Detailed information for compound 1542995

Basic information

Technical information
  • TDR Targets ID: 1542995
  • Name: 5-propyl-5-thiophen-3-ylimidazolidine-2,4-dio ne
  • MW: 224.279 | Formula: C10H12N2O2S
  • H donors: 2 H acceptors: 2 LogP: 1.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC1(NC(=O)NC1=O)c1cscc1
  • InChi: 1S/C10H12N2O2S/c1-2-4-10(7-3-5-15-6-7)8(13)11-9(14)12-10/h3,5-6H,2,4H2,1H3,(H2,11,12,13,14)
  • InChiKey: CHVNKXWWVIMRJQ-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 5-propyl-5-(3-thienyl)imidazolidine-2,4-dione
  • 5-propyl-5-(3-thienyl)hydantoin
  • 5-propyl-5-thiophen-3-yl-imidazolidine-2,4-dione
  • NSC109402

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0153 0.2357 0.2379
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0027 0.0164 0.0165
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0143 0.0144
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0146 0.2243 0.2263
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0178 0.2793 0.2818
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0007 0.0007
Loa Loa (eye worm) PAS-3 protein 0.0137 0.2081 0.2099
Toxoplasma gondii hypothetical protein 0.0024 0.0108 0.0109
Loa Loa (eye worm) hypothetical protein 0.0191 0.3017 0.3044
Schistosoma mansoni proteasome regulatory subunit-related 0.0029 0.0208 0.0208
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0316 0.0319
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0123 0.1832 0.1849
Loa Loa (eye worm) hypothetical protein 0.0084 0.1158 0.1168
Schistosoma mansoni carbonic anhydrase 0.0056 0.0674 0.0674
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0018 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0186 0.0186
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0034 0.028 0.028
Echinococcus granulosus Ankyrin 0.0032 0.0255 0.0255
Brugia malayi proteasome subunit alpha type 1 0.0151 0.2324 0.2324
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0009 0.0009
Leishmania major proteasome alpha 3 subunit, putative 0.0152 0.2332 0.2353
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0152 0.2339 0.236
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0027 0.0027
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0206 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0186 0.0186
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0034 0.028 0.028
Mycobacterium ulcerans hypothetical protein 0.0036 0.0316 0.0037
Echinococcus multilocularis Mastin 0.0034 0.028 0.028
Leishmania major proteasome alpha 7 subunit, putative 0.0153 0.2357 0.2379
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0152 0.2339 0.236
Brugia malayi Uncoordinated protein 44 0.0032 0.0253 0.0253
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0588 0.9911 1
Giardia lamblia 20S proteasome alpha subunit 2 0.0156 0.2409 0.2431
Plasmodium vivax proteasome subunit beta type-4, putative 0.0145 0.2217 0.2237
Leishmania major hypothetical protein, conserved 0.0018 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0319
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0186 0.0186
Leishmania major hypothetical protein, conserved 0.0044 0.0458 0.0462
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0027 0.0164 0.0164
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0152 0.2339 0.236
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0038 0.0367 0.037
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0007 0.0007
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0029 0.0206 0.0208
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0166 0.0168
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0163 0.2523 0.2546
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0588 0.9911 0.9911
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0171 0.2669 0.2693
Toxoplasma gondii PCI domain-containing protein 0.0027 0.0164 0.0165
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0027 0.0164 0.0165
Loa Loa (eye worm) hypothetical protein 0.0584 0.9843 0.9931
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0162 0.2508 0.2531
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0151 0.2327 0.2347
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0009 0.0009
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0166 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0186 0.0187
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0007 0.0007
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0163 0.2523 0.2546
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0178 0.2793 0.2818
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0027 0.0164 0.0165
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0162 0.2508 0.2531
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0009 0.0009
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0208 0.021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0143 0.0144
Loa Loa (eye worm) RPN-3 protein 0.0035 0.0302 0.0305
Onchocerca volvulus 0.0034 0.028 0.1189
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0178 0.2793 0.2818
Giardia lamblia 20S proteasome alpha subunit 1 0.0163 0.2523 0.2546
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0166 0.0168
Loa Loa (eye worm) hypothetical protein 0.0034 0.028 0.0283
Echinococcus multilocularis carbonic anhydrase 0.0056 0.0674 0.0674
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0153 0.2357 0.2379
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0195 0.3094 0.3122
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0146 0.2243 0.2243
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0018 0.0009 0.0009
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0156 0.2409 0.2431
Echinococcus multilocularis enteropeptidase 0.0034 0.028 0.028
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0151 0.2327 0.2327
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0253 0.1074
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0026 0.0143 0.0144
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0123 0.1832 0.1849
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0316 0.0319
Trichomonas vaginalis 26S proteasome subunit, putative 0.0027 0.0164 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0186 0.0187
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0253 0.0253
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0195 0.3094 0.3094
Loa Loa (eye worm) hypothetical protein 0.0056 0.0674 0.068
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0038 0.0367 0.0367
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0032 0.026 0.026
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0038 0.0367 0.0367
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0186 0.0788
Onchocerca volvulus 0.0028 0.0186 0.0788
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0162 0.2508 0.2531
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.026 0.0262
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0009 0.0009
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0593 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0319
Brugia malayi Death domain containing protein 0.0032 0.0253 0.0253
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0123 0.1832 0.1832
Loa Loa (eye worm) proteasome subunit beta type 2 0.0146 0.2243 0.2263
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0032 0.026 0.0262
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0027 0.0028
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0166 0.0168
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0186 0.0187
Loa Loa (eye worm) hypothetical protein 0.0034 0.028 0.0283
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0145 0.2217 0.2237
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Toxoplasma gondii PCI domain-containing protein 0.0032 0.026 0.0262
Schistosoma mansoni carbonic anhydrase-related 0.0056 0.0674 0.0674
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0186 0.0788
Brugia malayi Proteasome subunit alpha type 7-1 0.0195 0.3094 0.3094
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0027 0.0027
Mycobacterium ulcerans beta-lactamase 0.0036 0.0316 0.0037
Brugia malayi Protein kinase domain containing protein 0.0018 0.0007 0.0007
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0007 0.0007
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0027 0.0027
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0143 0.0144
Plasmodium vivax proteasome subunit beta type-2, putative 0.0146 0.2243 0.2263
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0123 0.1832 0.1849
Plasmodium vivax proteasome subunit beta type-6, putative 0.0152 0.2339 0.236
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0038 0.0367 0.037
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0029 0.0208 0.021
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0035 0.0302 0.0302
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0026 0.0026
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0035 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0024 0.0108 0.0109
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0032 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0255 0.0258
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0034 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0186 0.0186
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0151 0.2324 0.2345
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Entamoeba histolytica proteasome regulatory subunit, putative 0.0027 0.0164 0.0165
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0156 0.2409 0.2431
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0009 0.0009
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0029 0.0208 0.021
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0151 0.2324 0.2324
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0329 0.0329
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0253 0.0253
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0009 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.028 0.028
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0191 0.3017 0.3017
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0367 0.037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0186 0.0186
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0026 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0186 0.0187
Plasmodium vivax proteasome subunit beta type-3, putative 0.0146 0.2243 0.2263
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0253 0.0253
Echinococcus granulosus Proteasome subunit alpha beta 0.0153 0.2357 0.2357
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0035 0.0302 0.0305
Echinococcus granulosus Mastin 0.0034 0.028 0.028
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0056 0.0674 0.0674
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0056 0.0674 0.068
Onchocerca volvulus 0.0034 0.028 0.1189
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0195 0.3094 0.3122
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0332
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0313 0.513 0.513
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0034 0.028 0.0283
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0084 0.1158 0.1158
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0156 0.2409 0.2431
Leishmania major carbonic anhydrase-like protein 0.0151 0.2327 0.2347
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0145 0.2217 0.2237
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0163 0.2523 0.2523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0143 0.0144
Leishmania major proteasome alpha 1 subunit, putative 0.0151 0.2324 0.2345
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0253 0.0253
Echinococcus multilocularis Ankyrin 0.0032 0.0255 0.0255
Toxoplasma gondii ABC1 family protein 0.0036 0.0316 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0186 0.0187
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0027 0.0028
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0255 0.0255
Brugia malayi beta-lactamase family protein 0.0036 0.0316 0.0316
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0153 0.2357 0.2379
Echinococcus granulosus glycoprotein Antigen 5 0.0034 0.028 0.028
Giardia lamblia Proteasome subunit beta type 2 0.0146 0.2243 0.2263
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0186 0.0186
Leishmania major proteasome beta 2 subunit, putative 0.0178 0.2793 0.2818
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0367 0.0367
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0145 0.2217 0.2237
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0186 0.0186
Onchocerca volvulus 0.0036 0.0316 0.1339
Trichomonas vaginalis esterase, putative 0.0036 0.0316 0.0319
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0032 0.026 0.0262
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0026 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0186 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0186 0.0186
Loa Loa (eye worm) proteasome subunit beta type 1 0.0171 0.2669 0.2693
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0186 0.0186
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0146 0.2243 0.2263
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0186 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0186 0.0186
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0302 0.0305
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0253 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0186 0.0187
Onchocerca volvulus 0.0034 0.028 0.1189
Echinococcus granulosus subfamily T1A non peptidase ue 0.0162 0.2508 0.2508
Toxoplasma gondii hypothetical protein 0.0056 0.0674 0.068
Trypanosoma cruzi 20S proteasome subunit 0.0146 0.2243 0.2263
Brugia malayi nuclear hormone receptor 0.0028 0.0186 0.0186
Echinococcus granulosus carbonic anhydrase 0.0056 0.0674 0.0674
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0152 0.2339 0.236
Echinococcus granulosus proteasome subunit alpha type 6 0.0163 0.2523 0.2523
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0145 0.2217 0.2237
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0151 0.2324 0.2345
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0145 0.2217 0.2237
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0171 0.2669 0.2669
Loa Loa (eye worm) hypothetical protein 0.0034 0.028 0.0283
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0319
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0034 0.028 0.028
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0152 0.2332 0.2353
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0084 0.1158 0.1168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0316 0.0319
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0156 0.2409 0.2431
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0186 0.0186
Toxoplasma gondii proteasome subunit beta type, putative 0.0588 0.9911 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0146 0.2243 0.2263
Giardia lamblia Proteasome subunit beta type 3 0.0146 0.2243 0.2263
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0316 0.0319
Mycobacterium ulcerans lipase LipD 0.0036 0.0316 0.0037
Onchocerca volvulus 0.0034 0.028 0.1189
Plasmodium vivax proteasome subunit beta type-7, putative 0.0178 0.2793 0.2818
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0035 0.0302 0.0302
Echinococcus multilocularis proteasome subunit beta type 6 0.0152 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0032 0.0253 0.0255
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0152 0.2332 0.2353
Brugia malayi proteasome subunit beta type 1 0.0171 0.2669 0.2669
Echinococcus multilocularis proteasome (prosome, macropain) 0.0588 0.9911 0.9911
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0034 0.028 0.028
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0316 0.0319
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0186 0.0186
Toxoplasma gondii proteasome subunit alpha type, putative 0.0152 0.2332 0.2353
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0171 0.2669 0.2669
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0253 0.0253
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0195 0.3094 0.3122
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0186 0.0186
Leishmania major proteasome alpha 1 subunit, putative 0.0163 0.2523 0.2546
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0319
Onchocerca volvulus 0.0034 0.028 0.1189
Schistosoma mansoni 26S proteasome subunit S9 0.0032 0.026 0.026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0186 0.0788
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0009 0.0009
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0162 0.2508 0.2531
Echinococcus granulosus carbonic anhydrase 0.0056 0.0674 0.0674
Brugia malayi beta-lactamase family protein 0.0036 0.0316 0.0316
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0151 0.2324 0.2345
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0319
Echinococcus multilocularis adhesion regulating molecule 1 0.0084 0.1158 0.1158
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0027 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0316 0.0037
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0171 0.2669 0.2693
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0329 0.0329
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0153 0.2357 0.2379
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0146 0.2243 0.2263
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0153 0.2357 0.2379
Schistosoma mansoni carbonic anhydrase-related 0.0056 0.0674 0.0674
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0009 0.0009
Leishmania major proteasome beta 2 subunit, putative 0.0146 0.2243 0.2263
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.028 0.028
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0027 0.0028
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0018 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0186 0.0186
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0162 0.2508 0.2531
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0186 0.0186
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0038 0.0367 0.037
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0026 0.0027
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0146 0.2243 0.2243
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0195 0.3094 0.3122
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0152 0.2339 0.236
Echinococcus granulosus proteasome subunit beta type 6 0.0152 0.2339 0.2339
Loa Loa (eye worm) hypothetical protein 0.0028 0.0186 0.0187
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0171 0.2669 0.2669
Echinococcus granulosus carbonic anhydrase 0.0056 0.0674 0.0674
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0156 0.2409 0.2431
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0038 0.0367 0.0367
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0145 0.2217 0.2237
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0151 0.2324 0.2345
Leishmania major proteasome beta 3 subunit, putative 0.0146 0.2243 0.2263
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0186 0.0186
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0166 0.0166
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0166 0.0166
Echinococcus granulosus proteasome prosome macropain 0.0588 0.9911 0.9911
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0029 0.0206 0.0208
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0162 0.2508 0.2508
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0302 0.0302
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0145 0.2217 0.2217
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0053 0.0625 0.265
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0152 0.2332 0.2353
Toxoplasma gondii PCI domain-containing protein 0.0035 0.0302 0.0305
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0152 0.2332 0.2332
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0186 0.0186
Echinococcus granulosus geminin 0.0171 0.2674 0.2674
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0186 0.0187
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0186 0.0186
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0027 0.0028
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0146 0.2243 0.2263
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0026 0.0026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0186 0.0186
Giardia lamblia 20S proteasome alpha subunit 6 0.0151 0.2324 0.2345
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0588 0.9911 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0029 0.0206 0.0208
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0166 0.0168
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0145 0.2217 0.2237
Brugia malayi Kringle domain containing protein 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0186 0.0187
Loa Loa (eye worm) hypothetical protein 0.0028 0.0186 0.0187
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0152 0.2339 0.2339
Trypanosoma brucei proteasome beta 7 subunit 0.0145 0.2217 0.2237
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0166 0.0168
Loa Loa (eye worm) hypothetical protein 0.0034 0.028 0.0283
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0142 0.2158 0.2177
Brugia malayi Trypsin family protein 0.0034 0.028 0.028
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0145 0.2217 0.2217
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0367 0.0367
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0142 0.2158 0.2177
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0171 0.2669 0.2693
Leishmania major proteasome beta-1 subunit, putative 0.0152 0.2339 0.236
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0162 0.2508 0.2531
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0588 0.9911 1
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0163 0.2523 0.2546
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0166 0.0168
Loa Loa (eye worm) hypothetical protein 0.0028 0.0186 0.0187
Echinococcus granulosus carbonic anhydrase II 0.0151 0.2327 0.2327
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0588 0.9911 1
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0029 0.0208 0.021
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0029 0.0208 0.021
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0588 0.9911 1
Echinococcus granulosus proteasome subunit beta t family 0.0146 0.2243 0.2243
Plasmodium falciparum carbonic anhydrase 0.0056 0.0674 0.068
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0009 0.0009
Echinococcus multilocularis carbonic anhydrase 0.0056 0.0674 0.0674
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0195 0.3094 0.3122
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0153 0.2357 0.2379
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.026 0.0262
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0166 0.0166
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.028 0.028
Brugia malayi hypothetical protein 0.0034 0.028 0.028
Echinococcus granulosus death domain containing protein 0.0032 0.0253 0.0253
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0151 0.2327 0.2347
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0153 0.2357 0.2379
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0316 0.0037
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0009 0.0009
Brugia malayi Trypsin family protein 0.0034 0.028 0.028
Brugia malayi steroid hormone receptor 0.0028 0.0186 0.0186
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0195 0.3094 0.3122
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0163 0.2523 0.2546
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0178 0.2793 0.2818
Brugia malayi proteasome subunit alpha type 3 0.0153 0.2357 0.2357
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0162 0.2508 0.2531
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0146 0.2243 0.2243
Mycobacterium ulcerans proteasome PrcB 0.0588 0.9911 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0056 0.0674 0.0674
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0186 0.0187
Echinococcus multilocularis transmembrane protease serine 3 0.0034 0.028 0.028
Schistosoma mansoni hypothetical protein 0.0027 0.0164 0.0164
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0293 0.0296
Brugia malayi small heat shock protein 0.0584 0.9843 0.9843
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0035 0.0302 0.0305
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0302 0.0302
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0143 0.0144
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0191 0.3017 0.3017
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0029 0.0208 0.021
Trypanosoma brucei proteasome alpha 7 subunit 0.0153 0.2357 0.2379
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0027 0.0027
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0009 0.0009
Brugia malayi proteasome subunit beta type 3 0.0146 0.2243 0.2243
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0145 0.2217 0.2237
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0156 0.2409 0.2431
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0078 0.105 0.105
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0253 0.0255
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0146 0.2243 0.2263
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0052 0.0606 0.0606
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.3647 0.3472
Echinococcus multilocularis geminin 0.0171 0.2674 0.2674
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0206 0.0208
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0038 0.0367 0.0367
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0151 0.2324 0.2345
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0208 0.0208
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0143 0.0144
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.028 0.028
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0146 0.2243 0.2263
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0162 0.2508 0.2531
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0164 0.0165
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0038 0.0367 0.037
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0009 0.0009
Leishmania major hypothetical protein, conserved 0.0036 0.0316 0.0319
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0056 0.0674 0.0674
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0146 0.2243 0.2243
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0171 0.2669 0.2693
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0046 0.0047
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0186 0.0186
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0035 0.0302 0.0305
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0123 0.1832 0.1849
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0078 0.105 0.105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0009
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0026 0.0026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0186 0.0186
Onchocerca volvulus 0.0018 0.0009 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0186 0.0187
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Trypanosoma brucei proteasome beta 6 subunit 0.0171 0.2669 0.2693
Echinococcus granulosus proteasome subunit alpha type 2 0.0156 0.2409 0.2409
Leishmania major proteasome beta 5 subunit, putative 0.0588 0.9911 1
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0166 0.0168
Schistosoma mansoni netrin receptor unc5 0.0032 0.0253 0.0253
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0195 0.3094 0.3094
Giardia lamblia Hypothetical protein 0.0032 0.026 0.0262
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0316 0.0319
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0034 0.0293 0.0293
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0146 0.2243 0.2263
Giardia lamblia Proteasome subunit beta type 1 0.0171 0.2669 0.2693
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0009 0.0009
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.0171 0.2674 0.2674
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0027 0.0028
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0027 0.0028
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0123 0.1832 0.1849
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.028 0.028
Brugia malayi Proteasome A-type and B-type family protein 0.0152 0.2339 0.2339
Loa Loa (eye worm) trypsin family protein 0.0034 0.028 0.0283
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0162 0.2508 0.2508
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0186 0.0186
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0153 0.2357 0.2357
Brugia malayi proteasome subunit alpha type 4 0.0137 0.2081 0.2081
Loa Loa (eye worm) hypothetical protein 0.0034 0.028 0.0283
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0027 0.0028
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0007 0.0007
Brugia malayi Proteasome A-type and B-type family protein 0.0588 0.9911 0.9911
Echinococcus multilocularis proteasome subunit alpha type 6 0.0163 0.2523 0.2523
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0316 0.0316
Echinococcus granulosus proteasome subunit beta type 7 0.0593 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.028 0.028
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0186 0.0187
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0166 0.0168
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0032 0.026 0.0262
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.028 0.028
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0034 0.028 0.028
Brugia malayi Protein kinase domain containing protein 0.0032 0.0253 0.0253
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0034 0.0293 0.0293
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0143 0.0144
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0186 0.0186
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0166 0.0168
Loa Loa (eye worm) hypothetical protein 0.0056 0.0674 0.068
Brugia malayi hypothetical protein 0.0036 0.0329 0.0329
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0171 0.2669 0.2693
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0084 0.1158 0.1158
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0162 0.2508 0.2531
Schistosoma mansoni carbonic anhydrase-related 0.0056 0.0674 0.0674
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0151 0.2324 0.2345
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0178 0.2793 0.2818
Echinococcus granulosus adhesion regulating molecule 1 0.0084 0.1158 0.1158
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0588 0.9911 1
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0163 0.2523 0.2546
Schistosoma mansoni hypothetical protein 0.0056 0.0674 0.0674
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0164 0.0165
Entamoeba histolytica hypothetical protein 0.0034 0.0293 0.0296
Echinococcus granulosus enteropeptidase 0.0034 0.028 0.028
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0166 0.0168
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0206 0.0206
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0029 0.0208 0.021
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0027 0.0027
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0009 0.0009
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0009 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0152 0.2332 0.2332
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0029 0.0206 0.0208
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0046 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0316 0.0319
Leishmania major proteasome beta 7 subunit, putative 0.0145 0.2217 0.2237
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0146 0.2243 0.2263
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0152 0.2332 0.2353
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0123 0.1832 0.5
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0009 0.0009
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0152 0.2332 0.2353
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0163 0.2523 0.2546
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0146 0.2243 0.2263
Leishmania major proteasome alpha 7 subunit, putative 0.0195 0.3094 0.3122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0186 0.0186
Brugia malayi proteasome subunit beta type 2 0.0146 0.2243 0.2243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0032 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0007
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0026 0.0143 0.0143
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0152 0.2332 0.2353
Schistosoma mansoni hypothetical protein 0.0036 0.0329 0.0329
Loa Loa (eye worm) carbonic anhydrase 3 0.0151 0.2327 0.2347
Onchocerca volvulus 0.0018 0.0009 0.0037
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0038 0.0367 0.037
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0151 0.2324 0.2324
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0018 0.0018
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0151 0.2324 0.2345
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0027 0.0164 0.0164
Onchocerca volvulus 0.0036 0.0316 0.1339
Loa Loa (eye worm) proteasome Regulatory Particle 0.0029 0.0206 0.0208
Onchocerca volvulus 0.0036 0.0316 0.1339
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0018 0.0009 0.0009
Brugia malayi Proteasome subunit alpha type 1 0.0137 0.2073 0.2073
Echinococcus multilocularis carbonic anhydrase II 0.0151 0.2327 0.2327
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0588 0.9911 1
Loa Loa (eye worm) PCI domain-containing protein 0.0027 0.0164 0.0165
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0156 0.2409 0.2431
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0332
Leishmania major proteasome alpha 2 subunit, putative 0.0156 0.2409 0.2431
Plasmodium falciparum proteasome subunit beta type-5 0.0588 0.9911 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0674 0.068
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0056 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Echinococcus granulosus Proteasome subunit alpha type 7 0.0195 0.3094 0.3094
Brugia malayi Trypsin family protein 0.0034 0.028 0.028
Toxoplasma gondii proteasome subunit alpha type, putative 0.0073 0.096 0.0968
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0329 0.0329
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0009 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0316 0.0316
Plasmodium vivax proteasome subunit beta type-1, putative 0.0171 0.2669 0.2693
Schistosoma mansoni coup transcription factor 0.0028 0.0186 0.0186
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0027 0.0028
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0186 0.0186
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0027 0.0027
Giardia lamblia 20S proteasome alpha subunit 3 0.0152 0.2332 0.2353
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0145 0.2217 0.2237
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0029 0.0193 0.0195
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0186 0.0186
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0171 0.2669 0.2693
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0195 0.3094 0.3122
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0162 0.2508 0.2531
Schistosoma mansoni hypothetical protein 0.0171 0.2674 0.2674
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0026 0.0027
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0166 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0186 0.0186
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0145 0.2217 0.2217
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0316 0.0316
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0195 0.3094 0.3094
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0152 0.2332 0.2353
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0034 0.0293 0.0296
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0147 0.2257 0.2257
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0034 0.0293 0.0293
Onchocerca volvulus 0.0034 0.028 0.1189
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0195 0.3094 0.3094
Toxoplasma gondii SAC3/GANP family protein 0.0026 0.0143 0.0144
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.028 0.028
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0038 0.0367 0.037
Echinococcus multilocularis carbonic anhydrase 0.0056 0.0674 0.0674
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0029 0.0208 0.0208
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0032 0.026 0.0262
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0162 0.2508 0.2508
Toxoplasma gondii heat shock protein hslv, putative 0.0123 0.1832 0.1849
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0588 0.9911 1
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0166 0.0166
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0007 0.0007
Brugia malayi 20S proteasome alpha5 subunit 0.0162 0.2508 0.2508
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0186 0.0186
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0027 0.0164 0.0165
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0026 0.0143 0.0144
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0044 0.0458 0.0462
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0146 0.2243 0.2263
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0166 0.0168
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0145 0.2217 0.2237
Giardia lamblia 26S protease regulatory subunit 6B 0.0018 0.0009 0.0009
Brugia malayi ecdysteroid receptor 0.0028 0.0186 0.0186
Entamoeba histolytica proteasome regulatory subunit, putative 0.0029 0.0206 0.0208
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0166 0.0166
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0029 0.0206 0.0206
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0123 0.1832 0.1849
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0186 0.0186
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0027 0.0027
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0186 0.0186
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0026 0.0027
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0035 0.0302 0.0305
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0018 0.0009 0.0009
Giardia lamblia 20S proteasome alpha subunit 4 0.0195 0.3094 0.3122
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0151 0.2324 0.2324
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0152 0.2339 0.236
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0153 0.2357 0.2379
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0123 0.1832 0.158
Mycobacterium ulcerans proteasome PrcA 0.0123 0.1832 0.1611
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0186 0.0186
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0143 0.0143
Echinococcus granulosus transmembrane protease serine 3 0.0034 0.028 0.028
Brugia malayi nuclear receptor NHR-88 0.0028 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0028 0.0186 0.0187
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0143 0.0144
Brugia malayi proteasome subunit alpha type 2 0.0156 0.2409 0.2409
Toxoplasma gondii peptidase, T1 family protein 0.0153 0.2357 0.2379
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0032 0.026 0.0262
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0143 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0186 0.0186
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0186 0.0186
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0009 0.0009
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0186 0.0186
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0009 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Loa Loa (eye worm) proteasome subunit beta type 3 0.0146 0.2243 0.2263
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0009 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0186 0.0186
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0018 0.0009 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0186 0.0186
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0166 0.0166
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0178 0.2793 0.2818
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0034 0.0293 0.0296
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0146 0.2243 0.2243
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0032 0.026 0.026
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0143 0.0143
Brugia malayi PCI domain containing protein 0.0029 0.0208 0.0208
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0588 0.9911 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.028 0.0283
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0151 0.0152
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0316 0.0319
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0195 0.3094 0.3122
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0007 0.0007
Trypanosoma brucei carbonic anhydrase-like protein 0.0151 0.2327 0.2347
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0162 0.2508 0.2531
Echinococcus multilocularis proteasome subunit alpha type 2 0.0156 0.2409 0.2409
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0152 0.2339 0.236
Loa Loa (eye worm) PCI domain-containing protein 0.0029 0.0208 0.021
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0029 0.0206 0.0208
Loa Loa (eye worm) beta-lactamase 0.0036 0.0316 0.0319
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0151 0.2327 0.2347
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0151 0.2324 0.2345
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0145 0.2217 0.2237
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0027 0.0028
Brugia malayi Trypsin family protein 0.0034 0.028 0.028
Plasmodium vivax proteasome subunit beta type-5, putative 0.0588 0.9911 1
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0166 0.0168
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0029 0.0193 0.0195
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0027 0.0028
Loa Loa (eye worm) proteasome regulatory particle 0.0032 0.026 0.0262
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0156 0.2409 0.2409
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0123 0.1832 0.1849
Brugia malayi beta-lactamase 0.0036 0.0316 0.0316
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0009 0.0009
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0171 0.2669 0.2693
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0056 0.0674 0.0674
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0332
Toxoplasma gondii proteasome subunit alpha1, putative 0.0163 0.2523 0.2546
Onchocerca volvulus 0.0018 0.0007 0.003
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0029 0.0208 0.021
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0009 0.0009
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0152 0.2332 0.2353
Schistosoma mansoni hypothetical protein 0.0034 0.028 0.028
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0186 0.0186
Toxoplasma gondii proteasome beta subunit 0.0146 0.2243 0.2263
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0029 0.0206 0.0206
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0178 0.2793 0.2818
Plasmodium falciparum proteasome subunit beta type-4 0.0145 0.2217 0.2237
Echinococcus multilocularis glycoprotein Antigen 5 0.0034 0.028 0.028
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0153 0.2357 0.2357
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0151 0.2327 0.2327
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0009 0.0009
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0145 0.2217 0.2237
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0332
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0123 0.1832 0.158
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0143 0.0143
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0038 0.0367 0.037
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0163 0.2523 0.2546
Brugia malayi Trypsin-like protease protein 5 0.0034 0.028 0.028
Giardia lamblia 20S proteasome alpha subunit 7 0.0153 0.2357 0.2379
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0186 0.0186
Giardia lamblia 20S proteasome alpha subunit 5 0.0162 0.2508 0.2531
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0316 0.0319
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0178 0.2793 0.2818
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0146 0.2243 0.2243
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0166 0.0166
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0137 0.2084 0.2102
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0029 0.0206 0.0206
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0152 0.2332 0.2332
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0152 0.2339 0.236
Echinococcus granulosus nuclear factor of activated T cells 5 0.0313 0.513 0.513
Brugia malayi PCI domain containing protein 0.0027 0.0164 0.0164
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0146 0.2243 0.2243
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0186 0.0186
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0146 0.2243 0.2263
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0166 0.0166
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0009 0.0009
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0163 0.2523 0.2546
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0195 0.3094 0.3122
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0186 0.0186
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0166 0.0168
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0166 0.0168
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0146 0.2243 0.2263
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0193 0.0193
Brugia malayi proteasome subunit alpha type 6 0.0163 0.2523 0.2523
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0029 0.0206 0.0208
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0151 0.2327 0.2327
Toxoplasma gondii proteasome subunit 0.0152 0.2339 0.236
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0186 0.0186
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0151 0.2327 0.2327
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0186 0.0186
Brugia malayi Proteasome A-type and B-type family protein 0.0145 0.2217 0.2217
Onchocerca volvulus Notchless protein homolog 0.0153 0.2357 1
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0034 0.0293 0.0296
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.028 0.028
Schistosoma mansoni hypothetical protein 0.0078 0.105 0.105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0316 0.0316
Echinococcus multilocularis proteasome subunit beta type 7 0.0593 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.