Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0381 | 0.2501 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0381 | 0.2501 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0012 | 0.0111 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0381 | 0.3552 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0141 | 0.0262 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0381 | 0.0709 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0381 | 0.2501 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0328 | 0.0609 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0328 | 0.0609 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.005 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0141 | 0.1313 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0381 | 0.3552 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.005 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.005 | 0.0327 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.056 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.0714 | 0.1327 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0141 | 0.1313 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0381 | 0.0709 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.1525 | 0.2835 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0263 | 0.1721 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0263 | 0.1721 |
Brugia malayi | hypothetical protein | 0.0038 | 0.005 | 0.0093 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0381 | 0.2501 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0012 | 0.0022 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.005 | 0.0327 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0141 | 0.0925 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0381 | 0.3552 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.5379 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.005 | 0.0465 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.056 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.2074 | 0.3856 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.005 | 0.5 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0552 | 0.9847 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.2074 | 0.3856 |
Brugia malayi | hypothetical protein | 0.0318 | 0.5379 | 1 |
Onchocerca volvulus | 0.0318 | 0.5379 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0328 | 0.0609 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.1074 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.1525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0479 | 0.089 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0141 | 0.0262 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0141 | 0.0925 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.005 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0012 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.005 | 0.0465 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.1525 | 1 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.056 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0328 | 0.0609 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.2074 | 0.3856 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.