Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0391 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0442 | 0.0442 |
Mycobacterium ulcerans | glutaminase | 0.0281 | 0.6919 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0281 | 0.6919 | 0.6919 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0391 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.4958 | 0.4958 |
Schistosoma mansoni | glutaminase | 0.0281 | 0.6919 | 0.6919 |
Loa Loa (eye worm) | TAR-binding protein | 0.0391 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0391 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0391 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0281 | 0.6919 | 0.6919 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.438 | 0.438 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0211 | 0.4958 | 0.4958 |
Trichomonas vaginalis | glutaminase, putative | 0.0281 | 0.6919 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0281 | 0.6919 | 0.6919 |
Loa Loa (eye worm) | RNA binding protein | 0.0391 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0442 | 0.0442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0391 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.