Detailed information for compound 1544383

Basic information

Technical information
  • TDR Targets ID: 1544383
  • Name: 3,9-di(furan-2-yl)-2,4,8,10-tetraoxaspiro[5.5 ]undecane
  • MW: 292.284 | Formula: C15H16O6
  • H donors: 0 H acceptors: 0 LogP: 0.75 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1coc(c1)C1OCC2(CO1)COC(OC2)c1ccco1
  • InChi: 1S/C15H16O6/c1-3-11(16-5-1)13-18-7-15(8-19-13)9-20-14(21-10-15)12-4-2-6-17-12/h1-6,13-14H,7-10H2
  • InChiKey: RCPOYMZTZWMPSU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,9-bis(2-furyl)-2,4,8,10-tetraoxaspiro[5.5]undecane
  • 5115-25-3
  • 3,9-Di-2-furyl-2,4,8,10-tetraoxaspiro(5.5)undecane
  • EINECS 225-847-5
  • ZINC02476978
  • 3,9-Di-furan-2-yl-2,4,8,10-tetraoxa-spiro[5.5]undecane
  • MLS000769341
  • SMR000434075
  • A2625/0111703
  • 2,4,8,10-Tetraoxaspiro(5.5)undecane, 3,9-di-2-furanyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0396 1
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0396 0.3151
Schistosoma mansoni tar DNA-binding protein 0.0143 0.3309 0.3131
Schistosoma mansoni tar DNA-binding protein 0.0143 0.3309 0.3131
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0284 0.0079
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0955 0.0714
Trypanosoma cruzi DNA polymerase eta, putative 0.0073 0.1257 1
Leishmania major DNA polymerase kappa, putative 0.0044 0.0396 0.1153
Trypanosoma brucei DNA polymerase eta, putative 0.0073 0.1257 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0955 1
Brugia malayi RNA recognition motif domain containing protein 0.0143 0.3309 1
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.1257 0.3271
Onchocerca volvulus 0.004 0.0284 0.5
Loa Loa (eye worm) TAR-binding protein 0.0143 0.3309 1
Loa Loa (eye worm) RNA binding protein 0.0143 0.3309 1
Echinococcus multilocularis geminin 0.0371 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0396 0.1153
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0377 0.1386
Entamoeba histolytica deoxycytidyl transferase, putative 0.0044 0.0396 1
Brugia malayi beta-lactamase family protein 0.004 0.0284 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0143 0.3309 0.3131
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0396 0.1671
Echinococcus multilocularis dna polymerase eta 0.0073 0.1257 0.1024
Mycobacterium leprae Probable lipase LipE 0.004 0.0284 0.5
Echinococcus multilocularis tar DNA binding protein 0.0143 0.3309 0.3131
Echinococcus granulosus tar DNA binding protein 0.0143 0.3309 0.3131
Schistosoma mansoni terminal deoxycytidyl transferase 0.0044 0.0396 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0044 0.0396 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Leishmania major DNA polymerase eta, putative 0.0043 0.0377 0.0956
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0044 0.0396 0.014
Schistosoma mansoni tar DNA-binding protein 0.0143 0.3309 0.3131
Schistosoma mansoni hypothetical protein 0.0371 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Loa Loa (eye worm) hypothetical protein 0.0073 0.1257 0.3217
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0143 0.3309 1
Echinococcus granulosus dna polymerase kappa 0.0044 0.0396 0.014
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0955 0.0714
Brugia malayi TAR-binding protein 0.0143 0.3309 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0044 0.0396 0.0371
Leishmania major DNA polymerase eta, putative 0.0073 0.1257 1
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0955 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0284 0.0025
Plasmodium vivax hypothetical protein, conserved 0.004 0.0284 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0284 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0396 0.1153
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0955 0.0714
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0396 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0955 0.6899
Schistosoma mansoni tar DNA-binding protein 0.0143 0.3309 0.3131
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0396 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0377 0.0956
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0396 0.1153
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0396 0.0179
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0396 0.3151
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0396 0.0447
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0284 0.0025
Mycobacterium leprae conserved hypothetical protein 0.004 0.0284 0.5
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0284 0.2258
Trypanosoma brucei unspecified product 0.0044 0.0396 0.3151
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0396 0.3151
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0955 0.107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0955 1
Onchocerca volvulus 0.004 0.0284 0.5
Brugia malayi RNA binding protein 0.0143 0.3309 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.6558 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151
Onchocerca volvulus 0.004 0.0284 0.5
Giardia lamblia DINP protein human, muc B family 0.0044 0.0396 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0396 0.1671
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0955 1
Brugia malayi beta-lactamase family protein 0.004 0.0284 0.0079
Schistosoma mansoni hypothetical protein 0.0371 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0396 0.1153
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0396 0.0179
Echinococcus granulosus dna polymerase eta 0.0073 0.1257 0.1024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0396 0.1153
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0955 0.0714
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0044 0.0396 0.014
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0284 0.0025
Schistosoma mansoni DNA polymerase eta 0.0073 0.1257 0.1024
Brugia malayi beta-lactamase 0.004 0.0284 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0396 0.3151

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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