Detailed information for compound 1542002

Basic information

Technical information
  • TDR Targets ID: 1542002
  • Name: 2-(2-amino-6-dimethylaminopurin-9-yl)-5-(hydr oxymethyl)oxolan-3-ol
  • MW: 294.31 | Formula: C12H18N6O3
  • H donors: 3 H acceptors: 5 LogP: -1.02 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1CC(C(O1)n1cnc2c1nc(N)nc2N(C)C)O
  • InChi: 1S/C12H18N6O3/c1-17(2)9-8-10(16-12(13)15-9)18(5-14-8)11-7(20)3-6(4-19)21-11/h5-7,11,19-20H,3-4H2,1-2H3,(H2,13,15,16)
  • InChiKey: LNYKKRFEGRMIGR-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(2-amino-6-dimethylamino-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol
  • 2-(2-amino-6-dimethylamino-9-purinyl)-5-(hydroxymethyl)-3-tetrahydrofuranol
  • 2-(2-amino-6-dimethylamino-purin-9-yl)-5-methylol-tetrahydrofuran-3-ol
  • 2-(2-amino-6-dimethylamino-purin-9-yl)-5-(hydroxymethyl)oxolan-3-ol
  • NSC106542

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.012 0.02
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0025 0.0056
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0041 0.012 0.0257
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0025 0.0013
Leishmania major cathepsin L-like protease 0.0035 0.0094 0.1021
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0052 0.0839
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0107
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.015 0.2273
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0113 0.0414 0.0717
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0094 0.0077
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0026 0.0245
Loa Loa (eye worm) fibroinase 0.0035 0.0094 0.0212
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0025 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0031 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0025 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0026 0.02
Schistosoma mansoni hypothetical protein 0.0036 0.0102 0.0184
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0899 1
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0041 0.012 0.0226
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.015 0.2402
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0025 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0142 0.0257
Toxoplasma gondii type I fatty acid synthase, putative 0.0696 0.2797 1
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0202 0.0777 0.19
Brugia malayi Isocitrate dehydrogenase 0.0048 0.015 0.0299
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0066 0.0224 0.0445
Brugia malayi N-terminal motif family protein 0.0182 0.0696 0.1383
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.015 0.2402
Echinococcus granulosus geminin 0.0523 0.2089 0.3749
Brugia malayi Cathepsin L-like precursor 0.0035 0.0094 0.0188
Brugia malayi MH1 domain containing protein 0.0014 0.0009 0.0019
Brugia malayi Smad1 0.0025 0.0055 0.0109
Loa Loa (eye worm) fatty acid synthase 0.0647 0.2595 0.583
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0056
Leishmania major hypothetical protein, conserved 0.0197 0.076 1
Echinococcus multilocularis cpg binding protein 0.0063 0.0209 0.0192
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0066 0.0224 0.0491
Echinococcus granulosus GPCR family 2 0.0031 0.008 0.0113
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0041 0.0122 0.1608
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0113 0.0414 0.4558
Loa Loa (eye worm) hypothetical protein 0.0101 0.0364 0.0818
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0026 0.0408
Leishmania major protein kinase, putative 0.002 0.0035 0.0216
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0036 0.0418
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.012 0.0238
Toxoplasma gondii type I fatty acid synthase 0.0101 0.0364 0.1221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0025 0.0007
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0053 0.0172 0.0386
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0031 0.0257
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0113 0.0414 0.5335
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0197 0.0423
Echinococcus granulosus NADH dehydrogenase 0.0066 0.0224 0.0373
Schistosoma mansoni lamin 0.0053 0.0172 0.031
Schistosoma mansoni hypothetical protein 0.0067 0.0228 0.0411
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0056
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0026 0.0093
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0041 0.0122 0.171
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0562 0.0546
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.012 0.1252
Brugia malayi cathepsin L-like precursor 0.0023 0.0048 0.0095
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0165 0.0625 0.1515
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0696 0.2797 0.7049
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.098 0.3955 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0122 0.0275
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0066 0.0224 0.0491
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0026 0.0408
Chlamydia trachomatis acyl carrier protein 0.0066 0.0224 0.3381
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.012 0.2423
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0094 0.0077
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0052 0.0097
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0026 0.0046
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0026 0.0047
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0265 0.1036 0.2561
Trypanosoma cruzi acyl transferase-like protein 0.0041 0.0122 0.1957
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.012 0.0444 0.7098
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0025 0.0045
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0036 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0077 0.0139
Schistosoma mansoni smad1 5 8 and 0.0025 0.0055 0.0099
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0031 0.0167
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0142 0.0283
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0026 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0142 0.0225
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.0019 0.0118
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0026 0.0052
Onchocerca volvulus 0.0612 0.2455 0.5111
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0118 0.1527
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.015 0.024
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.012 0.1914
Onchocerca volvulus 0.0035 0.0094 0.0146
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0165 0.0625 0.1515
Echinococcus granulosus cpg binding protein 0.0063 0.0209 0.0346
Echinococcus multilocularis dna polymerase kappa 0.002 0.0036 0.0018
Onchocerca volvulus 0.0041 0.012 0.02
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.091 0.2044
Leishmania major cysteine peptidase A (CPA) 0.0035 0.0094 0.1021
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0655 0.2631 0.6625
Entamoeba histolytica acyl-CoA synthetase, putative 0.0066 0.0224 0.5103
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0269
Plasmodium falciparum acyl carrier protein 0.0066 0.0224 0.33
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0433 0.1724 0.4314
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.0019 0.0118
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.012 0.1252
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0052 0.0095
Brugia malayi isocitrate dehydrogenase 0.0048 0.015 0.0299
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0026 0.0408
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.012 0.1914
Schistosoma mansoni intermediate filament proteins 0.0053 0.0172 0.031
Echinococcus multilocularis AMP dependent ligase 0.0066 0.0224 0.0206
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0056
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0026 0.0093
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.015 0.0304
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0562 0.1015
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0036 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0133 0.0386
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0036 0.0418
Treponema pallidum acyl carrier protein 0.0066 0.0224 1
Brugia malayi follicle stimulating hormone receptor 0.0234 0.091 0.181
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0026 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0165 0.0625 0.1244
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0026 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.008 0.0113
Entamoeba histolytica hypothetical protein 0.0036 0.0102 0.1968
Onchocerca volvulus Fatty acid synthase homolog 0.1182 0.478 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0019 0.0118
Toxoplasma gondii acyl transferase domain-containing protein 0.0041 0.0122 0.0349
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0384
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.015 0.045
Schistosoma mansoni smad1 5 8 and 0.0025 0.0055 0.0099
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0026 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0031 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0077 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0025 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0026 0.02
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0025 0.0013
Echinococcus granulosus lamin 0.0053 0.0172 0.0279
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0118 0.2369
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0031 0.0075
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0113 0.0414 0.0824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0025 0.0056
Schistosoma mansoni ap endonuclease 0.0019 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0367 0.1454 0.3265
Mycobacterium ulcerans polyketide synthase MbtC 0.0165 0.0625 0.1515
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0055 0.0099
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.012 0.1363
Brugia malayi AMP-binding enzyme family protein 0.0612 0.2455 0.4882
Entamoeba histolytica cysteine protease, putative 0.0035 0.0094 0.1772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0039 0.0617
Mycobacterium ulcerans polyketide synthase Pks9 0.0433 0.1724 0.4314
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0066 0.0224 0.0503
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.0019 0.0118
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0026 0.0047
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0026 0.0093
Mycobacterium ulcerans dehydrogenase 0.0041 0.012 0.0226
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0036 0.0578
Brugia malayi PAS domain containing protein 0.0016 0.0019 0.0037
Onchocerca volvulus 0.0035 0.0094 0.0146
Brugia malayi nuclear hormone receptor 0.0017 0.0025 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Onchocerca volvulus Protein cycle homolog 0.0037 0.0107 0.0172
Brugia malayi Cathepsin L-like precursor 0.0035 0.0094 0.0188
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0019 0.0298
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0055 0.0067
Brugia malayi hypothetical protein 0.0037 0.0105 0.021
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0026 0.0408
Trypanosoma brucei unspecified product 0.002 0.0036 0.0418
Mycobacterium leprae Probable polyketide synthase Pks1 0.0696 0.2797 0.7059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0172 0.0386
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0036 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0025 0.0049
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.008 0.016
Plasmodium vivax vivapain-2 0.0035 0.0094 0.1509
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.012 0.0102
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0785 0.1763
Onchocerca volvulus 0.0035 0.0094 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0025 0.0049
Schistosoma mansoni microtubule-associated protein tau 0.1368 0.5543 1
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.012 0.0226
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0206 0.0794 0.1945
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0892 0.1582
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.012 0.1914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.015 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.012 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0113 0.0414 0.0397
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0026 0.0094
Loa Loa (eye worm) hypothetical protein 0.003 0.0077 0.0173
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0026 0.0416
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0094 0.0188
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0025 0.0045
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0033 0.0073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0195 0.0439
Leishmania major cathepsin L-like protease 0.0035 0.0094 0.1021
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0165 0.0625 0.11
Loa Loa (eye worm) hypothetical protein 0.0101 0.0364 0.0818
Echinococcus granulosus cathepsin l1 0.0035 0.0094 0.0139
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0066 0.0224 0.3469
Onchocerca volvulus 0.0041 0.012 0.02
Mycobacterium ulcerans hypothetical protein 0.0066 0.0224 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0031 0.0335
Leishmania major cathepsin L-like protease 0.0035 0.0094 0.1021
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0172 0.0386
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0562 0.1119
Trypanosoma brucei oxidoreductase, putative 0.0041 0.012 0.1776
Onchocerca volvulus 0.1141 0.4614 0.965
Brugia malayi Cathepsin L-like precursor 0.0023 0.0048 0.0095
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0019 0.0118
Schistosoma mansoni single-minded 0.0016 0.0019 0.0034
Giardia lamblia Methyltransferase like 2 0.0197 0.076 1
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.012 0.1914
Onchocerca volvulus 0.0053 0.0172 0.0309
Echinococcus multilocularis geminin 0.0523 0.2089 0.2075
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0066 0.0224 0.0491
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0107
Echinococcus granulosus acyl carrier protein mitochondrial 0.0066 0.0224 0.0373
Schistosoma mansoni DNA polymerase eta 0.002 0.0036 0.0065
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.0368 0.5713
Loa Loa (eye worm) ctsf protein 0.0035 0.0094 0.0212
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0025 0.0007
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0655 0.2631 0.6625
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.0414 0.6622
Echinococcus multilocularis NADH dehydrogenase 0.0066 0.0224 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Brugia malayi nuclear receptor NHR-88 0.0017 0.0025 0.0049
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0102 0.0152
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.012 0.2423
Brugia malayi CXXC zinc finger family protein 0.0059 0.0195 0.0388
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0026 0.0051
Loa Loa (eye worm) cysteine protease 0.0035 0.0094 0.0212
Toxoplasma gondii type I fatty acid synthase, putative 0.0467 0.1859 0.6616
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0066 0.0224 0.0206
Schistosoma mansoni cpg binding protein 0.0063 0.0209 0.0377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0037 0.0107 0.0212
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0025 0.0049
Brugia malayi intermediate filament protein 0.0053 0.0172 0.0342
Mycobacterium tuberculosis Hypothetical protein 0.0197 0.076 0.1858
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0048 0.0572
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0036 0.0013
Mycobacterium ulcerans thioesterase TesA 0.0546 0.2185 0.5488
Echinococcus multilocularis Smad4 0.0025 0.0055 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0025 0.0007
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0019 0.0298
Mycobacterium ulcerans polyketide synthase MbtD 0.0202 0.0777 0.19
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0094 0.1509
Toxoplasma gondii acyl carrier protein ACP 0.0066 0.0224 0.0715
Trypanosoma brucei oxidoreductase, putative 0.0041 0.012 0.1776
Echinococcus multilocularis expressed protein 0.0034 0.0091 0.0074
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0026 0.0052
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0036 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0025 0.0049
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0225 0.0874 0.2148
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0026 0.0014
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0025 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0224 0.0491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Mycobacterium ulcerans acyl-CoA synthetase 0.0066 0.0224 0.0491
Brugia malayi MH1 domain containing protein 0.0014 0.0009 0.0019
Brugia malayi MH1 domain containing protein 0.0025 0.0055 0.0109
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0172 0.0342
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.015 0.0338
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0041 0.012 0.0226
Echinococcus multilocularis microtubule associated protein 2 0.1368 0.5543 0.5535
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0026 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0094 0.0968
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.012 0.034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0025 0.0049
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0019 0.0118
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0025 0.0056
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.0414 0.6564
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0055 0.0037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0094 0.0212
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0066 0.0224 0.0521
Mycobacterium ulcerans acyl carrier protein 0.0066 0.0224 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0019 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0056
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0041 0.012 0.0226
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0612 0.2455 0.6177
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.012 0.1363
Mycobacterium ulcerans oxidoreductase 0.0041 0.012 0.0226
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.0414 0.6622
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0036 0.0418
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0041 0.012 0.0226
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0041 0.012 0.0226
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0655 0.2631 0.6636
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0025 0.0007
Mycobacterium ulcerans Type I modular polyketide synthase 0.0655 0.2631 0.6625
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0055 0.0123
Mycobacterium leprae Probable oxidireductase 0.0041 0.012 0.0257
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0094 0.017
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0197 0.0324
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0019 0.0298
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0433 0.1724 0.4332
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0197 0.0423
Echinococcus multilocularis dna polymerase eta 0.002 0.0036 0.0018
Toxoplasma gondii exonuclease III APE 0.0019 0.0031 0.002
Onchocerca volvulus 0.0231 0.0899 0.1838
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0165 0.0625 1
Brugia malayi MH2 domain containing protein 0.0025 0.0055 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0048 0.0444
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0059 0.0041
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0025 0.0007
Echinococcus granulosus cysteine protease 0.0018 0.0026 0.0015
Giardia lamblia DINP protein human, muc B family 0.002 0.0036 0.0145
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0026 0.0416
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.0696 0.141
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0094 0.0139
Toxoplasma gondii cathepsin CPL 0.0035 0.0094 0.0248
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0025 0.0049
Onchocerca volvulus 0.0053 0.0171 0.0307
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0025 0.0045
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0066 0.0224 0.0491
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0133 0.1396
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.008 0.0181
Schistosoma mansoni lamin 0.0053 0.0172 0.031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0031 0.0497
Loa Loa (eye worm) hypothetical protein 0.0053 0.0172 0.0386
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0094 0.0077
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0133 0.1396
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.015 0.045
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0165 0.0625 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Mycobacterium tuberculosis Polyketide synthase Pks13 0.098 0.3955 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0036 0.0418
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0088 0.0937
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0036 0.0578
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0123
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.0094 0.114
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.016 0.0608 0.1469
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0026 0.0416
Loa Loa (eye worm) hypothetical protein 0.0052 0.0168 0.0377
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0077 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Schistosoma mansoni smad 0.0025 0.0055 0.0099
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.007 0.0158
Brugia malayi Cathepsin L-like precursor 0.0035 0.0094 0.0188
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0471 0.0849
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0036 0.0314
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0031 0.0497
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0041 0.012 0.0226
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0055 0.0037
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0031 0.0497
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0181
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0066 0.0224 0.0491
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0042
Echinococcus granulosus aryl hydrocarbon receptor 0.0053 0.0172 0.0279
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0113 0.0414 0.5291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0612 0.2455 0.5515
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0026 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0025 0.0013
Mycobacterium leprae Polyketide synthase Pks13 0.098 0.3955 1
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0041 0.0122 0.1957
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0655 0.2631 0.6625
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0041 0.012 0.0226
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0066 0.0224 0.3243
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.0094 0.114
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0041 0.012 0.0226
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0094 0.0212
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0036 0.0018
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0026 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0355 0.0798
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0165 0.0625 0.8185
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0025 0.0049
Plasmodium vivax vivapain-3 0.0018 0.0026 0.0416
Entamoeba histolytica acyl-CoA synthetase, putative 0.0066 0.0224 0.5103
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0026 0.0245
Brugia malayi MH1 domain containing protein 0.0025 0.0055 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0025 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0036 0.0274
Loa Loa (eye worm) Smad1 0.0025 0.0055 0.0123
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0527 0.2108 0.5292
Schistosoma mansoni smad1 5 8 and 0.0025 0.0055 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0025 0.0056
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0026 0.0245
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.015 0.0133
Loa Loa (eye worm) acyl carrier protein 0.0066 0.0224 0.0503
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.012 0.0216
Loa Loa (eye worm) hypothetical protein 0.0113 0.0414 0.093
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Echinococcus multilocularis cathepsin L 0.0018 0.0026 0.0008
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0122 0.0221
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0031 0.0062
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0655 0.2631 0.6625
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0036 0.0578
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0033 0.0027
Schistosoma mansoni coup transcription factor 0.0017 0.0025 0.0045
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.012 0.0238
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0025 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0212
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.0019 0.0118
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0088 0.0226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0197 0.2406
Leishmania major quinone oxidoreductase, putative 0.0041 0.012 0.1363
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0036 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0025 0.0045
Trichomonas vaginalis rotamase, putative 0.0034 0.0091 0.0934
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0094 0.1772
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0041 0.0122 0.0105
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.015 0.2073
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0041 0.0122 0.0243
Loa Loa (eye worm) hypothetical protein 0.0098 0.0355 0.0798
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0037 0.0107 0.0239
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0026 0.0245
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0019 0.0298
Brugia malayi Cathepsin L-like precursor 0.0035 0.0094 0.0188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0026 0.0012
Leishmania major cathepsin L-like protease 0.0035 0.0094 0.1021
Loa Loa (eye worm) nuclear factor I 0.0014 0.0009 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0491 0.7843
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0033 0.0015
Echinococcus granulosus AMP dependent ligase 0.0066 0.0224 0.0373
Brugia malayi Latrophilin receptor protein 2 0.0031 0.008 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.012 0.0226
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0123
Mycobacterium ulcerans thioesterase 0.0546 0.2185 0.5488
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0036 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Echinococcus granulosus cathepsin L 0.0018 0.0026 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.012 0.0226
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0237
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0026 0.0057
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0048 0.0086
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0228 0.0453
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0055 0.0123
Leishmania major cathepsin L-like protease 0.0131 0.0491 0.6365
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.015 0.1775
Brugia malayi hypothetical protein 0.0037 0.0107 0.0212
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0025 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Schistosoma mansoni methyltransferase-related 0.0197 0.076 0.1371
Echinococcus multilocularis lamin dm0 0.0053 0.0172 0.0154
Mycobacterium ulcerans acyl carrier protein 0.0066 0.0224 0.0491
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0237
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0145 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0094 0.0146
Leishmania major cathepsin L-like protease 0.0131 0.0491 0.6365
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.0094 0.114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0142 0.0125
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0041 0.012 0.0226
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0068 0.009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0655 0.2631 0.6625
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.012 0.0226
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0696 0.2797 0.7059
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.012 0.1914
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0025 0.0007
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.002 0.0003
Schistosoma mansoni hypothetical protein 0.0031 0.008 0.0145
Echinococcus multilocularis musashi 0.0053 0.0172 0.0154
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0041 0.0122 0.0189
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0019 0.0298
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.008 0.0113
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0527 0.2108 0.5307
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0066 0.0224 0.0491
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.012 0.0269
Loa Loa (eye worm) acyl carrier protein 0.0301 0.1185 0.2661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0025 0.0056
Echinococcus granulosus smad 0.0025 0.0055 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.012 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Brugia malayi Pre-SET motif family protein 0.003 0.0077 0.0153
Onchocerca volvulus 0.003 0.0077 0.011
Brugia malayi steroid hormone receptor 0.0017 0.0025 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0026 0.0012
Brugia malayi Phosphopantetheine attachment site family protein 0.0066 0.0224 0.0445
Leishmania major DNA polymerase kappa, putative 0.002 0.0036 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Onchocerca volvulus 0.0035 0.0094 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0031 0.0143
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.012 0.0238
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0041 0.012 0.0226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Onchocerca volvulus 0.0035 0.0094 0.0146
Echinococcus multilocularis GPCR, family 2 0.0031 0.008 0.0063
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.012 0.1914
Echinococcus granulosus intermediate filament protein 0.0053 0.0172 0.0279
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0026 0.0008
Schistosoma mansoni survival motor neuron protein 0.0047 0.0145 0.0261
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.015 0.2402
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.012 0.1914
Onchocerca volvulus 0.0074 0.0255 0.0484
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0026 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0019 0.0118
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0094 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0113 0.0414 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0091 0.0934
Plasmodium vivax unspecified product 0.0018 0.0026 0.0416
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0066 0.0224 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Schistosoma mansoni hypothetical protein 0.0523 0.2089 0.3769
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0025 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Leishmania major DNA polymerase eta, putative 0.002 0.0036 0.0236
Echinococcus granulosus dna polymerase eta 0.002 0.0036 0.0033
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0025 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0036 0.0578
Echinococcus multilocularis lamin 0.0053 0.0172 0.0154
Onchocerca volvulus 0.0035 0.0094 0.0146
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0546 0.2185 0.5502
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0025 0.0013
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0026 0.0014
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0101 0.0364 0.0849
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0048 0.0095
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.012 0.1363
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0133 0.2118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0077 0.0059
Brugia malayi Methyltransferase-like protein 4 0.0197 0.076 0.1511
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0696 0.2797 0.7049
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0052 0.0683
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0696 0.2797 0.7049
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0036 0.0072
Loa Loa (eye worm) MH2 domain-containing protein 0.0364 0.1441 0.3237
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.012 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0048 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Echinococcus multilocularis cysteine protease 0.0035 0.0094 0.0077
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0041 0.012 0.0226
Echinococcus multilocularis smad 0.0025 0.0055 0.0037
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.012 0.0226
Brugia malayi Cathepsin L-like precursor 0.0035 0.0094 0.0188
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.012 0.1363
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0101 0.0364 0.0849
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0025 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Loa Loa (eye worm) hypothetical protein 0.1101 0.4452 1
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0041 0.012 0.0226
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0545 0.0955
Schistosoma mansoni cpg binding protein 0.0063 0.0209 0.0377
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0026 0.0047
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0025 0.0013
Trypanosoma cruzi cruzipain precursor, putative 0.0131 0.0491 0.7843
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0101 0.0364 0.0849
Entamoeba histolytica hypothetical protein 0.0036 0.0102 0.1968
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.012 0.0226
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0094 0.1772
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Brugia malayi Pre-SET motif family protein 0.0204 0.0785 0.1561
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0025 0.0049
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0536 0.2143 0.5382
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0026 0.0245
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0025 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0142 0.0125
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0118 0.1253
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0491 0.7843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Brugia malayi Cathepsin L-like precursor 0.0023 0.0048 0.0095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0018 0.0032
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0026 0.0012
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0026 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0355 0.0706
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0165 0.0625 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0088 0.161
Echinococcus granulosus dna polymerase kappa 0.002 0.0036 0.0033
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0471 0.1877 0.4704
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0052 0.0104
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0019 0.0298
Mycobacterium tuberculosis Conserved protein 0.0197 0.076 0.1858
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.076 0.8441
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0026 0.0416
Echinococcus granulosus microtubule associated protein 2 0.1368 0.5543 1
Echinococcus multilocularis cysteine protease 0.0035 0.0094 0.0077
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0102 0.0084
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0133 0.0386
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.015 0.2273
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0635 0.2549 0.6416
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0091 0.0205
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0088 0.1262
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0165 0.0625 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.012 0.2423
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0031 0.0013
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0026 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Loa Loa (eye worm) hypothetical protein 0.0041 0.012 0.0269
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0224 0.0491
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0166 0.0372
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0041 0.012 0.0226
Schistosoma mansoni acyl carrier protein 0.0066 0.0224 0.0404
Loa Loa (eye worm) acetyltransferase 0.0149 0.0562 0.1264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0026 0.0253
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0066 0.0224 0.0491
Mycobacterium ulcerans polyketide synthase 0.0655 0.2631 0.6625
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0026 0.0012
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0094 0.0146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.008 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0025 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0094 0.0968
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0036 0.0013
Leishmania major hypothetical protein, conserved 0.0041 0.0122 0.1399
Onchocerca volvulus 0.0053 0.0172 0.0309
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.002 0.0002
Plasmodium vivax vivapain-1 0.0018 0.0026 0.0416
Schistosoma mansoni hypothetical protein 0.0031 0.008 0.0145
Trichomonas vaginalis rotamase, putative 0.0033 0.0088 0.0897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0025 0.0056
Onchocerca volvulus 0.0023 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0036 0.0102 0.1968
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0113 0.0414 0.0717
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0197 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Leishmania major acyl carrier protein, putative 0.0066 0.0224 0.2768
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0026 0.0012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0031 0.0084
Loa Loa (eye worm) transcription factor SMAD2 0.0364 0.1441 0.3237
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0052 0.0035
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.008 0.0063
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0025 0.0045
Onchocerca volvulus 0.0059 0.0195 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0025 0.0049
Entamoeba histolytica hypothetical protein 0.0024 0.0052 0.0693
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0036 0.0578
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0696 0.2797 0.7049
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.0019 0.0118
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0094 0.017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0059 0.0074
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0101 0.0364 0.0877
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0025 0.0049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0202 0.0777 0.1544
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0052 0.0063
Schistosoma mansoni hypothetical protein 0.0031 0.008 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0056
Echinococcus multilocularis dnaJ subfamily B 0.0843 0.3398 0.3386
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0355 0.0706
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0696 0.2797 0.7059
Plasmodium vivax vivapain-2 0.0035 0.0094 0.1509
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0094 0.0139
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0133 0.0208
Brugia malayi hypothetical protein 0.0053 0.0171 0.034
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0197 0.018
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0102 0.0184
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0696 0.2797 0.7049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0025 0.0007
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0165 0.0625 0.0609
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0425 0.169 0.6006
Echinococcus granulosus lamin dm0 0.0053 0.0172 0.0279
Trypanosoma cruzi major cysteine proteinase, putative 0.0103 0.0376 0.6005
Mycobacterium ulcerans oxidoreductase FadB5 0.0041 0.012 0.0226
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0066 0.0224 0.3579
Trypanosoma cruzi cysteine peptidase, putative 0.0131 0.0491 0.7843
Mycobacterium ulcerans fatty acid synthase Fas 0.0206 0.0794 0.1945
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.007 0.014
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.012 0.0216
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0635 0.2549 0.6416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0025 0.0056
Schistosoma mansoni hypothetical protein 0.0523 0.2089 0.3769
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0142 0.0257
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0224 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.015 0.0133
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.012 0.1776
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0025 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0019 0.0118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0026 0.0253
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0036 0.0065
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0655 0.2631 0.6636
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0094 0.0077
Leishmania major cathepsin L-like protease 0.0131 0.0491 0.6365
Echinococcus granulosus Smad4 0.0025 0.0055 0.0067
Mycobacterium ulcerans polyketide synthase 0.0696 0.2797 0.7049
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.012 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0036 0.0418
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.012 0.1914
Leishmania major cathepsin L-like protease 0.0035 0.0094 0.1021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0025 0.0013
Mycobacterium tuberculosis Probable thioesterase TesA 0.0546 0.2185 0.5488
Schistosoma mansoni hypothetical protein 0.0843 0.3398 0.6129
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0142 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0066 0.0224 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0165 0.0625 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0036 0.0081
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0041 0.012 0.0257
Brugia malayi hypothetical protein 0.0036 0.0102 0.0203
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0088 0.1409
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0036 0.0314
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0091 0.0182
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0431 0.1462
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.015 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0165 0.0625 0.1405
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0066 0.0224 0.0491
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0142 0.0225
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0197 0.0392
Echinococcus multilocularis aryl hydrocarbon receptor 0.0053 0.0172 0.0154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0025 0.0045
Schistosoma mansoni hypothetical protein 0.0066 0.0224 0.0404
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0206 0.0794 0.1971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0055 0.0067
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0041 0.0122 0.0233
Schistosoma mansoni Smad4 0.0025 0.0055 0.0099
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0066 0.0224 0.0491
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0025 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0077 0.0139
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0037 0.0107 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0025 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0094 0.0968
Echinococcus granulosus dnaJ subfamily B 0.0843 0.3398 0.6117
Onchocerca volvulus 0.0035 0.0094 0.0146
Brugia malayi MH2 domain containing protein 0.0364 0.1441 0.2866
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0414 0.4558
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0237
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.012 0.0238
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0527 0.2108 0.5292
Trypanosoma brucei acyl transferase-like protein 0.0041 0.0122 0.182
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0113 0.0414 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0373 0.1476 0.3681
Mycobacterium ulcerans Type I modular polyketide synthase 0.0655 0.2631 0.6625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Mycobacterium ulcerans oxidoreductase 0.0041 0.012 0.0226
Plasmodium vivax SET domain protein, putative 0.003 0.0077 0.1234
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0041 0.0122 0.1536
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0113 0.0414 1
Entamoeba histolytica hypothetical protein 0.0036 0.0102 0.1968
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0368 0.5891
Brugia malayi ecdysteroid receptor 0.0017 0.0025 0.0049
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0037 0.0107 0.0212
Leishmania major oxidoreductase, putative 0.0041 0.012 0.1363
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0331 0.1307 0.4622
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0066 0.0224 0.0491
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1242 0.5029 1
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0041 0.012 0.0226
Plasmodium vivax acyl carrier protein, putative 0.0066 0.0224 0.3579
Mycobacterium ulcerans short-chain dehydrogenase 0.0048 0.0151 0.0306
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0041 0.012 0.1491
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0165 0.0625 0.2164
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0077 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Schistosoma mansoni hypothetical protein 0.0047 0.0145 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0066 0.0224 0.0491
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0031 0.0257
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.002 0.0036
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0041 0.012 0.0257
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0122 0.0221
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0066 0.0224 0.0419
Leishmania major oxidoreductase-like protein 0.0041 0.012 0.1363
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0037 0.0105 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0094 0.0968
Brugia malayi hypothetical protein 0.023 0.0892 0.1774
Schistosoma mansoni rotamase 0.0034 0.0091 0.0165
Schistosoma mansoni ap endonuclease 0.0019 0.0031 0.0056
Trypanosoma cruzi acyl transferase-like protein, putative 0.0041 0.0122 0.1957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0131 0.0491 0.7806
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0892 0.0876
Schistosoma mansoni [ACP] S-malonyltransferase 0.0041 0.0122 0.0221
Loa Loa (eye worm) hypothetical protein 0.0182 0.0696 0.1562
Onchocerca volvulus 0.0047 0.0145 0.0252
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.012 0.1914
Echinococcus granulosus expressed protein 0.0034 0.0091 0.0133
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0026 0.041
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.015 0.0133
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0101 0.0364 0.0849
Leishmania major d-xylulose reductase, putative 0.0041 0.012 0.1363
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Brugia malayi Cathepsin L-like precursor 0.0035 0.0094 0.0188
Mycobacterium ulcerans polyketide synthase Pks13 0.098 0.3955 1
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0165 0.0625 0.1128
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0077 0.0059
Echinococcus granulosus cathepsin l1 0.0023 0.0048 0.0054
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0066 0.0224 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0052 0.0497
Echinococcus granulosus ubiquitin specific protease 41 0.0113 0.0414 0.0717
Schistosoma mansoni hypothetical protein 0.0031 0.008 0.0145
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0041 0.012 0.0226
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0197 0.0423
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0025 0.0045
Echinococcus multilocularis ubiquitin specific protease 41 0.0113 0.0414 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0026 0.0195
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0041 0.012 0.0226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0142 0.0257
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0655 0.2631 0.5232
Mycobacterium ulcerans quinone reductase Qor 0.0041 0.012 0.0226
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0032 0.0063
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0066 0.0224 0.0491
Entamoeba histolytica cysteine protease, putative 0.0018 0.0026 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0077 0.0139
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0165 0.0625 1
Brugia malayi MH2 domain containing protein 0.0025 0.0055 0.0109
Schistosoma mansoni cpg binding protein 0.0059 0.0195 0.0352
Loa Loa (eye worm) hypothetical protein 0.0067 0.0228 0.0512
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0113 0.0414 0.0747
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0088 0.1409
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0113 0.0414 0.4558
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.012 0.1252
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0025 0.0049
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0165 0.0625 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.015 0.0133
Loa Loa (eye worm) hypothetical protein 0.023 0.0892 0.2004

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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