Detailed information for compound 1545339

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 312.365 | Formula: C21H16N2O
  • H donors: 0 H acceptors: 0 LogP: 4.94 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C=NN=C1c2ccccc2c2c1cccc2
  • InChi: 1S/C21H16N2O/c1-24-20-13-7-2-8-15(20)14-22-23-21-18-11-5-3-9-16(18)17-10-4-6-12-19(17)21/h2-14H,1H3
  • InChiKey: DTPXFXDZNYDOOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.0419
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0519 0.0885
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0034 0.0076 0.0285
Schistosoma mansoni hypothetical protein 0.0021 0.0021 0.0025
Brugia malayi Muscleblind-like protein 0.0152 0.0564 0.2159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.1333 1
Echinococcus granulosus tar DNA binding protein 0.007 0.0226 0.0386
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0061 0.0104
Brugia malayi hypothetical protein 0.0026 0.0041 0.0151
Loa Loa (eye worm) hypothetical protein 0.0064 0.0201 0.0766
Echinococcus multilocularis protein patched 0.0043 0.0111 0.0111
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0617 0.2361
Giardia lamblia PHD finger protein 15 0.0035 0.0081 0.0293
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0071 0.0303
Schistosoma mansoni hypothetical protein 0.0207 0.0788 0.1333
Onchocerca volvulus 0.0047 0.013 0.0383
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0067 0.0103
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0111 0.0111
Mycobacterium ulcerans hypothetical protein 0.0023 0.0031 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0064 0.0201 0.0766
Mycobacterium tuberculosis Probable hydrolase 0.011 0.039 0.0793
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0163 0.0163
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0007 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0064 0.0201 0.0766
Schistosoma mansoni ap endonuclease 0.004 0.01 0.016
Echinococcus multilocularis lamin 0.003 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0064 0.0201 0.0766
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0087 0.0521
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0176 0.0667
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0168
Echinococcus multilocularis zinc finger protein 0.0023 0.0031 0.0031
Brugia malayi Bromodomain containing protein 0.0039 0.0095 0.0356
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0152 0.3181
Mycobacterium tuberculosis Conserved protein 0.011 0.039 0.0793
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Toxoplasma gondii exonuclease III APE 0.004 0.01 0.0122
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0344 0.0344
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0519 0.0519
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.1015 0.3891
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0644 0.476
Mycobacterium ulcerans hypothetical protein 0.011 0.039 0.0786
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0163 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0644 0.476
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0152 0.0229
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0163 0.0268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.0201 0.0766
Plasmodium falciparum phd finger protein, putative 0.0035 0.0081 0.1783
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0064 0.0201 0.0201
Schistosoma mansoni nuclear receptor 0.003 0.0061 0.0093
Brugia malayi nuclear receptor NHR-88 0.0064 0.0201 0.0766
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0067 0.0103
Brugia malayi TAR-binding protein 0.007 0.0226 0.0861
Brugia malayi PHD-finger family protein 0.0035 0.0081 0.0303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0201 0.0343
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0031 0.0058
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0076 0.0285
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0137 0.0234
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0081 0.0381
Schistosoma mansoni transcription factor btf3 0.0035 0.0081 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1015 0.7584
Echinococcus multilocularis cpg binding protein 0.0063 0.0197 0.0197
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0064 0.0201 0.0343
Onchocerca volvulus 0.0243 0.0937 0.352
Brugia malayi Nuclear hormone receptor E75 0.003 0.0061 0.0227
Brugia malayi hypothetical protein 0.0034 0.0076 0.0285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.1333 1
Brugia malayi Bromodomain containing protein 0.0038 0.0091 0.034
Loa Loa (eye worm) hypothetical protein 0.0064 0.0201 0.0766
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0111 0.0189
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0644 0.476
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0031 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0303
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0052 0.0152 0.3181
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0152 0.0248
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.039 0.2823
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0081 0.1749
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.033 0.033
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Echinococcus multilocularis FTZ F1 alpha 0.0064 0.0201 0.0201
Trypanosoma brucei heat shock protein, putative 0.0033 0.0071 0.0842
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0087 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0644 0.476
Schistosoma mansoni hypothetical protein 0.0035 0.0081 0.0127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0201 0.0201
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0081 0.0082
Plasmodium falciparum endoplasmin, putative 0.002 0.0018 0.0275
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0564 0.0564
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0152 0.0152
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.1333 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0564 0.2159
Loa Loa (eye worm) hypothetical protein 0.0302 0.1182 0.4531
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0031 0.005
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0071 0.0842
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0061 0.0116
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0081 0.0082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0386 0.0658
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0031 0.0112
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0152 0.3653
Echinococcus granulosus cpg binding protein 0.0063 0.0197 0.0336
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0087 0.0087
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0041 0.0825
Schistosoma mansoni ap endonuclease 0.004 0.01 0.016
Schistosoma mansoni cpg binding protein 0.0063 0.0197 0.0326
Brugia malayi hypothetical protein 0.003 0.0061 0.0227
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0344 0.0587
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0087 0.0094
Loa Loa (eye worm) hypothetical protein 0.0064 0.0201 0.0766
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0644 0.476
Plasmodium falciparum heat shock protein 90 0.0033 0.0071 0.1534
Brugia malayi Latrophilin receptor protein 2 0.0096 0.033 0.126
Brugia malayi Steroid receptor seven-up type 2 0.0064 0.0201 0.0766
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.039 0.0664
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0087 0.0521
Schistosoma mansoni endoplasmin 0.0033 0.0071 0.0109
Schistosoma mansoni hypothetical protein 0.0096 0.033 0.0552
Mycobacterium leprae Probable lipase LipE 0.011 0.039 0.074
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0041 0.0692
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0168
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0064 0.0201 0.0343
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.01 0.0199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.1333 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0455 0.174
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0064 0.0201 0.0766
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0617 0.1051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0197 0.0197
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0118 0.0421 0.2931
Echinococcus granulosus heat shock protein 90 0.0033 0.0071 0.012
Entamoeba histolytica hypothetical protein 0.0109 0.0386 0.2729
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0064 0.0201 0.0766
Schistosoma mansoni retinoic acid receptor RXR 0.0064 0.0201 0.0333
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0043 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0064 0.0201 0.0766
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Loa Loa (eye worm) hypothetical protein 0.0046 0.0126 0.0477
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0047 0.007
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0015 0.0048
Schistosoma mansoni RAR-like nuclear receptor 0.0064 0.0201 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0064 0.0201 0.0766
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.1015 0.3891
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0152 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0031 0.005
Brugia malayi DnaJ domain containing protein 0.0062 0.0192 0.0729
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0031 0.005
Mycobacterium ulcerans beta-lactamase 0.011 0.039 0.0786
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0076 0.0076
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0041 0.0825
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0007 0.0007
Brugia malayi CHE-14 protein 0.0043 0.0111 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0682 0.505
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0197 0.0336
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.033 0.0562
Brugia malayi MH2 domain containing protein 0.0126 0.0455 0.174
Loa Loa (eye worm) hypothetical protein 0.0034 0.0076 0.0285
Loa Loa (eye worm) steroid hormone receptor 0.0064 0.0201 0.0766
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0087 0.1912
Brugia malayi tailless protein 0.003 0.0061 0.0227
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0152 0.0576
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0041 0.0825
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0118 0.0421 0.3064
Toxoplasma gondii pantoate-beta-alanine ligase 0.1198 0.4873 1
Brugia malayi beta-lactamase family protein 0.011 0.039 0.1488
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0071 0.0061
Brugia malayi hypothetical protein 0.0017 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0095 0.0357
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0031 0.005
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0038 0.009 0.0179
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0064 0.0201 0.0333
Onchocerca volvulus Protein ultraspiracle homolog 0.0064 0.0201 0.0661
Brugia malayi hypothetical protein 0.0648 0.2606 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0009 0.0027
Echinococcus multilocularis tumor protein p63 0.034 0.1337 0.1337
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0087 0.0521
Onchocerca volvulus 0.011 0.039 0.1392
Schistosoma mansoni nuclear hormone receptor 0.003 0.0061 0.0093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0449 0.0756
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0201 0.0343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0163 0.0268
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0076 0.0119
Loa Loa (eye worm) hypothetical protein 0.0231 0.0888 0.3401
Schistosoma mansoni nuclear hormone receptor 0.003 0.0061 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0019
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1198 0.4873 1
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0071 0.0263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.033 0.0562
Brugia malayi hypothetical protein 0.003 0.0061 0.0227
Echinococcus multilocularis tar DNA binding protein 0.007 0.0226 0.0226
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0031 0.005
Schistosoma mansoni hypothetical protein 0.0096 0.033 0.0552
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.1182 0.4531
Brugia malayi beta-lactamase family protein 0.011 0.039 0.1488
Echinococcus granulosus transcription factor btf3 0.0035 0.0081 0.0138
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0061 0.0104
Schistosoma mansoni tar DNA-binding protein 0.007 0.0226 0.0375
Brugia malayi intermediate filament protein 0.003 0.0059 0.0221
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0108 0.0381 0.0769
Brugia malayi ecdysone receptor 0.003 0.0061 0.0227
Loa Loa (eye worm) hypothetical protein 0.0064 0.0201 0.0766
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0111 0.0419
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0061 0.0104
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0071 0.0397
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0411 0.0701
Mycobacterium leprae conserved hypothetical protein 0.011 0.039 0.074
Brugia malayi nuclear receptor RXR 0.0034 0.0076 0.0285
Schistosoma mansoni lamin 0.003 0.0059 0.009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.01 0.2251
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.0644 0.238
Onchocerca volvulus 0.003 0.0061 0.0116
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.039 0.0654
Loa Loa (eye worm) hypothetical protein 0.0049 0.0137 0.052
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0081 0.1749
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.1632 0.1632
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0703 0.2835 0.5814
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.039 0.0793
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0644 0.476
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0137 0.0223
Schistosoma mansoni nuclear receptor 0.003 0.0061 0.0093
Brugia malayi nuclear receptor RXR 0.003 0.0061 0.0227
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.01 0.01
Schistosoma mansoni tar DNA-binding protein 0.007 0.0226 0.0375
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0648 0.2606 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0061 0.0227
Entamoeba histolytica hypothetical protein 0.0109 0.0386 0.2729
Trichomonas vaginalis ap endonuclease, putative 0.004 0.01 0.0623
Loa Loa (eye worm) hypothetical protein 0.0064 0.0201 0.0766
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.039 0.039
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.039 1
Loa Loa (eye worm) beta-lactamase 0.011 0.039 0.1488
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.039 0.2823
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0118 0.0421 0.3064
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0081 0.0127
Schistosoma mansoni steroid hormone receptor ad4bp 0.0064 0.0201 0.0333
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0071 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0081 0.0474
Brugia malayi PHD-finger family protein 0.0028 0.0053 0.0195
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0152 0.0229
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0059 0.0221
Schistosoma mansoni cpg binding protein 0.0058 0.0176 0.0289
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Echinococcus granulosus lamin dm0 0.003 0.0059 0.0101
Echinococcus multilocularis muscleblind protein 0.0152 0.0564 0.0564
Brugia malayi glucose-6-phosphate dehydrogenase 0.0108 0.0381 0.1457
Schistosoma mansoni hypothetical protein 0.1439 0.5867 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0229 0.0872
Loa Loa (eye worm) hypothetical protein 0.0064 0.0201 0.0766
Brugia malayi Pre-SET motif family protein 0.0214 0.0816 0.3128
Brugia malayi RNA binding protein 0.007 0.0226 0.0861
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0617 0.0617
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0201 0.0333
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0108 0.0381 0.9784
Loa Loa (eye worm) RNA binding protein 0.007 0.0226 0.0861
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0386 0.0648
Onchocerca volvulus 0.0648 0.2606 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0221
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0043 0.0074
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0152 0.0152
Brugia malayi nuclear receptor NHR-88 0.003 0.0061 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1015 0.7584
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0816 0.3128
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0455 0.174
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.039 0.2823
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.1488
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0087 0.0521
Schistosoma mansoni alpha glucosidase 0.0037 0.0087 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.0201 0.0766
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.01 0.1695
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0394
Onchocerca volvulus 0.011 0.039 0.1392
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0226 0.0861
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0061 0.0093
Trypanosoma brucei heat shock protein, putative 0.0033 0.0071 0.0842
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0061 0.0116
Loa Loa (eye worm) hypothetical protein 0.0064 0.0201 0.0766
Brugia malayi hypothetical protein 0.0231 0.0888 0.3401
Loa Loa (eye worm) DR-78 0.003 0.0061 0.0227
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0064 0.0201 0.0661
Schistosoma mansoni thyroid hormone receptor 0.0064 0.0201 0.0333
Brugia malayi jmjC domain containing protein 0.0115 0.0411 0.1571
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.1488
Plasmodium vivax endoplasmin, putative 0.0033 0.0071 0.1534
Loa Loa (eye worm) hypothetical protein 0.005 0.0141 0.0533
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.039 0.0654
Echinococcus granulosus endoplasmin 0.0026 0.0043 0.0074
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0087 0.0326
Echinococcus multilocularis lamin dm0 0.003 0.0059 0.0059
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.035 0.0587
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.01 0.0443
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0064 0.0201 0.0333
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.039 0.0793
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0061 0.0227
Schistosoma mansoni intermediate filament proteins 0.003 0.0059 0.009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0339 0.1333 1
Schistosoma mansoni heat shock protein 0.0033 0.0071 0.0109
Schistosoma mansoni alpha-glucosidase 0.0142 0.0522 0.0879
Schistosoma mansoni heat shock protein 0.0033 0.0071 0.0109
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.039 0.0786
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.1333 1
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0043 0.0743
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0344 0.2404
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0061 0.0104
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.0788 0.3017
Mycobacterium ulcerans lipase LipD 0.011 0.039 0.0786
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1015 0.7584
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0071 0.0842
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.0201 0.0766
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Schistosoma mansoni alpha-glucosidase 0.0142 0.0522 0.0879
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0076 0.0119
Echinococcus multilocularis endoplasmin 0.0026 0.0043 0.0043
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0059 0.0221
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.01 0.0377
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0133 0.0216
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.1488
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.033 0.033
Onchocerca volvulus 0.0032 0.0067 0.0137
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.0192 0.0192
Loa Loa (eye worm) endoplasmin 0.0033 0.0071 0.0263
Brugia malayi nuclear hormone receptor 0.0064 0.0201 0.0766
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0152 0.0152
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0071 0.1534
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0061 0.0227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0163 0.0163
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0405 0.0752
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0067 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.1182 0.4531
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0168
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0617 0.0617
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0888 0.1513
Echinococcus granulosus dnaJ subfamily B 0.0412 0.1632 0.2782
Echinococcus multilocularis heat shock protein 0.0033 0.0071 0.0071
Trypanosoma brucei hypothetical protein, conserved 0.011 0.039 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.01 0.2251
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0081 0.0474
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0133 0.0216
Echinococcus multilocularis ecdysone induced protein 78C 0.0064 0.0201 0.0201
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.033 0.126
Leishmania major basic transcription factor 3a, putative 0.0035 0.0081 0.1384
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0064 0.0201 0.0201
Echinococcus granulosus lamin 0.003 0.0059 0.0101
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0163 0.0279
Onchocerca volvulus 0.0058 0.0176 0.0561
Echinococcus granulosus zinc finger protein 0.0023 0.0031 0.0052
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0071 0.1476
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0064 0.0201 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0031 0.0058
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0081 0.1135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0137 0.0223
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0081 0.1783
Brugia malayi jmjC domain containing protein 0.0048 0.0133 0.0503
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0061 0.0093
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.039 0.0793
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0076 0.0285
Schistosoma mansoni hypothetical protein 0.1439 0.5867 1
Mycobacterium tuberculosis Conserved protein 0.011 0.039 0.0793
Loa Loa (eye worm) TAR-binding protein 0.007 0.0226 0.0861
Brugia malayi PHD-finger family protein 0.0017 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.057
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.039 0.0793
Brugia malayi CXXC zinc finger family protein 0.0058 0.0176 0.0667
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0339 0.1333 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.013 0.0211
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0071 0.0842
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.0192 0.0729
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.01 0.0443
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0061 0.0061
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0071 0.0227 0.0384
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0108 0.0381 0.064
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0118 0.0421 1
Entamoeba histolytica hypothetical protein 0.0109 0.0386 0.2729
Echinococcus granulosus expressed conserved protein 0.0093 0.0319 0.0544
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0226 0.0861
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0152 0.3501
Toxoplasma gondii ABC1 family protein 0.011 0.039 0.0721
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0138 0.0235
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.0192 0.0327
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0015 0.0015
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0344 0.1314
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0064 0.0201 0.0333
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.1333 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0043 0.0333
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0108 0.0381 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0226 0.0375
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0118 0.0421 1
Entamoeba histolytica hypothetical protein 0.0109 0.0386 0.2729
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0064 0.0201 0.0766
Plasmodium vivax SET domain protein, putative 0.0032 0.0067 0.1437
Schistosoma mansoni patched 1 0.0043 0.0111 0.0178
Echinococcus multilocularis expressed conserved protein 0.0093 0.0319 0.0319
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0071 0.1476
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0019
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.013 0.0491
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0081 0.0303
Echinococcus granulosus GPCR family 2 0.0096 0.033 0.0562
Echinococcus granulosus muscleblind protein 0.0152 0.0564 0.0961
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Brugia malayi Bromodomain containing protein 0.0079 0.0261 0.0993
Trichomonas vaginalis ap endonuclease, putative 0.004 0.01 0.0623
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1198 0.4873 1
Onchocerca volvulus 0.003 0.0061 0.0116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0076 0.0285
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0888 0.0888
Echinococcus multilocularis heat shock protein 90 0.0026 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0064 0.0201 0.0766
Onchocerca volvulus 0.003 0.0059 0.011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0163 0.062
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0061 0.0227
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.039 0.2823
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0112
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0087 0.0428
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0064 0.0201 0.0333
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0043 0.0062
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0087 0.0521
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0166 0.0618 0.1263
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0031 0.0112
Onchocerca volvulus 0.011 0.039 0.1392
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0061 0.0061
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0108 0.0381 0.9775
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0043 0.0188
Loa Loa (eye worm) hypothetical protein 0.0034 0.0076 0.0285
Onchocerca volvulus Alhambra homolog 0.0035 0.0081 0.0193
Leishmania major hypothetical protein, conserved 0.0026 0.0041 0.0281
Schistosoma mansoni hypothetical protein 0.0041 0.0105 0.0168
Schistosoma mansoni hypothetical protein 0.0412 0.1632 0.2774
Schistosoma mansoni lamin 0.003 0.0059 0.009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0067 0.0052
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.039 0.0786
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.01 0.1928
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0035 0.0079 0.1706
Loa Loa (eye worm) hypothetical protein 0.0207 0.0788 0.3017
Trypanosoma brucei heat shock protein, putative 0.0033 0.0071 0.0842
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0201 0.0333
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0061 0.0061
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0152 0.3501
Echinococcus granulosus FTZ F1 alpha 0.0064 0.0201 0.0343
Echinococcus multilocularis transcription factor btf3 0.0035 0.0081 0.0081
Brugia malayi ecdysteroid receptor 0.0064 0.0201 0.0766
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.0192 0.1319
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0108 0.0381 0.0381
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1198 0.4873 1
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Onchocerca volvulus 0.0064 0.0201 0.0661
Schistosoma mansoni hypothetical protein 0.0047 0.013 0.0211
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.1488
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0043 0.0188
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.1488
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0043 0.0025
Schistosoma mansoni bromodomain containing protein 0.0067 0.0212 0.035
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0937 0.6993
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0087 0.0521
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0061 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1015 0.7584
Echinococcus granulosus tumor protein p63 0.034 0.1337 0.2279
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0201 0.0201
Onchocerca volvulus 0.003 0.0059 0.011
Schistosoma mansoni hypothetical protein 0.0096 0.033 0.0552
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0201 0.0766
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0163 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0064 0.0201 0.0766
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.01 0.227
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0052 0.0152 0.0306
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0043 0.0043
Brugia malayi nuclear hormone receptor 0.003 0.0061 0.0227
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0166 0.0618 0.1256
Trichomonas vaginalis esterase, putative 0.011 0.039 0.2823
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0041 0.0692
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.1182 0.4531
Echinococcus multilocularis musashi 0.003 0.0059 0.0059
Schistosoma mansoni thyroid hormone receptor 0.0064 0.0201 0.0333
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0061 0.0104
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0081 0.0138
Plasmodium vivax hypothetical protein, conserved 0.011 0.039 0.9237
Brugia malayi conserved hypotetical protein 0.003 0.0061 0.0227
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0081 0.178
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0087 0.0521
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0111 0.0189
Schistosoma mansoni hypothetical protein 0.0109 0.0386 0.0648
Schistosoma mansoni cpg binding protein 0.0063 0.0197 0.0326
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0152 0.0576
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.0644 0.476
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0108 0.0381 0.1457
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0064 0.0201 0.0201
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0087 0.1554
Brugia malayi Pre-SET motif family protein 0.0032 0.0067 0.0248
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0141 0.0229
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.0201 0.0766
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0043 0.0188
Entamoeba histolytica hypothetical protein 0.0035 0.0081 0.0381
Brugia malayi beta-NAC-like protein 0.0035 0.0081 0.0302
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0052 0.0152 0.3653
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0043 0.0074
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.01 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0133 0.0503
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0617 0.2361
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0313 0.0524
Schistosoma mansoni coup transcription factor 0.0064 0.0201 0.0333
Trypanosoma brucei heat shock protein, putative 0.0033 0.0071 0.0842
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0071 0.1476
Loa Loa (eye worm) hypothetical protein 0.011 0.039 0.1488
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0235 0.0896
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0108 0.0381 0.065
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0064 0.0201 0.0201
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0152 0.0152
Onchocerca volvulus 0.005 0.0141 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0064 0.0201 0.0766
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0081 0.0302
Loa Loa (eye worm) hypothetical protein 0.0029 0.0057 0.0212
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0071 0.1476
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0071 0.0303
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.039 0.0793
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0015 0.0025
Trypanosoma brucei heat shock protein, putative 0.0033 0.0071 0.0842
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0087 0.0521
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0108 0.0381 0.9768
Echinococcus granulosus ecdysone induced protein 78C 0.0064 0.0201 0.0343
Schistosoma mansoni hypothetical protein 0.0062 0.0192 0.0316
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.01 0.0377
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0085 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.0201 0.0766
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.033 0.126
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0152 0.0259
Echinococcus granulosus peregrin 0.0038 0.0091 0.0155
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.039 0.1488
Echinococcus multilocularis peregrin 0.0038 0.0091 0.0091
Brugia malayi beta-lactamase 0.011 0.039 0.1488
Echinococcus multilocularis geminin 0.1439 0.5867 0.5867
Schistosoma mansoni tar DNA-binding protein 0.007 0.0226 0.0375
Schistosoma mansoni hypothetical protein 0.0096 0.033 0.0552
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0163 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0081 0.0474
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0004 0.0007
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0118 0.0421 0.3064
Loa Loa (eye worm) intermediate filament protein 0.003 0.0059 0.0221
Trypanosoma brucei glucosidase, putative 0.0037 0.0087 0.131
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0138 0.0138
Brugia malayi steroid hormone receptor 0.0064 0.0201 0.0766
Loa Loa (eye worm) hypothetical protein 0.0034 0.0076 0.0285
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0069 0.0257
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0031 0.005
Treponema pallidum fructose-bisphosphate aldolase 0.0339 0.1333 1
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Echinococcus granulosus intermediate filament protein 0.003 0.0059 0.0101
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0064 0.0201 0.0343
Schistosoma mansoni tar DNA-binding protein 0.007 0.0226 0.0375
Brugia malayi nuclear receptor NHR-67 0.003 0.0061 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0064 0.0201 0.0766
Loa Loa (eye worm) hypothetical protein 0.0064 0.0201 0.0766
Onchocerca volvulus Bile acid receptor homolog 0.0064 0.0201 0.0661
Brugia malayi hypothetical protein 0.0034 0.0076 0.0285
Echinococcus granulosus geminin 0.1439 0.5867 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0071 0.0842
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0007 0.0008
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0061 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0111 0.0704
Trypanosoma brucei heat shock protein, putative 0.0033 0.0071 0.0842
Brugia malayi Endoplasmin precursor 0.0033 0.0071 0.0263
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.1333 1
Onchocerca volvulus 0.0096 0.033 0.1159
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0061 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0087 0.1912
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1015 0.7584
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.039 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0081 0.0082
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0061 0.0061
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.01 0.0171
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0076 0.0285
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0151
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0108 0.0381 0.2624
Loa Loa (eye worm) hypothetical protein 0.0096 0.033 0.126
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.01 0.0531
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.1015 0.7584
Echinococcus granulosus heat shock protein 90 0.0026 0.0043 0.0074
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.039 0.1488
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0152 0.3373
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0166 0.0618 0.1212
Brugia malayi hypothetical protein 0.0109 0.0386 0.1476
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0137 0.0137
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0087 0.0521
Giardia lamblia Fructose-bisphosphate aldolase 0.0339 0.1333 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0071 0.0213
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0057 0.0097
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0021 0.0074
Schistosoma mansoni endoplasmin 0.0033 0.0071 0.0109
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0061 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0682 0.505
Brugia malayi isocitrate dehydrogenase 0.0052 0.0152 0.0576
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0043 0.0743
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.039 0.0793
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0036 0.0083 0.182
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.01 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0031 0.005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.0201 0.0766
Echinococcus granulosus heat shock protein 0.0033 0.0071 0.012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0064 0.0201 0.0766
Echinococcus granulosus lysine specific demethylase 5A 0.0048 0.0133 0.0227
Loa Loa (eye worm) hypothetical protein 0.006 0.0185 0.0701
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0087 0.0326
Brugia malayi photoreceptor-specific nuclear receptor 0.0064 0.0201 0.0766
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0076 0.013
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0227
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0043 0.0082
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0118 0.0421 0.0786
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0087 0.0148
Echinococcus multilocularis protein dispatched 1 0.0049 0.0136 0.0136
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0064 0.0201 0.0333
Trypanosoma brucei heat shock protein, putative 0.0033 0.0071 0.0842
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0064 0.0201 0.0766
Loa Loa (eye worm) hypothetical protein 0.0099 0.0344 0.1314
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0081 0.178
Echinococcus multilocularis GPCR, family 2 0.0096 0.033 0.033
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Leishmania major heat shock protein 83-1 0.0033 0.0071 0.1099
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0061 0.0227
Echinococcus multilocularis heat shock protein 90 0.0033 0.0071 0.0071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.01 0.227
Schistosoma mansoni zinc finger protein 0.0023 0.0031 0.0041
Leishmania major hypothetical protein, conserved 0.011 0.039 1
Brugia malayi Nuclear hormone receptor E75 0.003 0.0061 0.0227
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0071 0.0227 0.0452
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0386 0.0386
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.039 0.2823
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0071 0.0061
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0061 0.0227
Schistosoma mansoni zinc finger protein 0.003 0.0061 0.0093
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0064 0.0201 0.0343
Echinococcus multilocularis thyroid hormone receptor alpha 0.0064 0.0201 0.0201
Brugia malayi heat shock protein 90 0.0033 0.0071 0.0263
Loa Loa (eye worm) hypothetical protein 0.0152 0.0564 0.2159
Mycobacterium tuberculosis Conserved protein 0.011 0.039 0.0793
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0339 0.1333 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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