Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0035 | 0.577 | 0.4775 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.1904 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.4341 | 0.4129 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.1904 | 0.5 |
Echinococcus multilocularis | lamin | 0.003 | 0.4341 | 0.3011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Onchocerca volvulus | 0.003 | 0.4341 | 0.5 | |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0035 | 0.577 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.1904 | 0.5 |
Echinococcus granulosus | lamin | 0.003 | 0.4341 | 0.3011 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.1904 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Onchocerca volvulus | 0.003 | 0.4341 | 0.5 | |
Echinococcus multilocularis | dna polymerase eta | 0.005 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.005 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.4341 | 0.3011 |
Echinococcus granulosus | dna polymerase eta | 0.005 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0035 | 0.577 | 0.4775 |
Schistosoma mansoni | DNA polymerase eta | 0.005 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.1904 | 0.5 |
Brugia malayi | intermediate filament protein | 0.003 | 0.4341 | 0.4129 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.4341 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4184 | 0.3966 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.1904 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.1904 | 0.16 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.005 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.4341 | 0.4129 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.4341 | 0.3011 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.1904 | 0.1904 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.1904 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.1904 | 0.16 |
Leishmania major | DNA polymerase eta, putative | 0.005 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.4341 | 0.4129 |
Schistosoma mansoni | lamin | 0.003 | 0.4341 | 0.3011 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Schistosoma mansoni | lamin | 0.003 | 0.4341 | 0.3011 |
Echinococcus multilocularis | musashi | 0.003 | 0.4341 | 0.3011 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.1904 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.1904 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.4341 | 0.3011 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4341 | 0.4129 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.1904 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.