Detailed information for compound 1545700

Basic information

Technical information
  • TDR Targets ID: 1545700
  • Name: [2-oxo-2-[(2,3,4,5,6-pentafluorophenyl)amino] ethyl] 2-(4-bromophenyl)acetate
  • MW: 438.144 | Formula: C16H9BrF5NO3
  • H donors: 1 H acceptors: 2 LogP: 3.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccc(cc1)Br)OCC(=O)Nc1c(F)c(F)c(c(c1F)F)F
  • InChi: 1S/C16H9BrF5NO3/c17-8-3-1-7(2-4-8)5-10(25)26-6-9(24)23-16-14(21)12(19)11(18)13(20)15(16)22/h1-4H,5-6H2,(H,23,24)
  • InChiKey: ALEMTSYRWWPXQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-bromophenyl)acetic acid [2-oxo-2-[(2,3,4,5,6-pentafluorophenyl)amino]ethyl] ester
  • 2-(4-bromophenyl)acetic acid [2-keto-2-[(2,3,4,5,6-pentafluorophenyl)amino]ethyl] ester
  • [2-oxo-2-[(2,3,4,5,6-pentafluorophenyl)amino]ethyl] 2-(4-bromophenyl)ethanoate
  • MLS000390969
  • SMR000260006
  • T0508-5119

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.013 0.0875
Onchocerca volvulus 0.0036 0.0158 0.1154
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0174 1
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0174 0.1172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.013 0.1336
Loa Loa (eye worm) hypothetical protein 0.0031 0.013 0.0875
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0158 0.9093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0134 0.0905
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0048 0.0322
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0158 0.9093
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0158 0.1066
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0158 0.1066
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0048 0.0492
Trichomonas vaginalis esterase, putative 0.0036 0.0158 0.1066
Mycobacterium ulcerans glutaminase 0.0271 0.1483 0.1346
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.013 0.0288
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.013 0.0947
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.013 0.0875
Brugia malayi steroid hormone receptor 0.0031 0.013 0.0875
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.013 0.0875
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0158 0.0158
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0158 0.0158
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0174 0.0016
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0172 0.1158
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0038 0.0256
Loa Loa (eye worm) glutaminase 0.0271 0.1483 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0174 0.0174
Brugia malayi hypothetical protein 0.0015 0.0038 0.0256
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0048 0.0322
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1247 0.1247
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.013 0.0875
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0807 0.179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0134 0.0905
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0158 0.7664
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0206 0.139
Entamoeba histolytica hypothetical protein 0.0038 0.0172 0.9262
Schistosoma mansoni nuclear receptor 0.0015 0.0038 0.0256
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.0783 0.8057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0322
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0038 0.0256
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.013 0.0947
Brugia malayi nuclear hormone receptor 0.0015 0.0038 0.0256
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0174 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0172 0.0381
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.013 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.013 0.0875
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0048 0.0322
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0158 0.0158
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0038 0.0256
Echinococcus multilocularis geminin 0.018 0.0972 0.2157
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0158 0.1066
Brugia malayi hypothetical protein 0.0016 0.0048 0.0322
Toxoplasma gondii pantoate-beta-alanine ligase 0.1782 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0038 0.0084
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0174 0.9377
Toxoplasma gondii ABC1 family protein 0.0036 0.0158 0.0158
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0174 0.9377
Onchocerca volvulus 0.0015 0.0038 0.0277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0134 0.0298
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0038 0.0256
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0206 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0134 0.0905
Brugia malayi nuclear receptor RXR 0.0015 0.0038 0.0256
Brugia malayi nuclear hormone receptor 0.0031 0.013 0.0875
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0206 0.0206
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.013 0.1336
Brugia malayi nuclear receptor NHR-88 0.0015 0.0038 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.013 0.0875
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0134 0.1381
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.013 0.0288
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0038 0.0277
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0048 0.0322
Schistosoma mansoni ap endonuclease 0.0039 0.0174 0.1172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.013 0.0875
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Loa Loa (eye worm) hypothetical protein 0.0031 0.013 0.0875
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0158 0.9093
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0038 0.0256
Brugia malayi hypothetical protein 0.0038 0.0172 0.1158
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0158 0.1066
Schistosoma mansoni hypothetical protein 0.018 0.0972 0.6552
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.013 0.0875
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0185 1
Brugia malayi nuclear receptor NHR-88 0.0031 0.013 0.0875
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Entamoeba histolytica hypothetical protein 0.0038 0.0172 0.9262
Mycobacterium tuberculosis Conserved protein 0.0036 0.0158 0.0158
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0174 0.8429
Schistosoma mansoni nuclear receptor 0.0015 0.0038 0.0256
Schistosoma mansoni glutaminase 0.0271 0.1483 1
Schistosoma mansoni hypothetical protein 0.018 0.0972 0.6552
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.013 0.0875
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0128 0.1314
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0185 1
Onchocerca volvulus 0.0251 0.137 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0048 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.013 0.0875
Loa Loa (eye worm) hypothetical protein 0.0031 0.013 0.0875
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0038 0.0084
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0174 0.1172
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.013 0.0875
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0038 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0038 0.0391
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0495 0.3338
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.013 0.0875
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.013 0.1336
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0038 0.0277
Brugia malayi beta-lactamase family protein 0.0036 0.0158 0.1066
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.013 0.0875
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0495 0.3338
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0038 0.0391
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0158 0.1066
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0038 0.0084
Toxoplasma gondii exonuclease III APE 0.0039 0.0174 0.0174
Brugia malayi ecdysteroid receptor 0.0031 0.013 0.0875
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0158 0.0351
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0206 0.2122
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0038 0.0256
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0185 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.013 0.0875
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0322
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0038 0.0391
Onchocerca volvulus 0.0031 0.013 0.0947
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1066
Leishmania major hypothetical protein, conserved 0.0036 0.0158 0.9093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.013 0.0875
Onchocerca volvulus 0.0036 0.0158 0.1154
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.013 0.1336
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0174 0.1789
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.013 0.1336
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.013 0.0288
Loa Loa (eye worm) DR-78 0.0015 0.0038 0.0256
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0174 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0134 0.0905
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0495 0.3338
Brugia malayi ecdysone receptor 0.0015 0.0038 0.0256
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0158 0.0158
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0038 0.0391
Schistosoma mansoni ap endonuclease 0.0039 0.0174 0.1172
Entamoeba histolytica hypothetical protein 0.0038 0.0172 0.9262
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Loa Loa (eye worm) beta-lactamase 0.0036 0.0158 0.1066
Brugia malayi conserved hypotetical protein 0.0015 0.0038 0.0256
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.4506 1
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0038 0.0256
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0158 0.1066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.013 0.0288
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0038 0.0391
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.013 0.0875
Mycobacterium tuberculosis Conserved protein 0.0036 0.0158 0.0158
Brugia malayi glutaminase DH11.1 0.0271 0.1483 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0174 0.0386
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0322
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0495 0.1099
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.013 0.0947
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0038 0.0084
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0905
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0174 0.9377
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0322
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0174 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0038 0.0256
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.1198 0.8079
Schistosoma mansoni nuclear hormone receptor 0.0031 0.013 0.0875
Brugia malayi beta-lactamase 0.0036 0.0158 0.1066
Loa Loa (eye worm) hypothetical protein 0.0031 0.013 0.0875
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.013 0.0288
Onchocerca volvulus 0.0015 0.0038 0.0277
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0158 0.1066
Brugia malayi nuclear receptor RXR 0.0016 0.0048 0.0322
Schistosoma mansoni coup transcription factor 0.0031 0.013 0.0875
Loa Loa (eye worm) acetyltransferase 0.0151 0.0807 0.544
Loa Loa (eye worm) glutaminase 2 0.0271 0.1483 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0174 1
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0174 0.1172
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.013 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.013 0.0288
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.013 0.0875
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0038 0.0256
Brugia malayi beta-lactamase family protein 0.0036 0.0158 0.1066
Schistosoma mansoni thyroid hormone receptor 0.0031 0.013 0.0875
Loa Loa (eye worm) hypothetical protein 0.0031 0.013 0.0875
Echinococcus granulosus geminin 0.018 0.0972 1
Brugia malayi nuclear receptor NHR-67 0.0015 0.0038 0.0256
Brugia malayi tailless protein 0.0015 0.0038 0.0256
Plasmodium vivax SET domain protein, putative 0.0032 0.0134 0.6507
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1782 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0048 0.0322
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0807 0.544
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.013 0.0875
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0134 0.0905
Mycobacterium tuberculosis Conserved protein 0.0036 0.0158 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.013 0.0875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0495 0.3338
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Schistosoma mansoni zinc finger protein 0.0015 0.0038 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.013 0.0875
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0158 0.0158
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0038 0.0391
Schistosoma mansoni hypothetical protein 0.0038 0.0172 0.1158
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0172 0.1767
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.013 0.0875
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.013 0.0875
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0495 0.5095
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.013 0.0875
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0038 0.0256
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0038 0.0256
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0038 0.0084
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0206 0.139
Echinococcus granulosus FTZ F1 alpha 0.0031 0.013 0.1336
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0134 0.0134
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.013 0.1336
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.013 0.0288
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.013 0.0875
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.013 0.0875
Entamoeba histolytica hypothetical protein 0.0038 0.0172 0.9262
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.013 0.1336
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.013 0.0875
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.013 0.1336
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1782 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.013 0.0875
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1066
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0158 0.1626
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0206 0.0206
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0134 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0495 0.3338
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0256
Brugia malayi hypothetical protein 0.0015 0.0038 0.0256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0495 0.1099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.013 0.0875
Onchocerca volvulus 0.0032 0.0134 0.098
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.013 0.0875
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0158 0.1066
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0174 0.1172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1066
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.013 0.0875
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.013 0.0288
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0038 0.0256
Loa Loa (eye worm) hypothetical protein 0.0031 0.013 0.0875
Onchocerca volvulus 0.0036 0.0158 0.1154
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.013 0.0875
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0495 0.5095
Trichomonas vaginalis set domain proteins, putative 0.0251 0.137 0.9236
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0807 0.544
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0038 0.0256
Loa Loa (eye worm) hypothetical protein 0.0031 0.013 0.0875
Trichomonas vaginalis glutaminase, putative 0.0271 0.1483 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0158 0.1066
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0038 0.0256
Schistosoma mansoni thyroid hormone receptor 0.0031 0.013 0.0875
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.013 0.0875
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0174 1
Brugia malayi hypothetical protein 0.0016 0.0048 0.0322
Brugia malayi Pre-SET motif family protein 0.022 0.1198 0.8079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.013 0.0875

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.