Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.1697 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0984 | 0.0984 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0984 | 0.3355 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.1697 | 0.5783 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.081 | 0.4775 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2934 | 0.2934 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.1697 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0984 | 0.3355 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2035 | 0.6936 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2035 | 0.6936 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.1697 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2035 | 0.6936 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2934 | 0.2934 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.1697 | 0.1697 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2934 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.081 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2934 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.081 | 0.4775 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2934 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2934 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1697 | 0.5783 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2934 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2934 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2934 | 0.2934 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2035 | 0.6936 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 42.5615 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.