Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0042 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0042 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0042 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0042 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0042 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0042 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0042 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0042 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0042 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Animals (functional) | = 0 % | Animals with Ulcers in Carrageenan-induced paw edema test at a dose of 100 mg/kg perorally in rats | ChEMBL. | 11597401 |
Animals (functional) | = 20 % | Animals with Hyperemia in Carrageenan-induced paw edema test at a dose of 100 mg/kg perorally in rats | ChEMBL. | 11597401 |
Edema variation (functional) | = -76.62 % | Percent Edema variation in Carrageenan-induced paw edema test at a dose of 100 mg/kg perorally in rats after 180 min (p<0.001) | ChEMBL. | 11597401 |
Edema variation (functional) | = -30.13 % | Percent Edema variation in Carrageenan-induced paw edema test at a dose of 100 mg/kg perorally in rats after 120 min (p<0.05) | ChEMBL. | 11597401 |
Edema variation (functional) | = -2.13 % | Percent Edema variation in Carrageenan-induced paw edema test at a dose of 100 mg/kg perorally in rats after 60 min | ChEMBL. | 11597401 |
Inhibition (functional) | = 53 % | Analgesic activity was determined using acetic acid writing test at a dose of 100 mg/kg perorally in rats. (p<0.01) | ChEMBL. | 11597401 |
LC50 (ADMET) | > 1000 ug ml-1 | Minimum concentration of the compound which causes 50% of the Artemia salina larvae to lose mobility | ChEMBL. | 11597401 |
LD50 (ADMET) | > 1000 mg kg-1 | Peroral dose of the compound causing 50% death of the mice population | ChEMBL. | 11597401 |
LD50 (ADMET) | > 1000 mg kg-1 | Peroral dose of the compound causing 50% death of the mice population | ChEMBL. | 11597401 |
No. of writhings (functional) | = 9.6 | Number of writhings in Acetic acid Writhing test at a dose of 100 mg/kg perorally in rats | ChEMBL. | 11597401 |
Reaction time (functional) | = 16.8 s | Reaction time in Hot plate test at a dose of 100 mg/kg perorally in rats after 180 min (p<0.05) | ChEMBL. | 11597401 |
Reaction time (functional) | = 26.7 s | Reaction time in Hot plate test at a dose of 100 mg/kg perorally in rats after 120 min (p<0.01) | ChEMBL. | 11597401 |
Reaction time (functional) | = 30.4 s | Reaction time in Hot plate test at a dose of 100 mg/kg perorally in rats after 60 min (p<0.01) | ChEMBL. | 11597401 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.