Detailed information for compound 1542665

Basic information

Technical information
  • TDR Targets ID: 1542665
  • Name: 2-[(5-cyclopropyl-4-methyl-1,2,4-triazol-3-yl )sulfanyl]-N-(furan-2-ylmethyl)acetamide
  • MW: 292.357 | Formula: C13H16N4O2S
  • H donors: 1 H acceptors: 3 LogP: 0.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccco1)CSc1nnc(n1C)C1CC1
  • InChi: 1S/C13H16N4O2S/c1-17-12(9-4-5-9)15-16-13(17)20-8-11(18)14-7-10-3-2-6-19-10/h2-3,6,9H,4-5,7-8H2,1H3,(H,14,18)
  • InChiKey: RHYQOQXJBZQPNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5-cyclopropyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-furylmethyl)acetamide
  • 2-[(5-cyclopropyl-4-methyl-1,2,4-triazol-3-yl)thio]-N-(2-furylmethyl)acetamide
  • 2-[(5-cyclopropyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(furan-2-ylmethyl)ethanamide
  • ZINC07235507
  • T5590890

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0219 0.0219
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0019 0.0006 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0219 0.0236
Onchocerca volvulus 0.0035 0.0194 0.1026
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0191 0.2011 0.2158
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0028 0.0115 0.0124
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0129 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0129 0.0129
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.004 0.0254 0.0273
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0028 0.0114 0.0122
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0179 0.1873 0.201
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0114 0.0122
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0129 0.0129
Plasmodium falciparum carbonic anhydrase 0.0058 0.0468 0.0502
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0176 0.0189
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0181 0.1896 0.2035
Toxoplasma gondii proteasome beta subunit 0.0174 0.1816 0.1949
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0028 0.0115 0.0115
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.082 0.9318 1
Brugia malayi Trypsin family protein 0.0035 0.0194 0.0194
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0179 0.1873 0.1873
Brugia malayi proteasome subunit alpha type 2 0.0184 0.1932 0.1932
Giardia lamblia Proteasome subunit beta type 5 precursor 0.082 0.9318 1
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.015 0.1531 0.1643
Schistosoma mansoni hypothetical protein 0.0033 0.0176 0.0176
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0027 0.0099 0.0099
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Brugia malayi Probable 26S protease regulatory subunit 4 0.0019 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0129 0.0138
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0036 0.021 0.0225
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0129 0.0138
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.004 0.0254 0.0273
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0194 0.0194
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.018 0.1878 0.1878
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0177 0.0177
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0019 0.0006 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0219 0.0236
Schistosoma mansoni hypothetical protein 0.0038 0.0229 0.0229
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0143 0.0143
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0129 0.0129
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0019 0.0006 0.0007
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0037 0.0219 0.0236
Echinococcus multilocularis Ankyrin 0.0033 0.0177 0.0177
Leishmania major proteasome alpha 7 subunit, putative 0.0225 0.2407 0.2583
Schistosoma mansoni netrin receptor unc5 0.0033 0.0176 0.0176
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0019 0.0006 0.0007
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0028 0.0115 0.0124
Schistosoma mansoni hypothetical protein 0.0058 0.0468 0.0468
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0129 0.0129
Schistosoma mansoni ankyrin 23/unc44 0.0033 0.0176 0.0176
Echinococcus multilocularis proteasome (prosome, macropain) 0.082 0.9318 0.9318
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.018 0.1883 0.2021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0219 0.0236
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.2622 0.2814
Echinococcus multilocularis proteasome subunit alpha type 6 0.0191 0.2011 0.2011
Loa Loa (eye worm) hypothetical protein 0.0606 0.6832 0.7332
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0129 0.0129
Plasmodium vivax proteasome subunit beta type-5, putative 0.082 0.9318 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0219 0.0027
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.02 0.2112 0.2267
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0225 0.2407 0.2407
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0031 0.0144 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0219 0.0236
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0019 0.0006 0.0006
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0021 0.0032 0.0034
Brugia malayi beta-lactamase 0.0037 0.0219 0.0219
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.018 0.1883 0.2021
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0191 0.2011 0.2158
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0325 0.3561 0.3561
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0019 0.0006 0.0007
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.003 0.0143 0.0154
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0005 0.0005
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0087 0.0804 0.0804
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0099 0.0106
Loa Loa (eye worm) PCI domain-containing protein 0.0031 0.0144 0.0155
Mycobacterium ulcerans proteasome PrcB 0.082 0.9318 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0129 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0129 0.0129
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0028 0.0115 0.0124
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0019 0.0006 0.0007
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0028 0.0115 0.0115
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.082 0.9318 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0035 0.0194 0.0194
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0184 0.1932 0.2073
Schistosoma mansoni proteasome regulatory subunit-related 0.0031 0.0144 0.0144
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0179 0.1873 0.201
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0019 0.0006 0.0007
Giardia lamblia Proteasome subunit beta type 2 0.0174 0.1816 0.1949
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0129 0.068
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0181 0.1896 0.2035
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.018 0.1878 0.1878
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0174 0.1816 0.1816
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0028 0.0115 0.0124
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.082 0.9318 1
Loa Loa (eye worm) PCI domain-containing protein 0.0028 0.0114 0.0122
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0027 0.0099 0.0099
Loa Loa (eye worm) proteasome subunit beta type 2 0.0174 0.1816 0.1949
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.015 0.1531 0.1643
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0174 0.1816 0.1816
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0028 0.0115 0.0124
Giardia lamblia 20S proteasome alpha subunit 4 0.0225 0.2407 0.2583
Plasmodium vivax proteasome subunit beta type-7, putative 0.0244 0.2622 0.2814
Brugia malayi Proteasome/cyclosome repeat family protein 0.003 0.0134 0.0134
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0036 0.0203 0.0203
Giardia lamblia 20S proteasome alpha subunit 1 0.0191 0.2011 0.2158
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0036 0.021 0.021
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0157 0.1615 0.1615
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0099 0.0106
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0129 0.0138
Echinococcus granulosus death domain containing protein 0.0033 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0037 0.0219 0.0236
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0019 0.0006 0.0007
Entamoeba histolytica hypothetical protein 0.0038 0.0229 0.0245
Loa Loa (eye worm) proteasome Regulatory Particle 0.003 0.0143 0.0154
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0028 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0178 0.1856 0.1856
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.02 0.2112 0.2267
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0173 0.1798 0.193
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0033 0.0176 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0219 0.0236
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.002 0.0018 0.002
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0173 0.1798 0.1798
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.003 0.0143 0.0154
Entamoeba histolytica hypothetical protein 0.0038 0.0229 0.0245
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0036 0.0203 0.0218
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0169 0.1757 0.1886
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0174 0.1816 0.1816
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0144 0.0155
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.002 0.0019 0.002
Toxoplasma gondii proteasome subunit alpha1, putative 0.0191 0.2011 0.2158
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.002 0.0019 0.0019
Echinococcus granulosus carbonic anhydrase 0.0058 0.0468 0.0468
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0027 0.0099 0.0099
Echinococcus multilocularis geminin 0.0178 0.1856 0.1856
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0021 0.0032 0.0034
Toxoplasma gondii proteasome subunit beta type, putative 0.082 0.9318 1
Schistosoma mansoni hypothetical protein 0.0081 0.0729 0.0729
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0225 0.2407 0.2583
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.02 0.2112 0.2112
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0028 0.0115 0.0124
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0099 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0209
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0129 0.0129
Onchocerca volvulus 0.0018 0.0005 0.0026
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0181 0.1896 0.2035
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0027 0.0104 0.0112
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0129 0.0129
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0019 0.0006 0.0006
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0028 0.0114 0.0122
Toxoplasma gondii proteasome subunit beta type 1, putative 0.02 0.2112 0.2267
Brugia malayi Proteasome A-type and B-type family protein 0.082 0.9318 0.9318
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0191 0.2011 0.2158
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0019 0.0006 0.0006
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0174 0.1816 0.1816
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0129 0.0129
Trypanosoma brucei proteasome subunit beta type-5, putative 0.082 0.9318 1
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0036 0.0203 0.0203
Plasmodium vivax proteasome subunit beta type-2, putative 0.0174 0.1816 0.1949
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0027 0.0099 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0219 0.0236
Schistosoma mansoni 26S proteasome subunit S9 0.0034 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0058 0.0468 0.0502
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.019 0.2 0.2
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0028 0.0115 0.0124
Echinococcus granulosus Ankyrin 0.0033 0.0177 0.0177
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0129 0.0129
Echinococcus granulosus proteasome subunit alpha type 2 0.0184 0.1932 0.1932
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0019 0.0006 0.0006
Brugia malayi beta-lactamase family protein 0.0037 0.0219 0.0219
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0035 0.0194 0.0194
Entamoeba histolytica hypothetical protein 0.0038 0.0229 0.0245
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0028 0.0115 0.0115
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.004 0.0254 0.0273
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.019 0.2 0.2147
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0143 0.0154
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0129 0.0129
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.018 0.1878 0.2016
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0165 0.1706 0.1831
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.002 0.0018 0.0018
Onchocerca volvulus 0.0037 0.0219 0.1158
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.015 0.1531 0.1643
Brugia malayi PCI domain containing protein 0.0031 0.0144 0.0144
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0174 0.1816 0.1949
Entamoeba histolytica proteasome subunit beta type 1, putative 0.02 0.2112 0.2267
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.002 0.0019 0.002
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.003 0.0134 0.0144
Echinococcus multilocularis netrin receptor unc 5 0.0033 0.0176 0.0176
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0031 0.0144 0.0144
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0194 0.0194
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0174 0.1816 0.1949
Brugia malayi proteasome subunit beta type 2 0.0174 0.1816 0.1816
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.082 0.9318 1
Onchocerca volvulus 0.0019 0.0006 0.0032
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0244 0.2622 0.2814
Onchocerca volvulus 0.0037 0.0219 0.1158
Echinococcus multilocularis adhesion regulating molecule 1 0.0087 0.0804 0.0804
Brugia malayi small heat shock protein 0.0606 0.6832 0.6832
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0198 0.2094 0.2094
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.002 0.0018 0.002
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0173 0.1798 0.193
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0194 0.0194
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0225 0.2407 0.2407
Echinococcus granulosus geminin 0.0178 0.1856 0.1856
Leishmania major hypothetical protein, conserved 0.0045 0.0318 0.0341
Leishmania major proteasome alpha 1 subunit, putative 0.0179 0.1873 0.201
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0174 0.1816 0.1949
Schistosoma mansoni hypothetical protein 0.0178 0.1856 0.1856
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.002 0.0019 0.002
Giardia lamblia 26S protease regulatory subunit 6A 0.002 0.0019 0.002
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.003 0.0143 0.0154
Brugia malayi 20S proteasome alpha5 subunit 0.019 0.2 0.2
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0129 0.0129
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0176 0.0176
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0035 0.0194 0.0194
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.02 0.2112 0.2267
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0028 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0129 0.0129
Brugia malayi Uncoordinated protein 44 0.0033 0.0176 0.0176
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.015 0.1531 0.1442
Onchocerca volvulus 0.0037 0.0219 0.1158
Toxoplasma gondii ABC1 family protein 0.0037 0.0219 0.0236
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0028 0.0115 0.0124
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0036 0.0203 0.0218
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0129 0.0129
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.002 0.0019 0.002
Trichomonas vaginalis esterase, putative 0.0037 0.0219 0.0236
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0143 0.0154
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0005 0.0005
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.003 0.0143 0.0154
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.2534 0.2543
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0058 0.0468 0.0468
Brugia malayi Death domain containing protein 0.0033 0.0176 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0129 0.0129
Echinococcus granulosus 26s protease regulatory subunit 6a 0.002 0.0019 0.0019
Giardia lamblia Hypothetical protein 0.0034 0.018 0.0194
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0179 0.1873 0.1873
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0189
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0174 0.1816 0.1949
Leishmania major hypothetical protein, conserved 0.0037 0.0219 0.0236
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0129 0.0129
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.0468 0.0468
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0028 0.0114 0.0122
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0184 0.1932 0.2073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.004 0.0254 0.0273
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0219 0.0219
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.002 0.0019 0.002
Onchocerca volvulus 0.0029 0.0129 0.068
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0027 0.0099 0.0106
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0181 0.1896 0.2035
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0173 0.1798 0.193
Echinococcus granulosus carbonic anhydrase II 0.0157 0.1615 0.1615
Echinococcus multilocularis carbonic anhydrase 0.0058 0.0468 0.0468
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0031 0.0144 0.0155
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0143 0.0154
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0028 0.0115 0.0124
Brugia malayi Kringle domain containing protein 0.0018 0.0005 0.0005
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0027 0.0099 0.0106
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0028 0.0114 0.0122
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0035 0.0194 0.0194
Brugia malayi Protein kinase domain containing protein 0.0033 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0087 0.0804 0.0863
Echinococcus granulosus proteasome subunit beta type 7 0.0879 1 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0028 0.0115 0.0124
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0035 0.0194 0.0194
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0175 0.1826 0.1826
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0034 0.018 0.018
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0035 0.0194 0.0194
Echinococcus granulosus carbonic anhydrase 0.0058 0.0468 0.0468
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0174 0.1816 0.1949
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0225 0.2407 0.2583
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0028 0.0115 0.0115
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0157 0.1615 0.1615
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0037 0.0219 0.0236
Plasmodium vivax proteasome subunit alpha type-4, putative 0.018 0.1878 0.2016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0129 0.0129
Brugia malayi Trypsin family protein 0.0035 0.0194 0.0194
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0034 0.018 0.018
Toxoplasma gondii heat shock protein hslv, putative 0.015 0.1531 0.1643
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0129 0.0129
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0036 0.021 0.021
Brugia malayi proteasome subunit beta type 1 0.02 0.2112 0.2112
Giardia lamblia 20S proteasome alpha subunit 2 0.0184 0.1932 0.2073
Brugia malayi hypothetical protein 0.0035 0.0194 0.0194
Trypanosoma brucei carbonic anhydrase-like protein 0.0157 0.1615 0.1733
Giardia lamblia 20S proteasome alpha subunit 3 0.018 0.1878 0.2016
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.002 0.0018 0.0018
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0036 0.021 0.021
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0028 0.0115 0.0124
Leishmania major proteasome beta 2 subunit, putative 0.0244 0.2622 0.2814
Schistosoma mansoni carbonic anhydrase 0.0058 0.0468 0.0468
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0028 0.0115 0.0124
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0219 0.0219
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0181 0.1896 0.1896
Onchocerca volvulus Notchless protein homolog 0.0181 0.1896 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0219 0.0236
Toxoplasma gondii proteasome regulatory subunit 0.0028 0.0115 0.0124
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.018 0.1878 0.2016
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.004 0.0254 0.0273
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0181 0.1896 0.2035
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0019 0.0006 0.0007
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0179 0.1873 0.1873
Loa Loa (eye worm) hypothetical protein 0.0037 0.0219 0.0236
Onchocerca volvulus 0.0035 0.0194 0.1026
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.003 0.0143 0.0154
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0174 0.1816 0.1949
Toxoplasma gondii proteasome 26S regulatory subunit 0.0019 0.0012 0.0013
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0006 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0129 0.0129
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0036 0.0203 0.0218
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.002 0.0019 0.002
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0174 0.1816 0.1949
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0129 0.0129
Brugia malayi proteasome subunit alpha type 4 0.0165 0.1704 0.1704
Brugia malayi proteasome subunit alpha type 6 0.0191 0.2011 0.2011
Brugia malayi Trypsin family protein 0.0035 0.0194 0.0194
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0179 0.1873 0.201
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0006 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0229 0.0229
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0036 0.021 0.0225
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.018 0.1878 0.2016
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0036 0.0203 0.0218
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0028 0.0115 0.0124
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0174 0.1816 0.1949
Trypanosoma brucei proteasome beta 7 subunit 0.0173 0.1798 0.193
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0129 0.0138
Trichomonas vaginalis 26S proteasome subunit, putative 0.0028 0.0114 0.0122
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0174 0.1816 0.1816
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0028 0.0114 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0129 0.0129
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0157 0.1615 0.1733
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.019 0.2 0.2147
Loa Loa (eye worm) proteasome subunit beta type 3 0.0174 0.1816 0.1949
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0034 0.018 0.0194
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0174 0.1816 0.1949
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0225 0.2407 0.2407
Brugia malayi Protein kinase domain containing protein 0.0018 0.0005 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0129 0.0129
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0244 0.2622 0.2814
Echinococcus granulosus proteasome subunit alpha type 6 0.0191 0.2011 0.2011
Plasmodium vivax proteasome subunit beta type-6, putative 0.018 0.1883 0.2021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0138
Giardia lamblia Proteasome subunit beta type 1 0.02 0.2112 0.2267
Brugia malayi Proteasome A-type and B-type family protein 0.0173 0.1798 0.1798
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0143 0.0143
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0181 0.1896 0.1896
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0129 0.0138
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.015 0.1531 0.1643
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0219 0.0236
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0225 0.2407 0.2407
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0055 0.0434 0.2287
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.02 0.2112 0.2267
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0169 0.1757 0.1886
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0225 0.2407 0.2583
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0191 0.2011 0.2011
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0157 0.1615 0.1615
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0244 0.2622 0.2814
Giardia lamblia 26S protease regulatory subunit 6B 0.0019 0.0006 0.0007
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.082 0.9318 1
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.004 0.0254 0.0273
Brugia malayi hypothetical protein 0.0038 0.0229 0.0229
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0028 0.0114 0.0114
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.0468 0.0468
Toxoplasma gondii SAC3/GANP family protein 0.0027 0.0099 0.0106
Plasmodium falciparum proteasome subunit beta type-6, putative 0.018 0.1883 0.2021
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0005 0.0005
Schistosoma mansoni multiubiquitin binding protein S5a 0.002 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0038 0.0229 0.0245
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0879 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.019 0.2 0.2147
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.019 0.2 0.2147
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0028 0.0114 0.0122
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0191 0.2011 0.2158
Entamoeba histolytica proteasome regulatory subunit, putative 0.0036 0.021 0.0225
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0005 0.0005
Echinococcus granulosus adhesion regulating molecule 1 0.0087 0.0804 0.0804
Echinococcus multilocularis proteasome subunit alpha type 2 0.0184 0.1932 0.1932
Echinococcus granulosus proteasome subunit beta type 6 0.018 0.1883 0.1883
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.019 0.2 0.2147
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0229 0.0229
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0184 0.1932 0.2073
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0129 0.0129
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0157 0.1615 0.1733
Echinococcus multilocularis Mastin 0.0035 0.0194 0.0194
Echinococcus granulosus proteasome prosome macropain subunit beta 0.02 0.2112 0.2112
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.002 0.0019 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0129 0.068
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.004 0.0254 0.0273
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0219 0.0236
Echinococcus multilocularis carbonic anhydrase II 0.0157 0.1615 0.1615
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0031 0.0144 0.0155
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0027 0.0099 0.0106
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0219 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0129 0.0129
Echinococcus granulosus Mastin 0.0035 0.0194 0.0194
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.0468 0.0468
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0036 0.0203 0.0203
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0157 0.1615 0.1733
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0173 0.1798 0.193
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0174 0.1816 0.1949
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0138
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.018 0.1878 0.2016
Echinococcus granulosus glycoprotein Antigen 5 0.0035 0.0194 0.0194
Leishmania major proteasome beta 7 subunit, putative 0.0173 0.1798 0.193
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0191 0.2011 0.2158
Loa Loa (eye worm) proteasome subunit beta type 1 0.02 0.2112 0.2267
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0244 0.2622 0.2814
Brugia malayi 26S proteasome regulatory complex subunit p97 0.004 0.0254 0.0254
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0031 0.0144 0.0144
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0129 0.0129
Brugia malayi steroid hormone receptor 0.0029 0.0129 0.0129
Brugia malayi nuclear hormone receptor 0.0029 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0035 0.0194 0.0194
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.0468 0.0468
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0173 0.1798 0.1798
Leishmania major proteasome beta 2 subunit, putative 0.0174 0.1816 0.1949
Brugia malayi Ubiquitin interaction motif family protein 0.002 0.0018 0.0018
Plasmodium vivax proteasome subunit alpha type-5, putative 0.019 0.2 0.2147
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0019 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0138
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.004 0.0254 0.0254
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0173 0.1798 0.193
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0244 0.2622 0.2814
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0034 0.018 0.0194
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0006 0.0007
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0019 0.0006 0.0007
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0034 0.018 0.0194
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0174 0.1816 0.1949
Echinococcus granulosus Proteasome subunit alpha type 7 0.0225 0.2407 0.2407
Loa Loa (eye worm) RPN-3 protein 0.0036 0.021 0.0225
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0191 0.2011 0.2158
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0225 0.2407 0.2583
Loa Loa (eye worm) hypothetical protein 0.0037 0.0219 0.0236
Plasmodium vivax proteasome subunit beta type-1, putative 0.02 0.2112 0.2267
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.003 0.0143 0.0154
Plasmodium vivax proteasome subunit beta type-4, putative 0.0173 0.1798 0.193
Echinococcus multilocularis proteasome subunit beta type 6 0.018 0.1883 0.1883
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.0468 0.0468
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0129 0.0129
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0174 0.1816 0.1949
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.002 0.0019 0.002
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0031 0.0144 0.0155
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0019 0.0006 0.0007
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.015 0.1531 0.1531
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0087 0.0804 0.0863
Loa Loa (eye worm) beta-lactamase 0.0037 0.0219 0.0236
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0006 0.0007
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0244 0.2622 0.2814
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0034 0.018 0.0194
Echinococcus granulosus netrin receptor unc 5 0.0033 0.0176 0.0176
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0194 0.0194
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0184 0.1932 0.2073
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0173 0.1798 0.193
Plasmodium falciparum proteasome subunit beta type-1, putative 0.02 0.2112 0.2267
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0219 0.0236
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0219 0.0219
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0179 0.1873 0.201
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0173 0.1798 0.193
Brugia malayi 26S proteasome subunit P45 family protein 0.0019 0.0006 0.0006
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0179 0.1873 0.201
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.018 0.1878 0.2016
Trypanosoma cruzi 20S proteasome subunit 0.0174 0.1816 0.1949
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0028 0.0114 0.0114
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0225 0.2407 0.2583
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0028 0.0115 0.0124
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0173 0.1798 0.193
Brugia malayi beta-lactamase family protein 0.0037 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0209
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.002 0.0018 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0219 0.0219
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0129 0.0138
Echinococcus granulosus nuclear factor of activated T cells 5 0.0325 0.3561 0.3561
Leishmania major hypothetical protein, conserved 0.0018 0.0005 0.0005
Echinococcus granulosus Proteasome subunit alpha beta 0.0181 0.1896 0.1896
Onchocerca volvulus 0.0035 0.0194 0.1026
Brugia malayi proteasome subunit alpha type 3 0.0181 0.1896 0.1896
Mycobacterium ulcerans hypothetical protein 0.0037 0.0219 0.0027
Mycobacterium leprae proteasome (beta subunit) PrcB 0.082 0.9318 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0173 0.1798 0.193
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.0468 0.0468
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0036 0.021 0.0225
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0031 0.0144 0.0155
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.082 0.9318 0.9318
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.003 0.0134 0.0144
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0129 0.068
Schistosoma mansoni 26S protease regulatory subunit 6a 0.002 0.0019 0.0019
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0058 0.0468 0.0468
Echinococcus multilocularis subfamily T1A non peptidase ue 0.019 0.2 0.2
Leishmania major proteasome alpha 3 subunit, putative 0.018 0.1878 0.2016
Loa Loa (eye worm) PAS-3 protein 0.0165 0.1704 0.1828
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0028 0.0114 0.0114
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0184 0.1932 0.2073
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0027 0.0099 0.0106
Leishmania major proteasome beta 3 subunit, putative 0.0174 0.1816 0.1949
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0179 0.1873 0.201
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.018 0.1883 0.2021
Onchocerca volvulus 0.0035 0.0194 0.1026
Leishmania major proteasome alpha 2 subunit, putative 0.0184 0.1932 0.2073
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.018 0.0194
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0184 0.1932 0.1932
Toxoplasma gondii peptidase, T1 family protein 0.0181 0.1896 0.2035
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.002 0.0018 0.0018
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0173 0.1798 0.193
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0028 0.0115 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0007
Echinococcus granulosus carbonic anhydrase 0.0058 0.0468 0.0468
Echinococcus granulosus proteasome subunit beta t family 0.0174 0.1816 0.1816
Brugia malayi proteasome subunit beta type 3 0.0174 0.1816 0.1816
Echinococcus granulosus enteropeptidase 0.0035 0.0194 0.0194
Schistosoma mansoni coup transcription factor 0.0029 0.0129 0.0129
Plasmodium vivax proteasome subunit beta type-3, putative 0.0174 0.1816 0.1949
Loa Loa (eye worm) hypothetical protein 0.0027 0.0099 0.0106
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.082 0.9318 1
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.004 0.0254 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0129 0.0129
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.018 0.1883 0.1883
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0194 0.0194
Mycobacterium ulcerans lipase LipD 0.0037 0.0219 0.0027
Entamoeba histolytica proteasome regulatory subunit, putative 0.0027 0.0099 0.0106
Echinococcus granulosus transmembrane protease serine 3 0.0035 0.0194 0.0194
Toxoplasma gondii PCI domain-containing protein 0.0036 0.021 0.0225
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0194 0.0194
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0184 0.1932 0.2073
Onchocerca volvulus 0.0019 0.0006 0.0032
Schistosoma mansoni hypothetical protein 0.0054 0.0421 0.0421
Echinococcus multilocularis carbonic anhydrase 0.0058 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0209
Echinococcus multilocularis enteropeptidase 0.0035 0.0194 0.0194
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.019 0.2 0.2147
Loa Loa (eye worm) hypothetical protein 0.0198 0.2094 0.2248
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0129 0.0129
Entamoeba histolytica 26S protease regulatory subunit, putative 0.002 0.0019 0.002
Toxoplasma gondii PCI domain-containing protein 0.0028 0.0114 0.0122
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0027 0.0099 0.0106
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0225 0.2407 0.2583
Brugia malayi nuclear receptor NHR-88 0.0029 0.0129 0.0129
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.003 0.0143 0.0143
Leishmania major proteasome beta-1 subunit, putative 0.018 0.1883 0.2021
Giardia lamblia Proteasome subunit beta type 9 precursor 0.018 0.1883 0.2021
Loa Loa (eye worm) trypsin family protein 0.0035 0.0194 0.0209
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0219 0.0236
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0129 0.0129
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0036 0.021 0.021
Brugia malayi Proteasome A-type and B-type family protein 0.018 0.1883 0.1883
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0019 0.0006 0.0007
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0173 0.1798 0.1798
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0033 0.0176 0.0176
Entamoeba histolytica hypothetical protein 0.0036 0.0203 0.0218
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0005 0.0005
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0019 0.0006 0.0007
Echinococcus granulosus proteasome prosome macropain 0.082 0.9318 0.9318
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0179 0.1873 0.201
Echinococcus multilocularis proteasome subunit beta type 7 0.0879 1 1
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0184 0.1932 0.2073
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0173 0.1798 0.193
Brugia malayi Proteasome subunit alpha type 7-1 0.0225 0.2407 0.2407
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0019 0.0006 0.0006
Brugia malayi Proteasome/cyclosome repeat family protein 0.003 0.0134 0.0134
Brugia malayi proteasome subunit alpha type 1 0.0179 0.1873 0.1873
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0194 0.0194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0129 0.0129
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.015 0.1531 0.5
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0225 0.2407 0.2583
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.019 0.2 0.2147
Trypanosoma brucei ATP-dependent protease subunit HslV 0.015 0.1531 0.1643
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.015 0.1531 0.1643
Onchocerca volvulus Netrin receptor homolog 0.0033 0.0176 0.0927
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0129 0.0129
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.004 0.0254 0.0254
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0179 0.1873 0.201
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.018 0.1883 0.2021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0099 0.0106
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0174 0.1816 0.1949
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0174 0.1816 0.1816
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0129 0.0129
Toxoplasma gondii proteasome subunit alpha type, putative 0.0075 0.0666 0.0715
Leishmania major proteasome beta 5 subunit, putative 0.082 0.9318 1
Leishmania major proteasome alpha 7 subunit, putative 0.0181 0.1896 0.2035
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.018 0.1878 0.2016
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.018 0.1878 0.2016
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0181 0.1896 0.2035
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.018 0.1878 0.1878
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.004 0.0254 0.0254
Brugia malayi Proteasome subunit alpha type 1 0.0164 0.1698 0.1698
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.0035 0.0194 0.0194
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0191 0.2011 0.2158
Schistosoma mansoni hypothetical protein 0.0198 0.2094 0.2094
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.004 0.0254 0.0273
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0081
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0244 0.2622 0.2814
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.002 0.0019 0.002
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0157 0.1615 0.1615
Toxoplasma gondii PCI domain-containing protein 0.0034 0.018 0.0194
Toxoplasma gondii hypothetical protein 0.0058 0.0468 0.0502
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0019 0.0012 0.0013
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.019 0.2 0.2147
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0034 0.018 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0129 0.0138
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0191 0.2011 0.2158
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Loa Loa (eye worm) proteasome regulatory particle 0.0034 0.018 0.0194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0138
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.004 0.0254 0.0254
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0019 0.0006 0.0007
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0036 0.021 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0129 0.0129
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.002 0.0019 0.002
Brugia malayi Trypsin family protein 0.0035 0.0194 0.0194
Trypanosoma brucei proteasome beta 6 subunit 0.02 0.2112 0.2267
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0173 0.1798 0.193
Schistosoma mansoni 26S protease regulatory subunit 6a 0.002 0.0019 0.0019
Onchocerca volvulus 0.0035 0.0194 0.1026
Giardia lamblia Proteasome subunit beta type 3 0.0174 0.1816 0.1949
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.02 0.2112 0.2112
Plasmodium falciparum proteasome subunit beta type-5 0.082 0.9318 1
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0225 0.2407 0.2583
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0209
Loa Loa (eye worm) hypothetical protein 0.0058 0.0468 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0129 0.0129
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0181 0.1896 0.2035
Echinococcus multilocularis transmembrane protease serine 3 0.0035 0.0194 0.0194
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0036 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0129 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0129 0.0129
Brugia malayi ecdysteroid receptor 0.0029 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0138
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0225 0.2407 0.2583
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.015 0.1531 0.1442
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0034 0.018 0.0194
Toxoplasma gondii proteasome subunit 0.018 0.1883 0.2021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0129 0.0138
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0081 0.0729 0.0729
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0031 0.0144 0.0155
Mycobacterium ulcerans proteasome PrcA 0.015 0.1531 0.1465
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0081 0.0729 0.0729
Trypanosoma brucei proteasome alpha 7 subunit 0.0181 0.1896 0.2035
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0027 0.0099 0.0099
Schistosoma mansoni 26S protease regulatory subunit 6a 0.002 0.0019 0.0019
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0034 0.018 0.018
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.019 0.2 0.2147
Entamoeba histolytica proteasome regulatory subunit, putative 0.002 0.0018 0.002
Schistosoma mansoni 26S protease regulatory subunit 0.0019 0.0006 0.0006
Loa Loa (eye worm) carbonic anhydrase 3 0.0157 0.1615 0.1733
Leishmania major carbonic anhydrase-like protein 0.0157 0.1615 0.1733
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0045 0.0318 0.0341
Toxoplasma gondii hypothetical protein 0.0025 0.0075 0.0081
Echinococcus granulosus subfamily T1A non peptidase ue 0.019 0.2 0.2
Trypanosoma brucei proteasome beta-1 subunit, putative 0.018 0.1883 0.2021
Onchocerca volvulus 0.0035 0.0194 0.1026
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0194 0.0194
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.018 0.1883 0.2021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0177 0.019
Brugia malayi 26S protease regulatory subunit 6A 0.002 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0129 0.0129
Brugia malayi PCI domain containing protein 0.0028 0.0114 0.0114
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0087 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0058 0.0468 0.0502
Toxoplasma gondii proteasome subunit alpha type, putative 0.018 0.1878 0.2016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0209
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0181 0.1896 0.2035
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0028 0.0115 0.0115
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0219 0.0027
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0019 0.0006 0.0007
Echinococcus multilocularis carbonic anhydrase 0.0058 0.0468 0.0468
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.003 0.0143 0.0143
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0031 0.0144 0.0155
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0058 0.0468 0.0502
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0229 0.0229
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0028 0.0115 0.0115
Plasmodium falciparum proteasome subunit beta type-4 0.0173 0.1798 0.193
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0129 0.0129
Loa Loa (eye worm) RPT-2 protein 0.0019 0.0006 0.0007
Brugia malayi Trypsin-like protease protein 5 0.0035 0.0194 0.0194
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.015 0.1531 0.1643
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0129 0.0129
Leishmania major proteasome alpha 1 subunit, putative 0.0191 0.2011 0.2158
Giardia lamblia 20S proteasome alpha subunit 6 0.0179 0.1873 0.201
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0019 0.0012 0.0013
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0174 0.1816 0.1816
Giardia lamblia 20S proteasome alpha subunit 5 0.019 0.2 0.2147
Giardia lamblia 20S proteasome alpha subunit 7 0.0181 0.1896 0.2035
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.019 0.2 0.2147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0209
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.019 0.2 0.2

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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