Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin b | 0.0382 | 0.5664 | 0.5664 |
Onchocerca volvulus | Cathepsin L homolog | 0.0481 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0325 | 0.3182 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Onchocerca volvulus | 0.0481 | 1 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0382 | 0.5664 | 0.5664 |
Leishmania major | cysteine peptidase A (CPA) | 0.0481 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0481 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0481 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0481 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0481 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0481 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0481 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0481 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0325 | 0.3182 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Onchocerca volvulus | 0.0481 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Onchocerca volvulus | 0.0481 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0325 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0481 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Onchocerca volvulus | 0.0481 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0481 | 1 | 0.5 |
Onchocerca volvulus | 0.0481 | 1 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0382 | 0.5664 | 0.5664 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0481 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0481 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0325 | 0.3182 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0481 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0481 | 1 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0481 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0481 | 1 | 1 |
Onchocerca volvulus | 0.0481 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.5664 | 0.3641 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0481 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0481 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0481 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0382 | 0.5664 | 0.5664 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0481 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0325 | 0.3182 | 0.3182 |
Onchocerca volvulus | Cathepsin F homolog | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0481 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0325 | 0.3182 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0481 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0481 | 1 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0481 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0481 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0481 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0325 | 0.3182 | 0.3182 |
Echinococcus granulosus | cathepsin b | 0.0382 | 0.5664 | 0.5664 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0382 | 0.5664 | 0.5664 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0481 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0481 | 1 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0382 | 0.5664 | 0.5664 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0481 | 1 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0325 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0481 | 1 | 1 |
Onchocerca volvulus | 0.0481 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0481 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0382 | 0.5664 | 0.5664 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0481 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0382 | 0.5664 | 0.5664 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0325 | 0.3182 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0481 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0382 | 0.5664 | 0.5664 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0481 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0481 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0481 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0325 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0481 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0481 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0481 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0481 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 9.1 mg kg-1 | Ability to block the LTD4 pressor response in pithed rats after intravenous administration | ChEMBL. | 1654427 |
ED50 (functional) | = 9.1 mg kg-1 | Ability to block the LTD4 pressor response in pithed rats after intravenous administration | ChEMBL. | 1654427 |
pKB (functional) | = 7.28 | In vitro ability to antagonize LTD4-induced contractions of guinea pig ileum. | ChEMBL. | 1654427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.