Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.002 | 0.1312 | 0.2687 |
Echinococcus multilocularis | GPCR, family 2 | 0.0012 | 0.0259 | 0.0531 |
Loa Loa (eye worm) | TAR-binding protein | 0.0049 | 0.4881 | 0.4881 |
Echinococcus multilocularis | lamin | 0.002 | 0.1312 | 0.2687 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.1624 | 0.2953 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.002 | 0.1312 | 0.1193 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.4881 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.4881 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.4881 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0049 | 0.4881 | 1 |
Brugia malayi | TAR-binding protein | 0.0049 | 0.4881 | 0.4811 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.198 | 0.198 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.1624 | 0.151 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.1624 | 0.3328 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.1624 | 0.1624 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0012 | 0.0259 | 0.0126 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.1624 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.002 | 0.1312 | 0.2687 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.1624 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.198 | 0.3723 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.009 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0037 | 0.3463 | 0.3374 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0012 | 0.0259 | 0.0531 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0012 | 0.0259 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3463 | 0.3463 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0026 | 0.198 | 0.1871 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0012 | 0.0259 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1265 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1312 | 0.1312 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.1624 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.1624 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.1624 | 0.5 |
Brugia malayi | RNA binding protein | 0.0049 | 0.4881 | 0.4811 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.4881 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.1624 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0049 | 0.4881 | 0.4881 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0049 | 0.4881 | 0.4881 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0037 | 0.3463 | 0.3374 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0259 | 0.0259 |
Schistosoma mansoni | intermediate filament proteins | 0.002 | 0.1312 | 0.2277 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0012 | 0.0259 | 0.0531 |
Loa Loa (eye worm) | intermediate filament protein | 0.002 | 0.1312 | 0.1312 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.009 | 1 | 1 |
Schistosoma mansoni | lamin | 0.002 | 0.1312 | 0.2277 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.1624 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.1624 | 0.2953 |
Echinococcus granulosus | intermediate filament protein | 0.002 | 0.1312 | 0.2687 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0012 | 0.0259 | 0.0531 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.4881 | 1 |
Onchocerca volvulus | 0.002 | 0.1312 | 0.5 | |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.1624 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0049 | 0.4881 | 0.4811 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.1624 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.1624 | 0.3328 |
Onchocerca volvulus | 0.002 | 0.1312 | 0.5 | |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.1624 | 0.5 |
Schistosoma mansoni | lamin | 0.002 | 0.1312 | 0.2277 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.1624 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.1624 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0049 | 0.4881 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0012 | 0.0259 | 0.0531 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0012 | 0.0259 | 0.0259 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.1624 | 0.5 |
Echinococcus multilocularis | musashi | 0.002 | 0.1312 | 0.2687 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0011 | 0.0135 | 0.0135 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.1624 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0037 | 0.3463 | 0.3463 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.002 | 0.1312 | 0.1312 |
Echinococcus granulosus | lamin | 0.002 | 0.1312 | 0.2687 |
Brugia malayi | intermediate filament protein | 0.002 | 0.1312 | 0.1193 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.1624 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3359 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.