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0223	0.042	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0223	0.042	0.268
Schistosoma mansoni	twik family of potassium channels-related	0.078	0.1559	1
Brugia malayi	Nuclear hormone receptor E75	0.0105	0.0179	0.0181
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0298	0.0573	1
Loa Loa (eye worm)	hypothetical protein	0.0223	0.042	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0047	0.006	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0012	0.0012
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0223	0.042	0.268
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0047	0.006	0.0058
Brugia malayi	tailless protein	0.0105	0.0179	0.0181
Onchocerca volvulus		0.0105	0.0179	0.0167
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0223	0.042	0.0431
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0223	0.042	0.268
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0052	0.007	0.1414
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	Nuclear hormone receptor-like 1	0.0118	0.0205	0.0207
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0223	0.042	0.268
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0223	0.042	0.268
Brugia malayi	nuclear receptor RXR	0.0105	0.0179	0.0181
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0047	0.006	0.0198
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0039	0.004
Loa Loa (eye worm)	hypothetical protein	0.0223	0.042	0.0431
Brugia malayi	photoreceptor-specific nuclear receptor	0.0223	0.042	0.0427
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.006	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0205	0.021
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0223	0.042	0.268
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.006	0.0367
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0047	0.006	0.0198
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.006	0.0367
Echinococcus granulosus	small conductance calcium activated potassium	0.0047	0.006	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0733	0.1463	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0223	0.042	0.0431
Brugia malayi	Nuclear hormone receptor E75	0.0105	0.0179	0.0181
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0105	0.0179	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0205	0.021
Loa Loa (eye worm)	hypothetical protein	0.078	0.1559	0.1598
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0012	0.0009
Mycobacterium ulcerans	transmembrane cation transporter	0.0047	0.006	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0048	0.005
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	hypothetical protein	0.0105	0.0179	0.0181
Echinococcus granulosus	potassium channel subfamily K 8	0.0047	0.006	0.0367
Onchocerca volvulus		0.0047	0.006	0.0048
Schistosoma mansoni	hypothetical protein	0.0047	0.006	0.0367
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0118	0.0205	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0205	0.021
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0047	0.006	0.0058
Schistosoma mansoni	nuclear receptor	0.0105	0.0179	0.1132
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0047	0.006	0.0058
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0105	0.0179	0.1132
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0259	0.0265
Loa Loa (eye worm)	TWK-7 protein	0.0047	0.006	0.0062
Echinococcus granulosus	twik family of potassium channels	0.0047	0.006	0.0367
Brugia malayi	ecdysteroid receptor	0.0223	0.042	0.0427
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0105	0.0179	0.0167
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0223	0.042	0.268
Echinococcus multilocularis	twik family of potassium channels	0.0047	0.006	0.0367
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0223	0.042	0.268
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0047	0.006	0.0058
Echinococcus granulosus	FTZ F1 alpha	0.0223	0.042	0.268
Brugia malayi	nuclear hormone receptor	0.4792	0.9759	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.0253	0.4284
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0047	0.006	0.0062
Onchocerca volvulus		0.0047	0.006	0.0048
Schistosoma mansoni	nuclear hormone receptor	0.0105	0.0179	0.1132
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0223	0.042	0.0431
Brugia malayi	nuclear hormone receptor	0.0223	0.042	0.0427
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0223	0.042	0.268
Leishmania major	potassium channel subunit-like protein	0.0047	0.006	0.0859
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0223	0.042	0.268
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0012	0.0424
Schistosoma mansoni	RAR-like nuclear receptor	0.0223	0.042	0.268
Plasmodium vivax	potassium channel, putative	0.0047	0.006	1
Loa Loa (eye worm)	TWK-28 protein	0.0047	0.006	0.0062
Plasmodium falciparum	potassium channel	0.0047	0.006	1
Brugia malayi	conserved hypotetical protein	0.0105	0.0179	0.0181
Schistosoma mansoni	twik family of potassium channels-related	0.0047	0.006	0.0367
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0012	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0047	0.006	0.0062
Brugia malayi	hypothetical protein	0.0118	0.0205	0.0207
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0223	0.042	0.268
Schistosoma mansoni	hypothetical protein	0.0041	0.0048	0.029
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0179	0.0184
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0298	0.0573	1
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0047	0.006	0.0367
Brugia malayi	nuclear receptor NHR-88	0.0105	0.0179	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0223	0.042	0.0427
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0223	0.042	0.0431
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0012	0.0009
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0039	0.0228

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1901699

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1541674