TDR Targets

Basic information

Technical information

TDR Targets ID: 1544671
Name: N-[4-(difluoromethoxy)phenyl]-2-(6-methyl-2,4 -dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamid e
MW: 381.374 | Formula: C18H21F2N3O4
H donors: 2 H acceptors: 3 LogP: 3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CN1C(=O)NC2(C1=O)CCCCC2C)Nc1ccc(cc1)OC(F)F
InChi: 1S/C18H21F2N3O4/c1-11-4-2-3-9-18(11)15(25)23(17(26)22-18)10-14(24)21-12-5-7-13(8-6-12)27-16(19)20/h5-8,11,16H,2-4,9-10H2,1H3,(H,21,24)(H,22,26)
InChiKey: NKMCGCYKMBOLCS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-(difluoromethoxy)phenyl]-2-(2,4-diketo-6-methyl-1,3-diazaspiro[4.5]decan-3-yl)acetamide
N-[4-(difluoromethoxy)phenyl]-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)ethanamide
T0515-2439

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0337	0.4173	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0052	0.0533	0.056
Brugia malayi	nuclear receptor RXR	0.0021	0.013	0.0074
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0044	0.0425	0.0397
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0312	0.0808
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0122	0.0129
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0199	0.0243
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0021	0.013	0.0074
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.013	0.0137
Echinococcus multilocularis	ecdysone induced protein 78C	0.0044	0.0425	0.0397
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0021	0.013	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0297	0.0743
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0044	0.0425	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0312	0.0796
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0044	0.0425	0.0446
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0199	0.5563
Brugia malayi	Pre-SET motif family protein	0.0036	0.0322	0.0546
Schistosoma mansoni	zinc finger protein	0.0021	0.013	0.0137
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0044	0.0425	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0425	0.1191
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0312	0.0789
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0044	0.0425	0.0446
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.013	0.0102
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.1226	0.2766
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0021	0.013	0.0157
Echinococcus granulosus	zinc finger protein	0.0023	0.0156	0.0134
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.013	0.0107
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0652	0.0625
Brugia malayi	beta-lactamase family protein	0.0035	0.0312	0.0522
Brugia malayi	steroid hormone receptor	0.0044	0.0425	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0199	0.4246
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0425	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0103
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0297	0.0484
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0044	0.0425	0.0417
Schistosoma mansoni	hypothetical protein	0.0073	0.0796	0.0837
Mycobacterium ulcerans	lipase LipD	0.0035	0.0312	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0044	0.0425	0.1191
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.024	0.2934	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0044	0.0425	0.1191
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0016	0.0078	0.0049
Schistosoma mansoni	hypothetical protein	0.0348	0.4311	0.4528
Schistosoma mansoni	hypothetical protein	0.0034	0.0297	0.0312
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0312	0.0789
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0044	0.0425	0.0798
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0044	0.0425	0.1191
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0017	0.0085	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1226	0.4005
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0199	0.4246
Loa Loa (eye worm)	steroid hormone receptor	0.0044	0.0425	0.1191
Echinococcus granulosus	geminin	0.0348	0.4311	0.4512
Brugia malayi	hypothetical protein	0.0023	0.0162	0.0152
Entamoeba histolytica	hypothetical protein	0.0337	0.4173	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0796	0.171
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0162	0.017
Schistosoma mansoni	zinc finger protein	0.0015	0.0056	0.0059
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0044	0.0425	0.1191
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0162	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0021	0.013	0.0102
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0312	0.0808
Schistosoma mansoni	nuclear hormone receptor	0.0044	0.0425	0.0446
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0044	0.0425	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0742	0.2303
Schistosoma mansoni	hypothetical protein	0.002	0.0122	0.0128
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0228	0.5436
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0044	0.0425	0.0397
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0312	0.0808
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0064	0.0681	0.2091
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.013	0.0074
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0023	0.0162	0.014
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0023	0.0162	0.0267
Leishmania major	hypothetical protein, conserved	0.0035	0.0312	1
Echinococcus multilocularis	dnaJ subfamily B	0.0469	0.586	0.5848
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0199	0.4246
Brugia malayi	beta-lactamase	0.0035	0.0312	0.0522
Brugia malayi	nuclear receptor NHR-88	0.0021	0.013	0.0074
Schistosoma mansoni	nuclear receptor	0.0021	0.013	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0312	0.0796
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0017	0.0085	0.009
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0162	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0044	0.0425	0.0446
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.013	0.0107
Echinococcus granulosus	cpg binding protein	0.0069	0.0751	0.0761
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0312	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0044	0.0425	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0312	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0441	0.1247
Entamoeba histolytica	hypothetical protein	0.0337	0.4173	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0044	0.0425	0.0798
Brugia malayi	Steroid receptor seven-up type 2	0.0044	0.0425	0.0798
Onchocerca volvulus		0.0026	0.0199	0.0213
Brugia malayi	hypothetical protein	0.0023	0.0162	0.0152
Loa Loa (eye worm)	histone methyltransferase	0.0021	0.0135	0.0174
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0162	0.0152
Brugia malayi	nuclear hormone receptor	0.0021	0.013	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0162	0.0267
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0016	0.0078	0.0052
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.013	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0796	0.2495
Echinococcus granulosus	FTZ F1 alpha	0.0044	0.0425	0.0417
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0044	0.0425	0.0397
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0052	0.0533	0.056
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0044	0.0425	0.0417
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0021	0.0135	0.0107
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0044	0.0425	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0425	0.1191
Schistosoma mansoni	transcription factor LCR-F1	0.0337	0.4173	0.4384
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0312	0.0299
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0044	0.0425	0.0417
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0312	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0297	0.0269
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0044	0.0425	0.0397
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0017	0.0085	0.006
Onchocerca volvulus		0.0273	0.3355	1
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0312	1
Schistosoma mansoni	zinc finger protein	0.0023	0.0156	0.0164
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0312	0.0796
Echinococcus multilocularis	zinc finger protein	0.0023	0.0156	0.0127
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0297	0.0269
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0044	0.0425	0.1191
Brugia malayi	tailless protein	0.0021	0.013	0.0074
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0312	0.0789
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0044	0.0425	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0044	0.0425	0.0798
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0228	0.6692
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0297	0.0283
Onchocerca volvulus		0.0064	0.0681	0.1708
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0312	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.1226	0.4005
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0044	0.0425	0.0397
Toxoplasma gondii	ABC1 family protein	0.0035	0.0312	0.069
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0199	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0199	0.0397
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0017	0.0085	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0162	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0312	0.0796
Loa Loa (eye worm)	DR-78	0.0021	0.013	0.0157
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0228	0.6692
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0103
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0297	0.0283
Onchocerca volvulus		0.0036	0.0322	0.0596
Trichomonas vaginalis	set domain proteins, putative	0.0273	0.3355	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0021	0.013	0.0107
Echinococcus granulosus	thyroid hormone receptor alpha	0.0021	0.013	0.0107
Schistosoma mansoni	cpg binding protein	0.0069	0.0751	0.0789
Schistosoma mansoni	retinoic acid receptor RXR	0.0044	0.0425	0.0446
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0311	0.0298
Schistosoma mansoni	hypothetical protein	0.0034	0.0297	0.0312
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0199	0.5563
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0312	0.0808
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0199	0.4246
Loa Loa (eye worm)	nuclear hormone receptor	0.0021	0.013	0.0157
Schistosoma mansoni	thyroid hormone receptor	0.0044	0.0425	0.0446
Brugia malayi	F/Y-rich N-terminus family protein	0.0023	0.0156	0.0137
Brugia malayi	photoreceptor-specific nuclear receptor	0.0044	0.0425	0.0798
Brugia malayi	nuclear hormone receptor family member odr-7	0.0021	0.013	0.0074
Schistosoma mansoni	nuclear receptor nhr-48	0.0021	0.013	0.0137
Echinococcus multilocularis	microtubule associated protein 2	0.0755	0.9519	0.9517
Brugia malayi	hypothetical protein	0.0021	0.013	0.0074
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0021	0.013	0.0102
Echinococcus multilocularis	nuclear receptor nhr 48	0.0021	0.013	0.0102
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0162	0.0152
Schistosoma mansoni	nuclear receptor	0.0021	0.013	0.0137
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.013	0.0137
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0297	0.0743
Onchocerca volvulus		0.0035	0.0312	0.0565
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.2711	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0017	0.0085	0.006
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0044	0.0425	0.0446
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0044	0.0425	0.0417
Brugia malayi	CXXC zinc finger family protein	0.0064	0.0681	0.1427
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0044	0.0425	0.0798
Echinococcus granulosus	histone lysine methyltransferase setb	0.0052	0.0533	0.0531
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0078	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0371	0.1001
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0044	0.0425	0.0798
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0052	0.0533	0.0506
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0311	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0425	0.1191
Echinococcus granulosus	nuclear receptor nhr 48	0.0021	0.013	0.0107
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0288	0.0274
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0322	0.0771
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0312	0.0789
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0337	0.4173	0.4367
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0297	0.0269
Schistosoma mansoni	cpg binding protein	0.0069	0.0751	0.0789
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0312	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0425	0.1191
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0115	0.5
Echinococcus multilocularis	cpg binding protein	0.0069	0.0751	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0342	0.0899
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0021	0.013	0.0157
Schistosoma mansoni	hypothetical protein	0.0469	0.586	0.6156
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0312	0.0808
Echinococcus granulosus	ecdysone induced protein 78C	0.0044	0.0425	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0312	0.0796
Schistosoma mansoni	hypothetical protein	0.0034	0.0297	0.0312
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0192	0.0164
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0312	0.0789
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0021	0.013	0.0074
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0124	0.1455	1
Brugia malayi	hypothetical protein	0.0021	0.013	0.0074
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.1226	0.2766
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0425	0.1191
Onchocerca volvulus	Protein ultraspiracle homolog	0.0044	0.0425	0.0913
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0322	0.0339
Schistosoma mansoni	bromodomain containing protein	0.0065	0.0696	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0533	0.1571
Schistosoma mansoni	hypothetical protein	0.0034	0.0297	0.0312
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0044	0.0425	0.0798
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.013	0.0074
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0312	0.0796
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0312	0.0522
Schistosoma mansoni	hypothetical protein	0.0337	0.4173	0.4384
Brugia malayi	Nuclear hormone receptor-like 1	0.0044	0.0425	0.0798
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0312	0.0808
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0044	0.0425	0.1191
Brugia malayi	beta-lactamase family protein	0.0035	0.0312	0.0522
Schistosoma mansoni	cpg binding protein	0.0064	0.0681	0.0716
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0312	0.0328
Brugia malayi	nuclear receptor RXR	0.0023	0.0162	0.0152
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0044	0.0425	0.0798
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0199	0.0243
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0199	0.4246
Brugia malayi	ecdysteroid receptor	0.0044	0.0425	0.0798
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0322	0.0339
Brugia malayi	nuclear receptor NHR-88	0.0044	0.0425	0.0798
Schistosoma mansoni	hypothetical protein	0.0013	0.0029	0.003
Schistosoma mansoni	thyroid hormone receptor	0.0044	0.0425	0.0446
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0199	0.4246
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0199	0.0373
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0044	0.0425	0.0397
Brugia malayi	Bromodomain containing protein	0.0076	0.0841	0.1819
Trichomonas vaginalis	esterase, putative	0.0035	0.0312	0.0789
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0021	0.0135	0.0112
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0228	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0023	0.0162	0.017
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0115	0.0052
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0312	0.0808
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.013	0.0102
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0312	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0162	0.0267
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0192	0.0202
Schistosoma mansoni	hypothetical protein	0.0015	0.0056	0.0059
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0078	0.0082
Schistosoma mansoni	coup transcription factor	0.0044	0.0425	0.0446
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0192	0.0172
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.013	0.0107
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0652	0.0656
Brugia malayi	nuclear receptor NHR-67	0.0021	0.013	0.0074
Onchocerca volvulus		0.0035	0.0312	0.0565
Echinococcus granulosus	dnaJ subfamily B	0.0469	0.586	0.6144
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0312	0.952
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0044	0.0425	0.0798
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0228	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0103
Schistosoma mansoni	hypothetical protein	0.0348	0.4311	0.4528
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0199	0.0373
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0199	0.4246
Brugia malayi	ecdysone receptor	0.0021	0.013	0.0074
Leishmania major	hypothetical protein, conserved	0.0028	0.0228	0.6692
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0297	0.0484
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0044	0.0425	0.0417
Entamoeba histolytica	hypothetical protein	0.0337	0.4173	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0044	0.0425	0.0798
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0312	1
Echinococcus granulosus	GPCR family 2	0.0034	0.0297	0.0283
Brugia malayi	Bromodomain containing protein	0.0037	0.0341	0.0591
Brugia malayi	nuclear hormone receptor	0.0044	0.0425	0.0798
Echinococcus multilocularis	FTZ F1 alpha	0.0044	0.0425	0.0397
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0312	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0425	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0115	0.0103
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0312	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0021	0.013	0.0137
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0023	0.0162	0.0133
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0312	0.0808
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0199	0.5563
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0199	0.0397
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0199	0.0397
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0312	0.0808
Onchocerca volvulus		0.0044	0.0425	0.0913
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0044	0.0425	0.0798
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0044	0.0425	0.0798
Schistosoma mansoni	microtubule-associated protein tau	0.0755	0.9519	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0312	1
Brugia malayi	Pre-SET motif family protein	0.024	0.2934	0.6959
Brugia malayi	orphan nuclear receptor NR2E1	0.0021	0.013	0.0074
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0228	0.6692
Brugia malayi	hypothetical protein	0.0337	0.4173	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0136	0.161	0.1691
Onchocerca volvulus		0.0035	0.0312	0.0565
Brugia malayi	PHD-finger family protein	0.0028	0.0222	0.0299
Brugia malayi	hypothetical protein	0.0028	0.0228	0.0314
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0199	0.4246
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0044	0.0425	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0021	0.013	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0425	0.1191
Brugia malayi	conserved hypotetical protein	0.0021	0.013	0.0074
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0337	0.4173	0.4156
Echinococcus multilocularis	geminin	0.0348	0.4311	0.4294
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0044	0.0425	0.0446
Schistosoma mansoni	RAR-like nuclear receptor	0.0044	0.0425	0.0446
Plasmodium vivax	SET domain protein, putative	0.0036	0.0322	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0322	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0228	0.0499
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0044	0.0425	0.0397
Echinococcus granulosus	microtubule associated protein 2	0.0755	0.9519	1
Onchocerca volvulus	Bile acid receptor homolog	0.0044	0.0425	0.0913
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0044	0.0425	0.0798
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0312	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1882204

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1544671