Detailed information for compound 1544249

Basic information

Technical information
  • TDR Targets ID: 1544249
  • Name: 2-(2-methyl-4-pyrrolidin-1-ylsulfonylphenoxy) -1-piperidin-1-ylethanone
  • MW: 366.475 | Formula: C18H26N2O4S
  • H donors: 0 H acceptors: 3 LogP: 2.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCCC1)COc1ccc(cc1C)S(=O)(=O)N1CCCC1
  • InChi: 1S/C18H26N2O4S/c1-15-13-16(25(22,23)20-11-5-6-12-20)7-8-17(15)24-14-18(21)19-9-3-2-4-10-19/h7-8,13H,2-6,9-12,14H2,1H3
  • InChiKey: DJISFGPENMGRGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-methyl-4-pyrrolidin-1-ylsulfonyl-phenoxy)-1-(1-piperidyl)ethanone
  • 2-(2-methyl-4-1-pyrrolidinylsulfonylphenoxy)-1-(1-piperidyl)ethanone
  • 2-(2-methyl-4-pyrrolidin-1-ylsulfonyl-phenoxy)-1-piperidino-ethanone
  • 2-(2-methyl-4-pyrrolidin-1-ylsulfonyl-phenoxy)-1-piperidin-1-yl-ethanone
  • ZINC06703043

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0207 0.0399 0.2267
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.004 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0053 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0077 0.0074
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0024 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0024 0.0255
Echinococcus granulosus endoplasmin 0.0026 0.0029 0.0148
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0063 0.0105 0.0583
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.004 0.0208
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Trichomonas vaginalis esterase, putative 0.011 0.02 0.3824
Brugia malayi hypothetical protein 0.0033 0.0044 0.0468
Mycobacterium ulcerans beta-lactamase 0.011 0.02 0.0389
Brugia malayi hypothetical protein 0.0473 0.0942 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0017 0.0184
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0052 0.0554
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0105 0.0102
Onchocerca volvulus Bile acid receptor homolog 0.0063 0.0105 0.2174
Onchocerca volvulus 0.0096 0.0173 0.3583
Brugia malayi Bromodomain containing protein 0.0076 0.013 0.1383
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0045 0.0237
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0052 0.0969
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0063 0.0105 0.1114
Brugia malayi tailless protein 0.003 0.0037 0.0391
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0521 1
Brugia malayi ecdysteroid receptor 0.0063 0.0105 0.1114
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0068 0.1277
Plasmodium vivax SET domain protein, putative 0.0033 0.0043 0.2156
Echinococcus multilocularis protein patched 0.0083 0.0146 0.0143
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.0186 0.1975
Brugia malayi hypothetical protein 0.003 0.0037 0.0391
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0033 0.1555
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0017 0.0712
Trypanosoma brucei polo-like protein kinase 0.0091 0.0162 0.8083
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0063 0.0105 0.1114
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0334 0.6389
Echinococcus multilocularis heat shock protein 90 0.0026 0.0029 0.0026
Brugia malayi isocitrate dehydrogenase 0.0031 0.004 0.042
Schistosoma mansoni inositol monophosphatase 0.0036 0.0049 0.0263
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0037 0.0192
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.004 0.1841
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0037 0.0762
Trypanosoma brucei heat shock protein, putative 0.0033 0.0043 0.2056
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0334 0.6389
Trypanosoma brucei heat shock protein, putative 0.0033 0.0043 0.2056
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0043 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0105 0.0583
Entamoeba histolytica hypothetical protein 0.0036 0.0049 0.1236
Mycobacterium ulcerans hypothetical protein 0.0024 0.0024 0.0025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0049 0.0908
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0029 0.1311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0186 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Loa Loa (eye worm) beta-lactamase 0.011 0.02 0.2127
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0053 0.0561
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0044 0.0468
Schistosoma mansoni hypothetical protein 0.0041 0.0059 0.032
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0162 0.807
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0186 0.1047
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0052 0.0049
Schistosoma mansoni zinc finger protein 0.003 0.0038 0.0197
Schistosoma mansoni hypothetical protein 0.0868 0.1748 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Brugia malayi beta-lactamase family protein 0.011 0.02 0.2127
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0053 0.0561
Schistosoma mansoni hypothetical protein 0.0096 0.0172 0.0965
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0172 0.1823
Trypanosoma brucei ISWI complex protein 0.003 0.0038 0.1795
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.004 0.0208
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0053 0.2513
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0063 0.0105 0.1114
Onchocerca volvulus Protein ultraspiracle homolog 0.0063 0.0105 0.2174
Echinococcus granulosus Niemann Pick C1 protein 0.0194 0.0373 0.2117
Trichomonas vaginalis heat shock protein, putative 0.002 0.0017 0.0288
Schistosoma mansoni alpha-glucosidase 0.0145 0.0272 0.1539
Plasmodium vivax hypothetical protein, conserved 0.011 0.02 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0049 0.0908
Brugia malayi Niemann-Pick C1 protein precursor 0.0194 0.0373 0.3956
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.0105 0.1114
Schistosoma mansoni retinoic acid receptor RXR 0.0063 0.0105 0.0583
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0063 0.0105 0.0102
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0004 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0126
Entamoeba histolytica hypothetical protein 0.0036 0.0049 0.1236
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0334 0.6905
Schistosoma mansoni steroid hormone receptor ad4bp 0.0063 0.0105 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0029 0.1311
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0017 0.0716
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0037 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0105 0.0583
Echinococcus granulosus heat shock protein 90 0.0026 0.0029 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0022 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0063 0.0105 0.1114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0033 0.0595
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.1114
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0334 0.6389
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0046
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0024 0.0025
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0037 0.0391
Trypanosoma brucei hypothetical protein, conserved 0.011 0.02 1
Schistosoma mansoni patched 1 0.0083 0.0146 0.0819
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Loa Loa (eye worm) hypothetical protein 0.0194 0.0373 0.3956
Schistosoma mansoni hypothetical protein 0.0096 0.0173 0.0973
Echinococcus granulosus geminin 0.0868 0.1748 1
Onchocerca volvulus 0.003 0.0037 0.0762
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0033 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0068 0.1277
Loa Loa (eye worm) hypothetical protein 0.0067 0.0112 0.1188
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0043 0.1752
Loa Loa (eye worm) hypothetical protein 0.0089 0.0158 0.1676
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0017 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0162 0.3091
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0024 0.0255
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0483 0.9269
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0052 0.0969
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0041 0.0036
Schistosoma mansoni cpg binding protein 0.0095 0.017 0.0958
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0063 0.0105 0.0583
Schistosoma mansoni hypothetical protein 0.0096 0.0172 0.0965
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Entamoeba histolytica hypothetical protein 0.0036 0.0049 0.1236
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0334 0.6389
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0017 0.0712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0112 0.0623
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0033 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0037 0.0192
Brugia malayi hypothetical protein 0.0033 0.0044 0.0468
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0521 1
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0146 0.0819
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.02 0.113
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0049 0.0046
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.02 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.0105 0.1114
Schistosoma mansoni RAR-like nuclear receptor 0.0063 0.0105 0.0583
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0353 0.676
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0024 0.0255
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0043 0.2001
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.02 0.0197
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0037 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.0105 0.1114
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0126
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0046
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0173 0.1836
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0255
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0024 0.1053
Trypanosoma brucei heat shock protein, putative 0.0033 0.0043 0.2056
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.02 0.3824
Mycobacterium ulcerans lipase LipD 0.011 0.02 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0053 0.2565
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0024 0.0025
Brugia malayi nuclear hormone receptor 0.0063 0.0105 0.1114
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0047 0.05
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0049 0.2374
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0017 0.0712
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0052 0.0969
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0053 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0063 0.0105 0.0583
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.02 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0017 0.0775
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0063 0.0105 0.0583
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0173 0.0329 0.3491
Schistosoma mansoni heat shock protein 0.0033 0.0043 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Schistosoma mansoni hypothetical protein 0.0807 0.1624 0.9289
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0012 0.2252
Echinococcus granulosus ecdysone induced protein 78C 0.0063 0.0105 0.0583
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0003 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0043 0.0229
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0037 0.0391
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0334 0.6389
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0024 0.1053
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0003 0.0629
Entamoeba histolytica hypothetical protein 0.0036 0.0049 0.1236
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0052 0.2481
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0029 0.0524
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0012 0.0594
Schistosoma mansoni hypothetical protein 0.0096 0.0172 0.0965
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Brugia malayi nuclear hormone receptor 0.003 0.0037 0.0391
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0052 0.028
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0105 0.1117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.027
Giardia lamblia Grp94/Hsp90 0.0026 0.0029 0.0814
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0172 0.0168
Loa Loa (eye worm) hypothetical protein 0.0033 0.0044 0.0468
Brugia malayi Nuclear hormone receptor E75 0.003 0.0037 0.0391
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0037 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0186 0.1048
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0063 0.0105 0.0583
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0049 0.2321
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0162 0.3091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0017 0.0712
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0017 0.0184
Schistosoma mansoni alpha glucosidase 0.0037 0.0052 0.0281
Brugia malayi Isocitrate dehydrogenase 0.0031 0.004 0.042
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0037 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0033 0.0348
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0334 0.6389
Schistosoma mansoni nuclear hormone receptor 0.003 0.0037 0.0192
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.004 0.0036
Echinococcus granulosus Niemann Pick C1 protein 0.0278 0.0543 0.3092
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0043 0.0786
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0037 0.0192
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Loa Loa (eye worm) hypothetical protein 0.011 0.02 0.2127
Schistosoma mansoni ap endonuclease 0.0038 0.0053 0.0284
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0063 0.0105 0.0102
Trypanosoma brucei heat shock protein, putative 0.0033 0.0043 0.2056
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.004 0.1897
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.0399 0.4234
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0063 0.0105 0.1114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0186 0.0183
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0049 0.2321
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0242 0.0471 0.2681
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0045 0.0237
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.004 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0017 0.0184
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0172 0.0965
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.1114
Echinococcus multilocularis protein dispatched 1 0.0095 0.017 0.0167
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.004 0.0036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0004 0.0046
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0162 0.807
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0186 0.1047
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0004 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0017 0.0014
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0037 0.0391
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0521 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0043 0.004
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0003 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0063 0.0105 0.1114
Entamoeba histolytica hypothetical protein 0.0014 0.0004 0.0032
Echinococcus granulosus expressed conserved protein 0.0182 0.0349 0.1979
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0043 0.1068
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2389 0.4857 1
Brugia malayi Inositol-1 0.0036 0.0049 0.0521
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0037 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0024 0.0025
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0044 0.0234
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0017 0.0712
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0044 0.0234
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0049 0.0077
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0004 0.0052
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.032 0.0317
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0162 0.3091
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.02 0.3824
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0162 0.1724
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0172 0.1823
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0162 0.3091
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0105 0.1989
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0077 0.0422
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.0521 0.5529
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0052 0.1324
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0029 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.02 0.0393
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0017 0.038
Onchocerca volvulus 0.011 0.02 0.415
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.02 0.0393
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0242 0.0471 0.2681
Brugia malayi Pre-SET motif family protein 0.0218 0.0422 0.4478
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0063 0.0105 0.0583
Toxoplasma gondii ABC1 family protein 0.011 0.02 0.0413
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.0227 0.1279
Trypanosoma brucei glucosidase, putative 0.0037 0.0052 0.2533
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0052 0.1324
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0063 0.0105 0.2174
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.1114
Echinococcus multilocularis GPCR, family 2 0.0096 0.0172 0.0168
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0003 0.0068
Mycobacterium leprae Probable lipase LipE 0.011 0.02 0.0365
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.02 0.0393
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0053 0.0981
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0022 0.0108
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Brugia malayi DnaJ domain containing protein 0.0063 0.0105 0.1117
Trypanosoma brucei heat shock protein, putative 0.0033 0.0043 0.2056
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0024 0.1053
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0053 0.0981
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0043 0.0454
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0053 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0186 0.1048
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0063 0.0105 0.1114
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0146 0.0143
Schistosoma mansoni endoplasmin 0.0033 0.0043 0.0226
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0063 0.0105 0.0102
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0004 0.0052
Loa Loa (eye worm) endoplasmin 0.0033 0.0043 0.0454
Onchocerca volvulus 0.0087 0.0153 0.3161
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0017 0.0712
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0521 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0063 0.0105 0.0583
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0033 0.017
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0049 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0303 0.0595 0.6312
Trichomonas vaginalis endoplasmin, putative 0.002 0.0017 0.0288
Brugia malayi beta-lactamase 0.011 0.02 0.2127
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.02 1
Brugia malayi hypothetical protein 0.003 0.0037 0.0391
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Plasmodium vivax heat shock protein, putative 0.0013 0.0003 0.0166
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0121 0.0117
Brugia malayi steroid hormone receptor 0.0063 0.0105 0.1114
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0126
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0003 0.0629
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0037 0.0192
Mycobacterium ulcerans hypothetical protein 0.011 0.02 0.0389
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0033 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0043 0.0229
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.004 0.0424
Loa Loa (eye worm) hypothetical protein 0.0033 0.0044 0.0468
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0043 0.2001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0024 0.0562
Loa Loa (eye worm) hypothetical protein 0.0303 0.0595 0.6312
Schistosoma mansoni cpg binding protein 0.0087 0.0153 0.0856
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.027
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Schistosoma mansoni zinc finger protein 0.003 0.0037 0.0192
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0015 0.0612
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0037 0.0034
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.032 0.0317
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0105 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0021
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0043 0.1068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.0105 0.1114
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Schistosoma mansoni kinase 0.0046 0.0071 0.0386
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0037 0.0391
Echinococcus granulosus cpg binding protein 0.0095 0.017 0.0958
Trypanosoma cruzi ISWI complex protein 0.003 0.0038 0.1739
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0053 0.2448
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0043 0.2134
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0162 0.0912
Echinococcus multilocularis muscleblind protein 0.0155 0.0293 0.029
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Brugia malayi PHD-finger family protein 0.0054 0.0086 0.0917
Mycobacterium tuberculosis Conserved protein 0.011 0.02 0.0393
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0016 0.027
Echinococcus multilocularis Niemann Pick C1 protein 0.0278 0.0543 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Brugia malayi nuclear receptor RXR 0.003 0.0037 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0146 0.2779
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0063 0.0105 0.0583
Plasmodium vivax endoplasmin, putative 0.0033 0.0043 0.2134
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0017 0.008
Brugia malayi heat shock protein 90 0.0033 0.0043 0.0454
Brugia malayi ecdysone receptor 0.003 0.0037 0.0391
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0126
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0024 0.0562
Schistosoma mansoni zinc finger protein 0.0044 0.0065 0.0353
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0052 0.0969
Schistosoma mansoni myst-related protein 0.0014 0.0004 0.0007
Brugia malayi Nuclear hormone receptor E75 0.003 0.0037 0.0391
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0033 0.0068
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0044 0.0041
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0003 0.0035
Brugia malayi hypothetical protein 0.0036 0.0049 0.052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0303 0.0595 0.6312
Schistosoma mansoni bromodomain containing protein 0.013 0.0241 0.1363
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0052 0.0969
Trichomonas vaginalis helicase, putative 0.002 0.0016 0.027
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.032 0.3394
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0049 0.0262
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0185 0.0353 0.2005
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Echinococcus multilocularis endoplasmin 0.0026 0.0029 0.0026
Toxoplasma gondii pantoate-beta-alanine ligase 0.2389 0.4857 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.004 0.0036
Brugia malayi beta-lactamase family protein 0.011 0.02 0.2127
Schistosoma mansoni hypothetical protein 0.008 0.014 0.0784
Brugia malayi conserved hypotetical protein 0.003 0.0037 0.0391
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0049 0.0046
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0037 0.0391
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0044 0.0468
Trypanosoma brucei heat shock protein, putative 0.0033 0.0043 0.2056
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0004 0.0052
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0043 0.2056
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0334 0.6389
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0162 0.3091
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Mycobacterium tuberculosis Conserved protein 0.011 0.02 0.0393
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.1114
Loa Loa (eye worm) hypothetical protein 0.0139 0.0261 0.277
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0037 0.0762
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0126
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.02 0.3824
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Trypanosoma brucei heat shock protein, putative 0.0033 0.0043 0.2056
Brugia malayi Steroid receptor seven-up type 2 0.0063 0.0105 0.1114
Brugia malayi Hsp90 protein 0.0013 0.0003 0.0035
Brugia malayi MH2 domain containing protein 0.012 0.0221 0.235
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0017 0.0712
Onchocerca volvulus 0.011 0.02 0.415
Loa Loa (eye worm) hypothetical protein 0.011 0.02 0.2127
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0029 0.0148
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0121 0.0673
Loa Loa (eye worm) hypothetical protein 0.0024 0.0025 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0112 0.0623
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Plasmodium falciparum zinc finger protein, putative 0.0014 0.0004 0.0849
Echinococcus multilocularis FTZ F1 alpha 0.0063 0.0105 0.0102
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0162 0.0912
Schistosoma mansoni nuclear hormone receptor 0.0063 0.0105 0.0583
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0046
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0017 0.0184
Brugia malayi CHE-14 protein 0.0083 0.0146 0.1552
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0043 0.2056
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0043 0.2001
Echinococcus multilocularis dnaJ subfamily B 0.0807 0.1624 0.1622
Schistosoma mansoni nuclear receptor 0.003 0.0037 0.0192
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0029 0.004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0049 0.2321
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.032 0.1813
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0045 0.0041
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0017 0.038
Trypanosoma cruzi ISWI complex protein 0.003 0.0038 0.1739
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0025 0.1092
Brugia malayi Pre-SET motif family protein 0.0033 0.0043 0.0459
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.02 0.113
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0017 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0063 0.0105 0.0583
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0172 0.0965
Loa Loa (eye worm) hypothetical protein 0.0155 0.0293 0.3112
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0029 0.0524
Schistosoma mansoni endoplasmin 0.0033 0.0043 0.0226
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0197 0.0379 0.2152
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0017 0.0775
Echinococcus multilocularis cpg binding protein 0.0095 0.017 0.0167
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0013 0.0002 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0473 0.0942 0.538
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0004 0.0028
Echinococcus granulosus heat shock protein 0.0033 0.0043 0.0226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0186 0.0183
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0017 0.0775
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0702 0.141 0.2889
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0303 0.0595 0.6312
Schistosoma mansoni nuclear hormone receptor 0.003 0.0037 0.0192
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0146 0.1552
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0052 0.0969
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0043 0.0088
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0049 0.0101
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0029 0.0814
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Echinococcus granulosus FTZ F1 alpha 0.0063 0.0105 0.0583
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0012 0.0004
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.1114
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0003 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0017 0.0712
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0052 0.0108
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0003 0.0026
Echinococcus granulosus zinc finger protein 0.0044 0.0065 0.0353
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0017 0.0712
Schistosoma mansoni heat shock protein 0.0033 0.0043 0.0226
Plasmodium falciparum endoplasmin, putative 0.002 0.0017 0.3203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0105 0.0102
Loa Loa (eye worm) hypothetical protein 0.0123 0.0228 0.2418
Schistosoma mansoni ap endonuclease 0.0038 0.0053 0.0284
Echinococcus multilocularis thyroid hormone receptor alpha 0.0063 0.0105 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Echinococcus multilocularis zinc finger protein 0.0044 0.0065 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0052 0.2481
Loa Loa (eye worm) inositol-1 0.0036 0.0049 0.0521
Leishmania major hypothetical protein, conserved 0.003 0.0038 0.1739
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0422 0.4478
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0004 0.0046
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0033 0.1497
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.02 0.1129
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0052 0.0554
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0044 0.0468
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.004 0.1897
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0022 0.0019
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0024 0.0562
Schistosoma mansoni thyroid hormone receptor 0.0063 0.0105 0.0583
Loa Loa (eye worm) hypothetical protein 0.0207 0.0399 0.4234
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0162 0.4306
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0105 0.0102
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0049 0.0908
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Schistosoma mansoni hypothetical protein 0.008 0.014 0.0784
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0029 0.0036
Brugia malayi hypothetical protein 0.0173 0.0329 0.3491
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0037 0.0192
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0037 0.0391
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0153 0.162
Loa Loa (eye worm) hypothetical protein 0.0102 0.0185 0.1958
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.02 0.3824
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0077 0.0421
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0049 0.1238
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.004 0.0082
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0012 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0052 0.0969
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0221 0.235
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0293 0.029
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0037 0.0391
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0037 0.0034
Echinococcus multilocularis heat shock protein 0.0033 0.0043 0.0039
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0076 0.0131 0.1386
Schistosoma mansoni nuclear receptor 0.003 0.0037 0.0192
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0162 0.3091
Brugia malayi Muscleblind-like protein 0.0155 0.0293 0.3112
Brugia malayi nuclear receptor NHR-67 0.003 0.0037 0.0391
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0017 0.0081
Onchocerca volvulus Huntingtin homolog 0.0123 0.0228 0.4717
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0052 0.2481
Schistosoma mansoni hypothetical protein 0.0096 0.0172 0.0965
Entamoeba histolytica hypothetical protein 0.0028 0.0033 0.0799
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0029 0.1311
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0112 0.0622
Echinococcus multilocularis Niemann Pick C1 protein 0.0194 0.0373 0.037
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.02 0.3824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0063 0.0105 0.1114
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0041 0.0065
Loa Loa (eye worm) hypothetical protein 0.008 0.014 0.1487
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0052 0.0969
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.027
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.0521 0.5529
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Schistosoma mansoni hypothetical protein 0.008 0.014 0.0784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0063 0.0105 0.1114
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0044 0.0234
Mycobacterium leprae conserved hypothetical protein 0.011 0.02 0.0365
Schistosoma mansoni hypothetical protein 0.0036 0.0049 0.0262
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.004 0.7493
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Loa Loa (eye worm) hypothetical protein 0.0473 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.011 0.02 0.2127
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.02 0.0389
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0016 0.027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.027
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0017 0.0081
Schistosoma mansoni hypothetical protein 0.008 0.014 0.0784
Onchocerca volvulus 0.0097 0.0175 0.3619
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0353 0.676
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.1114
Echinococcus granulosus GPCR family 2 0.0096 0.0172 0.0965
Loa Loa (eye worm) steroid hormone receptor 0.0063 0.0105 0.1114
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0017 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0043 0.0089
Schistosoma mansoni hypothetical protein 0.0868 0.1748 1
Schistosoma mansoni survival motor neuron protein 0.0096 0.0173 0.0973
Loa Loa (eye worm) hypothetical protein 0.0123 0.0228 0.2418
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0146 0.0819
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0063 0.0105 0.1114
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.02 0.2127
Echinococcus granulosus heat shock protein 90 0.0033 0.0043 0.0226
Brugia malayi nuclear receptor NHR-88 0.0063 0.0105 0.1114
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0037 0.0034
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.0105 0.1114
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.0323 0.0664
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0053 0.2513
Loa Loa (eye worm) DR-78 0.003 0.0037 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0037 0.0193
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0045 0.0237
Schistosoma mansoni alpha-glucosidase 0.0145 0.0272 0.1539
Brugia malayi nuclear receptor NHR-88 0.003 0.0037 0.0391
Onchocerca volvulus 0.0024 0.0024 0.0498
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.1114
Plasmodium falciparum heat shock protein 90 0.0033 0.0043 0.8091
Toxoplasma gondii exonuclease III APE 0.0038 0.0053 0.0109
Schistosoma mansoni inositol monophosphatase 0.0036 0.0049 0.0263
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.02 0.0393
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0017 0.0036
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0022 0.0019
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0043 0.2001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0053 0.2513
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0044 0.0468
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0043 0.2001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0112 0.0109
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0221 0.235
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0059 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0063 0.0105 0.1114
Onchocerca volvulus Huntingtin homolog 0.0123 0.0228 0.4717
Schistosoma mansoni hypothetical protein 0.0063 0.0105 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Onchocerca volvulus 0.0063 0.0105 0.2174
Loa Loa (eye worm) hypothetical protein 0.011 0.02 0.2127
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.032 0.3394
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0194 0.0373 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0049 0.0262
Onchocerca volvulus 0.0033 0.0043 0.0895
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0022 0.0108
Loa Loa (eye worm) hypothetical protein 0.011 0.02 0.2127
Schistosoma mansoni cpg binding protein 0.0095 0.017 0.0958
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.004 0.1976
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0162 0.1724
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2389 0.4857 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0053 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.0391
Onchocerca volvulus 0.003 0.0037 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0063 0.0105 0.1114
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0162 0.3091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0044 0.0468
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Mycobacterium tuberculosis Conserved protein 0.011 0.02 0.0393
Brugia malayi hypothetical protein 0.0123 0.0228 0.2418
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.0227 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0063 0.0105 0.1114
Onchocerca volvulus 0.0173 0.0329 0.681
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0037 0.0192
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.0105 0.1114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0024 0.0029
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0172 0.1823
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0017 0.0775
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.011 0.02 0.2127
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0017 0.0775
Brugia malayi nuclear receptor RXR 0.0033 0.0044 0.0468
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0004 0.0046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0046
Echinococcus multilocularis survival motor neuron protein 1 0.0473 0.0942 0.0939
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0162 0.807
Brugia malayi CXXC zinc finger family protein 0.0087 0.0153 0.162
Echinococcus multilocularis geminin 0.0868 0.1748 0.1746
Echinococcus granulosus muscleblind protein 0.0155 0.0293 0.1661
Echinococcus multilocularis expressed conserved protein 0.0182 0.0349 0.0345
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0172 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0521 1
Schistosoma mansoni hypothetical protein 0.003 0.0038 0.0197
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.004 0.1841
Brugia malayi Bromodomain containing protein 0.0153 0.0288 0.3059
Loa Loa (eye worm) hypothetical protein 0.0096 0.0172 0.1823
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0004 0.012
Echinococcus granulosus dnaJ subfamily B 0.0807 0.1624 0.9289
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0017 0.008
Leishmania major heat shock protein 83-1 0.0033 0.0043 0.2001
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2389 0.4857 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.02 0.0393
Loa Loa (eye worm) hypothetical protein 0.0083 0.0146 0.1552
Echinococcus multilocularis ecdysone induced protein 78C 0.0063 0.0105 0.0102
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0033 0.035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0053 0.2637
Brugia malayi Endoplasmin precursor 0.0033 0.0043 0.0454
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0029 0.0524
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0063 0.0105 0.0583
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0053 0.0284
Giardia lamblia Kinase, PLK 0.0091 0.0162 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0053 0.1341
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0063 0.0105 0.0102
Schistosoma mansoni myst-related protein 0.0014 0.0004 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.0186 0.1975
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0004 0.009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0063 0.0105 0.0583
Loa Loa (eye worm) hypothetical protein 0.0063 0.0105 0.1114
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Schistosoma mansoni coup transcription factor 0.0063 0.0105 0.0583
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0052 0.0969
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.027
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.02 0.2127
Mycobacterium tuberculosis Probable hydrolase 0.011 0.02 0.0393
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.004 0.0036
Trypanosoma brucei heat shock protein, putative 0.0033 0.0043 0.2056
Onchocerca volvulus 0.0248 0.0483 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.0105 0.1114
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0017 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.02 0.0389
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0049 0.84
Loa Loa (eye worm) hypothetical protein 0.0155 0.0293 0.3112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0044 0.0468
Onchocerca volvulus 0.011 0.02 0.415
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0024 0.0025
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0043 0.2056
Leishmania major hypothetical protein, conserved 0.011 0.02 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0037 0.0192
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0016 0.027
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0162 0.0159
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.004 0.1841
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0242 0.0471 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0063 0.0105 0.1114
Brugia malayi photoreceptor-specific nuclear receptor 0.0063 0.0105 0.1114
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0162 0.3362
Echinococcus multilocularis heat shock protein 90 0.0033 0.0043 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0521 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0063 0.0105 0.0583
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.004 0.0082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.004 0.0036

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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