Detailed information for compound 1542828

Basic information

Technical information
  • TDR Targets ID: 1542828
  • Name: 3-dimethylaminopropyl 2-chlorobenzoate hydroc hloride
  • MW: 278.175 | Formula: C12H17Cl2NO2
  • H donors: 0 H acceptors: 1 LogP: 3.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCOC(=O)c1ccccc1Cl)C.Cl
  • InChi: 1S/C12H16ClNO2.ClH/c1-14(2)8-5-9-16-12(15)10-6-3-4-7-11(10)13;/h3-4,6-7H,5,8-9H2,1-2H3;1H
  • InChiKey: OEPKWIIHNVAIML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chlorobenzoic acid 3-dimethylaminopropyl ester hydrochloride
  • SMR000141820
  • 3-(dimethylamino)propyl 2-chlorobenzoate hydrochloride
  • MLS000534388

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0426 0.3188
Loa Loa (eye worm) hypothetical protein 0.0038 0.0541 0.1206
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0541 0.1206
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0541 0.1206
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1313 0.1391
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0891 0.2013
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0891 0.7191
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0323 0.027
Echinococcus granulosus dna polymerase kappa 0.0161 0.421 0.446
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0891 0.0944
Trypanosoma cruzi DNA polymerase kappa, putative 0.0161 0.421 0.4178
Schistosoma mansoni DNA polymerase IV / kappa 0.0031 0.0323 0.0343
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0541 0.1206
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0093 0.2163 0.2292
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0426 0.0892
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0037 0.0508 0.0539
Mycobacterium ulcerans hypothetical protein 0.0031 0.0323 0.0545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0748 0.0793
Loa Loa (eye worm) hypothetical protein 0.013 0.3282 0.7319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0541 0.0573
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0323 0.027
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 0.2763 0.5497
Onchocerca volvulus 0.015 0.3866 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.4414 0.4383
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.1313 0.1265
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0541 0.0573
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0541 0.0573
Loa Loa (eye worm) apoptosis regulator protein 0.0093 0.2163 0.4824
Plasmodium falciparum DNA repair protein REV1, putative 0.0031 0.0323 0.2609
Brugia malayi 6-phosphofructokinase 0.0128 0.3212 0.7162
Entamoeba histolytica phosphofructokinase, putative 0.0128 0.3212 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Brugia malayi nuclear hormone receptor 0.0038 0.0541 0.1206
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0541 0.0573
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0736 0.078
Schistosoma mansoni hypothetical protein 0.0336 0.944 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0886 0.0835
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.4484 0.475
Trypanosoma brucei DNA polymerase IV, putative 0.0146 0.3758 0.3724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0055 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0748 0.1669
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0037 0.0508 0.0456
Trypanosoma cruzi DNA damage repair protein, putative 0.0031 0.0323 0.027
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0541 0.1206
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0128 0.3212 0.3174
Leishmania major cathepsin L-like protease 0.0071 0.1528 0.1481
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.1713 0.3819
Trypanosoma brucei chrX additional, unordered contigs 0.0031 0.0323 0.027
Schistosoma mansoni hypothetical protein 0.0022 0.0054 0.0057
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0541 0.1277
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0459 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.2146 0.2103
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1528 0.1481
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0891 0.8103
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1619 0.1715
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1619 0.1715
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0541 0.0573
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0055 0.0123
Mycobacterium ulcerans 6-phosphofructokinase 0.0128 0.3212 0.6408
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0736 0.078
Leishmania major ubiquitin-activating enzyme-like protein 0.0037 0.0508 0.0456
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0128 0.3212 0.3174
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.2425 0.4811
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0426 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0541 0.1206
Mycobacterium tuberculosis Conserved hypothetical protein 0.01 0.2387 0.4735
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0541 0.1206
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0426 0.0892
Plasmodium vivax DNA repair protein REV1, putative 0.0031 0.0323 0.2609
Brugia malayi nuclear receptor NHR-88 0.0038 0.0541 0.1206
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.2146 0.2103
Trypanosoma brucei DNA polymerase eta, putative 0.013 0.3282 0.3245
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0723 0.1612
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0093 0.2163 0.2292
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0054 0.012
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0426 0.0892
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0037 0.0508 0.0456
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.1713 0.1814
Mycobacterium ulcerans DNA polymerase IV 0.0161 0.421 0.8436
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0541 0.0573
Leishmania major hypothetical protein, conserved 0.0025 0.014 0.0086
Leishmania major DNA polymerase kappa, putative 0.0031 0.0323 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0057 0.1087 0.1152
Brugia malayi hypothetical protein 0.015 0.3866 0.8622
Plasmodium falciparum thioredoxin reductase 0.0044 0.0723 0.6474
Brugia malayi hypothetical protein 0.0036 0.0459 0.1024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0459 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0541 0.1206
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0057 0.1087 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0767 0.2254
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.1619 0.361
Echinococcus granulosus dna polymerase eta 0.013 0.3282 0.3477
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0055 0.0058
Brugia malayi phosphofructokinase 0.0128 0.3212 0.7162
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.4341 0.4599
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.014 0.0086
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0541 0.1277
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0323 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.284 0.28
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0037 0.0508 0.4398
Brugia malayi hypothetical protein 0.0022 0.0054 0.012
Loa Loa (eye worm) hypothetical protein 0.0025 0.014 0.0313
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.014 0.0839
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0723 0.0672
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0355 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0128 0.3212 0.7596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0748 0.0793
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.2425 0.4811
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0093 0.2163 0.2292
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1911 0.1866
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0541 0.0573
Loa Loa (eye worm) acetyltransferase 0.017 0.4484 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0886 0.0835
Echinococcus granulosus tar DNA binding protein 0.0074 0.1619 0.1715
Schistosoma mansoni 6-phosphofructokinase 0.0128 0.3212 0.3402
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0426 0.1332
Echinococcus multilocularis dna polymerase kappa 0.0161 0.421 0.446
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0541 0.1206
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0541 0.1206
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0426 0.3599
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0055 0.0058
Trypanosoma brucei DNA damage repair protein, putative 0.0031 0.0323 0.027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0541 0.0573
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0541 0.0573
Leishmania major cathepsin L-like protease 0.0071 0.1528 0.1481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0541 0.1206
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0426 0.3188
Brugia malayi Thioredoxin reductase 0.0044 0.0723 0.1612
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0037 0.0508 0.4398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0748 0.0793
Leishmania major cathepsin L-like protease 0.0071 0.1528 0.1481
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1528 0.1481
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0426 0.0892
Mycobacterium tuberculosis Probable reductase 0.0101 0.2425 0.4811
Giardia lamblia DNA damage repair protein 0.0031 0.0323 0.0964
Mycobacterium tuberculosis Conserved hypothetical protein 0.0187 0.4981 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0459 0.0487
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0046 0.0776 0.6197
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0541 0.0573
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0037 0.0508 0.0539
Toxoplasma gondii hypothetical protein 0.0057 0.1087 0.8877
Brugia malayi RNA binding protein 0.0074 0.1619 0.361
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0051 0.0932 0.0987
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0541 0.0573
Leishmania major trypanothione reductase 0.0044 0.0723 0.0672
Schistosoma mansoni 6-phosphofructokinase 0.0128 0.3212 0.3402
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0132 0.3338 0.3536
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.014 0.0086
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.014 0.0086
Schistosoma mansoni terminal deoxycytidyl transferase 0.01 0.2387 0.2529
Echinococcus granulosus 6 phosphofructokinase 0.0128 0.3212 0.3402
Plasmodium falciparum glutathione reductase 0.0044 0.0723 0.6474
Schistosoma mansoni polycystin 1-related 0.0022 0.0054 0.0057
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0541 0.0573
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0541 0.1277
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0541 0.1206
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.4484 1
Schistosoma mansoni lipoxygenase 0.0132 0.3338 0.3536
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0128 0.3212 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0541 0.0573
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.1713 0.1667
Loa Loa (eye worm) 6-phosphofructokinase 0.0128 0.3212 0.7162
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.1313 0.2927
Schistosoma mansoni DNA polymerase eta 0.013 0.3282 0.3477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0748 0.0793
Schistosoma mansoni apoptosis regulator bax 0.0093 0.2163 0.2292
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.012
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.1713 0.1667
Schistosoma mansoni hypothetical protein 0.0036 0.0459 0.0487
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.01 0.2387 0.5324
Brugia malayi glutathione reductase 0.0044 0.0723 0.1612
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.1619 0.361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0541 0.1206
Schistosoma mansoni hypothetical protein 0.0093 0.2163 0.2292
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0113 0.2763 0.5497
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0323 0.027
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0541 0.0573
Entamoeba histolytica hypothetical protein 0.0036 0.0459 0.1281
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.01 0.2387 0.2529
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.2425 0.4811
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0093 0.2163 0.2292
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0541 0.0573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0541 0.0573
Brugia malayi hypothetical protein 0.0022 0.0054 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Toxoplasma gondii thioredoxin reductase 0.0044 0.0723 0.5743
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0161 0.421 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.4484 0.475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Echinococcus multilocularis 6 phosphofructokinase 0.0128 0.3212 0.3402
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0891 0.7191
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.1071 0.1022
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0054 0.0057
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0037 0.0508 0.0539
Entamoeba histolytica hypothetical protein 0.0036 0.0459 0.1281
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.4414 0.4383
Leishmania major DNA polymerase eta, putative 0.013 0.3282 0.3245
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0767 0.6897
Entamoeba histolytica phosphofructokinase, putative 0.0128 0.3212 1
Plasmodium vivax glutathione reductase, putative 0.0044 0.0723 0.6474
Echinococcus granulosus geminin 0.0336 0.944 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0891 0.2013
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1619 0.1715
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0057 0.1087 0.1152
Leishmania major DNA polymerase eta, putative 0.0061 0.1218 0.1169
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0054 0.0057
Brugia malayi ecdysteroid receptor 0.0038 0.0541 0.1206
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.1184 0.2639
Trypanosoma brucei unspecified product 0.0069 0.1459 0.1411
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.01 0.2387 0.2529
Schistosoma mansoni rab6-interacting 0.0022 0.0054 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0426 0.0892
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1313 0.2553
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.1713 0.1667
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0355 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0128 0.3212 0.7596
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0061 0.1218 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.014 0.0839
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.1313 0.1391
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0093 0.2163 0.2292
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0723 0.6474
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0541 0.1206
Mycobacterium ulcerans DNA polymerase IV 0.0161 0.421 0.8436
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.1713 0.5251
Trypanosoma brucei DNA polymerase IV, putative 0.0161 0.421 0.4178
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0541 0.0573
Trypanosoma cruzi DNA damage repair protein, putative 0.0031 0.0323 0.027
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0426 0.1175
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0115 0.284 0.5653
Trichomonas vaginalis phosphofructokinase, putative 0.0128 0.3212 0.7596
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0115 0.284 0.28
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0541 0.1206
Leishmania major DNA polymerase kappa, putative 0.0115 0.284 0.28
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.1713 0.3819
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0541 0.0573
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.1713 0.1814
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1911 0.1866
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0353 0.03
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0541 0.1206
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0541 0.0573
Schistosoma mansoni hypothetical protein 0.0093 0.2163 0.2292
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.1313 0.2553
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0541 0.1206
Brugia malayi TAR-binding protein 0.0074 0.1619 0.361
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0054 0.0057
Entamoeba histolytica phosphofructokinase, putative 0.0128 0.3212 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0541 0.1206
Loa Loa (eye worm) 6-phosphofructokinase 0.0128 0.3212 0.7162
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.014 0.0736
Loa Loa (eye worm) glutathione reductase 0.0044 0.0723 0.1612
Brugia malayi steroid hormone receptor 0.0038 0.0541 0.1206
Brugia malayi ThiF family protein 0.0037 0.0508 0.1134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0161 0.421 0.4178
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0541 0.0573
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0057 0.1087 0.1152
Schistosoma mansoni ap endonuclease 0.0022 0.0055 0.0058
Brugia malayi ThiF family protein 0.0057 0.1087 0.2425
Brugia malayi polk-prov protein 0.0092 0.2146 0.4786
Trypanosoma brucei DNA polymerase IV, putative 0.0161 0.421 0.4178
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.1212 0.1163
Loa Loa (eye worm) TAR-binding protein 0.0074 0.1619 0.361
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0541 0.0573
Schistosoma mansoni hypothetical protein 0.0093 0.2163 0.2292
Toxoplasma gondii ThiF family protein 0.0037 0.0508 0.3899
Plasmodium vivax ubiquitin activating enzyme, putative 0.0057 0.1087 1
Schistosoma mansoni coup transcription factor 0.0038 0.0541 0.0573
Loa Loa (eye worm) hypothetical protein 0.0038 0.0541 0.1206
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1619 0.1715
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0055 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0541 0.0573
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0426 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0541 0.0573
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0767 0.2555
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0355 1 1
Schistosoma mansoni lipoxygenase 0.0092 0.2151 0.2279
Entamoeba histolytica hypothetical protein 0.0036 0.0459 0.1281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0541 0.1206
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.1713 0.1667
Trichomonas vaginalis DNA polymerase eta, putative 0.0161 0.421 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1911 0.1866
Loa Loa (eye worm) hypothetical protein 0.0093 0.2163 0.4824
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0886 0.0835
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0055 0.0123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0541 0.1206
Onchocerca volvulus 0.0038 0.0541 0.1277
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0748 0.1669
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0541 0.1206
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0426 0.3599
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0054 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0541 0.1206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0054 0.0057
Loa Loa (eye worm) RNA binding protein 0.0074 0.1619 0.361
Toxoplasma gondii hypothetical protein 0.0057 0.1105 0.9029
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0168 0.4414 0.4383
Entamoeba histolytica deoxycytidyl transferase, putative 0.01 0.2387 0.7389
Brugia malayi Doublecortin family protein 0.0022 0.0054 0.012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1313 0.2553
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0741 0.0785
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.2425 0.4811
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0541 0.0573
Trichomonas vaginalis phosphofructokinase, putative 0.0128 0.3212 0.7596
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0541 0.1206
Echinococcus granulosus RUN 0.0022 0.0054 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Echinococcus multilocularis geminin 0.0336 0.944 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0748 0.0793
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0426 0.3188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0541 0.0573
Echinococcus multilocularis dna polymerase eta 0.013 0.3282 0.3477
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1528 0.1481
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0426 0.3599
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0541 0.1206
Giardia lamblia DINP protein human, muc B family 0.0115 0.284 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1528 0.1481
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0748 0.0793
Loa Loa (eye worm) phosphofructokinase 0.0128 0.3212 0.7162
Schistosoma mansoni ap endonuclease 0.0022 0.0055 0.0058
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0128 0.3212 0.6408
Mycobacterium ulcerans hypothetical protein 0.0187 0.4981 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.1087 0.2425
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.1343 0.1295
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0426 0.3599
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0541 0.0573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0161 0.421 0.4178
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0323 0.2308
Trypanosoma brucei DNA damage repair protein, putative 0.0031 0.0323 0.027
Brugia malayi ImpB/MucB/SamB family protein 0.013 0.3282 0.7319
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0723 0.1356
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0741 0.0785
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0541 0.0573
Leishmania major DNA damage repair protein, putative 0.0031 0.0323 0.027
Loa Loa (eye worm) hypothetical protein 0.0092 0.2146 0.4786
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0132 0.3338 0.3536
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0055 0.5
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.1713 0.1814
Trypanosoma cruzi DNA polymerase kappa, putative 0.0161 0.421 0.4178
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.014 0.0839
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0426 0.0892
Trypanosoma cruzi DNA polymerase eta, putative 0.013 0.3282 0.3245
Entamoeba histolytica hypothetical protein 0.0036 0.0459 0.1281
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0541 0.0573
Loa Loa (eye worm) hypothetical protein 0.0038 0.0541 0.1206
Loa Loa (eye worm) hypothetical protein 0.0038 0.0541 0.1206
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0113 0.2763 0.5497
Trypanosoma brucei unspecified product 0.0146 0.3758 0.3724
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0054 0.0057
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0128 0.3212 1
Brugia malayi ImpB/MucB/SamB family protein 0.01 0.2387 0.5324
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0541 0.1206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0541 0.1206
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.2425 0.4811
Loa Loa (eye worm) ThiF family protein 0.0037 0.0508 0.1134
Echinococcus multilocularis RUN 0.0022 0.0054 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0748 0.0793
Schistosoma mansoni hypothetical protein 0.0336 0.944 1
Brugia malayi hypothetical protein 0.0025 0.014 0.0313
Loa Loa (eye worm) hypothetical protein 0.0038 0.0541 0.1206
Loa Loa (eye worm) hypothetical protein 0.015 0.3866 0.8622
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1619 0.1715
Trypanosoma brucei DNA polymerase kappa, putative 0.0161 0.421 0.4178
Trypanosoma brucei trypanothione reductase 0.0044 0.0723 0.0672
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.01 0.2387 0.2529
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0541 0.0573
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0426 0.5
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0113 0.2763 0.4297
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0093 0.2163 0.4824
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1528 0.1481
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0886 0.0835
Loa Loa (eye worm) hypothetical protein 0.0038 0.0541 0.1206
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.1218 0.1169
Leishmania major ATP-dependent phosphofructokinase 0.0128 0.3212 0.3174
Echinococcus multilocularis tar DNA binding protein 0.0074 0.1619 0.1715
Schistosoma mansoni rab6-interacting 0.0022 0.0054 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0541 0.1206
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0541 0.0573
Trypanosoma brucei unspecified product 0.0069 0.1459 0.1411
Schistosoma mansoni loxhd1 0.0022 0.0054 0.0057
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1313 0.1391
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0426 0.1175
Brugia malayi 6-phosphofructokinase 0.0128 0.3212 0.7162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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