TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 694.816 | Formula: C40H46N4O7
H donors: 4 H acceptors: 4 LogP: 5.53 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: NCCCC[C@H]1NC(=O)C(NC(=O)C)Cc2cc3ccccc3c(c2OC)c2c(c(C/C=C/C[C@H](NC1=O)C(=O)OC)cc1c2cccc1)OC
InChi: 1S/C40H46N4O7/c1-24(45)42-33-23-28-22-26-14-6-9-17-30(26)35(37(28)50-3)34-29-16-8-5-13-25(29)21-27(36(34)49-2)15-7-10-19-32(40(48)51-4)44-38(46)31(43-39(33)47)18-11-12-20-41/h5-10,13-14,16-17,21-22,31-33H,11-12,15,18-20,23,41H2,1-4H3,(H,42,45)(H,43,47)(H,44,46)/b10-7+/t31-,32+,33?/m1/s1
InChiKey: UBNYPKYJUMLTEM-RBKNMYLZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	somatostatin receptor	0.0101	0.0707	0.2746
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Echinococcus granulosus	neuropeptide receptor A26	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0101	0.0707	0.2746
Loa Loa (eye worm)	neuropeptide F receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.004	0.0166	0.0644
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0101	0.0707	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	biogenic amine 5HT receptor	0.0101	0.0707	0.2746
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0068	0.515
Echinococcus multilocularis	neuropeptide Y receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0068	0.0266
Schistosoma mansoni	adenoreceptor	0.0101	0.0707	0.2746
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Echinococcus granulosus	neuropeptide s receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Echinococcus multilocularis	neuropeptide receptor	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	esterase, putative	0.0036	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	hypothetical protein	0.0101	0.0707	0.2746
Brugia malayi	Serotonin receptor	0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0101	0.0707	0.2746
Brugia malayi	G-protein coupled receptor	0.0101	0.0707	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0133	0.0516
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Brugia malayi	neuropeptide F receptor	0.0101	0.0707	1
Brugia malayi	larval opioid receptor	0.0101	0.0707	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	neuropeptide receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	neuropeptide Y receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0133	0.0516
Echinococcus multilocularis	fmrfamide receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Echinococcus multilocularis	allatostatin A receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0287	0.2355	1
Entamoeba histolytica	hypothetical protein	0.0024	0.0019	0.0082
Schistosoma mansoni	biogenic amine receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.0707	0.2746
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0133	0.0133
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0133	0.0133
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Schistosoma mansoni	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	neuropeptide Y receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Brugia malayi	follicle stimulating hormone receptor	0.0101	0.0707	1
Echinococcus multilocularis	serotonin receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0101	0.0707	0.2746
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0133	0.0133
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0133	0.5
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1148	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0133	0.1528
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0133	0.0133
Brugia malayi	Dopamine receptor protein 2	0.0101	0.0707	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0287	0.2355	0.2355
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Brugia malayi	beta-lactamase	0.0036	0.0133	0.1878
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.004	0.0166	0.0704
Echinococcus granulosus	neuropeptide FF receptor 2	0.0101	0.0707	0.2746
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0101	0.0707	0.2746
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.0166	1
Giardia lamblia	NADPH oxidoreductase, putative	0.1148	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0101	0.0707	0.2746
Brugia malayi	Melatonin receptor type 1A	0.0101	0.0707	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0101	0.0707	0.2746
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	amine GPCR	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.0166	0.1907
Loa Loa (eye worm)	melatonin receptor type 1A	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	neuropeptides capa receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0101	0.0707	0.2746
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Brugia malayi	sulfakinin receptor protein	0.0101	0.0707	1
Schistosoma mansoni	histamine h1 receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.0707	0.2746
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Onchocerca volvulus		0.0101	0.0707	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	g-protein coupled receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0101	0.0707	0.2746
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.004	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Brugia malayi	ORL1-like opioid receptor	0.0101	0.0707	1
Echinococcus granulosus	g protein coupled receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	neuropeptide f receptor 76f	0.0101	0.0707	0.2746
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0287	0.2355	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	G-protein coupled receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	importin beta-1	0.0029	0.0068	0.0266
Brugia malayi	RNA, U transporter 1	0.0083	0.0546	0.7723
Onchocerca volvulus		0.0101	0.0707	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0101	0.0707	0.2746
Brugia malayi	GnHR receptor homolog	0.0101	0.0707	1
Schistosoma mansoni	amine GPCR	0.0101	0.0707	0.2746
Echinococcus multilocularis	sex peptide receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0101	0.0707	0.2746
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0101	0.0707	0.2746
Brugia malayi	Importin beta-1 subunit	0.0029	0.0068	0.0967
Schistosoma mansoni	neuropeptide receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	hypothetical protein	0.0119	0.0869	0.3376
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0133	0.0516
Brugia malayi	putative neuropeptide receptor NPR1	0.0101	0.0707	1
Loa Loa (eye worm)	TYRA-2 protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0068	0.0787
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0133	0.0133
Onchocerca volvulus		0.0101	0.0707	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1148	1	1
Onchocerca volvulus		0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0133	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Leishmania major	hypothetical protein, conserved	0.0036	0.0133	0.801
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0019	0.117
Echinococcus multilocularis	neuropeptide receptor A26	0.0101	0.0707	0.2746
Echinococcus granulosus	allatostatin A receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Toxoplasma gondii	ABC1 family protein	0.0036	0.0133	1
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0133	0.5
Schistosoma mansoni	neuropeptide receptor	0.0101	0.0707	0.2746
Trypanosoma brucei	RNA helicase, putative	0.0119	0.0869	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.004	0.0166	0.0166
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0133	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Echinococcus multilocularis	orexin receptor type 2	0.0101	0.0707	0.2746
Schistosoma mansoni	neuropeptide receptor	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Brugia malayi	neuropeptide F receptor	0.0101	0.0707	1
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Brugia malayi	Serotonin receptor	0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Plasmodium falciparum	importin beta, putative	0.0029	0.0068	1
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0068	0.0266
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0101	0.0707	0.2746
Echinococcus granulosus	biogenic amine 5HT receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0133	0.0516
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Echinococcus granulosus	ubiquitin specific protease 41	0.004	0.0166	0.0644
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Brugia malayi	Dopamine receptor	0.0101	0.0707	1
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0133	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0133	0.0516
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.1876	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0166	0.0644
Echinococcus granulosus	neuropeptides capa receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0287	0.2355	0.2355
Brugia malayi	G protein-coupled receptor F59B2.13	0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	serotonin receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	serotonin receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	biogenic amine receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0101	0.0707	0.2746
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0019	0.0019
Echinococcus granulosus	snurportin 1	0.0312	0.2575	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.004	0.0166	1
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0133	0.801
Brugia malayi	beta-lactamase family protein	0.0036	0.0133	0.1878
Echinococcus granulosus	neuropeptide receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Entamoeba histolytica	hypothetical protein	0.0287	0.2355	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0166	0.0166
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.004	0.0166	0.0644
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0133	0.0516
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Brugia malayi	AKH receptor	0.0101	0.0707	1
Schistosoma mansoni	biogenic amine receptor	0.0101	0.0707	0.2746
Brugia malayi	beta-lactamase family protein	0.0036	0.0133	0.1878
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Echinococcus granulosus	g-protein coupled receptor	0.0101	0.0707	0.2746
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0101	0.0707	1
Schistosoma mansoni	hypothetical protein	0.0312	0.2575	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	G-protein coupled receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0133	0.0516
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1148	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0133	0.0516
Echinococcus granulosus	dro:myosuppressin receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	dro:myosuppressin receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0101	0.0707	0.2746
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0101	0.0707	1
Echinococcus granulosus	neuropeptide receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	sex peptide receptor	0.0101	0.0707	0.2746
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0133	0.5
Brugia malayi	G protein-coupled receptor	0.0101	0.0707	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.0707	0.2746
Echinococcus multilocularis	neuropeptide s receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	hypothetical protein	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.004	0.0166	0.0644
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0133	0.1878
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Brugia malayi	Dopamine receptor protein 1	0.0101	0.0707	1
Onchocerca volvulus		0.0101	0.0707	1
Trichomonas vaginalis	conserved hypothetical protein	0.0861	0.7454	0.7454
Echinococcus granulosus	neuropeptide Y receptor	0.0101	0.0707	0.2746
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0101	0.0707	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.004	0.0166	0.2345
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Mycobacterium ulcerans	lipase LipD	0.0036	0.0133	0.5
Schistosoma mansoni	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.004	0.0166	0.0644
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0019	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Schistosoma mansoni	opsin-like receptor	0.0101	0.0707	0.2746
Echinococcus granulosus	G protein coupled receptor 139	0.0101	0.0707	0.2746
Schistosoma mansoni	neuropeptide F-like receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	snurportin 1	0.0312	0.2575	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0101	0.0707	0.2746
Echinococcus multilocularis	ubiquitin specific protease 41	0.004	0.0166	0.0644
Schistosoma mansoni	opsin-like receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0133	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	amine GPCR	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0068	0.0266
Schistosoma mansoni	myosin xvIII	0.0101	0.0707	0.2746
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Schistosoma mansoni	opsin-like receptor	0.0101	0.0707	0.2746
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0101	0.0707	0.2746
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.0707	0.2746
Echinococcus multilocularis	G protein coupled receptor 139	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Schistosoma mansoni	hypothetical protein	0.0101	0.0707	0.2746
Echinococcus granulosus	g protein coupled receptor	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0019	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0101	0.0707	0.2746
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0133	0.0516
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.0166	1
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0019	0.117
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0312	0.2575	1
Echinococcus granulosus	g protein coupled receptor	0.0101	0.0707	0.2746
Echinococcus multilocularis	fmrfamide receptor	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.004	0.0166	0.0166
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Giardia lamblia	NADPH oxidoreductase, putative	0.1148	1	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0287	0.2355	0.2355
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0068	0.0787
Echinococcus granulosus	fmrfamide receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	neuropeptide receptor	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Brugia malayi	G-protein coupled receptor	0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Onchocerca volvulus		0.0101	0.0707	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.1148	1	1
Echinococcus multilocularis	somatostatin receptor	0.0101	0.0707	0.2746
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0101	0.0707	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0133	0.801
Loa Loa (eye worm)	neuropeptide F receptor	0.0101	0.0707	0.2746
Brugia malayi	hypothetical protein	0.0101	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0133	0.0516
Echinococcus granulosus	neuropeptides capa receptor	0.0101	0.0707	0.2746
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.004	0.0166	0.0644
Brugia malayi	RE15519p	0.0101	0.0707	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0287	0.2355	0.2355
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0707	0.2746
Schistosoma mansoni	memapsin-2 (A01 family)	0.0267	0.2182	0.8475
Schistosoma mansoni	amine GPCR	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0068	0.515
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0101	0.0707	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.004	0.0166	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0133	0.0516
Schistosoma mansoni	amine GPCR	0.0101	0.0707	0.2746
Brugia malayi	putative neuropeptide receptor	0.0101	0.0707	1
Echinococcus granulosus	orexin receptor type 2	0.0101	0.0707	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.0287	0.2355	0.2355
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0707	0.2746
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0707	0.2746
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0133	0.0516

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL505544

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1544666