Detailed information for compound 1543436

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 803.007 | Formula: C38H66N12O7
  • H donors: 11 H acceptors: 7 LogP: -2.22 Rotable bonds: 29
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@H]([C@H](C(=O)N[C@H](C(=O)O)CC(C)C)NC[C@H](Cc1ccc(cc1)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)N)CCCN=C(N)N)C
  • InChi: 1S/C38H66N12O7/c1-5-23(4)31(34(54)49-29(36(56)57)19-22(2)3)46-21-25(20-24-12-14-26(51)15-13-24)47-33(53)30-11-8-18-50(30)35(55)28(10-7-17-45-38(42)43)48-32(52)27(39)9-6-16-44-37(40)41/h12-15,22-23,25,27-31,46,51H,5-11,16-21,39H2,1-4H3,(H,47,53)(H,48,52)(H,49,54)(H,56,57)(H4,40,41,44)(H4,42,43,45)/t23-,25+,27+,28+,29+,30+,31-/m1/s1
  • InChiKey: KOENCZKDTYXAJY-VMDDQKJDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neurotensin receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis neuropeptides capa receptor Neurotensin receptor 1   424 aa 420 aa 23.6 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Neurotensin receptor 1   424 aa 344 aa 22.7 %
Onchocerca volvulus Neurotensin receptor 1   424 aa 457 aa 21.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Neurotensin receptor 1   424 aa 417 aa 24.0 %
Onchocerca volvulus Neurotensin receptor 1   424 aa 420 aa 23.6 %
Echinococcus granulosus g protein coupled receptor Neurotensin receptor 1   424 aa 407 aa 18.2 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Neurotensin receptor 1   424 aa 399 aa 22.1 %
Echinococcus multilocularis g protein coupled receptor Neurotensin receptor 1   424 aa 407 aa 17.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0059 0.0234 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0059 0.0234 0.0234
Leishmania major cytochrome p450-like protein 0.003 0.0018 0.0156
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0035 0.0051 0.0051
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0563 0.3943 0.3943
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0035 0.0051 0.0051
Loa Loa (eye worm) transcription factor SMAD2 0.0739 0.5238 0.5238
Echinococcus granulosus protein kinase c eta type 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0059 0.0234 0.0234
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0167 0.0167
Brugia malayi hypothetical protein 0.0119 0.067 0.067
Brugia malayi diacylglycerol kinase 0.0035 0.0051 0.0051
Onchocerca volvulus 0.0059 0.0234 0.0934
Echinococcus granulosus Diacylglycerol kinase theta 0.0035 0.0051 0.0051
Echinococcus granulosus Protein kinase C brain isozyme 0.0035 0.0051 0.0051
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0018 0.0156
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0551 0.0551
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0059 0.0234 1
Echinococcus granulosus myotubularin protein 13 0.0035 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Echinococcus multilocularis protein kinase c epsilon type 0.0035 0.0051 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0265 0.0265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1385 1 1
Toxoplasma gondii diacylglycerol kinase, putative 0.0035 0.0051 0.0443
Echinococcus granulosus N chimaerin 0.0035 0.0051 0.0051
Echinococcus granulosus tar DNA binding protein 0.0463 0.321 0.321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1385 1 1
Schistosoma mansoni hypothetical protein 0.007 0.0312 0.0312
Echinococcus granulosus protein kinase c iota type 0.0035 0.0051 0.0051
Echinococcus granulosus expressed protein 0.0059 0.0234 0.0234
Echinococcus granulosus raf serine:threonine protein kinase 0.0993 0.7111 0.7111
Plasmodium falciparum ataxin-2 like protein, putative 0.0184 0.1149 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0059 0.0234 0.0234
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0059 0.0234 0.0234
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0035 0.0051 0.0051
Brugia malayi Raf kinase 0.0958 0.6855 0.6855
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0051 0.0051
Schistosoma mansoni smad 0.005 0.0167 0.0167
Brugia malayi protein kinase C II. 0.0035 0.0051 0.0051
Brugia malayi RNA recognition motif domain containing protein 0.0463 0.321 0.321
Loa Loa (eye worm) hypothetical protein 0.0059 0.0234 0.0234
Echinococcus granulosus smad 0.005 0.0167 0.0167
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0028 0 0.5
Brugia malayi G-protein alpha subunit 0.0059 0.0234 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0051 0.0051
Toxoplasma gondii LsmAD domain-containing protein 0.0184 0.1149 1
Brugia malayi hypothetical protein 0.0059 0.0234 0.0234
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0035 0.0051 0.0051
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0028 0 0.5
Onchocerca volvulus 0.0035 0.0051 0.0203
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0082 0.0403 0.0403
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0035 0.0051 0.0051
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0035 0.0035
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0463 0.321 0.321
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0463 0.321 0.321
Brugia malayi C1-like domain containing protein 0.0035 0.0051 0.0051
Echinococcus multilocularis protein kinase c iota type 0.0035 0.0051 0.0051
Schistosoma mansoni atypical protein kinase C 0.0035 0.0051 0.0051
Echinococcus granulosus Rac GTPase activating protein 1 0.0035 0.0051 0.0051
Echinococcus granulosus protein kinase c epsilon type 0.0035 0.0051 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0551 0.0551
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0059 0.0234 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1385 1 1
Brugia malayi protein kinase C3,putative 0.0035 0.0051 0.0051
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0167 0.0167
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0035 0.0051 0.0051
Echinococcus multilocularis tar DNA binding protein 0.0463 0.321 0.321
Echinococcus multilocularis raf serine:threonine protein kinase 0.0993 0.7111 0.7111
Brugia malayi Pleckstrin Homology Domain 0.0035 0.0051 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0184 0.1149 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1385 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0035 0.0035
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0059 0.0234 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0059 0.0234 0.0234
Brugia malayi Cytochrome P450 family protein 0.003 0.0018 0.0018
Plasmodium vivax ataxin-2 like protein, putative 0.0184 0.1149 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0035 0.0035
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0059 0.0234 0.0234
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0059 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0059 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0059 0.0234 0.0234
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0059 0.0234 0.0234
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0035 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0184 0.1149 1
Schistosoma mansoni protein kinase C 0.0035 0.0051 0.0051
Giardia lamblia Hypothetical protein 0.0028 0 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0082 0.0403 0.0403
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Onchocerca volvulus 0.0035 0.0051 0.0203
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0059 0.0234 0.0234
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0059 0.0234 0.0234
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0059 0.0234 1
Brugia malayi Pax transcription factor protein 2 0.0251 0.1647 0.1647
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0035 0.0051 0.0051
Brugia malayi MH1 domain containing protein 0.005 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0184 0.1149 0.1149
Giardia lamblia DUB-1 0.0028 0 0.5
Schistosoma mansoni unc-13 (munc13) 0.0037 0.0066 0.0066
Loa Loa (eye worm) G protein alpha subunit 3 0.0059 0.0234 0.0234
Onchocerca volvulus 0.0059 0.0234 0.0934
Entamoeba histolytica G protein alpha subunit, putative 0.0059 0.0234 1
Echinococcus multilocularis Rac GTPase activating protein 1 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0059 0.0234 0.0234
Echinococcus multilocularis Diacylglycerol kinase theta 0.0035 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0001 0.0001
Loa Loa (eye worm) nuclear factor I 0.0028 0.0001 0.0001
Echinococcus multilocularis N chimaerin 0.0035 0.0051 0.0051
Schistosoma mansoni smad1 5 8 and 0.005 0.0167 0.0167
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0059 0.0234 0.0234
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0059 0.0234 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0051 0.0051
Brugia malayi MH2 domain containing protein 0.005 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0059 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0368 0.2507 0.2507
Onchocerca volvulus 0.0035 0.0051 0.0203
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0035 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0035 0.0051 0.2174
Entamoeba histolytica diacylglycerol kinase, putative 0.0035 0.0051 0.2174
Brugia malayi RhoGAP domain containing protein 0.0035 0.0051 0.0051
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0059 0.0234 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0028 0 0.5
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0059 0.0234 1
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0059 0.0234 0.0234
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1385 1 1
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0059 0.0234 0.0234
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0028 0 0.5
Schistosoma mansoni hypothetical protein 0.0032 0.0035 0.0035
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0059 0.0234 0.0234
Entamoeba histolytica diacylglycerol kinase, putative 0.0035 0.0051 0.2174
Loa Loa (eye worm) RasGEF domain-containing protein 0.0039 0.0083 0.0083
Brugia malayi diacylglycerol kinase 0.0035 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0102 0.0551 0.0551
Schistosoma mansoni rac gtpase activating protein 0.0035 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0082 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Loa Loa (eye worm) MH2 domain-containing protein 0.0739 0.5238 0.5238
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0035 0.0051 0.0051
Echinococcus multilocularis myotubularin protein 13 0.0035 0.0051 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0035 0.0035
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0059 0.0234 0.0234
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0059 0.0234 0.0234
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0035 0.0051 0.0051
Brugia malayi RNA binding protein 0.0463 0.321 0.321
Schistosoma mansoni serine/threonine protein kinase 0.0993 0.7111 0.7111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Loa Loa (eye worm) RNA binding protein 0.0463 0.321 0.321
Schistosoma mansoni hypothetical protein 0.0032 0.0035 0.0035
Schistosoma mansoni vav2 0.0035 0.0051 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0463 0.321 0.321
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0035 0.0051 0.0051
Onchocerca volvulus 0.0059 0.0234 0.0934
Brugia malayi Cytochrome P450 family protein 0.003 0.0018 0.0018
Brugia malayi Protein kinase domain containing protein 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0059 0.0234 0.0234
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1385 1 1
Echinococcus multilocularis Smad4 0.005 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0059 0.0234 0.0234
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0059 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0312 0.0312
Brugia malayi Protein kinase c protein 2 0.0035 0.0051 0.0051
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0035 0.0051 0.0051
Brugia malayi MH2 domain containing protein 0.0739 0.5238 0.5238
Brugia malayi RhoGAP domain containing protein 0.0035 0.0051 0.0051
Brugia malayi Ras association domain family 1 isoform A 0.0035 0.0051 0.0051
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0035 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0184 0.1149 1
Schistosoma mansoni tar DNA-binding protein 0.0463 0.321 0.321
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0167 0.0167
Brugia malayi MH2 domain containing protein 0.005 0.0167 0.0167
Echinococcus granulosus Smad4 0.005 0.0167 0.0167
Brugia malayi RhoGEF domain containing protein 0.0035 0.0051 0.0051
Schistosoma mansoni Smad4 0.005 0.0167 0.0167
Brugia malayi Cytochrome P450 family protein 0.0064 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0059 0.0234 0.0234
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0059 0.0234 0.0234
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0059 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0059 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0035 0.0051 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1385 1 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0251 0.1647 0.1647
Loa Loa (eye worm) TAR-binding protein 0.0463 0.321 0.321
Schistosoma mansoni smad1 5 8 and 0.005 0.0167 0.0167
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0368 0.2507 1
Loa Loa (eye worm) raf kinase 0.0988 0.7075 0.7075
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0051 0.0051
Brugia malayi hypothetical protein 0.0184 0.1149 0.1149
Echinococcus multilocularis protein kinase c eta type 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0059 0.0234 0.0234
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0035 0.0051 0.0051
Trypanosoma brucei cytochrome P450, putative 0.003 0.0018 0.0156
Schistosoma mansoni diacylglycerol kinase theta 0.0035 0.0051 0.0051
Schistosoma mansoni unc-13 (munc13) 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0059 0.0234 0.0234
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0059 0.0234 0.0234
Schistosoma mansoni GTP-binding protein alpha subunit 0.0059 0.0234 0.0234
Schistosoma mansoni smad1 5 8 and 0.005 0.0167 0.0167
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0167 0.0167
Loa Loa (eye worm) CYP4Cod1 0.003 0.0018 0.0018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0167 0.0167
Echinococcus granulosus unc 13 munc13 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein alpha subunit 0.0059 0.0234 0.0234
Echinococcus multilocularis unc 13 (munc13) 0.0035 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0059 0.0234 0.0234
Brugia malayi MH1 domain containing protein 0.0028 0.0001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0035 0.0035
Onchocerca volvulus 0.0251 0.1647 0.6569
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0059 0.0234 0.0234
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0059 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0051
Echinococcus granulosus GPCR family 2 0.0032 0.0035 0.0035
Schistosoma mansoni protein kinase C mu 0.0035 0.0051 0.0051
Brugia malayi TAR-binding protein 0.0463 0.321 0.321
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0059 0.0234 0.0234
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0035 0.0035
Echinococcus multilocularis expressed protein 0.0059 0.0234 0.0234
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0463 0.321 0.321
Plasmodium falciparum ataxin-2 like protein, putative 0.0184 0.1149 1
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0018 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0018 0.0018
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0059 0.0234 0.0234
Brugia malayi MH1 domain containing protein 0.0028 0.0001 0.0001
Schistosoma mansoni diacylglycerol kinase theta 0.0035 0.0051 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1385 1 1
Loa Loa (eye worm) Smad1 0.005 0.0167 0.0167
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0167 0.0167
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0059 0.0234 0.0234
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0018 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0551 0.0551
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0059 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0051 0.0051
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0167 0.0167
Brugia malayi Smad1 0.005 0.0167 0.0167
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0018 0.0156
Brugia malayi Variant SH3 domain containing protein 0.0035 0.0051 0.0051
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0035 0.0051 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0463 0.321 0.321
Schistosoma mansoni hypothetical protein 0.0032 0.0035 0.0035
Brugia malayi MH1 domain containing protein 0.005 0.0167 0.0167
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0059 0.0234 0.0234
Echinococcus multilocularis smad 0.005 0.0167 0.0167
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0035 0.0051 0.0051
Brugia malayi N-terminal motif family protein 0.0368 0.2507 0.2507
Trypanosoma brucei PAB1-binding protein , putative 0.0184 0.1149 1
Schistosoma mansoni protein kinase C mu 0.0035 0.0051 0.0051

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6310 nM IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer ChEMBL. 7699693
Relative potency (binding) = 0.1 Relative potency at neurotensin receptor compared to neurotensin (NT8-13) ChEMBL. 7699693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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