Detailed information for compound 1543131

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 469.53 | Formula: C25H31N3O6
  • H donors: 0 H acceptors: 3 LogP: 1.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=C(C(=O)OC)C2C3(C(=N1)N(CCCOC(C)C)C(=O)CC3)c1c(N2C)cccc1
  • InChi: 1S/C25H31N3O6/c1-15(2)34-14-8-13-28-18(29)11-12-25-16-9-6-7-10-17(16)27(3)21(25)19(22(30)32-4)20(23(31)33-5)26-24(25)28/h6-7,9-10,15,21H,8,11-14H2,1-5H3
  • InChiKey: RKDXRKWBPXAVEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0035 0.0035
Schistosoma mansoni nuclear hormone receptor 0.0114 0.1207 0.1207
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0062 0.0559 0.0997
Brugia malayi nuclear hormone receptor 0.0114 0.1207 0.2153
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.006 0.0542 0.0967
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0114 0.1207 0.2153
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0114 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Onchocerca volvulus 0.0034 0.0215 0.0323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0114 0.1207 0.2153
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0054 0.0462 0.0824
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0035 0.0062
Brugia malayi Steroid receptor seven-up type 2 0.0114 0.1207 0.2153
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0584 0.0584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0302 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0114 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0263 0.0517
Echinococcus multilocularis agrin 0.0038 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Echinococcus multilocularis thyroid hormone receptor alpha 0.0389 0.4594 0.4594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0062 0.0559 0.0997
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0054 0.0462 0.0462
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0038 0.0263 0.047
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0035 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0444 0.6107
Brugia malayi SPARC precursor 0.0038 0.0263 0.047
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0035 0.0035
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.006 0.0542 0.0542
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0263 0.047
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0019
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0114 0.1207 0.2153
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.2775 0.4949
Loa Loa (eye worm) hypothetical protein 0.0062 0.0559 0.0997
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0114 0.1207 0.1207
Loa Loa (eye worm) DR-78 0.0054 0.0462 0.0824
Echinococcus granulosus single minded 2 0.0037 0.0254 0.0254
Echinococcus granulosus cysteine protease 0.0017 0.0012 0.0012
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0263 0.047
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0035 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0035 0.0062
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Onchocerca volvulus 0.0034 0.0215 0.0323
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0826 1 1
Entamoeba histolytica cysteine protease, putative 0.0034 0.0215 0.2863
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0114 0.1207 0.1207
Echinococcus multilocularis carbonic anhydrase 0.0062 0.0559 0.0559
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0291 0.0291
Onchocerca volvulus 0.0114 0.1207 0.2104
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1388 0.7489
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0035 0.0062
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0274 0.3184 0.3184
Schistosoma mansoni ap endonuclease 0.0041 0.0302 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0114 0.1207 0.2153
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0444 0.0444
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0166 0.185 0.3299
Brugia malayi TAR-binding protein 0.0063 0.0573 0.1021
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0035 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0542 0.0967
Brugia malayi Nuclear hormone receptor E75 0.0054 0.0462 0.0824
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0215 0.2863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0077 0.0911
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0114 0.1207 0.2153
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0263 0.0517
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0166 0.185 0.185
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0302 0.4093
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0444 0.3409
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0114 0.1207 0.1207
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0114 0.1207 0.1207
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0035 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0444 0.6107
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0035 0.0035
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0415 0.0415
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0215 0.3702
Schistosoma mansoni nuclear receptor 0.0054 0.0462 0.0462
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0035 0.0062
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0075 0.072 0.1283
Loa Loa (eye worm) hypothetical protein 0.0114 0.1207 0.2153
Loa Loa (eye worm) hypothetical protein 0.0062 0.0559 0.0997
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Schistosoma mansoni hypothetical protein 0.004 0.0291 0.0291
Onchocerca volvulus 0.0055 0.048 0.0799
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0062 0.0559 0.0559
Echinococcus multilocularis carbonic anhydrase 0.0062 0.0559 0.0559
Echinococcus granulosus tumor protein p63 0.0359 0.423 0.423
Schistosoma mansoni hypothetical protein 0.0274 0.3184 0.3184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Brugia malayi Cathepsin L-like precursor 0.0034 0.0215 0.0383
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0444 0.235
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.072 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.1709 0.3048
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0263 0.047
Loa Loa (eye worm) hypothetical protein 0.0064 0.0584 0.1041
Schistosoma mansoni hypothetical protein 0.0348 0.4095 0.4095
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0215 0.0323
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0114 0.1207 0.2153
Echinococcus multilocularis nAChR subunit 0.0019 0.0035 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0114 0.1207 0.1207
Trypanosoma cruzi MFS transporter, putative 0.0055 0.048 0.2545
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0665 1
Brugia malayi tailless protein 0.0054 0.0462 0.0824
Echinococcus multilocularis Protein lozenge 0.0059 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0444 0.1403
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0114 0.1207 0.1207
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0263 0.047
Schistosoma mansoni organic anion transporter 0.0055 0.048 0.048
Onchocerca volvulus 0.0055 0.048 0.0799
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Onchocerca volvulus 0.0055 0.048 0.0799
Brugia malayi Cation transporter family protein 0.0019 0.0035 0.0062
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0302 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0114 0.1207 0.1207
Entamoeba histolytica hypothetical protein 0.004 0.0291 0.3934
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Schistosoma mansoni nAChR subunit 0.0019 0.0035 0.0035
Leishmania major cathepsin L-like protease 0.0129 0.1388 0.7178
Loa Loa (eye worm) nuclear receptor NHR-67 0.0054 0.0462 0.0824
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0254 0.0254
Brugia malayi hypothetical protein 0.006 0.0542 0.0967
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0035 0.0035
Brugia malayi nuclear hormone receptor family member odr-7 0.0054 0.0462 0.0824
Brugia malayi Nuclear hormone receptor-like 1 0.0114 0.1207 0.2153
Brugia malayi cathepsin L-like precursor 0.0023 0.0077 0.0137
Schistosoma mansoni coup transcription factor 0.0114 0.1207 0.1207
Echinococcus granulosus ubiquitin specific protease 41 0.0075 0.072 0.072
Echinococcus multilocularis carbonic anhydrase 0.0062 0.0559 0.0559
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0114 0.1207 0.1207
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.048 0.0856
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.125 0.6737
Loa Loa (eye worm) hypothetical protein 0.0138 0.1497 0.267
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0291 0.0291
Schistosoma mansoni organic anion transporter 0.0055 0.048 0.048
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0114 0.1207 0.1207
Onchocerca volvulus 0.0034 0.0215 0.0323
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0215 0.0323
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0114 0.1207 0.1207
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0054 0.0462 0.0767
Loa Loa (eye worm) runx1 0.0059 0.0526 0.0938
Echinococcus granulosus cpg binding protein 0.0061 0.0554 0.0554
Brugia malayi nuclear receptor NHR-88 0.0114 0.1207 0.2153
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0054 0.0462 0.0462
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0302 1
Brugia malayi orphan nuclear receptor NR2E1 0.0054 0.0462 0.0824
Echinococcus granulosus follistatin 0.0038 0.0263 0.0263
Brugia malayi hypothetical protein 0.0055 0.048 0.0856
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0215 0.2863
Brugia malayi Cation transporter family protein 0.0019 0.0035 0.0062
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0444 0.0444
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.2284 0.4073
Schistosoma mansoni cpg binding protein 0.0061 0.0554 0.0554
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0035 0.0035
Brugia malayi Cathepsin L-like precursor 0.0034 0.0215 0.0383
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0062 0.0559 0.0997
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0114 0.1207 0.2153
Onchocerca volvulus Putative organic anion transporter 0.0055 0.048 0.0799
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0444 0.0792
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0114 0.1207 0.1207
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0665 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0035 0.0062
Plasmodium falciparum carbonic anhydrase 0.0062 0.0559 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0012 0.0012
Toxoplasma gondii protease inhibitor PI2 0.0038 0.0263 0.0517
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0035 0.0062
Schistosoma mansoni retinoic acid receptor RXR 0.0114 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Echinococcus granulosus tar DNA binding protein 0.0063 0.0573 0.0573
Onchocerca volvulus 0.0055 0.048 0.0799
Loa Loa (eye worm) fibroinase 0.0034 0.0215 0.0383
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0437 0.5194 0.5194
Toxoplasma gondii hypothetical protein 0.0062 0.0559 0.3667
Brugia malayi nuclear receptor NHR-88 0.0054 0.0462 0.0824
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0665 0.2751
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0075 0.072 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0302 0.0302
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0128 0.0228
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0075 0.072 0.072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0114 0.1207 0.2153
Echinococcus multilocularis geminin 0.0348 0.4095 0.4095
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0215 0.2863
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0062 0.0559 0.0997
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Onchocerca volvulus 0.0037 0.0254 0.0394
Echinococcus granulosus ecdysone induced protein 78C 0.0114 0.1207 0.1207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0215 0.3702
Echinococcus multilocularis carbonic anhydrase II 0.0166 0.185 0.185
Loa Loa (eye worm) hypothetical protein 0.0114 0.1207 0.2153
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0114 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Schistosoma mansoni cpg binding protein 0.0058 0.0513 0.0513
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0444 0.6107
Loa Loa (eye worm) nuclear hormone receptor 0.0054 0.0462 0.0824
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0573 0.1021
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Onchocerca volvulus Putative organic anion transporter 0.0055 0.048 0.0799
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0075 0.072 0.072
Echinococcus granulosus agrin 0.0038 0.0263 0.0263
Echinococcus granulosus carbonic anhydrase 0.0062 0.0559 0.0559
Echinococcus multilocularis dnaJ subfamily B 0.0826 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0114 0.1207 0.2153
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0446 0.0446
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.048 0.048
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.048 0.048
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0054 0.0462 0.0462
Echinococcus granulosus nAChR subunit 0.0019 0.0035 0.0035
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.006 0.0542 0.0967
Loa Loa (eye worm) hypothetical protein 0.0168 0.187 0.3334
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0263 0.047
Loa Loa (eye worm) hypothetical protein 0.0055 0.048 0.0856
Brugia malayi Cathepsin L-like precursor 0.0034 0.0215 0.0383
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0215 0.0383
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0573
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0114 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0584 0.0584
Brugia malayi Cathepsin L-like precursor 0.0034 0.0215 0.0383
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0166 0.185 0.3299
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0114 0.1207 0.2153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.1154 1
Brugia malayi steroid hormone receptor 0.0114 0.1207 0.2153
Echinococcus multilocularis expressed protein 0.0038 0.0263 0.0263
Schistosoma mansoni ap endonuclease 0.0041 0.0302 0.0302
Loa Loa (eye worm) cysteine protease 0.0034 0.0215 0.0383
Brugia malayi nuclear receptor RXR 0.006 0.0542 0.0967
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0114 0.1207 0.2153
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.048 0.0856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0114 0.1207 0.1207
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0114 0.1207 0.2153
Loa Loa (eye worm) hypothetical protein 0.0038 0.0263 0.047
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0035 0.0062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0584 0.0584
Onchocerca volvulus 0.0054 0.0462 0.0767
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0114 0.1207 0.1207
Onchocerca volvulus 0.0038 0.0263 0.041
Brugia malayi hypothetical protein 0.0471 0.5608 1
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0584 0.1041
Onchocerca volvulus 0.0053 0.0446 0.0738
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0077 0.0911
Schistosoma mansoni hypothetical protein 0.0064 0.0584 0.0584
Echinococcus granulosus cathepsin l1 0.0023 0.0077 0.0077
Brugia malayi Cytochrome P450 family protein 0.0027 0.0128 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0665 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.2284 0.4073
Echinococcus multilocularis tumor protein p63 0.0359 0.423 0.423
Brugia malayi Cathepsin L-like precursor 0.0034 0.0215 0.0383
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0114 0.1207 0.2153
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0665 0.0665
Loa Loa (eye worm) RNA binding protein 0.0063 0.0573 0.1021
Echinococcus granulosus geminin 0.0348 0.4095 0.4095
Leishmania major cathepsin L-like protease 0.0129 0.1388 0.7178
Schistosoma mansoni carbonic anhydrase-related 0.0062 0.0559 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0114 0.1207 0.2153
Onchocerca volvulus 0.0471 0.5608 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0114 0.1207 0.2153
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0215 0.0383
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0665 0.0665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Entamoeba histolytica hypothetical protein 0.004 0.0291 0.3934
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0035 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0114 0.1207 0.2153
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0054 0.0462 0.0462
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0075 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0215 0.0383
Loa Loa (eye worm) hypothetical protein 0.0055 0.048 0.0856
Echinococcus multilocularis cathepsin L 0.0017 0.0012 0.0012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0302 0.5292
Onchocerca volvulus 0.0034 0.0215 0.0323
Schistosoma mansoni nAChR subunit 0.0019 0.0035 0.0035
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0215 0.0215
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0035 0.0062
Echinococcus multilocularis cysteine protease 0.0034 0.0215 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0302 0.1575
Schistosoma mansoni hypothetical protein 0.0138 0.1497 0.1497
Loa Loa (eye worm) hypothetical protein 0.006 0.0542 0.0967
Echinococcus multilocularis ecdysone induced protein 78C 0.0114 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0114 0.1207 0.2153
Loa Loa (eye worm) hypothetical protein 0.006 0.0542 0.0967
Loa Loa (eye worm) hypothetical protein 0.0055 0.048 0.0856
Echinococcus granulosus Nuclear hormone receptor HR96 0.0054 0.0462 0.0462
Brugia malayi prostaglandin transporter 0.0055 0.048 0.0856
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.1497 0.267
Loa Loa (eye worm) hypothetical protein 0.0053 0.0446 0.0795
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0075 0.072 0.072
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0075 0.072 0.3087
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0444 0.235
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0035 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0389 0.4594 0.4594
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0114 0.1207 0.2153
Echinococcus granulosus cathepsin l1 0.0034 0.0215 0.0215
Brugia malayi nuclear hormone receptor family member nhr-6 0.0054 0.0462 0.0824
Schistosoma mansoni nAChR subunit 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0034 0.0215 0.0323
Brugia malayi nuclear receptor RXR 0.0054 0.0462 0.0824
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0075 0.072 0.1283
Entamoeba histolytica hypothetical protein 0.004 0.0291 0.3934
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0444 0.1403
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0201 0.2284 0.4073
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.006 0.0542 0.0542
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0444 0.0444
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0075 0.072 0.072
Onchocerca volvulus Putative organic anion transporter 0.0055 0.048 0.0799
Echinococcus multilocularis nuclear receptor nhr 48 0.0054 0.0462 0.0462
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0062 0.0559 0.0997
Loa Loa (eye worm) steroid hormone receptor 0.0114 0.1207 0.2153
Schistosoma mansoni nuclear receptor 0.0054 0.0462 0.0462
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0035 0.0035
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.1048 0.5635
Loa Loa (eye worm) ctsf protein 0.0034 0.0215 0.0383
Schistosoma mansoni hypothetical protein 0.0348 0.4095 0.4095
Brugia malayi hypothetical protein 0.0054 0.0462 0.0824
Echinococcus granulosus carbonic anhydrase II 0.0166 0.185 0.185
Brugia malayi Cathepsin L-like precursor 0.0034 0.0215 0.0383
Brugia malayi Nuclear hormone receptor E75 0.0054 0.0462 0.0824
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0035 0.0035
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0302 0.4093
Plasmodium vivax vivapain-2 0.0034 0.0215 0.6995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0542 0.0967
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.072 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Schistosoma mansoni carbonic anhydrase-related 0.0062 0.0559 0.0559
Brugia malayi RNA binding protein 0.0063 0.0573 0.1021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Schistosoma mansoni agrin 0.0038 0.0263 0.0263
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0513 0.0916
Schistosoma mansoni nuclear receptor nhr-48 0.0054 0.0462 0.0462
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0012 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0665 0.4787
Echinococcus granulosus Nuclear hormone receptor HR96 0.0054 0.0462 0.0462
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0035 0.0035
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0055 0.048 0.0856
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0035 0.0062
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0012 0.0022
Brugia malayi hypothetical protein 0.006 0.0542 0.0967
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1388 0.7489
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0114 0.1207 0.1207
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0215 0.0215
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0114 0.1207 0.2104
Loa Loa (eye worm) hypothetical protein 0.006 0.0542 0.0967
Schistosoma mansoni zinc finger protein 0.0054 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Schistosoma mansoni lozenge 0.0059 0.0526 0.0526
Schistosoma mansoni steroid hormone receptor ad4bp 0.0114 0.1207 0.1207
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0444 0.235
Entamoeba histolytica hypothetical protein 0.004 0.0291 0.3934
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0542 0.0542
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0302 0.1575
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0054 0.0462 0.0824
Schistosoma mansoni nAChR subunit 0.0019 0.0035 0.0035
Onchocerca volvulus Protein ultraspiracle homolog 0.0114 0.1207 0.2104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Echinococcus multilocularis ubiquitin specific protease 41 0.0075 0.072 0.072
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0035 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0665 1
Echinococcus granulosus carbonic anhydrase 0.0062 0.0559 0.0559
Brugia malayi hypoxia-induced factor 1 0.0155 0.1709 0.3048
Loa Loa (eye worm) hypothetical protein 0.0471 0.5608 1
Schistosoma mansoni cpg binding protein 0.0061 0.0554 0.0554
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0263 0.0517
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0035 0.0062
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0054 0.0462 0.0462
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.1388 0.7489
Onchocerca volvulus 0.0055 0.048 0.0799
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0114 0.1207 0.2153
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0077 0.0911
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0054 0.0462 0.0462
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0302 0.0538
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0462 0.0462
Onchocerca volvulus 0.0034 0.0215 0.0323
Schistosoma mansoni carbonic anhydrase-related 0.0062 0.0559 0.0559
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.2284 0.4073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Brugia malayi PAS domain containing protein 0.005 0.0415 0.074
Schistosoma mansoni RAR-like nuclear receptor 0.0114 0.1207 0.1207
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.072 0.3849
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Echinococcus multilocularis cpg binding protein 0.0061 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0035 0.0062
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0302 0.0532
Brugia malayi MAP kinase sur-1 0.0052 0.0444 0.0792
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.048 0.2823
Schistosoma mansoni hypothetical protein 0.0064 0.0584 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0573 0.0573
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0573
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0166 0.185 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0584 0.1041
Schistosoma mansoni nAChR subunit 0.0019 0.0035 0.0035
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0075 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0055 0.048 0.0856
Plasmodium vivax vivapain-2 0.0034 0.0215 0.6995
Brugia malayi hypothetical protein 0.004 0.0291 0.0518
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0665 0.0665
Echinococcus multilocularis GPCR, family 2 0.0064 0.0584 0.0584
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0215 0.1102
Toxoplasma gondii exonuclease III APE 0.0041 0.0302 0.0926
Loa Loa (eye worm) hypothetical protein 0.0055 0.048 0.0856
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.072 0.3849
Trypanosoma brucei carbonic anhydrase-like protein 0.0166 0.185 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0166 0.185 0.185
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0114 0.1207 0.2153
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0444 0.235
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0215 0.0215
Brugia malayi Cathepsin L-like precursor 0.0023 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0055 0.048 0.0856
Onchocerca volvulus 0.0034 0.0215 0.0323
Echinococcus granulosus cathepsin L 0.0017 0.0012 0.0012
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0035 0.0035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0291 0.0291
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0035 0.0062
Loa Loa (eye worm) hypothetical protein 0.0471 0.5608 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0166 0.185 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0263 0.0517
Leishmania major cathepsin L-like protease 0.0129 0.1388 0.7178
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0215 0.0215
Onchocerca volvulus 0.0054 0.0462 0.0767
Brugia malayi Cation transporter family protein 0.0019 0.0035 0.0062
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0584 0.1041
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0035 0.0035
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0035 0.0062
Schistosoma mansoni single-minded 0.005 0.0415 0.0415
Brugia malayi conserved hypotetical protein 0.0054 0.0462 0.0824
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0016 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0302 0.1575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0035 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0444 0.6107
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.048 0.0856
Brugia malayi Cathepsin L-like precursor 0.0023 0.0077 0.0137
Schistosoma mansoni follistatin 0.0038 0.0263 0.0263
Echinococcus multilocularis cysteine protease 0.0034 0.0215 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.1388 0.7489
Schistosoma mansoni thyroid hormone receptor 0.0389 0.4594 0.4594
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0215 0.3702
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0035 0.0062
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.1388 0.7489
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0077 0.0137
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0035 0.0062
Echinococcus multilocularis follistatin 0.0038 0.0263 0.0263
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0215 0.0215
Brugia malayi MH2 domain containing protein 0.0241 0.2775 0.4949
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0444 0.235
Onchocerca volvulus 0.0058 0.0513 0.0859
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0302 0.4093
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.072 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0573 0.0573
Schistosoma mansoni hypothetical protein 0.0064 0.0584 0.0584
Brugia malayi secreted modular calcium-binding protein 1 0.0038 0.0263 0.047
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0035 0.0035
Schistosoma mansoni nAChR subunit 0.0019 0.0035 0.0035
Schistosoma mansoni nAChR subunit 0.0019 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0114 0.1207 0.2153
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0062
Onchocerca volvulus 0.0023 0.0077 0.0076
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0035 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.2775 0.4949
Loa Loa (eye worm) hypothetical protein 0.0062 0.0559 0.0997
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0254 0.0454
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0012 0.0012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0215 0.0383
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Loa Loa (eye worm) hypothetical protein 0.0038 0.0263 0.047
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0062 0.0559 0.0997
Echinococcus granulosus thyroid hormone receptor alpha 0.0054 0.0462 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0114 0.1207 0.2153
Onchocerca volvulus Bile acid receptor homolog 0.0114 0.1207 0.2104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0077 0.0077
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0302 0.0538
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0035 0.0062
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.048 0.0856
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0274 0.3184 0.3184
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0035 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0462 0.0462
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0573 0.1021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.048 0.048
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0462 0.0462
Schistosoma mansoni hypothetical protein 0.0064 0.0584 0.0584
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0035 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0215 0.2863
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0035 0.0035
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0035 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1317 0.1317
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0462 0.0462
Brugia malayi CXXC zinc finger family protein 0.0058 0.0513 0.0916
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0114 0.1207 0.2153
Echinococcus multilocularis FTZ F1 alpha 0.0114 0.1207 0.1207
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0166 0.185 0.3299
Leishmania major carbonic anhydrase-like protein 0.0166 0.185 1
Trypanosoma brucei protein kinase, putative 0.0052 0.0444 0.235
Brugia malayi nuclear receptor NHR-67 0.0054 0.0462 0.0824
Echinococcus granulosus FTZ F1 alpha 0.0114 0.1207 0.1207
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0444 0.2442
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0054 0.0462 0.0767
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0035 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.0114 0.1207 0.2153
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0114 0.1207 0.1207
Loa Loa (eye worm) carbonic anhydrase 3 0.0166 0.185 0.3299
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.0824
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0444 0.0444
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0573 0.1021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0584 0.0584
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0665 0.0665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0215 0.2863
Loa Loa (eye worm) hypothetical protein 0.0114 0.1207 0.2153
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0302 0.1156
Echinococcus granulosus GPCR family 2 0.0064 0.0584 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0114 0.1207 0.2153
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0263 0.047
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0215 0.0323
Loa Loa (eye worm) hypothetical protein 0.006 0.0542 0.0967
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0019
Brugia malayi hypothetical protein 0.0168 0.187 0.3334
Schistosoma mansoni carbonic anhydrase 0.0062 0.0559 0.0559
Loa Loa (eye worm) agrin synaptic family protein 0.0038 0.0263 0.047
Brugia malayi nuclear hormone receptor 0.0054 0.0462 0.0824
Brugia malayi hypothetical protein 0.0054 0.0462 0.0824
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0019 0.0033
Echinococcus granulosus carbonic anhydrase 0.0062 0.0559 0.0559
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0075 0.072 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.006 0.0542 0.0542
Echinococcus granulosus nuclear receptor nhr 48 0.0054 0.0462 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0114 0.1207 0.2153
Brugia malayi ecdysteroid receptor 0.0114 0.1207 0.2153
Brugia malayi ecdysone receptor 0.0054 0.0462 0.0824
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0215 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0215 0.2863
Loa Loa (eye worm) hypothetical protein 0.0055 0.048 0.0856
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.072 0.3849

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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