Detailed information for compound 1542715

Basic information

Technical information
  • TDR Targets ID: 1542715
  • Name: N-(4,5-dihydro-1,3-thiazol-2-yl)-2-methyl-5-m orpholin-4-ylsulfonylbenzamide
  • MW: 369.459 | Formula: C15H19N3O4S2
  • H donors: 1 H acceptors: 3 LogP: 0.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(ccc1C)S(=O)(=O)N1CCOCC1)NC1=NCCS1
  • InChi: 1S/C15H19N3O4S2/c1-11-2-3-12(24(20,21)18-5-7-22-8-6-18)10-13(11)14(19)17-15-16-4-9-23-15/h2-3,10H,4-9H2,1H3,(H,16,17,19)
  • InChiKey: VPRZAOBRBLCJHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4,5-dihydrothiazol-2-yl)-2-methyl-5-morpholinosulfonyl-benzamide
  • N-(4,5-dihydrothiazol-2-yl)-2-methyl-5-morpholinosulfonylbenzamide
  • N-(4,5-dihydro-1,3-thiazol-2-yl)-2-methyl-5-morpholin-4-ylsulfonyl-benzamide
  • ZINC02646328
  • T5239656

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/ABL protein kinase 0.0414 0.5525 0.5525
Brugia malayi TAR-binding protein 0.0262 0.3439 0.3439
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0074 0.0871 0.0871
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0258 0.0447
Schistosoma mansoni unc-13 (munc13) 0.0014 0.0038 0.0041
Loa Loa (eye worm) TAR-binding protein 0.0262 0.3439 0.3439
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0258 0.0258
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0066 0.0099
Echinococcus multilocularis tyrosine protein kinase Abl 0.0169 0.2164 0.3904
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0066 0.0066
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0258 0.0969
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0702 0.9478 0.9478
Schistosoma mansoni nuclear receptor 0.0014 0.0043 0.0049
Leishmania major hypothetical protein, conserved 0.0074 0.0871 0.6167
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0066
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0293 0.3876 0.7009
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0013 0.0034 0.0041
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0542 0.0542
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0258 0.0447
Brugia malayi MH1 domain containing protein 0.005 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0258 0.0384
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0258 0.0384
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0034 0.0041
Loa Loa (eye worm) Smad1 0.005 0.0542 0.0542
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0043 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0222 0.2897 0.5233
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0258
Schistosoma mansoni hypothetical protein 0.0222 0.2897 0.4494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0258 0.0258
Schistosoma mansoni thyroid hormone receptor 0.003 0.0258 0.0384
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0012 0.0012 0.0012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0262 0.3439 0.3439
Echinococcus granulosus Smad4 0.005 0.0542 0.0963
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.1389 0.2498
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0043 0.0043
Brugia malayi Smad1 0.005 0.0542 0.0542
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0034 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0023 0.016 0.016
Brugia malayi steroid hormone receptor 0.003 0.0258 0.0258
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.016 0.016
Echinococcus granulosus tyrosine protein kinase Lyn 0.0013 0.0034 0.0041
Brugia malayi hypothetical protein 0.0016 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0028 0.0233 0.0233
Brugia malayi Calcitonin receptor-like protein seb-1 0.0702 0.9478 0.9478
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0258 0.0258
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0112 0.1389 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.016 0.0528
Brugia malayi MH2 domain containing protein 0.005 0.0542 0.0542
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.016 0.0269
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Brugia malayi RNA recognition motif domain containing protein 0.0262 0.3439 0.3439
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.016 0.0269
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0043 0.0043
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.016 0.016
Schistosoma mansoni hypothetical protein 0.0222 0.2897 0.4494
Brugia malayi nuclear receptor NHR-88 0.003 0.0258 0.0258
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) nuclear factor I 0.0028 0.0233 0.0233
Brugia malayi hypothetical protein 0.0014 0.0043 0.0043
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0258 0.0447
Brugia malayi isocitrate dehydrogenase 0.0112 0.1389 0.1389
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.1389 0.2498
Schistosoma mansoni tyrosine kinase 0.0013 0.0034 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0258 0.0258
Brugia malayi hypothetical protein 0.0016 0.0066 0.0066
Loa Loa (eye worm) RNA binding protein 0.0262 0.3439 0.3439
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0034 0.0036
Brugia malayi nuclear hormone receptor 0.003 0.0258 0.0258
Echinococcus multilocularis tar DNA binding protein 0.0262 0.3439 0.6217
Echinococcus granulosus FTZ F1 alpha 0.003 0.0258 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0258 0.0258
Echinococcus multilocularis c src tyrosine kinase 0.0013 0.0034 0.0041
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0014 0.0038 0.5
Brugia malayi conserved hypotetical protein 0.0014 0.0043 0.0043
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0014 0.0038 0.0048
Schistosoma mansoni tyrosine kinase 0.0013 0.0034 0.0036
Schistosoma mansoni coup transcription factor 0.003 0.0258 0.0384
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0258
Brugia malayi MH2 domain containing protein 0.0023 0.016 0.016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0258 0.0447
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0043 0.0049
Brugia malayi RNA binding protein 0.0262 0.3439 0.3439
Loa Loa (eye worm) transcription factor SMAD2 0.074 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0043 0.0043
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0258
Brugia malayi nuclear receptor RXR 0.0014 0.0043 0.0043
Brugia malayi latrophilin 2 splice variant baaae 0.048 0.6432 0.6432
Echinococcus granulosus tar DNA binding protein 0.0262 0.3439 0.6217
Toxoplasma gondii isocitrate dehydrogenase 0.0112 0.1389 1
Entamoeba histolytica tartrate dehydrogenase, putative 0.0014 0.0038 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0034 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0258 0.0969
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0258 0.0384
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.2261 1
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0014 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0258
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0293 0.3876 0.7009
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.016 0.0269
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0308 0.0538
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0043 0.0049
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0258 0.0447
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0013 0.0034 0.0041
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0542 0.0827
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0258 0.0384
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0043 0.0057
Schistosoma mansoni tyrosine kinase 0.0013 0.0034 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0262 0.3439 0.5339
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0258 0.0258
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0014 0.0038 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0222 0.2897 0.2897
Brugia malayi nuclear receptor NHR-88 0.0014 0.0043 0.0043
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0043 0.0057
Loa Loa (eye worm) hypothetical protein 0.0157 0.2003 0.2003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0258 0.0447
Brugia malayi nuclear receptor NHR-67 0.0014 0.0043 0.0043
Schistosoma mansoni smad1 5 8 and 0.005 0.0542 0.0827
Loa Loa (eye worm) hypothetical protein 0.048 0.6432 0.6432
Brugia malayi hypothetical protein 0.0074 0.0871 0.0871
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.016 0.016
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0014 0.0038 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.1389 0.2498
Echinococcus multilocularis isocitrate dehydrogenase 0.0112 0.1389 0.2498
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0222 0.2897 0.2897
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0043 0.0043
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0542 0.0963
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0542 0.0963
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Echinococcus multilocularis Smad4 0.005 0.0542 0.0963
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0014 0.0038 0.0041
Loa Loa (eye worm) hypothetical protein 0.0702 0.9478 0.9478
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Brugia malayi Tyrosine-protein kinase abl-1 0.0169 0.2164 0.2164
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0013 0.0034 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0262 0.3439 0.5339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0258 0.0258
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0014 0.0038 0.0038
Schistosoma mansoni smad 0.005 0.0542 0.0827
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0258 0.0447
Schistosoma mansoni smad 0.0023 0.016 0.0231
Brugia malayi MH1 domain containing protein 0.0028 0.0233 0.0233
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0112 0.1389 0.2145
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0013 0.0034 0.0036
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0258 0.0384
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0043 0.0057
Loa Loa (eye worm) latrophilin receptor protein 2 0.0222 0.2897 0.2897
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0013 0.0034 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0542 0.0542
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0222 0.2897 0.5233
Onchocerca volvulus 0.003 0.0258 0.0969
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0043 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0066 0.0085
Echinococcus granulosus smad 0.005 0.0542 0.0963
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0258 0.0969
Schistosoma mansoni nuclear hormone receptor 0.003 0.0258 0.0384
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0014 0.0038 0.0048
Brugia malayi ecdysteroid receptor 0.003 0.0258 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0262 0.3439 0.5339
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0066 0.0085
Loa Loa (eye worm) isocitrate dehydrogenase 0.0112 0.1389 0.1389
Loa Loa (eye worm) DR-78 0.0014 0.0043 0.0043
Schistosoma mansoni smad1 5 8 and 0.005 0.0542 0.0827
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0043 0.0043
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0012 0.0012
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0258 0.0384
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0014 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0258 0.0384
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Brugia malayi Tyrosine-protein kinase abl-1 0.0251 0.3291 0.3291
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0066 0.0066
Brugia malayi nuclear receptor RXR 0.0016 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0066
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0414 0.5525 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0222 0.2897 0.5233
Schistosoma mansoni thyroid hormone receptor 0.003 0.0258 0.0384
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0702 0.9478 0.9478
Loa Loa (eye worm) nuclear hormone receptor 0.0278 0.3661 0.3661
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0258
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0258 0.0447
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0112 0.1389 0.2498
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0014 0.0038 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0258 0.0258
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0013 0.0034 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0293 0.3876 0.3876
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0013 0.0034 0.0041
Echinococcus granulosus GPCR family 2 0.0222 0.2897 0.5233
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.1389 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0013 0.0034 0.0041
Brugia malayi ecdysone receptor 0.0014 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0258 0.0258
Toxoplasma gondii isocitrate dehydrogenase 0.0112 0.1389 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0258 0.0258
Loa Loa (eye worm) SRC-1 0.0013 0.0034 0.0034
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0043 0.0057
Schistosoma mansoni hypothetical protein 0.0033 0.0308 0.0462
Echinococcus multilocularis smad 0.005 0.0542 0.0963
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.1389 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0013 0.0034 0.0041
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0258 0.0447
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0043 0.0057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0112 0.1389 0.2498
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0043 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0258 0.0447
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0043 0.0043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0258 0.0258
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.016 0.0269
Echinococcus multilocularis GPCR, family 2 0.0222 0.2897 0.5233
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0258 0.0384
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0043 0.0049
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0043 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0258 0.0258
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0258 0.0258
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0014 0.0038 0.0038
Brugia malayi N-terminal motif family protein 0.0176 0.2261 0.2261
Schistosoma mansoni hypothetical protein 0.0222 0.2897 0.4494
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0043 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0258 0.0258
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0043 0.0057
Brugia malayi MH2 domain containing protein 0.005 0.0542 0.0542
Loa Loa (eye worm) MH2 domain-containing protein 0.074 1 1
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0014 0.0038 0.0048
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0112 0.1389 1
Brugia malayi Probable isocitrate dehydrogenase 0.0014 0.0038 0.0038
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0258 0.0384
Schistosoma mansoni Smad4 0.0023 0.016 0.0231
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0112 0.1389 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.2261 0.2261
Schistosoma mansoni smad1 5 8 and 0.005 0.0542 0.0827
Brugia malayi Sex muscle abnormal protein 5 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0279 0.3684 0.3684
Schistosoma mansoni nuclear receptor 0.0014 0.0043 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0262 0.3439 0.5339
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0043 0.0057
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Brugia malayi nuclear hormone receptor 0.0014 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0258 0.0447
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0014 0.0038 0.5
Brugia malayi Probable isocitrate dehydrogenase 0.0014 0.0038 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0066
Schistosoma mansoni tyrosine kinase 0.0408 0.5444 0.8461
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0258 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0258 0.0258
Echinococcus granulosus tyrosine protein kinase Src64B 0.0013 0.0034 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0262 0.3439 0.5339
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0013 0.0034 0.0041
Echinococcus granulosus tyrosine protein kinase Src42A 0.0013 0.0034 0.0041
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.1389 1
Schistosoma mansoni hypothetical protein 0.0222 0.2897 0.4494
Schistosoma mansoni isocitrate dehydrogenase 0.0014 0.0038 0.0041
Schistosoma mansoni zinc finger protein 0.0014 0.0043 0.0049
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0043 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0222 0.2897 0.5233
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0112 0.1389 1
Brugia malayi MH1 domain containing protein 0.005 0.0542 0.0542
Brugia malayi hypothetical protein 0.0048 0.0509 0.0509
Brugia malayi Latrophilin receptor protein 2 0.0222 0.2897 0.2897
Echinococcus granulosus tyrosine protein kinase ABL1 0.0414 0.5525 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0013 0.0034 0.0041
Brugia malayi hypothetical protein 0.0014 0.0043 0.0043
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0043 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0258 0.0258
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0258 0.0447
Schistosoma mansoni hypothetical protein 0.048 0.6432 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0542 0.0963
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0066 0.0099
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0013 0.0034 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0258 0.0258
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0013 0.0034 0.0041
Schistosoma mansoni Smad4 0.0023 0.016 0.0231
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0043
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0308 0.0538
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0258
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0258 0.0447
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0258 0.0258
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0542 0.0963
Brugia malayi SRC-1 0.0013 0.0034 0.0034
Brugia malayi tailless protein 0.0014 0.0043 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0258 0.0447
Echinococcus granulosus c src tyrosine kinase 0.0013 0.0034 0.0041
Schistosoma mansoni Smad4 0.005 0.0542 0.0827
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0258
Brugia malayi MH1 domain containing protein 0.0028 0.0233 0.0233
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0112 0.1389 1
Brugia malayi Isocitrate dehydrogenase 0.0112 0.1389 0.1389

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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