Detailed information for compound 154432

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.453 | Formula: C22H25N3O
  • H donors: 1 H acceptors: 2 LogP: 3.4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1CCCN1C(=O)CNCCC(c1ccccc1)c1ccccc1
  • InChi: 1S/C22H25N3O/c23-16-20-12-7-15-25(20)22(26)17-24-14-13-21(18-8-3-1-4-9-18)19-10-5-2-6-11-19/h1-6,8-11,20-21,24H,7,12-15,17H2/t20-/m0/s1
  • InChiKey: XTQWVERKWAYRLX-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0162 0.3185
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0079 0.0192 0.2498
Echinococcus multilocularis carbonic anhydrase II 0.0031 0.0018 0.0261
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0078 0.085
Echinococcus granulosus carbonic anhydrase II 0.0031 0.0018 0.0261
Schistosoma mansoni hypothetical protein 0.0069 0.0156 0.1704
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0061 0.0955
Loa Loa (eye worm) ATP-citrate synthase 0.0155 0.0473 0.2983
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0086 0.0545
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0086 0.1283
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0439 0.2774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0086 0.0545
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0031 0.0018 0.0111
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0031 0.0018 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0086 0.1283
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0086 0.0545
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0086 0.0841
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0031 0.0018 0.0192
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0086 0.1283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0086 0.0545
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0086 0.1283
Plasmodium falciparum fructose-bisphosphate aldolase 0.0091 0.0239 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0048 0.1367
Echinococcus multilocularis Squalene phytoene synthase 0.0079 0.0192 0.286
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0091 0.0239 0.1511
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Brugia malayi nuclear receptor NHR-88 0.005 0.0086 0.0545
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0261
Schistosoma mansoni ATP-citrate synthase 0.0136 0.0403 0.4405
Brugia malayi PAS domain containing protein 0.0047 0.0078 0.0491
Loa Loa (eye worm) acetyltransferase 0.0146 0.0439 0.2774
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0086 0.1283
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0086 0.0944
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.0672 1
Brugia malayi hypothetical protein 0.0036 0.0036 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0031 0.0018 0.0192
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0061 0.0067
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0091 0.0239 0.356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0086 0.0545
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0086 0.1283
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0086 0.0545
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0086 0.0545
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0086 0.0545
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2747 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0086 0.0545
Schistosoma mansoni coup transcription factor 0.005 0.0086 0.0944
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Loa Loa (eye worm) carbonic anhydrase 3 0.0031 0.0018 0.0111
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.0672 0.7353
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0261
Brugia malayi polk-prov protein 0.0031 0.0018 0.0116
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0439 0.4806
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0086 0.0944
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Echinococcus multilocularis thyroid hormone receptor alpha 0.0196 0.0624 0.9273
Loa Loa (eye worm) hypothetical protein 0.0159 0.0488 0.3083
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0055 0.0464
Leishmania major hypothetical protein, conserved 0.0079 0.0192 0.215
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0086 0.0944
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0086 0.0545
Trypanosoma brucei squalene synthase, putative 0.0252 0.083 1
Brugia malayi ATP-citrate synthase 0.0155 0.0473 0.2983
Trypanosoma cruzi squalene synthase, putative 0.0252 0.083 1
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0086 0.0545
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0055 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0086 0.0545
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Mycobacterium ulcerans glutaminase 0.0275 0.0914 0.0885
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0079 0.0192 0.003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0162 0.2417
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0261
Schistosoma mansoni carbonic anhydrase 0.0031 0.0018 0.0192
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.356
Echinococcus granulosus dna polymerase kappa 0.0041 0.0055 0.0822
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0032 0.0482
Leishmania major fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.2729
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.0162 0.3173
Onchocerca volvulus 0.005 0.0086 0.0841
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0031 0.0018 0.0111
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0162 0.1776
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0086 0.1283
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0055 0.0822
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0086 0.0545
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0086 0.0944
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Schistosoma mansoni hypothetical protein 0.0146 0.0441 0.4819
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.0441 0.6553
Trypanosoma cruzi squalene synthase, putative 0.0252 0.083 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0086 0.0546
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.4875
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.0441 0.6553
Loa Loa (eye worm) glutaminase 2 0.0275 0.0914 0.5772
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.0672 0.4244
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0031 0.0018 0.0111
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.018
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0546
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0032 0.0205
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0162 0.1777
Brugia malayi fructose-bisphosphate aldolase 2 0.0091 0.0239 0.1511
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Brugia malayi hypoxia-induced factor 1 0.0147 0.0443 0.2797
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Brugia malayi nuclear hormone receptor 0.005 0.0086 0.0545
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0055 0.0023
Brugia malayi fructose-bisphosphate aldolase 1 0.0091 0.0239 0.1511
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0086 0.0944
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.008 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0086 0.0545
Brugia malayi Cytochrome P450 family protein 0.0048 0.008 0.0506
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.0672 1
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Loa Loa (eye worm) hypothetical protein 0.0054 0.0101 0.0637
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0162 0.1022
Schistosoma mansoni nuclear hormone receptor 0.005 0.0086 0.0944
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0116
Echinococcus multilocularis jun protein 0.0085 0.0214 0.3182
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0086 0.0545
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0086 0.0944
Echinococcus granulosus FTZ F1 alpha 0.005 0.0086 0.1283
Brugia malayi ecdysteroid receptor 0.005 0.0086 0.0545
Brugia malayi follicle stimulating hormone receptor 0.0457 0.1584 1
Echinococcus granulosus jun protein 0.0085 0.0214 0.3182
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Trypanosoma cruzi phytoene synthase, putative 0.0079 0.0192 0.215
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0162 0.1776
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0091 0.0239 0.2618
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0261
Brugia malayi bZIP transcription factor family protein 0.0085 0.0214 0.135
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0031 0.0018 0.0111
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0162 0.2408
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0214 0.3182
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0091 0.0239 0.2618
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0018 0.0009
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0457 0.1584 1
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0091 0.0239 1
Trypanosoma brucei unspecified product 0.0035 0.0031 0.0163
Schistosoma mansoni glutaminase 0.0275 0.0914 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0162 0.1771
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0018 0.0009
Loa Loa (eye worm) glutaminase 0.0275 0.0914 0.5772
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0162 0.1776
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.0443 0.2797
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0086 0.1283
Brugia malayi steroid hormone receptor 0.005 0.0086 0.0545
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0086 0.0944
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.356
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0061 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0086 0.0545
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0086 0.0841
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0086 0.1283
Brugia malayi hypothetical protein 0.0054 0.0101 0.0637
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0086 0.0545
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Echinococcus granulosus single minded 2 0.0035 0.0032 0.0482
Onchocerca volvulus 0.0066 0.0147 0.1794
Loa Loa (eye worm) hypothetical protein 0.0079 0.0192 0.1214
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0086 0.0545
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0086 0.1283
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0091 0.0239 0.1511
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0086 0.1283
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0162 0.1783
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0086 0.0545
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.4875
Schistosoma mansoni hypothetical protein 0.0079 0.0192 0.2103
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0162 0.1776
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0029 0.018
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0439 0.6536
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0086 0.0545
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0162 0.1777
Brugia malayi hypothetical protein 0.0066 0.0147 0.093
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.356
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0086 0.1283
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.356
Trichomonas vaginalis glutaminase, putative 0.0275 0.0914 1
Schistosoma mansoni thyroid hormone receptor 0.0196 0.0624 0.6819
Schistosoma mansoni hypothetical protein 0.0034 0.0029 0.0312
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2747 1 1
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0048 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0086 0.0944
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0162 0.2408
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0055 0.0464
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.356
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0086 0.0944
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0086 0.1283
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0214 0.3182
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.356
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0086 0.0545
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0061 0.0908
Schistosoma mansoni single-minded 0.0047 0.0078 0.085
Schistosoma mansoni jun-related protein 0.0069 0.0156 0.1704
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.0672 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0086 0.0545
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0036 0.0542
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.0672 0.4244
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0086 0.0545
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0162 0.1776
Mycobacterium ulcerans phytoene synthase, CrtB 0.0079 0.0192 0.016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0086 0.0546
Schistosoma mansoni hypothetical protein 0.0031 0.0018 0.0192
Toxoplasma gondii ATP-citrate lyase, putative 0.0155 0.0473 1
Brugia malayi hypothetical protein 0.0159 0.0488 0.3083
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0091 0.0239 0.356
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0031 0.0163
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0086 0.1283
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0086 0.1283
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0091 0.0239 0.4875
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0036 0.0542
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0048 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0162 0.2417
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0086 0.0841
Schistosoma mansoni thyroid hormone receptor 0.0196 0.0624 0.6819
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0086 0.0546
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0086 0.1283
Leishmania major squalene synthase, putative 0.0252 0.083 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0086 0.0545
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0424 0.6312
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0036 0.0398
Loa Loa (eye worm) hypothetical protein 0.0082 0.0205 0.1297
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0061 0.0955
Brugia malayi glutaminase DH11.1 0.0275 0.0914 0.5772
Echinococcus granulosus Squalene phytoene synthase 0.0079 0.0192 0.286

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 377 nM Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cells ChEMBL. 12801240
IC50 (binding) = 377 nM Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cells ChEMBL. 12801240

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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