Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.5463 | 0.4979 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9228 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0535 | 0.0592 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3818 | 0.4014 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.9039 | 0.8936 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.5463 | 0.5833 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2617 | 0.2684 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1992 | 0.1993 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0535 | 0.0592 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0535 | 0.0592 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.5463 | 0.4979 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4163 | 0.4395 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3514 | 0.3678 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7886 | 0.8724 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.5463 | 0.5833 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2617 | 0.2895 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3378 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3391 | 0.3541 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.3514 | 0.2824 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2617 | 0.183 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0191 | 0.0211 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.9039 | 0.979 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.3514 | 0.7399 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.405 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.