Detailed information for compound 1543241

Basic information

Technical information
  • TDR Targets ID: 1543241
  • Name: 1-[1-(4-fluorobenzoyl)piperidin-4-yl]-4-[(4-f luorophenyl)methyl]piperazine-2,3-dione
  • MW: 427.444 | Formula: C23H23F2N3O3
  • H donors: 0 H acceptors: 3 LogP: 2.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CN1CCN(C(=O)C1=O)C1CCN(CC1)C(=O)c1ccc(cc1)F
  • InChi: 1S/C23H23F2N3O3/c24-18-5-1-16(2-6-18)15-27-13-14-28(23(31)22(27)30)20-9-11-26(12-10-20)21(29)17-3-7-19(25)8-4-17/h1-8,20H,9-15H2
  • InChiKey: WCDDZDFAFITHAB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[1-(4-fluorobenzoyl)-4-piperidyl]-4-[(4-fluorophenyl)methyl]piperazine-2,3-dione
  • 1-[(4-fluorophenyl)methyl]-4-[1-[(4-fluorophenyl)-oxomethyl]-4-piperidinyl]piperazine-2,3-dione
  • 1-[1-(4-fluorobenzoyl)-4-piperidyl]-4-(4-fluorobenzyl)piperazine-2,3-quinone
  • 1-[1-(4-fluorophenyl)carbonylpiperidin-4-yl]-4-[(4-fluorophenyl)methyl]piperazine-2,3-dione
  • F116-0383
  • NCGC00127813-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.0232 0.0177
Mycobacterium ulcerans heat shock protein 90 0.0047 0.0279 0.4845
Echinococcus granulosus biogenic amine 5HT receptor 0.0175 0.1929 0.1884
Schistosoma mansoni hypothetical protein 0.0034 0.0119 0.0064
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0174 0.0239
Trypanosoma cruzi lanosterol synthase, putative 0.0378 0.453 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0045 0.0252 0.0334
Schistosoma mansoni hypothetical protein 0.0043 0.0232 0.0177
Schistosoma mansoni biogenic amine receptor 0.0043 0.0232 0.0177
Brugia malayi follicle stimulating hormone receptor 0.0293 0.3438 0.5152
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0263 0.3056 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0045 0.0252 0.037
Brugia malayi conserved hypotetical protein 0.0039 0.0174 0.0216
Brugia malayi nuclear hormone receptor 0.0039 0.0174 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0562 0.051
Onchocerca volvulus Huntingtin homolog 0.0133 0.1387 0.2297
Trypanosoma cruzi protein farnesyltransferase, putative 0.0035 0.0131 0.029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0233 0.0339
Echinococcus multilocularis microtubule associated protein 2 0.0805 1 1
Echinococcus multilocularis neuropeptide receptor 0.0043 0.0232 0.0177
Echinococcus multilocularis neuropeptide receptor A26 0.0043 0.0232 0.0177
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0041 0.0201 0.0257
Onchocerca volvulus Neuropeptide F receptor homolog 0.0043 0.0232 0.0304
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.037
Loa Loa (eye worm) hypothetical protein 0.0043 0.0233 0.0339
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0252 0.1067
Schistosoma mansoni endoplasmin 0.005 0.0318 0.0264
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0244 0.019
Entamoeba histolytica hypothetical protein 0.0223 0.2538 0.2609
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0055 0.0041
Brugia malayi RNA binding protein 0.0069 0.0562 0.0804
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0041 0.0201 0.0285
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0233 0.0306
Schistosoma mansoni hypothetical protein 0.0349 0.4158 0.4126
Echinococcus granulosus dro:myosuppressin receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0082 0.0728 0.1166
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0031 0.0068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0232 0.0177
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.0232 0.0177
Trypanosoma brucei heat shock protein, putative 0.005 0.0318 0.0702
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0201 0.0257
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0041 0.0201 0.0146
Onchocerca volvulus 0.0045 0.0252 0.0338
Schistosoma mansoni hypothetical protein 0.0056 0.04 0.0347
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0194 0.0139
Brugia malayi G-protein coupled receptor 0.0043 0.0232 0.0304
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0043 0.0232 0.0177
Onchocerca volvulus 0.0045 0.0252 0.0338
Schistosoma mansoni alpha-1 adrenergic receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) DR-78 0.0039 0.0174 0.0239
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0279 0.5514
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0041 0.0201 0.0146
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0045 0.0252 0.1198
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.0226 0.0499
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0041 0.0201 0.0257
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0174 0.0239
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0041 0.0201 0.0146
Brugia malayi nuclear hormone receptor 0.0082 0.0728 0.1053
Trichomonas vaginalis spcc417.12 protein, putative 0.0051 0.0329 0.6524
Schistosoma mansoni nAChR subunit 0.0041 0.0201 0.0146
Schistosoma mansoni neuropeptide receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Schistosoma mansoni neuroligin 3 (S09 family) 0.0051 0.0329 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0562 0.051
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0232 0.4563
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0233 0.0306
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.0481 0.5854 0.975
Loa Loa (eye worm) hypothetical protein 0.0043 0.0233 0.0339
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0045 0.0252 0.0334
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0131 0.254
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0201 0.0257
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0045 0.0252 0.0197
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0081 0.0387
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0174 0.0119
Schistosoma mansoni adenoreceptor 0.0043 0.0232 0.0177
Treponema pallidum sodium- and chloride- dependent transporter 0.0263 0.305 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.037
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0233 0.0179
Loa Loa (eye worm) MH2 domain-containing protein 0.0264 0.3065 0.5081
Schistosoma mansoni coup transcription factor 0.0082 0.0728 0.0676
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Brugia malayi Importin beta-1 subunit 0.0031 0.0081 0.0076
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0728 0.0676
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Schistosoma mansoni tyrosine kinase 0.0176 0.1943 0.1898
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0499
Loa Loa (eye worm) hypothetical protein 0.0043 0.0233 0.0339
Brugia malayi sulfakinin receptor protein 0.0043 0.0232 0.0304
Onchocerca volvulus 0.0051 0.0329 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Schistosoma mansoni tyrosine kinase 0.0172 0.189 0.1845
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0041 0.0201 0.0146
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0106 0.1038 0.0988
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0035 0.0131 0.0135
Schistosoma mansoni hypothetical protein 0.0043 0.0232 0.0177
Trypanosoma cruzi protein farnesyltransferase, putative 0.0035 0.0131 0.029
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0064 0.0502 1
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0131 0.0626
Loa Loa (eye worm) hypothetical protein 0.0082 0.0728 0.1166
Brugia malayi putative neuropeptide receptor 0.0043 0.0232 0.0304
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0064 0.0502 0.0449
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1069 0.1739
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0043 0.0232 0.0177
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.0232 0.0177
Giardia lamblia Grp94/Hsp90 0.0047 0.0279 0.0154
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0232 0.0177
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0051 0.0329 0.0275
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0035 0.0131 0.0168
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0043 0.0232 0.0177
Brugia malayi Carboxylesterase family protein 0.0051 0.0329 0.0451
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Schistosoma mansoni tyrosine kinase 0.0172 0.189 0.1845
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0052 0.0346 0.0292
Brugia malayi AKH receptor 0.0043 0.0232 0.0304
Brugia malayi hypothetical protein 0.0045 0.0252 0.0334
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0174 0.0119
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Brugia malayi ORL1-like opioid receptor 0.0043 0.0232 0.0304
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0041 0.0201 0.0146
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0201 0.0257
Echinococcus granulosus tyrosine protein kinase Fyn 0.0052 0.0346 0.0292
Echinococcus granulosus heat shock protein 90 0.005 0.0318 0.0264
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0191 0.0136
Schistosoma mansoni neuropeptide f receptor 76f 0.0043 0.0232 0.0177
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0174 0.0216
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0082 0.0728 0.0676
Echinococcus granulosus 7TM GPCR rhodopsin 0.0043 0.0232 0.0177
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0035 0.0131 0.0076
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0035 0.0131 0.0076
Echinococcus granulosus tyrosine protein kinase Fyn 0.0052 0.0346 0.0292
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0223 0.2538 0.2609
Onchocerca volvulus 0.0039 0.0174 0.0204
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.0232 0.0177
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1069 0.157
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0035 0.0131 0.0152
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0043 0.0232 0.0304
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0043 0.0232 0.0177
Brugia malayi Dopamine receptor 0.0043 0.0232 0.0304
Echinococcus granulosus GPCR family 2 0.0034 0.0119 0.0064
Trypanosoma cruzi lanosterol synthase, putative 0.0378 0.453 1
Schistosoma mansoni retinoic acid receptor RXR 0.0082 0.0728 0.0676
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0041 0.0201 0.0146
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0035 0.0131 0.0076
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0045 0.0252 0.0197
Schistosoma mansoni opsin-like receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.03 0.3525 0.5849
Onchocerca volvulus 0.0043 0.0232 0.0304
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0051 0.0914
Brugia malayi larval opioid receptor 0.0043 0.0232 0.0304
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0082 0.0728 0.0676
Schistosoma mansoni hypothetical protein 0.0034 0.0119 0.0064
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0041 0.0201 0.0146
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0318 0.0327
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0232 0.0512
Trypanosoma brucei lanosterol synthase 0.0378 0.453 1
Onchocerca volvulus 0.0481 0.5854 1
Loa Loa (eye worm) RNA binding protein 0.0069 0.0562 0.089
Schistosoma mansoni histamine h1 receptor 0.0043 0.0232 0.0177
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0035 0.0131 0.0076
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0064 0.0502 0.1107
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0232 0.0177
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0174 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus multilocularis serotonin transporter 0.0263 0.305 0.3012
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0033 0.0104 0.0083
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0052 0.0346 0.0292
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Onchocerca volvulus 0.0043 0.0232 0.0304
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0562 0.089
Echinococcus multilocularis 0.01 0.0966 0.0916
Loa Loa (eye worm) hypothetical protein 0.0082 0.0728 0.1166
Echinococcus multilocularis glycine receptor subunit beta 0.0041 0.0201 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus multilocularis GPCR, family 2 0.0034 0.0119 0.0064
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0043 0.0232 0.0336
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0047 0.0279 0.0364
Brugia malayi hypothetical protein 0.0043 0.0233 0.0306
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Trypanosoma cruzi Heat shock protein 83, putative 0.005 0.0318 0.0702
Plasmodium falciparum heat shock protein 90, putative 0.0189 0.21 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0133 0.1387 0.2271
Plasmodium falciparum heat shock protein 90 0.005 0.0318 0.1515
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0045 0.0252 0.037
Echinococcus granulosus acetylcholinesterase 0.03 0.3525 0.3489
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0318 0.0702
Schistosoma mansoni importin beta-1 0.0031 0.0081 0.0026
Plasmodium vivax heat shock protein 86, putative 0.005 0.0318 0.1389
Plasmodium falciparum transporter, putative 0.0045 0.0252 0.1198
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0041 0.0201 0.0146
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0232 0.0238
Echinococcus multilocularis neuropeptide s receptor 0.0043 0.0232 0.0177
Brugia malayi RNA, U transporter 1 0.0089 0.0822 0.1197
Brugia malayi tailless protein 0.0039 0.0174 0.0216
Echinococcus granulosus 7tm_1 domain containing protein 0.0043 0.0232 0.0177
Echinococcus multilocularis dro:myosuppressin receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus granulosus glycine receptor subunit alpha 1 0.0041 0.0201 0.0146
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0041 0.0201 0.0285
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Schistosoma mansoni lozenge 0.006 0.0454 0.0401
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0035 0.0131 0.0135
Schistosoma mansoni neuropeptide receptor 0.0043 0.0232 0.0177
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0035 0.0131 0.254
Echinococcus granulosus carboxylesterase 5A 0.03 0.3525 0.3489
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0728 0.1053
Brugia malayi hypothetical protein 0.0133 0.1387 0.2051
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0045 0.0252 0.0334
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0031 0.0068
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0035 0.0131 0.0152
Loa Loa (eye worm) carboxylesterase 0.0051 0.0329 0.0499
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0055 0.0041
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0174 0.0119
Loa Loa (eye worm) hypothetical protein 0.0064 0.0502 0.0788
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0043 0.0232 0.0304
Entamoeba histolytica hypothetical protein 0.0117 0.1185 0.1219
Loa Loa (eye worm) hypothetical protein 0.0475 0.5772 0.9612
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Onchocerca volvulus Bile acid receptor homolog 0.0082 0.0728 0.1159
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.037
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.3216 0.3178
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0082 0.0728 0.1166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0082 0.0728 0.1166
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0499
Schistosoma mansoni autophagin-1 (C54 family) 0.0064 0.0502 0.0449
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Brugia malayi Serotonin receptor 0.0543 0.6645 1
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.0232 0.0177
Mycobacterium tuberculosis Carboxylesterase LipT 0.0051 0.0329 0.0539
Schistosoma mansoni amine GPCR 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0232 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0082 0.0728 0.1053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus granulosus epidermal growth factor receptor 0.0176 0.1943 0.1898
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0045 0.0252 0.0197
Echinococcus granulosus fmrfamide receptor 0.0043 0.0232 0.0177
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0194 0.0139
Echinococcus multilocularis cysteine protease atg4b 0.0064 0.0502 0.0449
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0043 0.0232 0.0304
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0082 0.0728 0.0676
Entamoeba histolytica protein kinase, putative 0.0036 0.0139 0.0143
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Echinococcus multilocularis serotonin receptor 0.0175 0.1929 0.1884
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.0232 0.0177
Echinococcus granulosus heat shock protein 0.005 0.0318 0.0264
Schistosoma mansoni BC026374 protein (S09 family) 0.0051 0.0329 0.0275
Schistosoma mansoni hypothetical protein 0.0034 0.0119 0.0064
Onchocerca volvulus 0.0041 0.0201 0.0251
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0293 0.3438 0.5705
Onchocerca volvulus Phospholipase A2 homolog 0.01 0.0962 0.1564
Echinococcus granulosus cysteine protease atg4b 0.0064 0.0502 0.0449
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0051 0.0241
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0035 0.0131 0.0076
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0064 0.0502 1
Schistosoma mansoni inositol monophosphatase 0.0043 0.0232 0.0177
Echinococcus granulosus snurportin 1 0.0335 0.3971 0.3937
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0201 0.0257
Plasmodium falciparum geranylgeranyltransferase, putative 0.0035 0.0131 0.0626
Schistosoma mansoni biogenic amine receptor 0.0043 0.0232 0.0177
Echinococcus granulosus g protein coupled receptor 0.0043 0.0232 0.0177
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0318 0.0702
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0081 0.0026
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Loa Loa (eye worm) TYRA-2 protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) carboxylesterase 0.0051 0.0329 0.0499
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0045 0.0252 0.0197
Leishmania major importin beta-1 subunit, putative 0.0025 0.0005 0.0013
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Giardia lamblia Heat shock protein HSP 90-alpha 0.005 0.0318 0.0195
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0045 0.0252 0.0197
Schistosoma mansoni thyroid hormone receptor 0.0082 0.0728 0.0676
Echinococcus granulosus g-protein coupled receptor 0.0043 0.0232 0.0177
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0119 0.0134
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0064 0.0502 0.123
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0201 0.0257
Echinococcus granulosus tyrosine protein kinase Src42A 0.0052 0.0346 0.0292
Echinococcus granulosus serotonin receptor 0.0043 0.0232 0.0177
Trypanosoma brucei heat shock protein, putative 0.005 0.0318 0.0702
Onchocerca volvulus Huntingtin homolog 0.0133 0.1387 0.2297
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Echinococcus granulosus tyrosine kinase 0.0044 0.0244 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.1185 0.1136
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0139 0.0084
Schistosoma mansoni gliotactin 0.0051 0.0329 0.0275
Echinococcus multilocularis acetylcholinesterase 0.03 0.3525 0.3489
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0045 0.0252 0.0197
Onchocerca volvulus 0.0041 0.0201 0.0251
Loa Loa (eye worm) hypothetical protein 0.0263 0.305 0.5055
Brugia malayi hypothetical protein 0.0039 0.0174 0.0216
Echinococcus multilocularis para nitrobenzyl esterase 0.0051 0.0329 0.0275
Loa Loa (eye worm) hypothetical protein 0.0175 0.1929 0.3179
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0041 0.0201 0.0146
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0035 0.0131 0.0076
Echinococcus granulosus neuropeptide receptor A26 0.0043 0.0232 0.0177
Brugia malayi TAR-binding protein 0.0069 0.0562 0.0804
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0082 0.0728 0.0676
Schistosoma mansoni tyrosine kinase 0.0172 0.189 0.1845
Brugia malayi hypothetical protein 0.0117 0.1185 0.1745
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Echinococcus multilocularis neuropeptide receptor 0.0043 0.0232 0.0177
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0232 0.0568
Echinococcus granulosus Peptidase C54 0.0064 0.0502 0.0449
Echinococcus multilocularis glycine receptor subunit beta 0.0041 0.0201 0.0146
Brugia malayi protein-tyrosine kinase 0.0044 0.0244 0.0322
Brugia malayi intermediate filament protein 0.0029 0.0055 0.0037
Plasmodium falciparum endoplasmin, putative 0.0036 0.0143 0.0681
Brugia malayi Dopamine receptor protein 2 0.0043 0.0232 0.0304
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0318 0.0702
Schistosoma mansoni sodium/chloride dependent transporter 0.0263 0.305 0.3012
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.0232 0.0336
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0131 0.254
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0119 0.0134
Onchocerca volvulus 0.0051 0.0329 0.0472
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.0232 0.0336
Plasmodium vivax amine transporter, putative 0.0045 0.0252 0.1067
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0043 0.0232 0.0177
Echinococcus multilocularis epidermal growth factor receptor 0.0176 0.1943 0.1898
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0035 0.0131 0.254
Schistosoma mansoni nAChR subunit 0.0041 0.0201 0.0146
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0082 0.0728 0.0676
Onchocerca volvulus 0.0043 0.0232 0.0304
Brugia malayi Dopamine receptor protein 1 0.0043 0.0232 0.0304
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus multilocularis nAChR subunit 0.0041 0.0201 0.0146
Schistosoma mansoni hypothetical protein 0.0117 0.1185 0.1136
Onchocerca volvulus 0.0041 0.0201 0.0251
Brugia malayi Tachykinin-like peptides receptor 99D 0.0043 0.0232 0.0304
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0035 0.0131 0.254
Toxoplasma gondii Hsp90 domain-containing protein 0.0189 0.21 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0041 0.0201 0.0285
Echinococcus multilocularis conserved hypothetical protein 0.075 0.93 0.9296
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0201 0.0257
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.063 0.0905
Loa Loa (eye worm) hypothetical protein 0.0276 0.3216 0.5333
Onchocerca volvulus Phospholipase A2 homolog 0.0475 0.5772 0.9859
Onchocerca volvulus Putative nachr subunit 0.0041 0.0201 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0082 0.0728 0.1053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0082 0.0728 0.1166
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0041 0.0201 0.0146
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0176 0.1943 0.1898
Schistosoma mansoni nuclear receptor 0.0039 0.0174 0.0119
Brugia malayi hypothetical protein 0.0481 0.5854 0.8804
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus granulosus nAChR subunit 0.0041 0.0201 0.0146
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0131 0.029
Onchocerca volvulus 0.0043 0.0232 0.0304
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.0232 0.0177
Leishmania major lanosterol synthase, putative 0.0343 0.4078 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0082 0.0728 0.0676
Echinococcus multilocularis somatostatin receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0041 0.0201 0.0146
Loa Loa (eye worm) hypothetical protein 0.0082 0.0728 0.1166
Plasmodium falciparum importin beta, putative 0.0031 0.0081 0.0387
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.0232 0.0177
Toxoplasma gondii heat shock protein HSP90 0.005 0.0318 0.1515
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0043 0.0232 0.0177
Echinococcus granulosus hypothetical protein 0.0793 0.9852 0.9851
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0082 0.0728 0.0676
Echinococcus granulosus sex peptide receptor 0.0043 0.0232 0.0177
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0045 0.0252 0.0197
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.1185 0.1136
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.0329 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0082 0.0728 0.1053
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.0232 0.0177
Entamoeba histolytica hypothetical protein 0.0025 0.0005 0.0005
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0045 0.0252 0.1198
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0033 0.0104 0.0049
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0174 0.0119
Schistosoma mansoni zinc finger protein 0.0039 0.0174 0.0119
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0174 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0119 0.0064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0082 0.0728 0.0676
Echinococcus granulosus G protein coupled receptor 139 0.0043 0.0232 0.0177
Schistosoma mansoni biogenic amine (5HT) receptor 0.0175 0.1929 0.1884
Brugia malayi Carboxylesterase family protein 0.0051 0.0329 0.0451
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0263 0.305 0.4565
Echinococcus multilocularis serotonin receptor 0.0175 0.1929 0.1884
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0035 0.0131 0.0168
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0174 0.0119
Echinococcus granulosus tachykinin peptides receptor 99D 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0064 0.0502 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.0244 0.019
Echinococcus granulosus sodium and chloride dependent glycine 0.0045 0.0252 0.0197
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0045 0.0252 0.0334
Plasmodium vivax heat shock protein, putative 0.0189 0.21 1
Schistosoma mansoni hypothetical protein 0.0043 0.0232 0.0177
Brugia malayi Steroid receptor seven-up type 2 0.0082 0.0728 0.1053
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0043 0.0232 0.0336
Echinococcus granulosus insulin receptor 0.0106 0.1038 0.0988
Schistosoma mansoni inositol monophosphatase 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.03 0.3525 0.5849
Onchocerca volvulus 0.0043 0.0232 0.0304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0728 0.0676
Loa Loa (eye worm) hypothetical protein 0.01 0.0962 0.1559
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Brugia malayi nuclear receptor RXR 0.0043 0.0233 0.0306
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0041 0.0201 0.0146
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0728 0.1053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0232 0.0177
Onchocerca volvulus 0.0043 0.0232 0.0304
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0045 0.0252 0.0197
Echinococcus multilocularis snurportin 1 0.0335 0.3971 0.3937
Brugia malayi hypothetical protein 0.0051 0.0329 0.0451
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0064 0.0502 1
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0035 0.0131 0.0626
Echinococcus multilocularis neuroligin 0.0051 0.0329 0.0275
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0043 0.0232 0.0177
Schistosoma mansoni heat shock protein 0.005 0.0318 0.0264
Loa Loa (eye worm) SRC-1 0.0052 0.0346 0.0528
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0041 0.0201 0.0146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0081 0.0085
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0052 0.0346 0.0292
Trypanosoma brucei Heat shock protein 83, putative 0.005 0.0318 0.0702
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0562 0.051
Brugia malayi Phospholipase A2 family protein 0.01 0.0962 0.1408
Schistosoma mansoni microtubule-associated protein tau 0.0805 1 1
Onchocerca volvulus 0.0045 0.0252 0.0338
Loa Loa (eye worm) hypothetical protein 0.0082 0.0728 0.1166
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0051 0.0329 0.0539
Brugia malayi Cation transporter family protein 0.0041 0.0201 0.0257
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0052 0.0346 0.0292
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0728 0.1053
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0041 0.0201 0.0146
Echinococcus granulosus neuroligin 0.0051 0.0329 0.0275
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0041 0.0201 0.0257
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0174 0.0216
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Echinococcus granulosus glycine receptor subunit beta 0.0041 0.0201 0.0146
Brugia malayi putative neuropeptide receptor NPR1 0.0043 0.0232 0.0304
Brugia malayi Hsp90 protein 0.0033 0.0104 0.011
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0052 0.0346 0.0292
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0035 0.0131 0.0076
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Brugia malayi neuropeptide F receptor 0.0043 0.0232 0.0304
Echinococcus multilocularis ecdysone induced protein 78C 0.0082 0.0728 0.0676
Schistosoma mansoni growth hormone secretagogue receptor 0.0043 0.0232 0.0177
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0041 0.0201 0.0146
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0106 0.1038 0.0988
Echinococcus multilocularis epidermal growth factor receptor 0.0326 0.3867 0.3833
Loa Loa (eye worm) ACC-1 protein 0.0041 0.0201 0.0285
Brugia malayi G-protein coupled receptor 0.0043 0.0232 0.0304
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0232 0.0512
Trypanosoma brucei heat shock protein, putative 0.005 0.0318 0.0702
Brugia malayi Cation transporter family protein 0.0041 0.0201 0.0257
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0052 0.0346 0.0292
Brugia malayi nuclear receptor NHR-67 0.0039 0.0174 0.0216
Loa Loa (eye worm) LGC-31 protein 0.0041 0.0201 0.0285
Leishmania major heat shock protein, putative 0.0033 0.0104 0.0254
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0174 0.0119
Onchocerca volvulus 0.0039 0.0174 0.0204
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0033 0.0104 0.0049
Schistosoma mansoni sodium/chloride dependent transporter 0.0045 0.0252 0.0197
Brugia malayi nuclear receptor NHR-88 0.0082 0.0728 0.1053
Echinococcus multilocularis heat shock protein 90 0.0043 0.0226 0.0171
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.0232 0.0177
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0232 0.0512
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0082 0.0728 0.1159
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0562 0.051
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0035 0.0131 0.0135
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0194 0.0246
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.0232 0.0177
Brugia malayi Peptidase family C54 containing protein 0.0064 0.0502 0.0712
Onchocerca volvulus 0.0263 0.305 0.5165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0174 0.0119
Trypanosoma cruzi heat shock protein, putative 0.0033 0.0104 0.0229
Onchocerca volvulus 0.0043 0.0232 0.0304
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0045 0.0252 0.0197
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0174 0.0119
Onchocerca volvulus 0.0041 0.0201 0.0251
Schistosoma mansoni opsin-like receptor 0.0043 0.0232 0.0177
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Loa Loa (eye worm) carboxylesterase 0.03 0.3525 0.5849
Onchocerca volvulus 0.0043 0.0232 0.0304
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0318 0.0327
Loa Loa (eye worm) hypothetical protein 0.0481 0.5854 0.975
Schistosoma mansoni steroid hormone receptor ad4bp 0.0082 0.0728 0.0676
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0241 0.0187
Schistosoma mansoni biogenic amine receptor 0.0043 0.0232 0.0177
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0226 0.4445
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.0232 0.0177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Schistosoma mansoni acetylcholinesterase 0.0051 0.0329 0.0275
Brugia malayi Protein kinase domain containing protein 0.0106 0.1038 0.1522
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0064 0.0502 0.1107
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Brugia malayi nuclear receptor NHR-88 0.0039 0.0174 0.0216
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0499
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0082 0.0728 0.1166
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0051 0.0329 0.0275
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0318 0.0702
Onchocerca volvulus 0.0056 0.0401 0.0596
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.3971 0.6596
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0232 0.0177
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0318 0.0702
Schistosoma mansoni sodium-dependent amino acid transporter 0.0045 0.0252 0.0197
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0041 0.0201 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0082 0.0728 0.1166
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0033 0.0104 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0728 0.1053
Trypanosoma brucei heat shock protein, putative 0.005 0.0318 0.0702
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.0244 0.019
Schistosoma mansoni nAChR subunit 0.0041 0.0201 0.0146
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Trypanosoma brucei heat shock protein, putative 0.005 0.0318 0.0702
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.1185 0.1136
Brugia malayi Inositol-1 0.0043 0.0232 0.0304
Loa Loa (eye worm) hypothetical protein 0.0493 0.6004 1
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0728 0.0676
Echinococcus multilocularis FTZ F1 alpha 0.0082 0.0728 0.0676
Loa Loa (eye worm) endoplasmin 0.005 0.0318 0.0481
Schistosoma mansoni neuropeptide receptor 0.0043 0.0232 0.0177
Trypanosoma brucei heat shock protein 84, putative 0.0033 0.0104 0.0229
Brugia malayi Carboxylesterase family protein 0.03 0.3525 0.5282
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0174 0.0119
Brugia malayi Carboxylesterase family protein 0.0051 0.0329 0.0451
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0174 0.0204
Echinococcus granulosus para nitrobenzyl esterase 0.0051 0.0329 0.0275
Schistosoma mansoni tyrosine kinase 0.0052 0.0346 0.0292
Plasmodium vivax geranylgeranyltransferase, putative 0.0035 0.0131 0.0486
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0401 0.0559
Trichomonas vaginalis endoplasmin, putative 0.0036 0.0143 0.2774
Entamoeba histolytica hypothetical protein 0.0117 0.1185 0.1219
Schistosoma mansoni tyrosine kinase 0.0176 0.1943 0.1898
Echinococcus multilocularis carboxylesterase 5A 0.03 0.3525 0.3489
Echinococcus multilocularis Protein lozenge 0.006 0.0454 0.0401
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.037
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0081 0.018
Plasmodium vivax importin-beta 2, putative 0.0031 0.0081 0.0244
Loa Loa (eye worm) norepinephrine transporter 0.0263 0.305 0.5055
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0131 0.029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0194 0.0273
Onchocerca volvulus 0.0043 0.0232 0.0304
Echinococcus multilocularis allatostatin A receptor 0.0043 0.0232 0.0177
Leishmania major farnesyltransferase beta subunit 0.0035 0.0131 0.0322
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.016 0.3112
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) melatonin receptor type 1A 0.0043 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Loa Loa (eye worm) TK protein kinase 0.0036 0.0139 0.0181
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0043 0.0232 0.0177
Echinococcus multilocularis endoplasmin 0.0047 0.0279 0.0225
Schistosoma mansoni heat shock protein 0.0033 0.0104 0.0049
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0052 0.0346 0.0292
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Brugia malayi Melatonin receptor type 1A 0.0043 0.0232 0.0304
Loa Loa (eye worm) hypothetical protein 0.0082 0.0728 0.1166
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Echinococcus multilocularis heat shock protein 0.005 0.0318 0.0264
Entamoeba histolytica hypothetical protein 0.0117 0.1185 0.1219
Loa Loa (eye worm) hypothetical protein 0.0034 0.0119 0.0148
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Echinococcus granulosus glycine receptor subunit alpha 1 0.0041 0.0201 0.0146
Echinococcus multilocularis sodium and chloride dependent glycine 0.0045 0.0252 0.0197
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0232 0.0177
Brugia malayi nuclear receptor RXR 0.0039 0.0174 0.0216
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0174 0.0119
Loa Loa (eye worm) TK/EGFR protein kinase 0.0326 0.3867 0.6423
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Schistosoma mansoni hypothetical protein 0.0074 0.063 0.0577
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0035 0.0131 0.0152
Loa Loa (eye worm) hypothetical protein 0.0074 0.063 0.1002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0082 0.0728 0.0676
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0499
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0047 0.0279 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0043 0.0232 0.0177
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0035 0.0131 0.254
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0233 0.0179
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0064 0.0502 0.0449
Echinococcus granulosus neuropeptide receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) transcription factor SMAD2 0.0264 0.3065 0.5081
Echinococcus granulosus ecdysone induced protein 78C 0.0082 0.0728 0.0676
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0043 0.0232 0.0304
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1069 0.157
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0047 0.0279 0.0684
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0562 0.0804
Schistosoma mansoni hypothetical protein 0.0335 0.3971 0.3937
Echinococcus multilocularis orexin receptor type 2 0.0043 0.0232 0.0177
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Brugia malayi G protein-coupled receptor 0.0043 0.0232 0.0304
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0041 0.0201 0.0257
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0045 0.0252 0.5
Loa Loa (eye worm) hypothetical protein 0.0263 0.305 0.5055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Onchocerca volvulus 0.0051 0.0329 0.0472
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.0232 0.0336
Onchocerca volvulus 0.0051 0.0329 0.0472
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0043 0.0226 0.0171
Schistosoma mansoni amine GPCR 0.0043 0.0232 0.0177
Echinococcus granulosus orexin receptor type 2 0.0043 0.0232 0.0177
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0232 0.0177
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0043 0.0232 0.0177
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0035 0.0131 0.029
Schistosoma mansoni nuclear hormone receptor 0.0082 0.0728 0.0676
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0041 0.0201 0.0285
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0055 0.0037
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0263 0.305 0.3012
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0499
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0201 0.0257
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0143 0.2774
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Echinococcus multilocularis G-protein coupled receptor, putative 0.0043 0.0232 0.0177
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0045 0.0252 0.0197
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0174 0.0216
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0064 0.0502 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0783 0.9725 1
Brugia malayi Serotonin receptor 0.0043 0.0232 0.0304
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0082 0.0728 0.0676
Echinococcus multilocularis acetylcholinesterase 0.03 0.3525 0.3489
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0562 0.051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Leishmania major geranylgeranyltransferase, putative 0.0035 0.0131 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0082 0.0728 0.1166
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0043 0.0232 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0082 0.0728 0.1053
Echinococcus granulosus g protein coupled receptor 0.0043 0.0232 0.0177
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0043 0.0232 0.0177
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.016 0.3112
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Brugia malayi excitatory GABA receptor EXP-1A 0.0041 0.0201 0.0257
Brugia malayi hypothetical protein 0.0043 0.0233 0.0306
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Echinococcus granulosus endoplasmin 0.0047 0.0279 0.0225
Echinococcus granulosus tyrosine protein kinase Src64B 0.0052 0.0346 0.0292
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0045 0.0252 0.1198
Schistosoma mansoni nuclear receptor 0.0039 0.0174 0.0119
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Toxoplasma gondii heat shock protein 90, putative 0.005 0.0318 0.1515
Entamoeba histolytica hypothetical protein 0.0117 0.1185 0.1219
Echinococcus granulosus tyrosine protein kinase Lyn 0.0052 0.0346 0.0292
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0174 0.0119
Onchocerca volvulus 0.0051 0.0329 0.0472
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0043 0.0232 0.0177
Brugia malayi GnHR receptor homolog 0.0043 0.0232 0.0304
Echinococcus multilocularis heat shock protein 90 0.005 0.0318 0.0264
Schistosoma mansoni hypothetical protein 0.0056 0.0401 0.0347
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0174 0.0216
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Echinococcus granulosus glycine receptor subunit alpha 1 0.0041 0.0201 0.0146
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0082 0.0728 0.0676
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0191 0.0136
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.0244 0.019
Schistosoma mansoni tyrosine kinase 0.0106 0.1038 0.0988
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0035 0.0131 0.0076
Brugia malayi hypothetical protein 0.0276 0.3216 0.4816
Schistosoma mansoni survival motor neuron protein 0.0056 0.0401 0.0347
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0232 0.0177
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0174 0.0119
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.0329 0.0275
Loa Loa (eye worm) inositol-1 0.0043 0.0232 0.0337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0041 0.0201 0.0257
Brugia malayi G protein-coupled receptor F59B2.13 0.0043 0.0232 0.0304
Schistosoma mansoni heat shock protein 0.005 0.0318 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus multilocularis thyroid hormone receptor alpha 0.0082 0.0728 0.0676
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0043 0.0232 0.0304
Echinococcus granulosus glycine receptor subunit beta 0.0041 0.0201 0.0146
Echinococcus multilocularis g-protein coupled receptor 0.0043 0.0232 0.0177
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0232 0.0177
Brugia malayi RE15519p 0.0043 0.0232 0.0304
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0119 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0131 0.029
Toxoplasma gondii hypothetical protein 0.0045 0.0252 0.1198
Onchocerca volvulus 0.0082 0.0728 0.1159
Echinococcus granulosus neuropeptide receptor 0.0043 0.0232 0.0177
Brugia malayi photoreceptor-specific nuclear receptor 0.0082 0.0728 0.1053
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0041 0.0201 0.0146
Echinococcus granulosus peptide allatostatin:somatostatin 0.0043 0.0232 0.0177
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0043 0.0232 0.0177
Onchocerca volvulus 0.0041 0.0201 0.0251
Brugia malayi neuropeptide F receptor 0.0043 0.0232 0.0304
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0035 0.0131 0.254
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0174 0.0119
Echinococcus granulosus FTZ F1 alpha 0.0082 0.0728 0.0676
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Echinococcus granulosus sodium and chloride dependent glycine 0.0045 0.0252 0.0197
Brugia malayi SRC-1 0.0052 0.0346 0.0477
Loa Loa (eye worm) heat shock protein 90 0.005 0.0318 0.0481
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0119 0.0064
Schistosoma mansoni hypothetical protein 0.0349 0.4158 0.4126
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0043 0.0232 0.0177
Brugia malayi ecdysone receptor 0.0039 0.0174 0.0216
Plasmodium vivax heat shock protein 90, putative 0.0033 0.0104 0.0353
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0045 0.0252 0.0197
Echinococcus granulosus serotonin transporter 0.0263 0.305 0.3012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus multilocularis fmrfamide receptor 0.0043 0.0232 0.0177
Onchocerca volvulus 0.0043 0.0232 0.0304
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0035 0.0131 0.0486
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0493 0.6004 1
Loa Loa (eye worm) serotonin transporter b 0.0263 0.305 0.5055
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0241 0.0187
Plasmodium falciparum amino acid transporter, putative 0.0045 0.0252 0.1198
Loa Loa (eye worm) hypothetical protein 0.0043 0.0233 0.0339
Echinococcus granulosus neuropeptide FF receptor 2 0.0043 0.0232 0.0177
Schistosoma mansoni nAChR subunit 0.0041 0.0201 0.0146
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0052 0.0346 0.0292
Schistosoma mansoni amine GPCR 0.0043 0.0232 0.0177
Trichomonas vaginalis heat shock protein, putative 0.005 0.0318 0.6304
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0035 0.0131 0.0486
Giardia lamblia Heat shock protein HSP 90-alpha 0.0043 0.0226 0.0098
Brugia malayi MH2 domain containing protein 0.0264 0.3065 0.4588
Schistosoma mansoni nAChR subunit 0.0041 0.0201 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0047 0.0279 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.0329 0.0275
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0279 0.5514
Echinococcus granulosus alpha 1A adrenergic receptor 0.0043 0.0232 0.0177
Toxoplasma gondii heat shock protein 75, putative 0.0033 0.0104 0.0494
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0233 0.0339
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0082 0.0728 0.1166
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0035 0.0131 0.254
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0031 0.0068
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0043 0.0232 0.0177
Schistosoma mansoni opsin-like receptor 0.0043 0.0232 0.0177
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0041 0.0201 0.0257
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0051 0.0329 0.6524
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.0232 0.0177
Onchocerca volvulus 0.0043 0.0232 0.0304
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.3216 0.3178
Schistosoma mansoni hypothetical protein 0.0034 0.0119 0.0064
Schistosoma mansoni sodium/chloride dependent transporter 0.0045 0.0252 0.0197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0041 0.0201 0.0257
Echinococcus granulosus epidermal growth factor receptor 0.0326 0.3867 0.3833
Giardia lamblia DNA repair protein RAD52 0.0783 0.9725 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0043 0.0232 0.0336
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0045 0.0252 0.0197
Echinococcus granulosus neuropeptide s receptor 0.0043 0.0232 0.0177
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0043 0.0232 0.0177
Leishmania major hypothetical protein, conserved 0.0027 0.0031 0.0075
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0233 0.0179
Echinococcus multilocularis neuropeptide FF receptor 2 0.0043 0.0232 0.0177
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0174 0.0204
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0052 0.0346 0.0292
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0041 0.0201 0.0146
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.0244 0.019
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0035 0.0131 0.0076
Brugia malayi Endoplasmin precursor 0.005 0.0318 0.0434
Loa Loa (eye worm) hypothetical protein 0.0108 0.1069 0.1739
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Brugia malayi Carboxylesterase family protein 0.03 0.3525 0.5282
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0052 0.0346 0.0292
Echinococcus granulosus acetylcholinesterase 0.03 0.3525 0.3489
Loa Loa (eye worm) hypothetical protein 0.0082 0.0728 0.1166
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0045 0.0252 0.0197
Onchocerca volvulus 0.0043 0.0232 0.0304
Schistosoma mansoni nAChR subunit 0.0041 0.0201 0.0146
Onchocerca volvulus 0.0043 0.0232 0.0304
Schistosoma mansoni thyroid hormone receptor 0.0082 0.0728 0.0676
Loa Loa (eye worm) steroid hormone receptor 0.0082 0.0728 0.1166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0232 0.0177
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0045 0.0252 0.0197
Schistosoma mansoni amine GPCR 0.0043 0.0232 0.0177
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0043 0.0232 0.0304
Brugia malayi hypothetical protein 0.0039 0.0174 0.0216
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0728 0.0676
Loa Loa (eye worm) ACC-1 protein 0.0041 0.0201 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0035 0.0131 0.0626
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0233 0.0179
Brugia malayi steroid hormone receptor 0.0082 0.0728 0.1053
Onchocerca volvulus 0.0041 0.0201 0.0251
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0035 0.0131 0.0626
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0035 0.0131 0.254
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0082 0.0728 0.0676
Echinococcus multilocularis BC026374 protein (S09 family) 0.0051 0.0329 0.0275
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0041 0.0201 0.0257
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0232 0.4563
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.0232 0.0177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0119 0.0064
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0499
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Echinococcus multilocularis insulin receptor 0.0106 0.1038 0.0988
Loa Loa (eye worm) hypothetical protein 0.0133 0.1387 0.2271
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0041 0.0201 0.0146
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Entamoeba histolytica peptidase, C54 family 0.0064 0.0502 0.0516
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0174 0.0216
Onchocerca volvulus Protein ultraspiracle homolog 0.0082 0.0728 0.1159
Schistosoma mansoni nAChR subunit 0.0041 0.0201 0.0146
Echinococcus granulosus importin subunit beta 1 0.0031 0.0081 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0562 0.051
Echinococcus granulosus heat shock protein 90 0.0043 0.0226 0.0171
Schistosoma mansoni endoplasmin 0.005 0.0318 0.0264
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0174 0.0119
Trypanosoma brucei heat shock protein, putative 0.005 0.0318 0.0702
Echinococcus multilocularis sodium and chloride dependent glycine 0.0045 0.0252 0.0197
Echinococcus granulosus tar DNA binding protein 0.0069 0.0562 0.051
Schistosoma mansoni tyrosine kinase 0.0326 0.3867 0.3833
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) runx1 0.006 0.0454 0.0708
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0035 0.0131 0.0626
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0131 0.029
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0041 0.0201 0.0146
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0045 0.0252 0.0197
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Loa Loa (eye worm) hypothetical protein 0.0263 0.305 0.5055
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0082 0.0728 0.1053
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0728 0.1053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0119 0.0148
Echinococcus granulosus allatostatin A receptor 0.0043 0.0232 0.0177
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0232 0.4563
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0081 0.018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0082 0.0728 0.1166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0728 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0082 0.0728 0.1053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0168
Plasmodium vivax endoplasmin, putative 0.005 0.0318 0.1389
Trypanosoma cruzi heat shock protein 90, putative 0.005 0.0318 0.0702
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0041 0.0201 0.0146
Loa Loa (eye worm) hypothetical protein 0.0035 0.0126 0.0159
Brugia malayi Furin-like cysteine rich region family protein 0.0326 0.3867 0.58
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.0728 0.1053
Schistosoma mansoni neuropeptide receptor 0.0043 0.0232 0.0177
Schistosoma mansoni RAR-like nuclear receptor 0.0082 0.0728 0.0676
Schistosoma mansoni amine GPCR 0.0043 0.0232 0.0177
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0051 0.0329 0.0539
Brugia malayi heat shock protein 90 0.005 0.0318 0.0434
Loa Loa (eye worm) hypothetical protein 0.0175 0.1929 0.3179
Mycobacterium ulcerans carboxylesterase, LipT 0.0051 0.0329 1
Leishmania major heat shock protein 83-1 0.005 0.0318 0.078
Loa Loa (eye worm) acetylcholinesterase 1 0.03 0.3525 0.5849
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.03 0.3525 0.3489
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0082 0.0728 0.0676
Schistosoma mansoni tyrosine kinase 0.0106 0.1038 0.0988
Schistosoma mansoni tyrosine kinase 0.0052 0.0346 0.0292
Echinococcus granulosus BC026374 protein S09 family 0.0051 0.0329 0.0275
Loa Loa (eye worm) solute carrier family 6 member 4 0.0263 0.305 0.5055
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0041 0.0201 0.0146
Schistosoma mansoni myosin xvIII 0.0043 0.0232 0.0177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0174 0.0239
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0226 0.0499
Echinococcus granulosus somatostatin receptor 0.0043 0.0232 0.0177
Onchocerca volvulus 0.0043 0.0232 0.0304
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0041 0.0201 0.0285
Echinococcus multilocularis fmrfamide receptor 0.0043 0.0232 0.0177
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0082 0.0728 0.0676
Trypanosoma brucei heat shock protein, putative 0.005 0.0318 0.0702
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0041 0.0201 0.0285
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0174 0.0119
Echinococcus granulosus tyrosine protein kinase Fyn 0.0052 0.0346 0.0292
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0041
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0043 0.0232 0.0336
Brugia malayi ecdysteroid receptor 0.0082 0.0728 0.1053
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.0232 0.0336
Trypanosoma brucei heat shock protein, putative 0.005 0.0318 0.0702
Loa Loa (eye worm) heat shock protein 75 0.0033 0.0104 0.0122
Echinococcus multilocularis geminin 0.0349 0.4158 0.4126
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0043 0.0232 0.0177
Brugia malayi hypothetical protein 0.0043 0.0232 0.0304
Echinococcus multilocularis sex peptide receptor 0.0043 0.0232 0.0177
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0052 0.0346 0.0292
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0041 0.0201 0.0146
Brugia malayi Cation transporter family protein 0.0041 0.0201 0.0257
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.037
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0239
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.0232 0.0177
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0174 0.0119
Onchocerca volvulus 0.0043 0.0232 0.0304
Loa Loa (eye worm) TK/INSR protein kinase 0.0106 0.1038 0.1686
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0082 0.0728 0.1053
Onchocerca volvulus 0.0043 0.0232 0.0304
Brugia malayi Carboxylesterase family protein 0.0051 0.0329 0.0451
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0201 0.0257
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0139 0.0084
Echinococcus multilocularis Peptidase C54 0.0064 0.0502 0.0449
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0041 0.0201 0.0146
Echinococcus granulosus g protein coupled receptor 0.0043 0.0232 0.0177
Loa Loa (eye worm) TK protein kinase 0.0044 0.0244 0.0357
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Toxoplasma gondii hypothetical protein 0.0045 0.0252 0.1198
Onchocerca volvulus 0.0043 0.0232 0.0304
Schistosoma mansoni hypothetical protein 0.0043 0.0232 0.0177
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0031 0.0147
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0232 0.1104
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0562 0.089
Echinococcus granulosus geminin 0.0349 0.4158 0.4126
Loa Loa (eye worm) hypothetical protein 0.0043 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.0285
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0232 0.0177
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0232 0.0177
Echinococcus multilocularis G protein coupled receptor 139 0.0043 0.0232 0.0177
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0082 0.0728 0.0676

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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