Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 1 | 1 |
Onchocerca volvulus | 0.0009 | 0.0146 | 0.0146 | |
Brugia malayi | RNA binding protein | 0.0068 | 0.3314 | 0.3314 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0146 | 0.0442 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.2365 | 0.7135 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0146 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3314 | 0.5992 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3314 | 0.3314 |
Entamoeba histolytica | hypothetical protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3314 | 0.3314 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0146 | 0.0265 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2365 | 0.7135 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2365 | 0.7135 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.5531 | 0.5531 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.5531 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.016 | 0.8259 | 0.8259 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.016 | 0.8259 | 0.8259 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.5531 | 0.5531 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0146 | 0.0442 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3314 | 1 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0146 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0146 | 0.0442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3314 | 0.5992 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0146 | 0.0146 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0146 | 0.0442 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2365 | 0.4275 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3314 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0146 | 0.0146 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.2365 | 0.2365 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0146 | 0.0442 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.2365 | 0.2365 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2365 | 0.4275 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0146 | 0.0265 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3314 | 0.3314 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0146 | 0.0265 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0146 | 0.0442 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.2365 | 0.2365 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0146 | 0.0265 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.2365 | 0.7135 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0146 | 0.0265 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0146 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2365 | 0.2365 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3314 | 0.3314 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2365 | 0.7135 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0009 | 0.0146 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0146 | 0.0442 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0146 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0146 | 0.0442 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0146 | 0.0146 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.016 | 0.8259 | 0.8259 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0.0146 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0146 | 0.0265 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0146 | 0.0442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3314 | 0.5992 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2365 | 0.4275 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.8259 | 0.8259 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0146 | 0.0146 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0146 | 0.0146 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2365 | 0.4275 |
Trypanosoma cruzi | hypothetical protein | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3314 | 0.3314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3314 | 0.5992 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3314 | 0.5992 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2365 | 0.7135 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.