Detailed information for compound 1541723

Basic information

Technical information
  • TDR Targets ID: 1541723
  • Name: T5557241
  • MW: 347.412 | Formula: C17H25N5O3
  • H donors: 0 H acceptors: 4 LogP: 1.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)Cn1cnc2c1c(=O)n(C)c(=O)n2C)C1CCCCC1
  • InChi: 1S/C17H25N5O3/c1-4-22(12-8-6-5-7-9-12)13(23)10-21-11-18-15-14(21)16(24)20(3)17(25)19(15)2/h11-12H,4-10H2,1-3H3
  • InChiKey: RSVRKZZNRLUXIR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0102 0.0102
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.1363 0.1729
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.1363 0.1363
Chlamydia trachomatis dihydrofolate reductase 0.0299 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0141 0.0159
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0029 0.0029
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0102 0.0109
Schistosoma mansoni cpg binding protein 0.0037 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0454 0.0423
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0102 0.0131
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.1363 0.1748
Schistosoma mansoni nck2/grb4 0.0007 0.0118 0.0118
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0006 0.007 0.007
Brugia malayi protein-tyrosine kinase 0.0033 0.0987 0.0957
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1746 0.1746
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0238 0.0238
Schistosoma mansoni myst-related protein 0.0004 0.0013 0.0013
Echinococcus granulosus basement membrane specific heparan sulfate 0.0006 0.007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0234 0.7796 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0118 0.0086
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0166 0.0166
Echinococcus granulosus tyrosine protein kinase Src64B 0.0036 0.1107 0.1107
Onchocerca volvulus 0.0006 0.007 0.0048
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0102 0.0131
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.065 0.0554
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.065 0.0834
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0141 0.0159
Brugia malayi intracellular kinase 0.0234 0.7796 0.7788
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.1107 0.1107
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0102 0.007
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0005 0.0032 0.0032
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0238 0.0206
Onchocerca volvulus 0.0006 0.007 0.0048
Plasmodium vivax protein kinase Crk2 0.0044 0.1363 0.1638
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.065 0.0834
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.1363 0.1335
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0234 0.7796 0.7788
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0299 1 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0005 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0036 0.1107 0.1107
Schistosoma mansoni cpg binding protein 0.0037 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0454 0.0423
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0102 0.0102
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0007 0.0118 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1746 0.1746
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.065 0.0834
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0102 0.0109
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0114 0.3746 0.4736
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0102 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.1107 0.1107
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0102 0.007
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0233 0.0202
Onchocerca volvulus 0.0006 0.0086 0.0069
Echinococcus multilocularis c src tyrosine kinase 0.0008 0.0152 0.0152
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0006 0.007 0.007
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.1363 0.1748
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0141 0.0159
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.1363 0.1335
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.065 0.0554
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0102 0.0131
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.065 0.0584
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0234 0.7796 0.7796
Echinococcus multilocularis tyrosine kinase 0.0005 0.0032 0.0032
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.1363 0.1748
Onchocerca volvulus 0.0006 0.007 0.0048
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0102 0.0131
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.1107 0.1107
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0102 0.0131
Brugia malayi Dihydrofolate reductase 0.0299 1 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0006 0.007 0.007
Echinococcus granulosus cpg binding protein 0.0037 0.1116 0.1116
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1746 0.1719
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.1363 0.1748
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.1107 0.1107
Echinococcus multilocularis low density lipoprotein receptor protein 0.0006 0.007 0.007
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0036 0.1107 0.1107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0043 0.0043
Echinococcus multilocularis dihydrofolate reductase 0.0299 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.065 0.0554
Trichomonas vaginalis helicase, putative 0.0008 0.0141 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Echinococcus granulosus cyclin dependent kinase 0.0044 0.1363 0.1363
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0166 0.0166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0141 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0238 0.0238
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0006 0.007 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0141 0.0159
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.1198 0.1198
Echinococcus granulosus basement membrane specific heparan sulfate 0.0006 0.007 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.1363 0.1729
Echinococcus multilocularis cpg binding protein 0.0037 0.1116 0.1116
Entamoeba histolytica protein kinase, putative 0.0006 0.0089 0.0114
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.065 0.0554
Loa Loa (eye worm) hypothetical protein 0.0023 0.065 0.062
Entamoeba histolytica protein kinase, putative 0.0029 0.0863 0.1108
Plasmodium falciparum zinc finger protein, putative 0.0004 0.0013 0.0017
Plasmodium falciparum glycogen synthase kinase 3 0.0234 0.7796 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1049 0.102
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0102 0.0131
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0102 0.0131
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0114 0.3746 0.4805
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0114 0.3746 0.4805
Brugia malayi AMP-binding enzyme family protein 0.0023 0.065 0.062
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0006 0.0089 0.0114
Loa Loa (eye worm) hypothetical protein 0.0041 0.1272 0.1243
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0005 0.0032 0.0032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0454 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0423 0.0354
Schistosoma mansoni hypothetical protein 0.0006 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0006 0.007 0.007
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0036 0.1107 0.1107
Loa Loa (eye worm) TK protein kinase 0.0033 0.0987 0.0957
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0036 0.1107 0.1107
Onchocerca volvulus 0.0006 0.007 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0006 0.007 0.0037
Echinococcus granulosus protein kinase shaggy 0.0234 0.7796 0.7796
Brugia malayi enteropeptidase precursor 0.0006 0.007 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.1363 0.1363
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0102 0.007
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0102 0.0032
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.1363 0.1363
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0299 1 1
Onchocerca volvulus 0.0023 0.065 0.0796
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0008 0.0152 0.0152
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0102 0.0131
Entamoeba histolytica protein kinase, putative 0.0234 0.7796 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0423 0.0354
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0234 0.7796 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0234 0.7796 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0423 0.0354
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0008 0.0152 0.0152
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.1363 0.1748
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0005 0.0032 0.0041
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0102 0.0032
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0118 0.0086
Loa Loa (eye worm) dihydrofolate reductase 0.0299 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0033 0.0987 0.0987
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0118 0.0086
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0006 0.007 0.0037
Loa Loa (eye worm) hypothetical protein 0.0007 0.0102 0.007
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0234 0.7796 0.7796
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0006 0.007 0.007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.065 0.0554
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0006 0.007 0.0037
Schistosoma mansoni cpg binding protein 0.0035 0.1049 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Schistosoma mansoni growth factor receptor-bound protein 0.0007 0.0118 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0023 0.065 0.062
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0102 0.0131
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0102 0.0131
Echinococcus granulosus low density lipoprotein receptor protein 0.0006 0.007 0.007
Schistosoma mansoni myst-related protein 0.0004 0.0013 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.065 0.0554
Trichomonas vaginalis CMGC family protein kinase 0.0234 0.7796 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0952 0.0952
Onchocerca volvulus 0.0035 0.1049 0.131
Echinococcus granulosus c src tyrosine kinase 0.0008 0.0152 0.0152
Trypanosoma brucei protein kinase, putative 0.0234 0.7796 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.065 0.0834
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.1363 0.1748
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.1363 0.1363
Echinococcus granulosus NCK adaptor protein 0.0007 0.0118 0.0118
Echinococcus multilocularis tyrosine protein kinase Srms 0.0033 0.0987 0.0987
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Echinococcus multilocularis tyrosine protein kinase Blk 0.0033 0.0987 0.0987
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0114 0.3746 0.4805
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0102 0.0032
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Schistosoma mansoni adapter molecule crk 0.0007 0.0118 0.0118
Echinococcus multilocularis tyrosine protein kinase Abl 0.0008 0.0152 0.0152
Entamoeba histolytica protein kinase domain containing protein 0.0234 0.7796 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0008 0.0152 0.0152
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.1363 0.1363
Brugia malayi CUB domain containing protein 0.0006 0.007 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.2367 0.2367
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Brugia malayi Calcium binding EGF domain containing protein 0.0006 0.007 0.0037
Brugia malayi CXXC zinc finger family protein 0.0035 0.1049 0.102
Giardia lamblia Kinase, CMGC GSK 0.0234 0.7796 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Echinococcus granulosus tyrosine protein kinase HCK 0.0029 0.0863 0.0863
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0118 0.0086
Onchocerca volvulus 0.0234 0.7796 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.065 0.062
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0006 0.007 0.007
Echinococcus granulosus growth factor receptor bound protein 2 0.0007 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0454 0.0423
Onchocerca volvulus 0.0007 0.0102 0.009
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0005 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Schistosoma mansoni growth factor receptor-bound protein 0.0007 0.0118 0.0118
Echinococcus multilocularis tyrosine protein kinase shark 0.0005 0.0032 0.0032
Plasmodium vivax glycogen synthase kinase 3, putative 0.0234 0.7796 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0102 0.0032
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0234 0.7796 1
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0102 0.0131
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.1363 0.1748
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.065 0.0554
Echinococcus multilocularis growth factor receptor bound protein 2 0.0007 0.0118 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1746 0.1746
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.1363 0.1363
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.1363 0.1748
Echinococcus granulosus dihydrofolate reductase 0.0299 1 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0102 0.0032
Brugia malayi Sex muscle abnormal protein 5 0.0007 0.0118 0.0086
Loa Loa (eye worm) SRC-1 0.0036 0.1107 0.1078
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.1363 0.1729
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0141 0.0159
Plasmodium falciparum protein kinase 5 0.0044 0.1363 0.1748
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.1363 0.1363
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0006 0.007 0.0048
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.065 0.0834
Loa Loa (eye worm) oxidoreductase 0.0007 0.0102 0.007
Echinococcus granulosus tyrosine kinase 0.0033 0.0987 0.0987
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.1107 0.1107
Onchocerca volvulus 0.0006 0.007 0.0048
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0102 0.007
Brugia malayi SRC-1 0.0036 0.1107 0.1078
Loa Loa (eye worm) TK protein kinase 0.0029 0.0863 0.0834
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0006 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0036 0.1107 0.1107
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0102 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.065 0.0584
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0006 0.007 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Loa Loa (eye worm) hypothetical protein 0.0023 0.065 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Echinococcus granulosus low density lipoprotein receptor ldl 0.0006 0.007 0.007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0454 0.0356
Loa Loa (eye worm) hypothetical protein 0.0017 0.0454 0.0423
Schistosoma mansoni tyrosine kinase 0.0005 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0036 0.1107 0.1107
Schistosoma mansoni dihydrofolate reductase 0.0299 1 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0006 0.007 0.0037
Echinococcus multilocularis NCK adaptor protein 0.0007 0.0118 0.0118
Echinococcus granulosus low density lipoprotein receptor ldl 0.0006 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0234 0.7796 0.7796
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1746 0.1746
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0102 0.0032
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.1363 0.1363
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1746 0.1746
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.1107 0.1107
Brugia malayi Protein kinase domain containing protein 0.0044 0.1363 0.1335
Onchocerca volvulus 0.0007 0.0102 0.009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0102 0.007
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0036 0.1107 0.1107
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.1363 0.1748
Brugia malayi cell division control protein 2 homolog 0.0044 0.1363 0.1335
Loa Loa (eye worm) hypothetical protein 0.0017 0.0454 0.0423
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0102 0.0032
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0006 0.007 0.007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1746 0.1719
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0234 0.7796 0.7788
Onchocerca volvulus Arrow homolog 0.0006 0.007 0.0048
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0166 0.0166
Onchocerca volvulus 0.0006 0.007 0.0048
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.1363 0.1335
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.065 0.0554
Loa Loa (eye worm) hypothetical protein 0.0023 0.065 0.062
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0102 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0234 0.7796 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0299 1 1
Schistosoma mansoni tyrosine kinase 0.0008 0.0152 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1746 0.1746
Echinococcus multilocularis protein kinase shaggy 0.0234 0.7796 0.7796
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0423 0.0354
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0102 0.007
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0006 0.007 0.007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0141 0.0159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0141 0.0159
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0114 0.3746 0.4805
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0102 0.0102
Entamoeba histolytica hypothetical protein 0.0004 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0006 0.007 0.007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0166 0.0166
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0006 0.007 0.007
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0454 0.0583
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0102 0.0131
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.1363 0.1748
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.1107 0.1107
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0007 0.0118 0.0118
Giardia lamblia Kinase, CMGC GSK 0.0234 0.7796 1
Schistosoma mansoni tyrosine kinase 0.0008 0.0152 0.0152
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.1107 0.1107
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0102 0.0131
Echinococcus granulosus tyrosine protein kinase Srms 0.0005 0.0032 0.0032
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Echinococcus multilocularis tyrosine protein kinase HCK 0.0029 0.0863 0.0863
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0114 0.3746 0.4805
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0102 0.0032
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0952 0.0952
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1746 0.1746
Onchocerca volvulus 0.0007 0.0102 0.009
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0033 0.0987 0.0987
Echinococcus granulosus tyrosine protein kinase shark 0.0005 0.0032 0.0032
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0037
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0454 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0141 0.0159
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.2101 0.2694
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0102 0.0032
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0006 0.007 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.065 0.0554
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0102 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.065 0.0834
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.1363 0.1748
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0102 0.007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0102 0.0131
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Echinococcus granulosus tyrosine protein kinase Blk 0.0033 0.0987 0.0987
Mycobacterium ulcerans hypothetical protein 0.0023 0.065 0.0554
Brugia malayi Tyrosine-protein kinase abl-1 0.0008 0.0152 0.0121
Echinococcus granulosus tyrosine kinase 0.0005 0.0032 0.0032
Brugia malayi basement membrane proteoglycan precursor 0.0006 0.007 0.0037
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.007 0.0037
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.1363 0.1363
Schistosoma mansoni tyrosine kinase 0.0036 0.1107 0.1107
Schistosoma mansoni tyrosine kinase 0.0005 0.0032 0.0032
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0006 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0036 0.1107 0.1107
Onchocerca volvulus 0.0007 0.0102 0.009

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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