Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.005 | 0.175 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0166 | 0.9672 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 0.8299 | 0.858 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.8299 | 0.8299 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0171 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | acetyltransferase | 0.0171 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.005 | 0.175 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 0.8299 | 0.8299 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0146 | 0.8299 | 0.8299 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0146 | 0.8299 | 0.858 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.8299 | 0.8299 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.005 | 0.175 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0146 | 0.8299 | 0.8299 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.005 | 0.175 | 0.1809 |
Loa Loa (eye worm) | carboxylesterase | 0.0146 | 0.8299 | 0.8299 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0422 | 0.0422 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 0.8299 | 0.858 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.8299 | 0.8299 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0046 | 0.1463 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.8299 | 0.8299 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0046 | 0.1463 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0422 | 0.0422 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.005 | 0.175 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 0.8299 | 0.8299 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0046 | 0.1463 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0146 | 0.8299 | 0.8299 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.005 | 0.175 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.