Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.3392 | 0.3619 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0096 | 0.1797 | 0.1797 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.3392 | 0.3619 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0137 | 0.3392 | 0.3392 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.3392 | 0.3619 |
Brugia malayi | RNA binding protein | 0.0137 | 0.3392 | 0.3392 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0305 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0305 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.3392 | 0.3619 |
Brugia malayi | TAR-binding protein | 0.0137 | 0.3392 | 0.3392 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0137 | 0.3392 | 0.3392 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0137 | 0.3392 | 0.3392 |
Schistosoma mansoni | hypothetical protein | 0.0208 | 0.6203 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0096 | 0.1797 | 0.1797 |
Echinococcus multilocularis | tar DNA binding protein | 0.0137 | 0.3392 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0096 | 0.1797 | 0.1797 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.3392 | 0.3619 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0137 | 0.3392 | 0.3392 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.6203 | 0.6203 |
Echinococcus granulosus | tar DNA binding protein | 0.0137 | 0.3392 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0208 | 0.6203 | 0.6203 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.