Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.2485 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.2737 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0657 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.3459 | 0.2999 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0657 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3459 | 0.2999 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.2737 | 0.2297 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3459 | 0.2999 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.9711 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.3459 | 0.2999 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3459 | 0.2999 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0657 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3459 | 0.2999 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.3459 | 0.2999 |
Brugia malayi | RNA binding protein | 0.0064 | 0.3459 | 0.2999 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0657 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0657 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.3459 | 0.2999 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.2737 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3459 | 0.2999 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.2737 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.2485 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.2485 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0657 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.2737 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.3459 | 0.2999 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.3459 | 0.2999 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.3459 | 0.3094 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.2737 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.