Detailed information for compound 1544397

Basic information

Technical information
  • TDR Targets ID: 1544397
  • Name: 2-(2,6-dimethyl-3-oxo-1,4-benzoxazin-4-yl)-N- (oxolan-2-ylmethyl)acetamide
  • MW: 318.368 | Formula: C17H22N2O4
  • H donors: 1 H acceptors: 2 LogP: 1.58 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)C(C)Oc2c1cc(C)cc2)NCC1CCCO1
  • InChi: 1S/C17H22N2O4/c1-11-5-6-15-14(8-11)19(17(21)12(2)23-15)10-16(20)18-9-13-4-3-7-22-13/h5-6,8,12-13H,3-4,7,9-10H2,1-2H3,(H,18,20)
  • InChiKey: CPKUBPXAPAWDNZ-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(2,6-dimethyl-3-oxo-1,4-benzoxazin-4-yl)-N-(tetrahydrofuran-2-ylmethyl)acetamide
  • 2-(2,6-dimethyl-3-oxo-1,4-benzoxazin-4-yl)-N-(2-tetrahydrofuranylmethyl)acetamide
  • 2-(3-keto-2,6-dimethyl-1,4-benzoxazin-4-yl)-N-(tetrahydrofurfuryl)acetamide
  • 2-(2,6-dimethyl-3-oxo-1,4-benzoxazin-4-yl)-N-(oxolan-2-ylmethyl)ethanamide
  • SMR000119606
  • MLS000122130
  • 2-(2,6-Dimethyl-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-N-(tetrahydro-furan-2-ylmethyl)-acetamide
  • ASN 06913587

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0098 0.0177
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0148 0.0148
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0108 0.1405
Schistosoma mansoni cathepsin s 0.0017 0.001 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.004 0.0518
Loa Loa (eye worm) acetyltransferase 0.015 0.0551 0.1242
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0138 0.0138
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0148 0.0148
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.0108 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0293
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0052 0.0108
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0003 0.0005
Brugia malayi jmjC domain containing protein 0.0015 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Onchocerca volvulus 0.0041 0.0108 0.0224
Onchocerca volvulus 0.0094 0.0322 0.0674
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0052 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0092 0.0207
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.0043
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0211
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0052 0.0095
Leishmania major quinone oxidoreductase, putative 0.0041 0.0108 0.1405
Brugia malayi Cathepsin L-like precursor 0.0051 0.0148 0.0295
Echinococcus multilocularis Smad4 0.0033 0.0075 0.0075
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0013 0.0143
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0001 0.0002
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0427 0.1678 0.6022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Mycobacterium ulcerans thioesterase 0.0549 0.2172 0.5488
Entamoeba histolytica hypothetical protein 0.0071 0.0231 0.5598
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0108 0.144
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0013 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0106 0.1255
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0148 0.3461
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0212 0.0491
Echinococcus multilocularis cysteine protease 0.0051 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0699 0.2785 0.7049
Echinococcus granulosus geminin 0.069 0.2745 0.4958
Brugia malayi Cathepsin L-like precursor 0.0034 0.008 0.0159
Plasmodium vivax vivapain-2 0.0051 0.0148 0.2381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.011 0.0199
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0041 0.0108 0.0226
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0165 0.0613 0.8397
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0024 0.0024
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0121 0.1294
Echinococcus granulosus aryl hydrocarbon receptor 0.0054 0.016 0.0289
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0223
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0322 0.0643
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0067 0.0212 0.0422
Brugia malayi Methyltransferase-like protein 4 0.0198 0.0748 0.1491
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0024 0.0054
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0034
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.001 0.0019
Onchocerca volvulus 0.006 0.0183 0.0383
Loa Loa (eye worm) hypothetical protein 0.0047 0.013 0.0294
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0165 0.0613 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.035 0.0789
Loa Loa (eye worm) hypothetical protein 0.0034 0.008 0.018
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.004 0.0073
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0076 0.1008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.013 0.0236
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0118
Brugia malayi isocitrate dehydrogenase 0.0048 0.0138 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.004 0.0384
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0048 0.0883
Toxoplasma gondii acyl transferase domain-containing protein 0.0042 0.011 0.0386
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0042 0.011 0.022
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0108 0.144
Brugia malayi ecdysteroid receptor 0.0027 0.0052 0.0105
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.004 0.0081
Echinococcus multilocularis dna polymerase kappa 0.002 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0054
Echinococcus multilocularis smad 0.0033 0.0075 0.0075
Entamoeba histolytica cysteine protease, putative 0.0051 0.0148 0.3461
Onchocerca volvulus 0.0615 0.2443 0.5123
Brugia malayi Phosphopantetheine attachment site family protein 0.0067 0.0212 0.0422
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0038 0.0095 0.0213
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0118
Echinococcus multilocularis cathepsin L 0.0026 0.0048 0.0048
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0041 0.0108 0.149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0165 0.0613 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0013 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0048 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.013 0.013
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.0108 0.0194
Loa Loa (eye worm) hypothetical protein 0.0101 0.0352 0.0793
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0051 0.0148 0.2381
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0172 0.0311
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0108 0.1146
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.013 0.0294
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0265
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0108 0.144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0052 0.0095
Chlamydia trachomatis acyl carrier protein 0.0067 0.0212 0.338
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0024 0.0048
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0138 0.1865
Onchocerca volvulus 0.0041 0.0108 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0041 0.0108 0.0226
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0265
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0141
Toxoplasma gondii cathepsin CPL 0.0051 0.0148 0.0522
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0052 0.0105
Onchocerca volvulus 0.0027 0.0052 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0052 0.0105
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0048 0.0883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0118
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0659 0.2618 0.5221
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0113 0.0403 0.0803
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0334
Brugia malayi jmjC domain containing protein 0.006 0.0186 0.0371
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0067 0.0212 0.0491
Echinococcus granulosus cathepsin l1 0.0051 0.0148 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0052 0.0105
Echinococcus granulosus cpg binding protein 0.0063 0.0197 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0052 0.0118
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0013 0.0027
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0041 0.0108 0.0226
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0108 0.1405
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0038 0.0095 0.0189
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.0212 0.0491
Mycobacterium ulcerans Type I modular polyketide synthase 0.0659 0.2618 0.6625
Entamoeba histolytica hypothetical protein 0.0024 0.004 0.0693
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0138 0.025
Mycobacterium ulcerans polyketide synthase MbtC 0.0165 0.0613 0.1514
Echinococcus multilocularis lamin dm0 0.008 0.0266 0.0266
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0212 0.0521
Loa Loa (eye worm) mucolipin 1 0.0063 0.0197 0.0445
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0108 0.144
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0148 0.1607
Brugia malayi jmjC domain containing protein 0.0015 0.0003 0.0006
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0048 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0048 0.0095
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0052 0.0095
Mycobacterium ulcerans oxidoreductase 0.0041 0.0108 0.0226
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0108 0.0226
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0108 0.0226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0185 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Mycobacterium ulcerans polyketide synthase 0.0659 0.2618 0.6625
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0121 0.1929
Echinococcus multilocularis microtubule associated protein 2 0.1376 0.5537 0.5537
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0108 0.2417
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0048 0.0086
Giardia lamblia Methyltransferase like 2 0.0198 0.0748 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0076 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Schistosoma mansoni methyltransferase-related 0.0198 0.0748 0.135
Brugia malayi MH2 domain containing protein 0.0482 0.19 0.3788
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0108 0.144
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0052 0.0095
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0101 0.0352 0.0848
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0024 0.0199
Schistosoma mansoni smad1 5 8 and 0.0033 0.0075 0.0135
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0165 0.0613 0.2194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0013 0.0013
Echinococcus multilocularis GPCR, family 2 0.0047 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0052 0.0118
Brugia malayi Pre-SET motif family protein 0.0205 0.0773 0.1542
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0034
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0549 0.2172 0.5502
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0108 0.0214
Onchocerca volvulus 0.0051 0.0148 0.0309
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0121 0.0423
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0052 0.0095
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0108 0.144
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0356 0.5791
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0165 0.0613 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0019 0.0217
Onchocerca volvulus Cathepsin F homolog 0.0051 0.0148 0.0309
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0165 0.0613 0.1107
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0048 0.0883
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0067 0.0212 0.0491
Loa Loa (eye worm) hypothetical protein 0.1106 0.4439 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0403 0.4495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.013 0.0236
Loa Loa (eye worm) cysteine protease 0.0051 0.0148 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.013 0.013
Schistosoma mansoni smad 0.0033 0.0075 0.0135
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0108 0.0226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0065 0.0118
Mycobacterium ulcerans oxidoreductase FadB5 0.0041 0.0108 0.0226
Plasmodium vivax vivapain-3 0.0026 0.0048 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0699 0.2785 0.7049
Brugia malayi Smad1 0.0033 0.0075 0.0149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0052 0.0095
Echinococcus granulosus survival motor neuron protein 1 0.046 0.1809 0.3268
Leishmania major hypothetical protein, conserved 0.0198 0.0748 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0699 0.2785 0.7058
Brugia malayi hypothetical protein 0.0037 0.0094 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0148 0.0295
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.0356 0.5791
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0008 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0065 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0048 0.0619
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.0108 0.0214
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0615 0.2443 0.6177
Echinococcus granulosus serine protein kinase ATM 0.0024 0.004 0.0073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0019 0.0223
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0067 0.0212 0.0491
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0052 0.0095
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0052 0.0118
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0118
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0165 0.0613 0.1107
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0022
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.053 0.2095 0.5307
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Toxoplasma gondii acyl carrier protein ACP 0.0067 0.0212 0.0751
Plasmodium vivax unspecified product 0.0017 0.001 0.0112
Leishmania major protein kinase, putative 0.002 0.0023 0.0266
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0041 0.0108 0.0226
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0113 0.0403 0.53
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0008 0.0014
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0101 0.0352 0.0848
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0108 0.2417
Leishmania major hypothetical protein, conserved 0.0042 0.011 0.1442
Leishmania major cysteine peptidase A (CPA) 0.0051 0.0148 0.1951
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0048 0.0619
Brugia malayi CXXC zinc finger family protein 0.006 0.0183 0.0366
Loa Loa (eye worm) hypothetical protein 0.0054 0.0159 0.0358
Echinococcus multilocularis cpg binding protein 0.0063 0.0197 0.0197
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0108 0.144
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0052 0.0095
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0115 0.023
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0055 0.01
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0138 0.222
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0067 0.0212 0.0491
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.073 1
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0165 0.0613 0.0613
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0148 0.0334
Echinococcus multilocularis dnaJ subfamily B 0.0848 0.339 0.339
Brugia malayi AMP-binding enzyme family protein 0.0615 0.2443 0.487
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0013 0.003
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0108 0.0214
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0138 0.0138
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0148 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0052 0.0095
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0699 0.2785 0.7058
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0007 0.0052
Echinococcus multilocularis expressed protein 0.0034 0.0079 0.0079
Plasmodium vivax SET domain protein, putative 0.003 0.0065 0.1021
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0165 0.0613 0.1223
Mycobacterium ulcerans Type I modular polyketide synthase 0.0659 0.2618 0.6625
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0242
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0019 0.0142
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0108 0.0108
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.011 0.0199
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0138 0.0138
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0048 0.0086
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0186 0.0336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0231 0.0231
Onchocerca volvulus 0.0054 0.0159 0.0331
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0048 0.0619
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.053 0.2095 0.5292
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0013 0.0024
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.008 0.0159
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0659 0.2618 0.6625
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0138 0.025
Mycobacterium ulcerans fatty acid synthase Fas 0.0207 0.0782 0.1945
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0003 0.0005
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0165 0.0613 1
Onchocerca volvulus 0.008 0.0266 0.0556
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.0148 0.0268
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0113 0.0403 0.4495
Loa Loa (eye worm) hypothetical protein 0.046 0.1809 0.4077
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0212 0.0521
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0699 0.2785 0.7058
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.073 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0067 0.0212 0.0491
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0042 0.011 0.0232
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0067 0.0212 0.3242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0108 0.1405
Mycobacterium ulcerans quinone reductase Qor 0.0041 0.0108 0.0226
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.035 0.0698
Mycobacterium ulcerans polyketide synthase 0.0699 0.2785 0.7049
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0017 0.003
Echinococcus granulosus dnaJ subfamily B 0.0848 0.339 0.6122
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0041 0.0108 0.0226
Echinococcus granulosus smad 0.0033 0.0075 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0202 0.0764 0.1524
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0008 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0003 0.0006
Leishmania major oxidoreductase, putative 0.0041 0.0108 0.1405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Toxoplasma gondii type I fatty acid synthase, putative 0.0699 0.2785 1
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.008 0.083
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0101 0.0352 0.0848
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0052 0.0052
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.001 0.0022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0019 0.0075
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0067 0.0212 0.2873
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0076 0.0263
Brugia malayi hypothetical protein 0.0038 0.0095 0.0189
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0075 0.0135
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0013 0.0143
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0435 0.1712 0.4314
Brugia malayi hypothetical protein 0.0071 0.0231 0.0461
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0003 0.0005
Leishmania major DNA polymerase kappa, putative 0.002 0.0024 0.0286
Trypanosoma brucei unspecified product 0.002 0.0024 0.0293
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0052 0.0052
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0067 0.0212 0.0442
Loa Loa (eye worm) hypothetical protein 0.0113 0.0403 0.0907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0065 0.0224
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0121 0.0218
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0221
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0108 0.144
Brugia malayi jmjC domain containing protein 0.0015 0.0003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0052 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0013 0.0146
Brugia malayi follicle stimulating hormone receptor 0.0236 0.0899 0.1793
Schistosoma mansoni mucolipin 0.0058 0.0176 0.0318
Leishmania major cathepsin L-like protease 0.0194 0.073 0.9758
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0459 0.0829
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0041 0.0108 0.0226
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0113 0.0403 0.0727
Schistosoma mansoni hypothetical protein 0.0094 0.0322 0.0582
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0003 0.0005
Echinococcus granulosus acyl carrier protein mitochondrial 0.0067 0.0212 0.0382
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Echinococcus granulosus expressed protein 0.0034 0.0079 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0048 0.0619
Mycobacterium ulcerans Type I modular polyketide synthase 0.0659 0.2618 0.6625
Loa Loa (eye worm) fibroinase 0.0051 0.0148 0.0334
Onchocerca volvulus 0.0074 0.0243 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0052 0.0105
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0006 0.001
Echinococcus multilocularis dna polymerase eta 0.002 0.0024 0.0024
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0113 0.0403 0.0727
Onchocerca volvulus 0.0051 0.0148 0.0309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Plasmodium vivax vivapain-2 0.0051 0.0148 0.2381
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0067 0.0212 0.2873
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.0038
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0106 0.2369
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0113 0.0403 0.0403
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0076 0.161
Loa Loa (eye worm) hypothetical protein 0.0037 0.0092 0.0207
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0147
Loa Loa (eye worm) intermediate filament protein 0.008 0.0266 0.0599
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0242
Mycobacterium ulcerans polyketide synthase Pks13 0.0984 0.3942 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0185 0.0334
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0027 0.0326
Brugia malayi Cathepsin L-like precursor 0.0051 0.0148 0.0295
Loa Loa (eye worm) hypothetical protein 0.0101 0.0352 0.0793
Echinococcus multilocularis aryl hydrocarbon receptor 0.0054 0.016 0.016
Leishmania major cathepsin L-like protease 0.0194 0.073 0.9758
Brugia malayi Cathepsin L-like precursor 0.0051 0.0148 0.0295
Echinococcus granulosus cysteine protease 0.0026 0.0048 0.0086
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0041 0.0108 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0165 0.0613 0.1382
Loa Loa (eye worm) ctsf protein 0.0051 0.0148 0.0334
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.0899 0.2026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0052 0.0095
Onchocerca volvulus 0.0233 0.0888 0.186
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0041 0.0108 0.0226
Echinococcus granulosus GPCR family 2 0.0047 0.013 0.0236
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0108 0.144
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0148 0.0148
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0138 0.0304
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0138 0.0487
Loa Loa (eye worm) hypothetical protein 0.0078 0.026 0.0586
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0013 0.0024
Schistosoma mansoni coup transcription factor 0.0027 0.0052 0.0095
Echinococcus granulosus lamin 0.008 0.0266 0.048
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0172 0.0172
Trypanosoma cruzi major cysteine proteinase, putative 0.0152 0.0561 0.7678
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0079 0.0158
Plasmodium falciparum cysteine proteinase falcipain 3 0.0051 0.0148 0.2381
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0185 0.2447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Entamoeba histolytica hypothetical protein 0.0071 0.0231 0.5598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0067 0.0212 0.0491
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1248 0.5016 1
Schistosoma mansoni hypothetical protein 0.0047 0.013 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0148 0.2
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0435 0.1712 0.4332
Echinococcus granulosus dna polymerase eta 0.002 0.0024 0.0044
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0113 0.0403 0.4495
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0042 0.011 0.1535
Echinococcus granulosus phd:f box containing protein 0.0015 0.0003 0.0005
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0113 0.0403 0.0727
Leishmania major cathepsin L-like protease 0.0051 0.0148 0.1951
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0211
Brugia malayi PAS domain containing protein 0.0016 0.0007 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.013 0.013
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0003 0.0005
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.011 0.0199
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0659 0.2618 0.6625
Brugia malayi hypothetical protein 0.046 0.1809 0.3608
Mycobacterium ulcerans oxidoreductase 0.0041 0.0108 0.0226
Echinococcus multilocularis ubiquitin specific protease 41 0.0113 0.0403 0.0403
Mycobacterium ulcerans thioesterase TesA 0.0549 0.2172 0.5488
Schistosoma mansoni hypothetical protein 0.0047 0.013 0.0236
Leishmania major cathepsin L-like protease 0.0051 0.0148 0.1951
Onchocerca volvulus 0.0051 0.0148 0.0309
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.0403 0.55
Trypanosoma cruzi acyl transferase-like protein 0.0042 0.011 0.1477
Schistosoma mansoni hypothetical protein 0.0848 0.339 0.6122
Mycobacterium ulcerans polyketide synthase Pks9 0.0435 0.1712 0.4314
Mycobacterium ulcerans dehydrogenase 0.0041 0.0108 0.0226
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0034
Schistosoma mansoni hypothetical protein 0.0047 0.013 0.0236
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0037 0.0094 0.0186
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0013 0.0143
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0067 0.0212 0.0491
Schistosoma mansoni smad1 5 8 and 0.0033 0.0075 0.0135
Mycobacterium ulcerans short-chain dehydrogenase 0.0049 0.0139 0.0305
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0006 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0024 0.0048
Schistosoma mansoni rotamase 0.0034 0.0079 0.0143
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0207 0.0782 0.1971
Loa Loa (eye worm) acyl carrier protein 0.0067 0.0212 0.0477
Loa Loa (eye worm) hypothetical protein 0.008 0.0266 0.0599
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0013 0.0146
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0067 0.0212 0.0422
Schistosoma mansoni acyl carrier protein 0.0067 0.0212 0.0382
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0154 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0539 0.1215
Brugia malayi jmjC domain containing protein 0.0057 0.0172 0.0343
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0041 0.0108 0.0226
Echinococcus multilocularis cysteine protease 0.0051 0.0148 0.0148
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0185 0.0334
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0638 0.2536 0.6416
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.013 0.0236
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0048 0.0883
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0052 0.0118
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0054 0.016 0.036
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0052 0.0108
Trichomonas vaginalis rotamase, putative 0.0034 0.0079 0.0826
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0001 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0052 0.0052
Brugia malayi MH2 domain containing protein 0.0033 0.0075 0.0149
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0013 0.0146
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0539 0.1075
Leishmania major cathepsin L-like protease 0.0051 0.0148 0.1951
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0374 0.1463 0.3681
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0003 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0052 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0041 0.0108 0.0226
Echinococcus granulosus Smad4 0.0033 0.0075 0.0135
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0024 0.0293
Echinococcus granulosus intermediate filament protein 0.008 0.0266 0.048
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0048 0.0619
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0266 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0984 0.3942 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.001 0.0019
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0699 0.2785 0.7049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0177 0.0661 0.9059
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0076 0.1008
Loa Loa (eye worm) hypothetical protein 0.0183 0.0684 0.1542
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Echinococcus multilocularis NADH dehydrogenase 0.0067 0.0212 0.0212
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0101 0.0352 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0048 0.0468
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0013 0.0146
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0113 0.0403 0.0403
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0003 0.0006
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0067 0.0212 0.0477
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0212 0.0491
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0101 0.0352 0.0848
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0052 0.0105
Loa Loa (eye worm) histone methyltransferase 0.002 0.0021 0.0046
Schistosoma mansoni cpg binding protein 0.0063 0.0197 0.0356
Brugia malayi Cathepsin L-like precursor 0.0051 0.0148 0.0295
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0052 0.0095
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0052 0.0095
Plasmodium vivax unspecified product 0.0026 0.0048 0.0737
Toxoplasma gondii type I fatty acid synthase 0.0101 0.0352 0.1255
Brugia malayi Cathepsin L-like precursor 0.0051 0.0148 0.0295
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.0403 0.55
Onchocerca volvulus Protein cycle homolog 0.0038 0.0095 0.0197
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.0212 0.0491
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0293
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0659 0.2618 0.6625
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0075 0.0075
Mycobacterium tuberculosis Hypothetical protein 0.0198 0.0748 0.1857
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0212 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.0108 0.0376
Schistosoma mansoni cpg binding protein 0.006 0.0183 0.0331
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0539 0.2131 0.5382
Schistosoma mansoni survival motor neuron protein 0.0094 0.0322 0.0582
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0186 0.0336
Leishmania major cathepsin L-like protease 0.0194 0.073 0.9758
Mycobacterium ulcerans polyketide synthase MbtD 0.0202 0.0764 0.19
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0699 0.2785 0.7049
Brugia malayi jmjC domain containing protein 0.0015 0.0003 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0065 0.0118
Brugia malayi hypothetical protein 0.0054 0.0159 0.0317
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0186 0.0336
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0013 0.0024
Loa Loa (eye worm) acyl carrier protein 0.0303 0.1172 0.2641
Leishmania major cathepsin L-like protease 0.0051 0.0148 0.1951
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0007 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.001 0.0094
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0014 0.0145
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0115 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0052 0.0105
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0019
Leishmania major oxidoreductase-like protein 0.0041 0.0108 0.1405
Brugia malayi nuclear receptor NHR-88 0.0027 0.0052 0.0105
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0041 0.0108 0.0256
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0007 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0539 0.1075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0065 0.0118
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0185 0.0423
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0007 0.005
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0108 0.144
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0024 0.0013
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0075 0.0135
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0138 0.0312
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0138 0.0276
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0013 0.0146
Trypanosoma cruzi acyl transferase-like protein, putative 0.0042 0.011 0.1477
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0013 0.0143
Echinococcus granulosus microtubule associated protein 2 0.1376 0.5537 1
Onchocerca volvulus 0.0051 0.0148 0.0309
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0773 0.1742
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.0108 0.2417
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0052 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0293
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0038 0.0095 0.0189
Echinococcus granulosus AMP dependent ligase 0.0067 0.0212 0.0382
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0699 0.2785 0.7049
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0022
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0052 0.0108
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.013 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.008 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0121 0.1294
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0108 0.0194
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0022
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0042 0.011 0.1759
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0024 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0118
Trypanosoma brucei acyl transferase-like protein 0.0042 0.011 0.1477
Brugia malayi MH1 domain containing protein 0.0018 0.0015 0.003
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.0108 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0148 0.1607
Schistosoma mansoni hypothetical protein 0.0047 0.013 0.0236
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0024 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0048 0.0883
Leishmania major protein kinase, putative 0.0016 0.0007 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Loa Loa (eye worm) nuclear factor I 0.0018 0.0015 0.0034
Echinococcus granulosus cathepsin L 0.0026 0.0048 0.0086
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0473 0.1864 0.4703
Schistosoma mansoni intermediate filament proteins 0.008 0.0266 0.048
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0242
Onchocerca volvulus 0.003 0.0065 0.0135
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0001 0.0001
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0007 0.0052
Leishmania major d-xylulose reductase, putative 0.0041 0.0108 0.1405
Brugia malayi MH2 domain containing protein 0.0015 0.0001 0.0002
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0659 0.2618 0.6636
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.013 0.0236
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0161 0.0595 0.1469
Loa Loa (eye worm) Smad1 0.0033 0.0075 0.0168
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0001 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0052 0.0105
Echinococcus multilocularis survival motor neuron protein 1 0.046 0.1809 0.1809
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.002 0.0039
Echinococcus granulosus ubiquitin specific protease 41 0.0113 0.0403 0.0727
Echinococcus multilocularis mucolipin 3 0.0063 0.0197 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.013 0.0236
Leishmania major DNA polymerase eta, putative 0.002 0.0024 0.0286
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0052 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0211
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0048 0.0883
Echinococcus granulosus cathepsin l1 0.0034 0.008 0.0144
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0183 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0138 0.1819
Brugia malayi Coelomocyte uptake defective protein 5 0.0063 0.0197 0.0394
Onchocerca volvulus Fatty acid synthase homolog 0.1187 0.4767 1
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0106 0.1685
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0121 0.0423
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0024 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.004 0.0518
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0333 0.1294 0.4642
Schistosoma mansoni DNA polymerase eta 0.002 0.0024 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0052 0.0118
Plasmodium vivax acyl carrier protein, putative 0.0067 0.0212 0.3421
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0003 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0148 0.3461
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0052 0.0052
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0165 0.0613 0.8397
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0186 0.0419
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0165 0.0613 0.1514
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.0108 0.1405
Treponema pallidum acyl carrier protein 0.0067 0.0212 1
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0212 0.0491
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0013 0.0146
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0172 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0048 0.0619
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0148 0.1607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.0148 0.0334
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0076 0.1008
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0013 0.003
Toxoplasma gondii type I fatty acid synthase, putative 0.0469 0.1847 0.6629
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0052 0.0105
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0231 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Schistosoma mansoni lamin 0.008 0.0266 0.048
Loa Loa (eye worm) hypothetical protein 0.0369 0.1441 0.3247
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0108 0.1146
Schistosoma mansoni hypothetical protein 0.069 0.2745 0.4958
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0067 0.0212 0.0521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.013 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0052 0.0118
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.0108 0.0242
Schistosoma mansoni lamin 0.008 0.0266 0.048
Mycobacterium leprae Probable oxidireductase 0.0041 0.0108 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0079 0.0826
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0419 0.1497
Echinococcus granulosus dna polymerase kappa 0.002 0.0024 0.0044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0006 0.0006
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0013 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Schistosoma mansoni smad 0.0015 0.0001 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0138 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Schistosoma mansoni microtubule-associated protein tau 0.1376 0.5537 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0185 0.0423
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0051 0.0148 0.2381
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0024 0.0013
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.011 0.0199
Toxoplasma gondii FATC domain-containing protein 0.0024 0.004 0.0135
Brugia malayi cathepsin L-like precursor 0.0034 0.008 0.0159
Schistosoma mansoni hypothetical protein 0.0067 0.0212 0.0382
Echinococcus granulosus lamin dm0 0.008 0.0266 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0165 0.0613 0.1514
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0212 0.5092
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0013 0.0143
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0021 0.0037
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0013 0.0146
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0226 0.0862 0.2147
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0065 0.0065
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.0108 0.0376
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0007 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.013 0.0236
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0212 0.0491
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0041 0.0108 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0202 0.0764 0.19
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0034 0.008 0.018
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0615 0.2443 0.5503
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0052 0.0118
Schistosoma mansoni smad1 5 8 and 0.0033 0.0075 0.0135
Schistosoma mansoni Smad4 0.0015 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0748 0.8412
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0148 0.0268
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0024 0.0044
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0052 0.0095
Schistosoma mansoni cpg binding protein 0.0063 0.0197 0.0356
Onchocerca volvulus 0.0034 0.008 0.0166
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.013 0.026
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0551 0.0995
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0067 0.0212 0.0491
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0108 0.144
Loa Loa (eye worm) MH2 domain-containing protein 0.0482 0.19 0.428
Schistosoma mansoni hypothetical protein 0.0071 0.0231 0.0418
Plasmodium falciparum cysteine proteinase falcipain 1 0.0026 0.0048 0.0737
Leishmania major acyl carrier protein, putative 0.0067 0.0212 0.2803
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.0148 0.0268
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0266 0.0599
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0165 0.0613 0.8194
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0013 0.0146
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.011 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0293
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0113 0.0403 1
Schistosoma mansoni hypothetical protein 0.069 0.2745 0.4958
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.0403 0.55
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0041 0.0108 0.0226
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0052 0.0105
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0067 0.0212 0.0491
Schistosoma mansoni single-minded 0.0016 0.0007 0.0012
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0071 0.0231 0.5598
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.053 0.2095 0.5292
Schistosoma mansoni Smad4 0.0033 0.0075 0.0135
Echinococcus granulosus NADH dehydrogenase 0.0067 0.0212 0.0382
Mycobacterium tuberculosis Conserved protein 0.0198 0.0748 0.1857
Onchocerca volvulus 0.0051 0.0148 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0034
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0075 0.0135
Onchocerca volvulus 0.1146 0.4601 0.9651
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0138 0.0138
Echinococcus granulosus mucolipin 3 0.0063 0.0197 0.0356
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0165 0.0613 0.8397
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0108 0.1146
Brugia malayi steroid hormone receptor 0.0027 0.0052 0.0105
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0041 0.0108 0.0226
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0148 0.0148
Echinococcus multilocularis lamin 0.008 0.0266 0.0266
Onchocerca volvulus 0.008 0.0266 0.0556
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0041 0.0108 0.0256
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0113 0.0403 0.5367
Brugia malayi N-terminal motif family protein 0.0183 0.0684 0.1365
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0108 0.0226
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0014 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0052 0.0105
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0067 0.0212 0.0491
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0108 0.0226
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0001 0.0002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0052 0.0095
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0038 0.0095 0.0171
Brugia malayi Latrophilin receptor protein 2 0.0047 0.013 0.026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0006 0.001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0534 0.0965
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0172 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0888 1
Onchocerca volvulus 0.0051 0.0148 0.0309
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0048 0.0095
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0207 0.0782 0.1945
Brugia malayi Cathepsin L-like precursor 0.0051 0.0148 0.0295
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.0017 0.001 0.0019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0075 0.0075
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0141
Mycobacterium tuberculosis Probable thioesterase TesA 0.0549 0.2172 0.5488
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0052 0.0105
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0013 0.0024
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0024 0.0199
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.008 0.1703
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0042 0.011 0.1708
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0052 0.0095
Brugia malayi Cathepsin L-like precursor 0.0034 0.008 0.0159
Plasmodium vivax vivapain-1 0.0026 0.0048 0.0737
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0052 0.0095
Mycobacterium ulcerans hypothetical protein 0.0067 0.0212 0.0491
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0024 0.0293
Trypanosoma cruzi cruzipain precursor, putative 0.0194 0.073 1
Schistosoma mansoni hypothetical protein 0.0101 0.035 0.0632
Entamoeba histolytica cysteine protease, putative 0.0026 0.0048 0.0883
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0108 0.0214
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0118
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0248
Entamoeba histolytica hypothetical protein 0.0071 0.0231 0.5598
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0138 0.1865
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0007 0.0052
Echinococcus multilocularis geminin 0.069 0.2745 0.2745
Leishmania major cathepsin L-like protease 0.0051 0.0148 0.1951
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0052 0.0095
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0984 0.3942 1
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0138 0.0487
Toxoplasma gondii exonuclease III APE 0.0019 0.0019 0.0058
Loa Loa (eye worm) fatty acid synthase 0.065 0.2583 0.5819
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0048 0.0086
Schistosoma mansoni mucolipin 0.0063 0.0197 0.0356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0539 0.1215
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0551 0.1099
Echinococcus multilocularis musashi 0.008 0.0266 0.0266
Brugia malayi MH1 domain containing protein 0.0018 0.0015 0.003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0098 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0052 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0075 0.0168
Onchocerca volvulus 0.0051 0.0148 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0052 0.0105
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0052 0.0095
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0108 0.0226
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0551 0.0551
Brugia malayi MH2 domain containing protein 0.0033 0.0075 0.0149
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.008 0.0144
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0118
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0079 0.0179
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0185 0.0423
Schistosoma mansoni Smad4 0.0015 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0293
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.0684 0.1434
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.0108 0.0194
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0052 0.0105
Trichomonas vaginalis rotamase, putative 0.0033 0.0076 0.0789
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0042 0.011 0.1759
Brugia malayi Pre-SET motif family protein 0.003 0.0065 0.013
Mycobacterium leprae Polyketide synthase Pks13 0.0984 0.3942 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0108 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0148 0.1607
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0041 0.0108 0.0226
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0185 0.0369
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0003 0.0005
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0067 0.0212 0.0212
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0041 0.0108 0.0226
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0052 0.0052
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0212 0.5092
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0001 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0065 0.0118
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0231 0.0418
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0013 0.0146
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0148 0.0268
Echinococcus multilocularis AMP dependent ligase 0.0067 0.0212 0.0212
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0108 0.144
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0041 0.0108 0.0256
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0065 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.073 1
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0048 0.0619
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0052 0.0095
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0024 0.0286
Giardia lamblia DINP protein human, muc B family 0.002 0.0024 0.0145
Brugia malayi MH1 domain containing protein 0.0033 0.0075 0.0149
Loa Loa (eye worm) hypothetical protein 0.0034 0.008 0.018
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0075 0.0168
Brugia malayi nuclear hormone receptor 0.0027 0.0052 0.0105
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.073 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0266 0.1024 0.2561
Plasmodium falciparum acyl carrier protein 0.0067 0.0212 0.3421
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0013 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0482 0.19 0.428
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0067 0.0212 0.0491
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0138 0.1865
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0041 0.0108 0.0226
Brugia malayi MH1 domain containing protein 0.0033 0.0075 0.0149
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0659 0.2618 0.6625
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0024 0.0274
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0659 0.2618 0.6636
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0138 0.222
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0052 0.0095
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0138 0.1865
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.013 0.0294
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.001 0.0094
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0006 0.0006
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0113 0.0403 0.0727
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0638 0.2536 0.6416
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0148 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0013 0.0078
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0024 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.013 0.026
Brugia malayi intermediate filament protein 0.008 0.0266 0.053

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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