Detailed information for compound 1546272

Basic information

Technical information
  • TDR Targets ID: 1546272
  • Name: 3-ethoxy-N-pyridin-2-ylnaphthalene-2-carboxam ide
  • MW: 292.332 | Formula: C18H16N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc2ccccc2cc1C(=O)Nc1ccccn1
  • InChi: 1S/C18H16N2O2/c1-2-22-16-12-14-8-4-3-7-13(14)11-15(16)18(21)20-17-9-5-6-10-19-17/h3-12H,2H2,1H3,(H,19,20,21)
  • InChiKey: TYPDXWDBOSYOBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-ethoxy-N-(2-pyridyl)naphthalene-2-carboxamide
  • 3-ethoxy-N-(2-pyridyl)-2-naphthalenecarboxamide
  • 3-ethoxy-N-(2-pyridyl)-2-naphthamide
  • 3-ethoxy-N-pyridin-2-yl-naphthalene-2-carboxamide
  • A3995/0170227
  • ZINC04708873
  • 3-ethoxy-N-2-pyridinyl-2-naphthamide
  • MLS001001784
  • SMR000499338

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0117 0.0273
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0647 0.1013
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.058 0.1351
Schistosoma mansoni autophagin-1 (C54 family) 0.0061 0.058 0.058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0607 0.0957
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0119 0.143 0.143
Entamoeba histolytica peptidase, C54 family 0.0024 0.0027 0.0471
Echinococcus multilocularis importin subunit beta 1 0.003 0.0117 0.0117
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0146 0.0228
Schistosoma mansoni importin beta-1 0.003 0.0117 0.0117
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0428 0.6007 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0036 0.0059
Loa Loa (eye worm) hypothetical protein 0.0096 0.1088 0.1702
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0146 0.0146
Brugia malayi thymidylate synthase 0.0119 0.143 0.238
Onchocerca volvulus 0.0119 0.143 0.2193
Echinococcus granulosus snurportin 1 0.032 0.4404 0.4404
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0428 0.6007 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0061 0.058 0.0908
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0647 0.0647
Schistosoma mansoni hypothetical protein 0.0043 0.0316 0.0316
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0554 0.0554
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0036 0.0083
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0607 0.1414
Loa Loa (eye worm) hypothetical protein 0.003 0.0117 0.0183
Loa Loa (eye worm) hypothetical protein 0.0454 0.639 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0607 0.1414
Onchocerca volvulus Phospholipase A2 homolog 0.0096 0.1088 0.1656
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0 0.5
Schistosoma mansoni hypothetical protein 0.032 0.4404 0.4404
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0428 0.6007 1
Entamoeba histolytica peptidase, C54 family 0.0024 0.0027 0.0471
Entamoeba histolytica peptidase, C54 family 0.0024 0.0027 0.0471
Loa Loa (eye worm) dihydrofolate reductase 0.0428 0.6007 0.94
Echinococcus multilocularis Peptidase C54 0.0061 0.058 0.058
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.058 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0647 0.0647
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0647 0.0647
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0312 0.4293 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0036 0.0059
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1496 0.234
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.058 1
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0024 0.0027 0.0064
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0316 0.0316
Echinococcus granulosus dihydrofolate reductase 0.0428 0.6007 0.6007
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0119 0.143 0.2334
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0036 0.0083
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0033 0.0572
Loa Loa (eye worm) thymidylate synthase 0.0119 0.143 0.2237
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0316 0.0316
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0554 0.0867
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0554 0.0554
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.5452
Echinococcus granulosus GPCR family 2 0.0032 0.0146 0.0146
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1166 0.1941
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0117 0.0273
Echinococcus multilocularis thymidylate synthase 0.0119 0.143 0.143
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0027 0.0064
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0312 0.4293 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0146 0.0146
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0146 0.0243
Schistosoma mansoni microtubule-associated protein tau 0.0698 1 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0312 0.4293 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1166 0.1824
Brugia malayi hypothetical protein 0.0043 0.0316 0.0527
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0647 0.0647
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0117 0.0273
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0146 0.0146
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0036 0.0614
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0032 0.0146 0.0146
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0119 0.143 0.2334
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.058 0.058
Echinococcus multilocularis cysteine protease atg4b 0.0061 0.058 0.058
Brugia malayi hypothetical protein 0.0056 0.0509 0.0848
Brugia malayi MH2 domain containing protein 0.0123 0.1496 0.249
Plasmodium vivax importin-beta 2, putative 0.003 0.0117 0.0273
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0056
Echinococcus granulosus importin subunit beta 1 0.003 0.0117 0.0117
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0607 0.0607
Brugia malayi Peptidase family C54 containing protein 0.0061 0.058 0.0966
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0607 0.0957
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.5452
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0036 0.0614
Schistosoma mansoni hypothetical protein 0.0032 0.0146 0.0146
Echinococcus granulosus tar DNA binding protein 0.0066 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0056
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0146 0.0243
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0694 0.1155
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1496 0.234
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0312 0.4293 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0647 0.1078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1166 0.1941
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0607 0.0957
Brugia malayi Dihydrofolate reductase 0.0428 0.6007 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.058 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0146 0.0146
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.058 0.058
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0312 0.4293 1
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.5452
Plasmodium falciparum importin beta, putative 0.003 0.0117 0.0273
Schistosoma mansoni dihydrofolate reductase 0.0428 0.6007 0.6007
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0033 0.0077
Echinococcus multilocularis microtubule associated protein 2 0.0698 1 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0647 0.1013
Plasmodium falciparum cysteine protease ATG4, putative 0.0024 0.0027 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0647 0.0647
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0554 0.0554
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0033 0.0572
Brugia malayi TAR-binding protein 0.0066 0.0647 0.1078
Brugia malayi dihydrofolate reductase family protein 0.0428 0.6007 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0312 0.4293 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.4404 0.6892
Brugia malayi jmjC domain containing protein 0.006 0.0554 0.0922
Echinococcus granulosus Peptidase C54 0.0061 0.058 0.058
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0607 0.0607
Entamoeba histolytica hypothetical protein 0.0024 0.0033 0.0572
Schistosoma mansoni hypothetical protein 0.0069 0.0694 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0027 0.0064
Echinococcus multilocularis snurportin 1 0.032 0.4404 0.4404
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0056 0.0509 0.1186
Leishmania major importin beta-1 subunit, putative 0.0024 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0032 0.0146 0.0228
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0036 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0607 0.0957
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.058 0.1351
Schistosoma mansoni hypothetical protein 0.0032 0.0146 0.0146
Entamoeba histolytica hypothetical protein 0.0043 0.0316 0.5452
Entamoeba histolytica peptidase, C54 family 0.0024 0.0027 0.0471
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0033 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0509 0.8775
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.058 1
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0027 0.0064
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.058 0.1351
Mycobacterium tuberculosis Hypothetical protein 0.0056 0.0509 0.0793
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0647 0.1013
Brugia malayi RNA binding protein 0.0066 0.0647 0.1078
Brugia malayi Importin beta-1 subunit 0.003 0.0117 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0056
Loa Loa (eye worm) hypothetical protein 0.0101 0.1166 0.1824
Entamoeba histolytica peptidase, C54 family 0.0061 0.058 1
Schistosoma mansoni jumonji domain containing protein 0.006 0.0554 0.0554
Mycobacterium ulcerans thymidylate synthase 0.0119 0.143 0.2334
Loa Loa (eye worm) hypothetical protein 0.0069 0.0694 0.1086
Onchocerca volvulus Phospholipase A2 homolog 0.0454 0.639 1
Echinococcus multilocularis dihydrofolate reductase 0.0428 0.6007 0.6007
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0554 0.0554
Echinococcus granulosus cysteine protease atg4b 0.0061 0.058 0.058
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.058 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0554 0.0554
Brugia malayi RNA, U transporter 1 0.0085 0.0934 0.1555
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0607 0.0607
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0554 0.0554
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0607 0.0607
Brugia malayi Phospholipase A2 family protein 0.0096 0.1088 0.1811
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0036 0.0614
Chlamydia trachomatis dihydrofolate reductase 0.0428 0.6007 0.5
Brugia malayi jmjC domain containing protein 0.006 0.0554 0.0922
Echinococcus granulosus thymidylate synthase 0.0119 0.143 0.143
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0036 0.0059
Schistosoma mansoni hypothetical protein 0.0032 0.0146 0.0146
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0027 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0647 0.0647

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 5.3582 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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