Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peptidase Clp S14 family | 0.0062 | 0.532 | 0.5159 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.8701 | 0.8701 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3069 | 0.2512 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0062 | 0.532 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7408 | 0.7408 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2665 | 0.2665 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.6786 | 0.6676 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2665 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0062 | 0.532 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3492 | 0.3492 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2665 | 0.2414 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2665 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2665 | 0.2077 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2665 | 0.2414 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2657 | 0.2405 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0062 | 0.532 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0062 | 0.532 | 0.5159 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.6786 | 0.6676 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2665 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0332 | 0.0332 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2657 | 0.2405 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3824 | 0.3824 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2665 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.9444 | 0.9399 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2665 | 0.2665 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3081 | 0.3081 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0046 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.