Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0889 | 0.2555 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3481 | 0.3481 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.3481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0497 | 0.1429 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0889 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0497 | 0.139 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.037 | 0.1064 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.037 | 0.037 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.3481 | 1 |
Echinococcus multilocularis | geminin | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.037 | 0.1064 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.037 | 0.037 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0889 | 0.2555 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3481 | 0.3481 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3481 | 0.3481 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.2599 | 0.7465 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0889 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.1691 | 0.1691 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0497 | 0.1429 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0889 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0497 | 0.1429 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0889 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.1691 | 0.1691 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.037 | 0.037 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0889 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3481 | 0.3481 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.2599 | 0.7465 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1567 | 0.4503 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1691 | 0.1691 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1691 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0497 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.3481 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.037 | 0.037 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1691 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.3481 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1691 | 0.1691 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0497 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.3481 | 0.3481 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0889 | 0.2555 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.3481 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.037 | 0.1064 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0889 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0889 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0889 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0889 | 0.2555 |
Onchocerca volvulus | 0.0027 | 0.0889 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2599 | 0.7465 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0889 | 0.2555 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0497 | 0.1429 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1567 | 0.4503 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.2599 | 0.7465 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.037 | 0.037 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0497 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3481 | 0.3481 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1567 | 0.1567 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0889 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.037 | 0.037 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.037 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0497 | 0.1429 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.037 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0889 | 0.2555 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.037 | 0.037 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.037 | 0.1064 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1691 | 0.4859 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.037 | 0.037 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0889 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0889 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.3481 | 0.3481 |
Brugia malayi | RNA binding protein | 0.0072 | 0.3481 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0889 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.